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ES8704976A1 - Metodo pra la fabricacion de un polipeptido firiologicamente activo en el hombre. - Google Patents

Metodo pra la fabricacion de un polipeptido firiologicamente activo en el hombre.

Info

Publication number
ES8704976A1
ES8704976A1 ES541920A ES541920A ES8704976A1 ES 8704976 A1 ES8704976 A1 ES 8704976A1 ES 541920 A ES541920 A ES 541920A ES 541920 A ES541920 A ES 541920A ES 8704976 A1 ES8704976 A1 ES 8704976A1
Authority
ES
Spain
Prior art keywords
physiologically active
active polypeptide
novel human
human physiologically
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541920A
Other languages
English (en)
Other versions
ES541920A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Asahi Kasei Corp
Asahi Chemical Industry Co Ltd
Original Assignee
Asahi Chemical Industry Co Ltd
Asahi Kasei Kogyo KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Chemical Industry Co Ltd, Asahi Kasei Kogyo KK filed Critical Asahi Chemical Industry Co Ltd
Publication of ES541920A0 publication Critical patent/ES541920A0/es
Publication of ES8704976A1 publication Critical patent/ES8704976A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/828—Cancer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Image Analysis (AREA)

Abstract

METODO DE PRODUCCION DE POLIPEPTIDOS FISIOLOGICAMENTE ACTIVOS. CONSISTE EN LIGAR UN DNA QUE CODIFICA PARA UN POLIPEPTIDO QUE TIENE ACTIVIDAD DE FACTOR DE NECROSIS TUMORAL A UN VEHICULO DE EXPRESION REPLICABLE; TRANSFORMAR CELULAS DE UN MICROORGANISMO O DE UN CULTIVO DE CELULAS CON EL DNA RECOMBINANTE REPLICABLE ASI FORMADO; SELECCIONAR LOS TRANSFORMANTES DE CELULAS OBTENIDOS E INCUBARLOS HACIENDO QUE EXPRESEN DICHO DNA; Y AISLAR EL POLIPEPTIDO ASI PRODUCIDO. ESTOS POLIPEPTIDOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTITUMORAL.
ES541920A 1984-04-06 1985-04-03 Metodo pra la fabricacion de un polipeptido firiologicamente activo en el hombre. Expired ES8704976A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/597,372 US4879226A (en) 1984-04-06 1984-04-06 Novel human physiologically active polypeptide

Publications (2)

Publication Number Publication Date
ES541920A0 ES541920A0 (es) 1987-05-01
ES8704976A1 true ES8704976A1 (es) 1987-05-01

Family

ID=24391235

Family Applications (1)

Application Number Title Priority Date Filing Date
ES541920A Expired ES8704976A1 (es) 1984-04-06 1985-04-03 Metodo pra la fabricacion de un polipeptido firiologicamente activo en el hombre.

Country Status (39)

Country Link
US (1) US4879226A (es)
EP (2) EP0158286A3 (es)
JP (1) JPS60252496A (es)
KR (1) KR920007399B1 (es)
AR (1) AR240475A1 (es)
AU (2) AU595480B2 (es)
BE (1) BE902119A (es)
BG (1) BG43355A3 (es)
BR (1) BR8501624A (es)
CA (1) CA1341348C (es)
CH (2) CH672790A5 (es)
DD (1) DD251785A5 (es)
DK (1) DK151985A (es)
EG (1) EG17965A (es)
ES (1) ES8704976A1 (es)
FI (1) FI86992C (es)
FR (1) FR2564097B1 (es)
GB (1) GB2158829B (es)
GR (1) GR850836B (es)
HK (1) HK102192A (es)
HU (1) HUT37813A (es)
IE (1) IE58833B1 (es)
IL (1) IL74804A (es)
IN (1) IN163653B (es)
IT (1) IT1218469B (es)
JO (1) JO1365B1 (es)
LU (1) LU85835A1 (es)
MA (1) MA20402A1 (es)
MT (1) MTP963B (es)
MY (1) MY101887A (es)
NO (1) NO174473C (es)
NZ (2) NZ211666A (es)
OA (1) OA07983A (es)
PL (1) PL156392B1 (es)
PT (1) PT80239B (es)
RO (1) RO93650B (es)
SG (1) SG77892G (es)
YU (1) YU57885A (es)
ZA (1) ZA852563B (es)

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US5288852A (en) * 1984-03-06 1994-02-22 Dainippon Pharmaceutical Co., Ltd. Human tumor necrosis factor polypeptides
JP2584206B2 (ja) * 1984-08-17 1997-02-26 大日本製薬株式会社 ヒト癌壊死因子
EP0155549B1 (en) * 1984-03-06 1991-03-20 Dainippon Pharmaceutical Co., Ltd. Dna encoding human tumor necrosis factor and human tumor necrosis factor polypeptide
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
JPS60228297A (ja) * 1984-04-24 1985-11-13 株式会社　東京タツノ 給油装置
US5672347A (en) * 1984-07-05 1997-09-30 Genentech, Inc. Tumor necrosis factor antagonists and their use
US6686455B1 (en) * 1984-07-05 2004-02-03 Genentech, Inc. Tumor necrosis factor
GR851626B (es) * 1984-07-05 1985-11-26 Genentech Inc
EP0200748B1 (en) * 1984-10-15 1991-02-06 Cetus Corporation Human tumor necrosis factor
JP2675294B2 (ja) * 1984-10-15 1997-11-12 カイロン コーポレイション ヒト腫瘍壊死因子
US4959314A (en) 1984-11-09 1990-09-25 Cetus Corporation Cysteine-depleted muteins of biologically active proteins
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IL73883A (en) * 1984-12-20 1990-12-23 Yeda Res & Dev Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
EP0216786B1 (en) * 1984-12-21 1992-03-18 Biogen, Inc. Purification, production and use of tumor necrosis factors
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US5342613A (en) * 1988-12-27 1994-08-30 Health Research Inc. Pharmaceutical compositions and use thereof in the treatment of psoriasis
CA2003981C (en) * 1988-12-27 2000-06-13 Hiroshi Ishimaru Pharmaceutical compositions and use thereof in the treatment of psoriasis
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AU5940090A (en) 1989-08-16 1991-04-03 Cetus Oncology Corporation Compositions for the inhibition of protein hormone formation and uses thereof
US6586222B1 (en) 1989-08-16 2003-07-01 Chiron Corporation Recombinant PR-3 and compositions thereof
US5998378A (en) * 1989-08-16 1999-12-07 Chiron Corporation Compositions for the inhibition of TNF hormone formation and uses thereof
US5843693A (en) * 1989-08-16 1998-12-01 Chiron Corporation Assay method for screening for inhibitors of proTNF conversion
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US5653974A (en) * 1990-10-18 1997-08-05 Board Of Regents,The University Of Texas System Preparation and characterization of liposomal formulations of tumor necrosis factor
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Also Published As

Publication number Publication date
IN163653B (es) 1988-10-22
BG43355A3 (en) 1988-05-16
GB2158829B (en) 1992-04-22
HUT37813A (en) 1986-02-28
GR850836B (es) 1985-06-26
NZ231317A (en) 1991-01-29
EP0158286A3 (en) 1987-05-13
EG17965A (en) 1994-01-30
FI86992C (fi) 1992-11-10
CA1341348C (en) 2002-03-19
AR240475A1 (es) 1990-04-30
RO93650B (ro) 1988-03-31
MTP963B (en) 1985-11-25
IT8520242A0 (it) 1985-04-05
ES541920A0 (es) 1987-05-01
BE902119A (fr) 1985-10-04
KR850007273A (ko) 1985-12-02
IL74804A (en) 1991-06-30
PT80239A (en) 1985-05-01
IE58833B1 (en) 1993-11-17
DK151985D0 (da) 1985-04-03
PL156392B1 (pl) 1992-03-31
NZ211666A (en) 1990-01-29
BR8501624A (pt) 1985-12-03
IL74804A0 (en) 1985-07-31
US4879226A (en) 1989-11-07
AU637054B2 (en) 1993-05-20
GB8508864D0 (en) 1985-05-09
EP0158286A2 (en) 1985-10-16
PT80239B (pt) 1988-02-17
FR2564097A1 (fr) 1985-11-15
NO174473B (no) 1994-01-31
FR2564097B1 (fr) 1989-09-22
NO851400L (no) 1985-10-07
YU57885A (en) 1989-02-28
PL252807A1 (en) 1986-02-25
IT1218469B (it) 1990-04-19
DK151985A (da) 1985-10-07
ZA852563B (en) 1986-05-28
JPH025760B2 (es) 1990-02-05
LU85835A1 (fr) 1985-12-16
IE850863L (en) 1985-10-06
FI86992B (fi) 1992-07-31
FI851336L (fi) 1985-10-07
GB2158829A (en) 1985-11-20
NO174473C (no) 1994-05-11
AU595480B2 (en) 1990-04-05
JPS60252496A (ja) 1985-12-13
MY101887A (en) 1992-02-15
RO93650A (ro) 1988-03-30
CH675423A5 (es) 1990-09-28
KR920007399B1 (ko) 1992-08-31
AU4016289A (en) 1989-12-07
SG77892G (en) 1992-10-02
MA20402A1 (fr) 1985-12-31
DD251785A5 (de) 1987-11-25
EP0354592A1 (en) 1990-02-14
HK102192A (en) 1992-12-24
CH672790A5 (es) 1989-12-29
JO1365B1 (en) 1986-11-30
OA07983A (en) 1987-01-31
FI851336A0 (fi) 1985-04-03
AU4088285A (en) 1985-10-10

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