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ES479273A1 - Un procedimiento de preparacion de nuevas cefalosporinas. - Google Patents

Un procedimiento de preparacion de nuevas cefalosporinas.

Info

Publication number
ES479273A1
ES479273A1 ES479273A ES479273A ES479273A1 ES 479273 A1 ES479273 A1 ES 479273A1 ES 479273 A ES479273 A ES 479273A ES 479273 A ES479273 A ES 479273A ES 479273 A1 ES479273 A1 ES 479273A1
Authority
ES
Spain
Prior art keywords
group
carboxymethyloxyimino
ceph
eme
acetamido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479273A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of ES479273A1 publication Critical patent/ES479273A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un procedimiento de preparación de nuevas cefalosporinas de fórmula general I **fórmula** isómero sin, donde R representa un radical alcohilo que tiene de 1 a 3 átomos de carbono, o un radical -CH2¿S-R1, donde R1 representa un heterociclo de 5 o 6 eslabones que comprende de 1 a 4 heteroátomos elegidos entre azufre, oxígeno y nitrógeno eventualmente sustituido, a representa un átomo de hidrógeno o un equivalente de metal alcalino, alcalinotérreo, magnesio, amonio o una base orgánica aminada, o A representa un grupo éster fácilmente escindible, A1 representa un radical alcohilo que tiene de 1 a 3 átomos de carbono, un átomo de hidrógeno o un equivalente de metal alcalino, alcalinotérreo, magnesio, amonio o una base orgánica aminada, o A1 representa un grupo éster fácilmente escindible, así como sales de productos de fórmula I con ácidos minerales u orgánicos.
ES479273A 1978-04-07 1979-04-04 Un procedimiento de preparacion de nuevas cefalosporinas. Expired ES479273A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7810387A FR2421907A1 (fr) 1978-04-07 1978-04-07 Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments

Publications (1)

Publication Number Publication Date
ES479273A1 true ES479273A1 (es) 1979-12-01

Family

ID=9206849

Family Applications (2)

Application Number Title Priority Date Filing Date
ES479273A Expired ES479273A1 (es) 1978-04-07 1979-04-04 Un procedimiento de preparacion de nuevas cefalosporinas.
ES484074A Expired ES484074A1 (es) 1978-04-07 1979-09-11 Un procedimiento de preparacion de nuevas cefalosporinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES484074A Expired ES484074A1 (es) 1978-04-07 1979-09-11 Un procedimiento de preparacion de nuevas cefalosporinas

Country Status (11)

Country Link
US (1) US4287193A (es)
JP (1) JPS54135793A (es)
AT (1) AT365194B (es)
BE (1) BE875379A (es)
CH (1) CH639388A5 (es)
DE (1) DE2914060A1 (es)
ES (2) ES479273A1 (es)
FR (1) FR2421907A1 (es)
GB (1) GB2021561B (es)
IT (1) IT1162463B (es)
NL (1) NL7902784A (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE878514A (fr) * 1978-09-04 1980-02-29 Fujisawa Pharmaceutical Co Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne
US4284631A (en) * 1978-07-31 1981-08-18 Fujisawa Pharmaceutical Co., Ltd. 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them
FR2462439A1 (fr) * 1979-07-26 1981-02-13 Roussel Uclaf Nouveau procede de preparation de produits derives de l'acide 7-/(2-aryl) 2-hydroxyimino acetamido/cephalosporanique
US4507293A (en) * 1980-09-26 1985-03-26 Fujisawa Pharmaceutical Co., Ltd. Antimicrobial cephem compounds
DK416681A (da) * 1980-09-26 1982-03-27 Fujisawa Pharmaceutical Co Femgangsmaade til fremstilling af cephemforbindelser
DE3177090D1 (en) 1980-12-31 1989-09-28 Fujisawa Pharmaceutical Co 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof
IE53429B1 (en) * 1981-08-03 1988-11-09 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
GB8410992D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
CA2054126A1 (en) * 1990-10-26 1992-04-27 Michiyuki Sendai Cephem compounds, their production and use

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4091209A (en) * 1971-05-14 1978-05-23 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl or naphthylacetamido)]cephalosporins having a 2-haloalkylcarbamoyloxymethyl group at the 3-position
US4144393A (en) * 1973-12-21 1979-03-13 Glaxo Laboratories Limited 3-Acetoxymethyl cephalosporins having at position-7 a carboxy substituted α-etherified hydroxyiminoarylacetamido group
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
FR2345153A1 (fr) * 1976-03-25 1977-10-21 Roussel Uclaf Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
US4166115A (en) * 1976-04-12 1979-08-28 Fujisawa Pharmaceutical Co., Ltd. Syn 7-oxoimino substituted derivatives of cephalosporanic acid
GB1576625A (en) * 1976-04-12 1980-10-08 Fujisawa Pharmaceutical Co Syn isomer 3,7 disubstituted 3 cephem 4 carboxylic acid compounds and processes for the preparation thereof
DK162391C (da) * 1976-04-12 1992-03-09 Fujisawa Pharmaceutical Co Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser
US4066762A (en) * 1976-07-12 1978-01-03 Smithkline Corporation Derivatives of 7-(2-substituted-2-hydroxyiminoacetamido)-3-(1-substituted tetrazol-5-ylthiomethyl-3-cephem-4-carboxylic acid
CA1115267A (en) * 1976-08-30 1981-12-29 William J. Gottstein 7-(2-alkyloxyimino-2-furylacetamido)-3-(1- carboxyalkyltetrazolyl-5-thiomethyl)-3-cephem-4- carboxylic acid)
GB1592149A (en) * 1976-10-08 1981-07-01 Fujisawa Pharmaceutical Co 3 7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for preparation thereof
PH17188A (en) * 1977-03-14 1984-06-14 Fujisawa Pharmaceutical Co New cephem and cepham compounds and their pharmaceutical compositions and method of use
SE439312B (sv) * 1977-03-25 1985-06-10 Roussel Uclaf Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra
DE2714880A1 (de) * 1977-04-02 1978-10-26 Hoechst Ag Cephemderivate und verfahren zu ihrer herstellung
DE2716677C2 (de) * 1977-04-15 1985-10-10 Hoechst Ag, 6230 Frankfurt Cephemderivate und Verfahren zu ihrer Herstellung

Also Published As

Publication number Publication date
IT1162463B (it) 1987-04-01
JPS6360758B2 (es) 1988-11-25
FR2421907B1 (es) 1981-07-24
CH639388A5 (fr) 1983-11-15
DE2914060C2 (es) 1991-01-24
ES484074A1 (es) 1980-06-16
GB2021561B (en) 1982-11-17
AT365194B (de) 1981-12-28
ATA255279A (de) 1981-05-15
DE2914060A1 (de) 1979-10-18
NL7902784A (nl) 1979-10-09
BE875379A (fr) 1979-10-08
JPS54135793A (en) 1979-10-22
IT7948631A0 (it) 1979-04-05
US4287193A (en) 1981-09-01
GB2021561A (en) 1979-12-05
FR2421907A1 (fr) 1979-11-02

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603