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ES8703481A1 - Un procedimiento para la preparacion de fosfatidos de eter de glicol - Google Patents

Un procedimiento para la preparacion de fosfatidos de eter de glicol

Info

Publication number
ES8703481A1
ES8703481A1 ES550920A ES550920A ES8703481A1 ES 8703481 A1 ES8703481 A1 ES 8703481A1 ES 550920 A ES550920 A ES 550920A ES 550920 A ES550920 A ES 550920A ES 8703481 A1 ES8703481 A1 ES 8703481A1
Authority
ES
Spain
Prior art keywords
residues
alkyl
residue
substituted
glycerin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES550920A
Other languages
English (en)
Other versions
ES550920A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES8703481A1 publication Critical patent/ES8703481A1/es
Publication of ES550920A0 publication Critical patent/ES550920A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/13—Saturated ethers containing hydroxy or O-metal groups
    • C07C43/135—Saturated ethers containing hydroxy or O-metal groups having more than one ether bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE FOSFATIDOS DE ETER DE GLICOL. CONSISTENTE EN: HACER REACCIONAR UN ETER DE GLICEROL DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UNA BASE ORGANICA COMO LA TRIETILAMINA, PIRIDINA O COLIDINA, EN UN DISOLVENTE ORGANICO INERTE COMO BENCENO, TOLUENO O CLOROFORMO, A TEMPERATURAS ENTRE 0JC Y LA TEMPERATURA AMBIENTE; Y LUEGO CON UNA TRI-ALQUILAMINA INFERIOR PARA OBTENER LOS COMPUESTOS DE FORMULA (I). SIENDO: DOS DE LOS RADICALES R1, R2 Y R3 RADICALES ALQUILO DE 10 A 30C CON POR LO MENOS 8C EN UNA CADENA LINEAL, ESTANDO AL MENOS UNO DE ELLOS SUSTITUIDO POR AL MENOS DOS RADICALES ALQUILO DE 1 A 3 C, Y SIENDO LA SUMA DE LOS C EN LOS DOS RADICALES SUPERIOR A 20; Y EL TERCER RADICAL ES UN RADICAL -P(O)(OC)OR4 DONDE R4 ES UN RADICAL ALQUILO INFERIOR U OTROS; R11, R12 Y R13, UNO ES H Y EL RESTO RADICALES ALQUILO DE 10 A 30C; Y M ES 2 O 3. UTILES PARA SOLUBILIZAR MEDICAMENTOS LIPOSOLUBLES EN SISTEMAS ACUOSOS.
ES550920A 1984-03-15 1986-01-16 Un procedimiento para la preparacion de fosfatidos de eter de glicol Expired ES8703481A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH128784 1984-03-15
CH49185 1985-02-04

Publications (2)

Publication Number Publication Date
ES8703481A1 true ES8703481A1 (es) 1987-02-16
ES550920A0 ES550920A0 (es) 1987-02-16

Family

ID=25684726

Family Applications (2)

Application Number Title Priority Date Filing Date
ES541242A Expired ES8606233A1 (es) 1984-03-15 1985-03-14 Un procedimiento para la preparacion de fosfatidos de eter de glicol
ES550920A Expired ES8703481A1 (es) 1984-03-15 1986-01-16 Un procedimiento para la preparacion de fosfatidos de eter de glicol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES541242A Expired ES8606233A1 (es) 1984-03-15 1985-03-14 Un procedimiento para la preparacion de fosfatidos de eter de glicol

Country Status (16)

Country Link
US (1) US4694084A (es)
EP (1) EP0154977B1 (es)
AR (1) AR241022A1 (es)
AU (1) AU574440B2 (es)
CA (1) CA1264162A (es)
DE (1) DE3570239D1 (es)
DK (1) DK117985A (es)
ES (2) ES8606233A1 (es)
FI (1) FI78299C (es)
HU (1) HU195828B (es)
IL (1) IL74540A (es)
MC (1) MC1649A1 (es)
NO (1) NO851006L (es)
NZ (1) NZ211368A (es)
PH (1) PH20750A (es)
PT (1) PT80112B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1319886C (en) 1987-02-03 1993-07-06 Alberto Ferro Mixed micelle solutions
US4962096A (en) * 1987-03-24 1990-10-09 Nippon Chemiphar Co., Ltd. Heterocyclic glycerol derivatives and their use as anti-hypertensive agents
CA2033725C (en) * 1990-01-24 2001-05-29 Folker Pittrof Pharmaceutical and cosmetic compositions containing a salt of cholanic acid
FR2687314A1 (fr) * 1992-02-18 1993-08-20 Oreal Dispersion de vesicules lipidiques, composition cosmetique et/ou pharmaceutique la contenant et procede de preparation de ladite dispersion.
AU2245295A (en) * 1994-04-15 1995-11-10 Hemagen/Pfc Fluorochemical emulsions containing 1,3-dialkylglycerophosphoryl choline surfactants and methods of use
JP2740153B2 (ja) * 1995-03-07 1998-04-15 エフ・ホフマン−ラ ロシユ アーゲー 混合ミセル
CN1268321C (zh) * 2001-07-13 2006-08-09 那野伽利阿株式会社 内部包有药物的高分子胶束的冻结干燥用组合物和该胶束的制备方法
AU2002951216A0 (en) * 2002-09-05 2002-09-19 Dbl Australia Pty Ltd Surfactants and lyotropic phases formed therefrom
WO2005021046A1 (en) * 2003-09-01 2005-03-10 Fh Faulding & Co Ltd Compositions and methods for delivery of biologically active agents
DE102005016152A1 (de) * 2005-04-07 2006-10-12 Basf Ag Herstellung von (Co)Tensiden durch Umsetzung von Polyolen mit Olefinen
CA2856742A1 (en) 2011-12-07 2013-06-13 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
WO2016037128A1 (en) 2014-09-04 2016-03-10 Nano Precision Medical, Inc. Polymeric stabilizing formulations
US12071516B2 (en) 2014-09-04 2024-08-27 Nano Precision Medical, Inc. Polymeric stabilizing formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (it) * 1976-07-12 1989-02-09 Hoffmann La Roche Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti
DE2820893C2 (de) * 1978-05-12 1986-02-20 A. Nattermann & Cie GmbH, 5000 Köln Strukturanaloga von natürlichen Phospholipiden und Verfahren zur Herstellung dieser Verbindungen
CA1173360A (en) * 1979-06-22 1984-08-28 Jurg Schrank Pharmaceutical preparations
DE3011738A1 (de) * 1980-03-26 1981-10-01 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Neue glycerin-3-phosphorsaeurehalogenalkylester
IL64397A0 (en) * 1981-01-07 1982-02-28 Weder Hans G Process for the preparation of liposomal medicaments
US4493832A (en) * 1981-07-03 1985-01-15 Fujisawa Pharmaceutical Co., Ltd. Certain glycerol-phosphoryl choline derivatives, compositions containing same and method of using same
US4562179A (en) * 1982-04-19 1985-12-31 Fujisawa Pharmaceutical Co., Ltd. Phospholipid derivatives, and pharmaceutical composition of the same
JPS59163389A (ja) * 1983-03-07 1984-09-14 Takeda Chem Ind Ltd リン脂質
JPS59184195A (ja) * 1983-04-04 1984-10-19 Takeda Chem Ind Ltd グリセロ−ル誘導体

Also Published As

Publication number Publication date
PT80112A (en) 1985-04-01
AU3971085A (en) 1985-09-19
EP0154977A2 (de) 1985-09-18
NO851006L (no) 1985-09-16
AR241022A1 (es) 1991-04-30
CA1264162A (en) 1990-01-02
HU195828B (en) 1988-07-28
EP0154977A3 (en) 1986-02-19
IL74540A (en) 1989-02-28
IL74540A0 (en) 1985-06-30
NZ211368A (en) 1988-11-29
FI78299B (fi) 1989-03-31
ES8606233A1 (es) 1986-04-16
PH20750A (en) 1987-04-02
PT80112B (en) 1987-03-24
FI850972A0 (fi) 1985-03-12
MC1649A1 (fr) 1986-04-07
DK117985D0 (da) 1985-03-14
DE3570239D1 (en) 1989-06-22
FI78299C (fi) 1989-07-10
DK117985A (da) 1985-09-16
ES541242A0 (es) 1986-04-16
HUT36824A (en) 1985-10-28
EP0154977B1 (de) 1989-05-17
FI850972L (fi) 1985-09-16
US4694084A (en) 1987-09-15
AR241022A2 (es) 1991-04-30
ES550920A0 (es) 1987-02-16
AU574440B2 (en) 1988-07-07

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