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ES8406481A1 - Bicyclic compounds - Google Patents

Bicyclic compounds

Info

Publication number
ES8406481A1
ES8406481A1 ES518724A ES518724A ES8406481A1 ES 8406481 A1 ES8406481 A1 ES 8406481A1 ES 518724 A ES518724 A ES 518724A ES 518724 A ES518724 A ES 518724A ES 8406481 A1 ES8406481 A1 ES 8406481A1
Authority
ES
Spain
Prior art keywords
general formula
image
group
compound
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES518724A
Other languages
Spanish (es)
Other versions
ES518724A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of ES518724A0 publication Critical patent/ES518724A0/en
Publication of ES8406481A1 publication Critical patent/ES8406481A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Bicyclic compounds of the general formula (I), < IMAGE > wherein Y<1> and Y<2> represent a removable carbonyl protecting group, and Q is a C1-5 alkyl group or a substituted benzyl group, are prepared in such a way that a) a compound of the general formula (V), < IMAGE > wherein Y<1> and Y<2> are as defined above and R' is a removable amido protecting group other than phenyl group, is activated on the carboxy group and then reacted with a salt of a malonic acid hemiester, wherein the alcohol component is a C1-5 aliphatic alcohol or a substituted benzyl alcohol, the resulting new compound of the general formula (IV), < IMAGE > wherein R', Q, Y<1> and Y<2> are as defined above, is reacted with a sulfonic azide in the presence of a tertiary amine, or b) a compound of the general formula (V) is activated on its carboxy group and reacted then with a diazoacetic acid ester, thereafter the R' protecting group of a resulting new compound of the general formula (III> < IMAGE > is removed, and the resulting compound of the general formula (II> < IMAGE > is subjected to ring closure to form the desired end-product.
ES518724A 1981-12-30 1982-12-30 Bicyclic compounds Expired ES8406481A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU814016A HU185492B (en) 1981-12-30 1981-12-30 Process for producing new azetidinyl-butanoates

Publications (2)

Publication Number Publication Date
ES518724A0 ES518724A0 (en) 1984-07-16
ES8406481A1 true ES8406481A1 (en) 1984-07-16

Family

ID=10966525

Family Applications (1)

Application Number Title Priority Date Filing Date
ES518724A Expired ES8406481A1 (en) 1981-12-30 1982-12-30 Bicyclic compounds

Country Status (18)

Country Link
JP (1) JPS58118589A (en)
AT (1) AT376218B (en)
AU (1) AU9197282A (en)
BE (1) BE895491A (en)
CA (1) CA1191854A (en)
DE (1) DE3248677A1 (en)
ES (1) ES8406481A1 (en)
FI (1) FI824521L (en)
FR (1) FR2519003A1 (en)
GB (1) GB2114123B (en)
GR (1) GR77072B (en)
HU (1) HU185492B (en)
IT (1) IT1218332B (en)
LU (1) LU84570A1 (en)
NL (1) NL8205066A (en)
PL (1) PL239883A1 (en)
SE (1) SE8207479L (en)
ZA (1) ZA829599B (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536334A (en) * 1979-06-28 1985-08-20 Sumitomo Chemical Company, Limited Preparation of β-lactam derivatives
IE52147B1 (en) * 1980-03-27 1987-07-08 Merck & Co Inc 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation

Also Published As

Publication number Publication date
PL239883A1 (en) 1984-01-02
DE3248677A1 (en) 1983-07-07
FI824521A0 (en) 1982-12-30
FI824521L (en) 1983-07-01
GB2114123B (en) 1985-10-02
AU9197282A (en) 1983-07-07
ES518724A0 (en) 1984-07-16
BE895491A (en) 1983-06-28
SE8207479L (en) 1983-07-01
LU84570A1 (en) 1984-10-22
IT8225064A0 (en) 1982-12-30
IT1218332B (en) 1990-04-12
CA1191854A (en) 1985-08-13
ZA829599B (en) 1983-10-26
JPS58118589A (en) 1983-07-14
FR2519003A1 (en) 1983-07-01
HU185492B (en) 1985-02-28
GB2114123A (en) 1983-08-17
AT376218B (en) 1984-10-25
NL8205066A (en) 1983-07-18
GR77072B (en) 1984-09-05
SE8207479D0 (en) 1982-12-29
ATA453582A (en) 1984-03-15

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