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ES8407018A1 - Procedimiento para la sintesis de 1-4-isopropiltiofenil)-2-n.octilaminopropanol. - Google Patents

Procedimiento para la sintesis de 1-4-isopropiltiofenil)-2-n.octilaminopropanol.

Info

Publication number
ES8407018A1
ES8407018A1 ES522440A ES522440A ES8407018A1 ES 8407018 A1 ES8407018 A1 ES 8407018A1 ES 522440 A ES522440 A ES 522440A ES 522440 A ES522440 A ES 522440A ES 8407018 A1 ES8407018 A1 ES 8407018A1
Authority
ES
Spain
Prior art keywords
synthesis
octylaminopropanol
isopropylthiophenyl
ester
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522440A
Other languages
English (en)
Other versions
ES522440A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Continental Pharma Inc
Original Assignee
Continental Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Continental Pharma Inc filed Critical Continental Pharma Inc
Publication of ES8407018A1 publication Critical patent/ES8407018A1/es
Publication of ES522440A0 publication Critical patent/ES522440A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C1/00—Preparation of hydrocarbons from one or more compounds, none of them being a hydrocarbon
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA SINTESIS DE 1-(4-ISOPROPILTIOFENIL) -2-N.OCTILAMINOPROPANOL.CONSISTE EN SOMETER 1-(4-TIOFENILO)-2-N.OCTALAMINOPROPANOL A UN PROCESO DE ALQUILACION, HACIENDO REACCIONAR ESTE CON UN AGENTE ALQUILIZANTE IC3H7X, PARA OBTENER COMPUESTOS DE FORMULA (I), DONDE X REPRESENTA UN GRUPO ELIMINABLE, CON PROPENO EN MEDIO ACIDO. LA REACCION SE REALIZA EN PRESENCIA DE AGUA O DE UN DISOLVENTE ORGANICO INERTE TAL COMO CLOROFORMO O DICLOROMETANO; UNA BASE ORGANICA TAL COMO HIDROXIDO SODICO O POTASICO; UN CATALIZADOR DE TRANSFERENCIA DE FASE TAL COMO HIDROXIDO DE TETRA-N.BUTILAMONIO.
ES522440A 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil)-2-n.octilaminopropanol. Granted ES522440A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU83039A LU83039A1 (fr) 1980-12-24 1980-12-24 Procedes de synthese du 1-(4 isopropylthiophenyl)-2-n octylaminopropanol

Publications (2)

Publication Number Publication Date
ES8407018A1 true ES8407018A1 (es) 1984-08-16
ES522440A0 ES522440A0 (es) 1984-08-16

Family

ID=19729552

Family Applications (4)

Application Number Title Priority Date Filing Date
ES508313A Granted ES508313A0 (es) 1980-12-24 1981-12-23 "procedimiento para la sintesis de 1-(4-isopropiltiofenil)-2-n.-octilaminopropanol".
ES522442A Granted ES522442A0 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol.
ES522441A Granted ES522441A0 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol.
ES522440A Granted ES522440A0 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil)-2-n.octilaminopropanol.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES508313A Granted ES508313A0 (es) 1980-12-24 1981-12-23 "procedimiento para la sintesis de 1-(4-isopropiltiofenil)-2-n.-octilaminopropanol".
ES522442A Granted ES522442A0 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol.
ES522441A Granted ES522441A0 (es) 1980-12-24 1983-05-16 Procedimiento para la sintesis de 1-4-isopropiltiofenil-2n.octilaminopropanol.

Country Status (11)

Country Link
JP (4) JPS5912665B2 (es)
KR (1) KR860000340B1 (es)
AR (1) AR229799A1 (es)
AT (1) AT380872B (es)
AU (1) AU548084B2 (es)
CH (2) CH654296A5 (es)
ES (4) ES508313A0 (es)
IL (1) IL64631A0 (es)
IT (1) IT1140399B (es)
LU (1) LU83039A1 (es)
PT (1) PT74203B (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1321701A (en) * 1969-10-01 1973-06-27 Continental Pharma Amino-alcohols their salts and process for prepairing the same
GB1390748A (en) * 1973-04-09 1975-04-16 Continental Pharma Alkyl and cycloalkylthiophenylalkylaminoalkanols their salts and the preparation thereof
LU77237A1 (es) * 1977-05-03 1979-01-18
IT1082122B (it) * 1977-07-11 1985-05-21 Medea Res Srl Processo per la preparazione dell'1-(4-isopropilmercapto-fenil)-2-n.ottilammino-propanolo
LU79970A1 (fr) * 1978-07-13 1980-02-14 Continental Pharma Procede de preparation de derives de 1-phenyl-1-propanol

Also Published As

Publication number Publication date
KR830007541A (ko) 1983-10-21
IT1140399B (it) 1986-09-24
CH653325A5 (en) 1985-12-31
PT74203B (fr) 1983-05-20
ES8407019A1 (es) 1984-08-16
JPS5915905B2 (ja) 1984-04-12
CH654296A5 (en) 1986-02-14
LU83039A1 (fr) 1982-07-07
ES522441A0 (es) 1984-08-16
ES8308844A1 (es) 1983-10-01
AU7902581A (en) 1982-07-01
ES8407020A1 (es) 1984-08-16
JPS58113169A (ja) 1983-07-05
JPS5938224B2 (ja) 1984-09-14
ES522440A0 (es) 1984-08-16
JPS5915906B2 (ja) 1984-04-12
JPS58113171A (ja) 1983-07-05
IT8125853A0 (it) 1981-12-24
ES522442A0 (es) 1984-08-16
ATA549881A (de) 1985-12-15
JPS58113170A (ja) 1983-07-05
AU548084B2 (en) 1985-11-21
PT74203A (fr) 1982-01-01
AT380872B (de) 1986-07-25
KR860000340B1 (ko) 1986-04-12
JPS57134459A (en) 1982-08-19
AR229799A1 (es) 1983-11-30
IL64631A0 (en) 1982-03-31
ES508313A0 (es) 1983-10-01
JPS5912665B2 (ja) 1984-03-24

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