[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES8401754A1 - "procedimiento de preparar derivados sulfonato". - Google Patents

"procedimiento de preparar derivados sulfonato".

Info

Publication number
ES8401754A1
ES8401754A1 ES513184A ES513184A ES8401754A1 ES 8401754 A1 ES8401754 A1 ES 8401754A1 ES 513184 A ES513184 A ES 513184A ES 513184 A ES513184 A ES 513184A ES 8401754 A1 ES8401754 A1 ES 8401754A1
Authority
ES
Spain
Prior art keywords
derivative
compositions containing
preparing same
sulfonate derivatives
antilipemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513184A
Other languages
English (en)
Other versions
ES513184A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP7853081A external-priority patent/JPS57193444A/ja
Priority claimed from JP21295081A external-priority patent/JPS58135850A/ja
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of ES513184A0 publication Critical patent/ES513184A0/es
Publication of ES8401754A1 publication Critical patent/ES8401754A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/64—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/18—Saturated compounds containing keto groups
    • C07C62/24—Saturated compounds containing keto groups the keto group being part of a ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO DE PREPARAR DERIVADOS SULFONATO.CONSISTE EN HACER REACCIONAR COMPUESTOS DE FORMULA GENERAL (II) CON COMPUESTOS DE FORMULA GENERAL (III) PARA OBTENER DERIVADOS SULFONATO DE FORMULA GENERAL (I), DONDE R1 ES ALQUILO INFERIOR, ALCOXI INFERIOR O HALOGENO, TAL COMO FLUOR, CLORO, BROMO Y YODO, 1 ES UN ENTERO DE 0 A 3, N ES 0 O 1, A ES ALQUILENO DE CADENA RECTA O RAMIFICADA CON C 1 A 4, R2 ES HIDROGENO O ALQUILO INFERIOR, Z ES N2CHCO O NCH2 Y M ES 0, 1 O 2. LA REACCION SE REALIZA EN PRESENCIA DE DISOLVENTES, TALES COMO ETER DE DIMETILO, ETER DE DIETILO, TETRAHIDROFURANOY OTROS, Y A UNA TEMPERATURA COMPRENDIDA ENTRE C10 Y 60JC. SE EMPLEA DE 1 A 1,5 MOLES DEL COMPUESTO (III) POR MOL DEL COMPUESTO (II).TIENE APLICACIONES FARMACOLOGICAS POR SUS EFECTOS ANTILIPEMICOS, ANTIINFLAMATORIOS Y AGENTES DE CONTROL DE LA INMUNIDAD.
ES513184A 1981-05-22 1982-05-21 "procedimiento de preparar derivados sulfonato". Expired ES8401754A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7853081A JPS57193444A (en) 1981-05-22 1981-05-22 Sulfonate derivative, its preparation and antilipemic agent containing the same
JP21295081A JPS58135850A (ja) 1981-12-29 1981-12-29 トランス−１−（ベンゼンスルホニルオキシ）−２−シクロヘキシル−２−エタノン誘導体及びこれを含有する抗脂血症剤

Publications (2)

Publication Number Publication Date
ES513184A0 ES513184A0 (es) 1984-01-01
ES8401754A1 true ES8401754A1 (es) 1984-01-01

Family

ID=26419587

Family Applications (2)

Application Number Title Priority Date Filing Date
ES513184A Expired ES8401754A1 (es) 1981-05-22 1982-05-21 "procedimiento de preparar derivados sulfonato".
ES83522317A Granted ES522317A0 (es) 1981-05-22 1983-05-12 Metodo de preparar derivados sulfonato.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES83522317A Granted ES522317A0 (es) 1981-05-22 1983-05-12 Metodo de preparar derivados sulfonato.

Country Status (11)

Country Link
US (1) US4452813A (es)
KR (1) KR880002298B1 (es)
AU (1) AU536817B2 (es)
CA (1) CA1189082A (es)
CH (1) CH649079A5 (es)
DE (1) DE3219244C2 (es)
ES (2) ES8401754A1 (es)
FR (1) FR2509297A1 (es)
GB (1) GB2101124B (es)
IT (1) IT1157013B (es)
NL (1) NL187352C (es)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0117876B1 (en) * 1982-09-06 1986-12-10 Taiho Pharmaceutical Company Limited Sulfonic ester derivatives and process for their preparation
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
CA2551037A1 (en) 2003-09-22 2005-03-31 Banyu Pharmaceutical Co., Ltd. Novel piperidine derivative
KR20060109926A (ko) 2003-11-19 2006-10-23 메타베이시스 테라퓨틱스, 인크. 새로운 인-함유 갑상선 호르몬 모방약들
EP1734963A4 (en) 2004-04-02 2008-06-18 Merck & Co Inc METHOD FOR TREATING PEOPLE WITH METABOLIC AND ANTHROPOMETRIC DISORDER
BRPI0518300A2 (pt) * 2004-11-23 2008-11-11 Warner Lambert Co derivados de Ácido 7-(2h-pirazol-3-il)-3,5-diidràxi-heptanàico como inibidores da hmg co-a reductase para o tratamento de lipidemia
WO2006129826A1 (ja) 2005-05-30 2006-12-07 Banyu Pharmaceutical Co., Ltd. 新規ピペリジン誘導体
EP1916239A4 (en) 2005-08-10 2009-10-21 Banyu Pharma Co Ltd PYRIDONE COMPOUND
WO2007024004A1 (ja) 2005-08-24 2007-03-01 Banyu Pharmaceutical Co., Ltd. フェニルピリドン誘導体
CA2621470A1 (en) 2005-09-07 2007-03-15 Banyu Pharmaceutical Co., Ltd. Bicyclic aromatic substituted pyridone derivative
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US20080255084A1 (en) 2005-10-21 2008-10-16 Randy Lee Webb Combination of Organic Compounds
WO2007049798A1 (ja) 2005-10-27 2007-05-03 Banyu Pharmaceutical Co., Ltd. 新規ベンゾオキサチイン誘導体
EP1953165B1 (en) 2005-11-10 2012-02-01 Msd K.K. Aza-substituted spiro derivative
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US20090247560A1 (en) 2006-09-28 2009-10-01 Banyu Pharmaceutical Co., Ltd. Diaryl ketimine derivative
CL2007002958A1 (es) * 2006-10-12 2008-05-09 Epix Delaware Inc Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
CA2682727C (en) 2007-04-02 2016-03-22 Banyu Pharmaceutical Co., Ltd. Indoledione derivative
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP5546451B2 (ja) 2007-06-04 2014-07-09 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
WO2009076404A1 (en) * 2007-12-10 2009-06-18 Epix Delaware, Inc. Carboxamide compounds and their use as antagonists of the chemokine ccr2 receptor
CN101925383A (zh) 2007-12-11 2010-12-22 赛特帕斯凡德株式会社 甲酰胺化合物及其作为趋化因子受体激动剂的应用
EP2264026A4 (en) 2008-03-06 2012-03-28 Msd Kk ALKYLAMINOPYRIDINE DERIVATIVE
US20110015198A1 (en) 2008-03-28 2011-01-20 Banyu Pharmaceutical Co., Inc. Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
EP2810951B1 (en) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009261248A1 (en) 2008-06-19 2009-12-23 Banyu Pharmaceutical Co., Ltd. Spirodiamine-diarylketoxime derivative
EP3241839B1 (en) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US20110124674A1 (en) 2008-07-30 2011-05-26 Hiroyuki Kishino 5/5-or 5/6-membered condensed ring cycloalkylamine derivative
US8410284B2 (en) 2008-10-22 2013-04-02 Merck Sharp & Dohme Corp Cyclic benzimidazole derivatives useful as anti-diabetic agents
CN102271509A (zh) 2008-10-31 2011-12-07 默沙东公司 用于抗糖尿病药的新型环苯并咪唑衍生物
US20120046364A1 (en) 2009-02-10 2012-02-23 Metabasis Therapeutics, Inc. Novel Sulfonic Acid-Containing Thyromimetics, and Methods for Their Use
CA2786314A1 (en) 2010-02-25 2011-09-01 Merck Sharp & Dohme Corp. Novel cyclic benzimidazole derivatives useful anti-diabetic agents
WO2011145022A1 (en) 2010-05-21 2011-11-24 Pfizer Inc. 2-phenyl benzoylamides
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103476258B (zh) 2011-02-25 2017-04-26 默沙东公司 用作抗糖尿病药剂的新的环状氮杂苯并咪唑衍生物
JP2014513923A (ja) 2011-03-04 2014-06-19 ファイザー・インク Ｅｄｎ３様ペプチドおよびその使用
CA2880901A1 (en) 2012-08-02 2014-02-06 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
RU2015140066A (ru) 2013-02-22 2017-03-30 Мерк Шарп И Доум Корп. Противодиабетические бициклические соединения
EP2970119B1 (en) 2013-03-14 2021-11-03 Merck Sharp & Dohme Corp. Novel indole derivatives useful as anti-diabetic agents
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
EP4424697A2 (en) 2013-06-05 2024-09-04 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
WO2015051496A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Antidiabetic tricyclic compounds
WO2016030534A1 (en) 2014-08-29 2016-03-03 Tes Pharma S.R.L. INHIBITORS OF α-AMINO-β-CARBOXYMUCONIC ACID SEMIALDEHYDE DECARBOXYLASE
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
AU2017342083A1 (en) 2016-10-14 2019-04-11 Tes Pharma S.R.L. Inhibitors of alpha-amino-beta-carboxymuconic acid semialdehyde decarboxylase
US11072602B2 (en) 2016-12-06 2021-07-27 Merck Sharp & Dohme Corp. Antidiabetic heterocyclic compounds
US10968232B2 (en) 2016-12-20 2021-04-06 Merck Sharp & Dohme Corp. Antidiabetic spirochroman compounds
CN113302189A (zh) 2018-11-20 2021-08-24 Tes制药有限责任公司 α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411911A (en) * 1980-01-31 1983-10-25 Taiho Pharmaceutical Company, Limited Method of treating hyperlipidemia and inflammation with sulfonate derivatives

Also Published As

Publication number Publication date
ES8406426A1 (es) 1984-08-16
KR880002298B1 (ko) 1988-10-22
KR830010060A (ko) 1983-12-24
IT1157013B (it) 1987-02-11
FR2509297A1 (fr) 1983-01-14
CH649079A5 (de) 1985-04-30
DE3219244A1 (de) 1982-12-09
ES522317A0 (es) 1984-08-16
NL187352B (nl) 1991-04-02
ES513184A0 (es) 1984-01-01
US4452813A (en) 1984-06-05
FR2509297B1 (es) 1984-10-26
GB2101124A (en) 1983-01-12
CA1189082A (en) 1985-06-18
IT8267661A0 (it) 1982-05-20
AU536817B2 (en) 1984-05-24
NL8202064A (nl) 1982-12-16
AU8367982A (en) 1982-11-25
DE3219244C2 (de) 1986-06-05
GB2101124B (en) 1985-05-01
NL187352C (nl) 1991-09-02

Similar Documents

Publication Publication Date Title
ES8401754A1 (es) "procedimiento de preparar derivados sulfonato".
ZA83328B (en) 5,6,7-trinor-4,8-itner-m-phenylene prostaglandin i2 derivative
PT77410A (en) Process for the preparation of a fungicidal composition containing substituted 1-hydroxymethyltriazolyl derivatives
YU43373B (en) Process for preparing oligoglucoside derivatives
ES8104321A1 (es) Procedimiento para separar un derivado de alquil-cetohexopi-ranosida
ES8505518A1 (es) Procedimiento para preparar derivados de aminoacidos
PT81545A (en) Process for the preparation of 5-alkyl-1-phenyl-2-pyperazino-alkyl-pyrazolin-3-one
DE3266708D1 (en) Pyridazinone derivatives, process for their preparation and their use as fungicides
ES8404347A1 (es) Un procedimiento para la preparacion de derivados de fenilpiperazina.
GB2125403B (en) Fused thieno (3,2-6)thiozole-2-anure derivitives
IL67509A0 (en) 2-amino-(1,3-dioxolan-4-yl)ethanol derivatives,methods for their production and compositions containing the same
ES8400743A1 (es) "procedimiento para la preparacion de compuestos de 1-fenilindazol-3-ona".
CA1273946C (en) ANTICONVULSANT GAMMA-THIOBUTYROLACTONE DERIVATIVES
ES8304972A1 (es) Procedimiento de preparar derivados de acido carboxilico quetienen actividad antibacteriana.
DE3560110D1 (en) Derivatives of 2-alkoxyaminosulfonylbenzenesulfonylurea
ES467861A1 (es) Procedimiento de preparacion de espiro-oxazolidinas esteroi-des y sus esteroisomeros.
ES471267A1 (es) Procedimiento para la preparacion de alquilo inferior 2-tri-(inferior) alquilsililacetileno-n-carbetoxiglicinatos y ami-no acidos derivados de ellos
ES8403891A1 (es) Un procedimiento para la preparacion de un derivado del acido furiloxazolila-cetico
DE3160968D1 (en) Cardenolide-bis-digitoxoside derivatives, process for their preparation and their utilization as medicines
ES8705426A1 (es) Un procedimiento para la preparacion de un derivado de piperazina.
DE3564426D1 (en) Polyprenyl compound, process of producing it and pharmaceutical use
DE3268984D1 (en) Imidazolylcarboxylic acids, their derivatives and production
HUT36814A (en) Process for producing new corbacyylin derivatives and pharmaceutical compositions containing them
JPS5283570A (en) Thioacetals of glutarimido-beta-acetaldehydes