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ES552048A0 - Un procedimiento para la preparacion de esteres del acido 1,4, dihidro-3,5-piridincarboxilico. - Google Patents

Un procedimiento para la preparacion de esteres del acido 1,4, dihidro-3,5-piridincarboxilico.

Info

Publication number
ES552048A0
ES552048A0 ES552048A ES552048A ES552048A0 ES 552048 A0 ES552048 A0 ES 552048A0 ES 552048 A ES552048 A ES 552048A ES 552048 A ES552048 A ES 552048A ES 552048 A0 ES552048 A0 ES 552048A0
Authority
ES
Spain
Prior art keywords
piridincarboxilico
dihidro
esters
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES552048A
Other languages
English (en)
Other versions
ES8707931A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline SpA
Original Assignee
Glaxo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT22383/84A external-priority patent/IT1175620B/it
Priority claimed from IT21460/85A external-priority patent/IT1187678B/it
Application filed by Glaxo SpA filed Critical Glaxo SpA
Publication of ES8707931A1 publication Critical patent/ES8707931A1/es
Publication of ES552048A0 publication Critical patent/ES552048A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B2205/00—Fibre drawing or extruding details
    • C03B2205/44—Monotoring or regulating the preform feed rate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES552048A 1984-08-22 1986-02-14 Un procedimiento para la preparacion de esteres del acido 1,4, dihidro-3,5-piridincarboxilico. Expired ES8707931A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22383/84A IT1175620B (it) 1984-08-22 1984-08-22 Derivati piridinici
IT21460/85A IT1187678B (it) 1985-07-05 1985-07-05 Procedimento di preparazione di derivati eterociclici

Publications (2)

Publication Number Publication Date
ES8707931A1 ES8707931A1 (es) 1987-09-01
ES552048A0 true ES552048A0 (es) 1987-09-01

Family

ID=26327905

Family Applications (5)

Application Number Title Priority Date Filing Date
ES546324A Expired ES8703839A1 (es) 1984-08-22 1985-08-21 Un procedimiento para la preparacion de esteres de acidos 1,4-dihidro-3,5-piridin-dicarbaxolicos.
ES552049A Expired ES8802497A1 (es) 1984-08-22 1986-02-14 Un procedimiento para la preparacion de esteres del acido 1,4-dihidro -3,5-piridindi-carboxilico.
ES552051A Expired ES8707932A1 (es) 1984-08-22 1986-02-14 Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3,5, piridincarboxilico.
ES552048A Expired ES8707931A1 (es) 1984-08-22 1986-02-14 Un procedimiento para la preparacion de esteres del acido 1,4, dihidro-3,5-piridincarboxilico.
ES552050A Expired ES8707930A1 (es) 1984-08-22 1986-02-14 Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3, 5, piridincarboxilico.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ES546324A Expired ES8703839A1 (es) 1984-08-22 1985-08-21 Un procedimiento para la preparacion de esteres de acidos 1,4-dihidro-3,5-piridin-dicarbaxolicos.
ES552049A Expired ES8802497A1 (es) 1984-08-22 1986-02-14 Un procedimiento para la preparacion de esteres del acido 1,4-dihidro -3,5-piridindi-carboxilico.
ES552051A Expired ES8707932A1 (es) 1984-08-22 1986-02-14 Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3,5, piridincarboxilico.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES552050A Expired ES8707930A1 (es) 1984-08-22 1986-02-14 Un procedimiento para la preparacion de esteres del acido 1,4-dihidro-3, 5, piridincarboxilico.

Country Status (33)

Country Link
US (2) US4801599A (es)
JP (2) JPS6193162A (es)
KR (1) KR920004482B1 (es)
AT (1) AT394042B (es)
AU (1) AU578724B2 (es)
BE (1) BE903103A (es)
BG (1) BG60409B2 (es)
CA (1) CA1268180A (es)
CH (1) CH666684A5 (es)
CS (1) CS403091A3 (es)
CY (1) CY1494A (es)
DE (1) DE3529997C2 (es)
DK (1) DK165949C (es)
ES (5) ES8703839A1 (es)
FI (1) FI81568C (es)
FR (1) FR2569402B1 (es)
GB (1) GB2164336B (es)
GR (1) GR852016B (es)
HK (1) HK52990A (es)
HU (1) HU196754B (es)
IE (1) IE58486B1 (es)
LU (2) LU88267I2 (es)
MX (1) MX159974A (es)
NL (2) NL193065C (es)
NO (2) NO167142C (es)
NZ (1) NZ212895A (es)
PH (1) PH22014A (es)
PT (1) PT81000B (es)
SA (1) SA91120277B1 (es)
SE (1) SE459920B (es)
SG (1) SG40889G (es)
SK (1) SK278327B6 (es)
ZW (1) ZW13185A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions
JPH0696552B2 (ja) * 1985-08-21 1994-11-30 グラクソ・ソシエタ・ペル・アツイオ−ニ 複素環式化合物
EP0226271B1 (en) * 1985-08-21 1990-11-22 GLAXO S.p.A. 1,4-dihydropyridine compounds and their preparation and pharmaceutical formulation
IT1204461B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204462B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1204460B (it) * 1986-02-20 1989-03-01 Glaxo Spa Derivati eterociclici
IT1233370B (it) * 1988-11-21 1992-03-27 Glaxo Spa Procedimento di preparazione di derivati diidropipiridinici utili nel trattamento di disturbi cardiovascolari
EP0395369B1 (en) 1989-04-27 1997-07-02 Canon Inc. Optical recording medium and process for production thereof
US5177202A (en) * 1990-10-09 1993-01-05 Merck & Co., Inc. 2-phenanthrenyl-carbapenems
US5196529A (en) * 1990-10-09 1993-03-23 Merck & Co., Inc. 2-phenanthrenyl carbapenem intermediates
US5132422A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5132421A (en) * 1990-10-09 1992-07-21 Merck & Co., Inc. 2-naphthyl-carbapenem intermediates
US5356889A (en) * 1990-08-01 1994-10-18 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5144028A (en) * 1990-10-09 1992-09-01 Merck & Co., Inc. 2-(9-fluorenonyl)-carbapenem intermediates
US5208329A (en) * 1990-10-09 1993-05-04 Merck & Co., Inc. 2-biphenyl carbapenem intermediates
IT1244728B (it) * 1991-02-13 1994-08-08 Glaxo Spa Impiego medicamentoso di derivati diidropiridinici
TW483763B (en) * 1994-09-02 2002-04-21 Astra Ab Pharmaceutical composition comprising of ramipril and dihydropyridine compound
AU1042199A (en) * 1998-11-06 2000-05-29 Boehringer Ingelheim International Gmbh Antihypertensive medicaments containing lacidipine and telmisartan
WO2004017964A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
WO2004106299A2 (en) * 2003-05-30 2004-12-09 Ranbaxy Laboratories Limited Substituted pyrrole derivatives and their use as hmg-co inhibitors
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
KR20070054644A (ko) * 2004-07-26 2007-05-29 액테리온 파마슈티칼 리미티드 미립자 제형으로 흡입된 일로프로스트에 의한 폐고혈압의치료
EP1868577A4 (en) 2005-04-15 2009-12-09 Reddys Lab Inc Dr Lacidipine PARTICLE
US20070043088A1 (en) * 2005-08-16 2007-02-22 Eswaraiah Sajja Process for preparing lacidipine
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2111863B1 (en) 2005-10-26 2012-03-28 Asahi Kasei Pharma Corporation Fasudil in combination with bosentan for the treament of pulmonary arterial hypertension
EP1948599A1 (en) * 2005-11-08 2008-07-30 Ranbaxy Laboratories Limited Process for (3r, 5r)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- [(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3, 5-dihydroxy-heptanoic acid hemi calcium salt
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
US20070238716A1 (en) * 2006-03-14 2007-10-11 Murthy Ayanampudi S R Statin stabilizing dosage formulations
BRPI0714361A2 (pt) * 2006-07-14 2013-03-26 Ranbaxy Lab Ltd polimorfo cristalino, composiÇço farmacÊutica contendo o mesmo, mÉtodo para sua preparaÇço e mÉtodo de tratamento
US20080089947A1 (en) * 2006-08-18 2008-04-17 Knox Clayton D Calcium Influx Inhibitors in the Treatment of Ischemia
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
WO2012037665A1 (en) 2010-09-24 2012-03-29 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
EP2705839B1 (en) 2012-09-10 2018-02-21 Rivopharm SA Pharmaceutical composition comprising lacidipine and process of preparation
BR112015026513A2 (pt) 2013-04-17 2017-07-25 Pfizer derivados de n-piperidin-3-ilbenzamida para tratar as doenças cardiovasculares
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
CA3125765A1 (en) 2019-01-18 2020-07-23 Astrazeneca Ab Pcsk9 inhibitors and methods of use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3455945A (en) * 1967-06-07 1969-07-15 Smithkline Corp 4-(carboxy (and carbo-lower alkoxy)phenyl)-1,4-dihydropyridines
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
US4307103A (en) * 1978-09-08 1981-12-22 Fujisawa Pharmaceutical Co., Ltd. Dihydropyridine derivative, processes for preparation thereof and pharmaceutical composition comprising the same
DE3018259A1 (de) * 1980-05-13 1981-11-19 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines
DE3207982A1 (de) * 1982-03-05 1983-09-08 Bayer Ag, 5090 Leverkusen Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihrer verwendung in arzneimitteln
NZ212895A (en) * 1984-08-22 1988-07-28 Glaxo Spa 1,4-dihydropyridine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
ES546324A0 (es) 1987-03-01
HU196754B (en) 1989-01-30
NL8502296A (nl) 1986-03-17
IE58486B1 (en) 1993-09-22
PT81000A (en) 1985-09-01
ES8707932A1 (es) 1987-09-01
DK165949B (da) 1993-02-15
CA1268180A (en) 1990-04-24
US5011848A (en) 1991-04-30
ATA245485A (de) 1991-07-15
FI853206A0 (fi) 1985-08-21
SE8503888L (sv) 1986-02-23
NL980037I1 (nl) 1999-02-01
GR852016B (es) 1985-12-19
US4801599A (en) 1989-01-31
ES552051A0 (es) 1987-09-01
CH666684A5 (de) 1988-08-15
SE8503888D0 (sv) 1985-08-20
FR2569402A1 (fr) 1986-02-28
GB2164336A (en) 1986-03-19
LU86047A1 (fr) 1986-02-28
NO853293L (no) 1986-02-24
ES552050A0 (es) 1987-09-01
DK165949C (da) 1993-07-05
ES8707930A1 (es) 1987-09-01
DK378085D0 (da) 1985-08-20
ES552049A0 (es) 1988-07-01
BG60409B2 (bg) 1995-02-28
JPH0550506B2 (es) 1993-07-29
AU578724B2 (en) 1988-11-03
ES8802497A1 (es) 1988-07-01
SA91120277B1 (ar) 2006-05-15
ZW13185A1 (en) 1986-03-19
JPS6479152A (en) 1989-03-24
BE903103A (fr) 1986-02-24
DE3529997A1 (de) 1986-03-06
DE3529997C2 (de) 1996-01-18
KR920004482B1 (ko) 1992-06-05
CY1494A (en) 1990-02-16
SK278327B6 (en) 1996-11-06
MX159974A (es) 1989-10-17
NO167142B (no) 1991-07-01
LU88267I2 (es) 1994-02-03
DK378085A (da) 1986-02-23
AU4657685A (en) 1986-02-27
JPH0686430B2 (ja) 1994-11-02
NO167142C (no) 1991-10-09
JPS6193162A (ja) 1986-05-12
FI81568C (fi) 1990-11-12
NL193065C (nl) 1998-09-08
IE852054L (en) 1986-02-22
NL193065B (nl) 1998-05-06
HK52990A (en) 1990-07-20
GB2164336B (en) 1988-06-08
SG40889G (en) 1989-12-22
GB8520924D0 (en) 1985-09-25
HUT40625A (en) 1987-01-28
FR2569402B1 (fr) 1989-09-22
FI81568B (fi) 1990-07-31
ES8707931A1 (es) 1987-09-01
AT394042B (de) 1992-01-27
NO1999007I1 (no) 1999-04-23
PH22014A (en) 1988-05-02
KR870002073A (ko) 1987-03-28
CS403091A3 (en) 1992-06-17
NZ212895A (en) 1988-07-28
NL980037I2 (nl) 1999-03-01
PT81000B (pt) 1988-03-03
SE459920B (sv) 1989-08-21
ES8703839A1 (es) 1987-03-01
FI853206L (fi) 1986-02-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20070613