ES8202788A1 - Un procedimiento para la preparacion de oligopeptidos lisi- na-triptofano y de sus derivados y sales fisiologicamente aprovechables - Google Patents
Un procedimiento para la preparacion de oligopeptidos lisi- na-triptofano y de sus derivados y sales fisiologicamente aprovechablesInfo
- Publication number
- ES8202788A1 ES8202788A1 ES501583A ES501583A ES8202788A1 ES 8202788 A1 ES8202788 A1 ES 8202788A1 ES 501583 A ES501583 A ES 501583A ES 501583 A ES501583 A ES 501583A ES 8202788 A1 ES8202788 A1 ES 8202788A1
- Authority
- ES
- Spain
- Prior art keywords
- residue
- general formula
- group
- trp
- lys
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 102000015636 Oligopeptides Human genes 0.000 title 1
- 108010038807 Oligopeptides Proteins 0.000 title 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 125000005454 tryptophanyl group Chemical group 0.000 abstract 2
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- 101710176384 Peptide 1 Proteins 0.000 abstract 1
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 1
- 125000006242 amine protecting group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000006386 neutralization reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0815—Tripeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1019—Tetrapeptides with the first amino acid being basic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE OLIGOPEPTIDOS LISINA-TRIPTOFANO Y DE SUS DERIVADOS Y SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A Y B SON DISTINTOS DE O, DE MODO QUE SI EL GRUPO AMINO FORMADOR DEL ENLACE PEPTIDICO -CONH- PROCEDE DE LA LISINA, HA DE SER EL GRUPO AMINO EN POSICION A RESPECTO AL CARBOXILO EL QUE PARTICIPE EN LA FORMACION DEL ENLACE. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UNA SAL DE UN COMPUESTO DE FORMULA (III), EN LAS QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES, EN UN DISOLVENTE INERTE Y EN PRESENCIA DE UNA BASE APROTICA, SEGUIDA DE LA REACCION DEL PRODUCTO OBTENIDO CON UN ACIDO DILUIDO, A UNA TEMPERATURA ENTRE -5 C Y 5 C, Y POSTERIOR REACCION CON UNA DISOLUCION DE UN HIDRACIDO CON ACIDO ACETICO EN PRESENCIA DE UN CATALIZADOR, EN ATMOSFERA NO OXIDANTE, A UNA TEMPERATURA ENTRE 80 C Y 100 C.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES501583A ES8202788A1 (es) | 1981-04-23 | 1981-04-23 | Un procedimiento para la preparacion de oligopeptidos lisi- na-triptofano y de sus derivados y sales fisiologicamente aprovechables |
| DE19823213501 DE3213501A1 (de) | 1981-04-23 | 1982-04-10 | Verfahren zur herstellung von lysin-tryptophan-oligopeptiden und deren physiologisch annehmbaren derivaten und salzen |
| CH2266/82A CH657861A5 (de) | 1981-04-23 | 1982-04-15 | Lysin-tryptophan-oligopeptide und verfahren zur herstellung solcher verbindungen. |
| SE8202414A SE8202414L (sv) | 1981-04-23 | 1982-04-19 | Metod for framstellning av oligopeptider bestaende av lysinyl-och tryptofanylrester |
| GB8211276A GB2097404B (en) | 1981-04-23 | 1982-04-19 | A process for the preparation of lysine-tryptophan oligopeptides and of their physiologically-useful derivatives and salts |
| IT20834/82A IT1151728B (it) | 1981-04-23 | 1982-04-20 | Procedimento per la preparazione di oligopeptidi lisina-triptofano e dei loro derivati e sali fisiologicamente utilizzabili |
| NL8201649A NL8201649A (nl) | 1981-04-23 | 1982-04-21 | Werkwijze voor de bereiding van lysine-tryptofaan oligopeptiden, alsmede fysiologisch bruikbare en voor therapeutische toepassing geschikte derivaten en zouten daarvan. |
| DK179682A DK179682A (da) | 1981-04-23 | 1982-04-22 | Fremgangsmaade til fremstilling af lysin-tryptofan-oligopeptider eller fysiologisk vaerdifulde derivater eller salte deraf |
| BE0/207896A BE892932A (fr) | 1981-04-23 | 1982-04-22 | Procede de preparation d'oligopeptides lysinetryptophane, de leurs derives et de leurs sels physiologiquement utilisables |
| FR8206966A FR2504525B1 (fr) | 1981-04-23 | 1982-04-22 | Procede de preparation d'oligopeptides lysine-tryptophane, de leurs derives et de leurs sels physiologiquement utilisables |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES501583A ES8202788A1 (es) | 1981-04-23 | 1981-04-23 | Un procedimiento para la preparacion de oligopeptidos lisi- na-triptofano y de sus derivados y sales fisiologicamente aprovechables |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES501583A0 ES501583A0 (es) | 1982-02-16 |
| ES8202788A1 true ES8202788A1 (es) | 1982-02-16 |
Family
ID=8482278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES501583A Expired ES8202788A1 (es) | 1981-04-23 | 1981-04-23 | Un procedimiento para la preparacion de oligopeptidos lisi- na-triptofano y de sus derivados y sales fisiologicamente aprovechables |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE892932A (es) |
| CH (1) | CH657861A5 (es) |
| DE (1) | DE3213501A1 (es) |
| DK (1) | DK179682A (es) |
| ES (1) | ES8202788A1 (es) |
| FR (1) | FR2504525B1 (es) |
| GB (1) | GB2097404B (es) |
| IT (1) | IT1151728B (es) |
| NL (1) | NL8201649A (es) |
| SE (1) | SE8202414L (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3823464A1 (de) * | 1988-07-11 | 1990-01-18 | Asta Pharma Ag | Neue tryptophandipeptide |
| ITMI20061607A1 (it) * | 2006-08-09 | 2008-02-10 | Maria Vincenza Carriero | Peptidi con attivita farmacologica |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5116667A (es) * | 1974-07-30 | 1976-02-10 | Shionogi Seiyaku Kk |
-
1981
- 1981-04-23 ES ES501583A patent/ES8202788A1/es not_active Expired
-
1982
- 1982-04-10 DE DE19823213501 patent/DE3213501A1/de not_active Withdrawn
- 1982-04-15 CH CH2266/82A patent/CH657861A5/de not_active IP Right Cessation
- 1982-04-19 SE SE8202414A patent/SE8202414L/ not_active Application Discontinuation
- 1982-04-19 GB GB8211276A patent/GB2097404B/en not_active Expired
- 1982-04-20 IT IT20834/82A patent/IT1151728B/it active
- 1982-04-21 NL NL8201649A patent/NL8201649A/nl not_active Application Discontinuation
- 1982-04-22 BE BE0/207896A patent/BE892932A/fr not_active IP Right Cessation
- 1982-04-22 FR FR8206966A patent/FR2504525B1/fr not_active Expired
- 1982-04-22 DK DK179682A patent/DK179682A/da not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ES501583A0 (es) | 1982-02-16 |
| IT1151728B (it) | 1986-12-24 |
| CH657861A5 (de) | 1986-09-30 |
| DK179682A (da) | 1982-10-24 |
| GB2097404B (en) | 1985-05-30 |
| GB2097404A (en) | 1982-11-03 |
| FR2504525B1 (fr) | 1986-10-24 |
| IT8220834A0 (it) | 1982-04-20 |
| BE892932A (fr) | 1982-08-16 |
| SE8202414L (sv) | 1982-10-24 |
| FR2504525A1 (fr) | 1982-10-29 |
| NL8201649A (nl) | 1982-11-16 |
| DE3213501A1 (de) | 1982-11-11 |
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