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ES432131A1 - Esters and carbamates of aminoalkanols - Google Patents

Esters and carbamates of aminoalkanols

Info

Publication number
ES432131A1
ES432131A1 ES432131A ES432131A ES432131A1 ES 432131 A1 ES432131 A1 ES 432131A1 ES 432131 A ES432131 A ES 432131A ES 432131 A ES432131 A ES 432131A ES 432131 A1 ES432131 A1 ES 432131A1
Authority
ES
Spain
Prior art keywords
alkyl
aryl
carbon atoms
heteroaryl
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES432131A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Antonio Gallardo SA
Original Assignee
Antonio Gallardo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antonio Gallardo SA filed Critical Antonio Gallardo SA
Publication of ES432131A1 publication Critical patent/ES432131A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for the preparation of compounds of general structure (I). **(See formula)** wherein each of the radicals R1, R2 and R3 which may be the same or different, is hydrogen, alkyl group of 1-6 carbon atoms, hydroxyl, alkoxy of 1-6 carbon atoms, trifluoromethyl or halogen; R4 is hydrogen, alkyl group of 1-6 carbon atoms, cycloalkyl or aryl; R5 and R6, which may be the same or different, are each hydrogen, alkyl group of 1-6 carbon atoms or aryl alkyl, or the two radicals R5 and R6 together with the neighboring nitrogen atom form a ring that can contain another heteroatom; R7 is an alkyl, aryl alkyl, aryl, aryl-alkenyl, diaryl-alkyl, aryl-cycloalkyl-alkyl, heteroaryl, amino group or an amino group substituted by an alkyl-heteroaryl or aryl; x, y and z are each zero or one; characterized in that the alcohol of structure (II) is reacted **(See formula)** with an R'7-COCl acid chloride or other acid reagent, with an R''7-CNO isocyanate or with an R''7-CON3 acid azide where R'7 is an alkyl, aryl-alkyl, aryl group, aryl-alkenyl, diaryl-alkyl, aryl-cycloalkyl-alkyl or heteroaryl; and R''7 is an alkyl group of 1-6 carbon atoms, heteroaryl such as phenyl or phenyl substituted by one or more of the following groups: lower alkyl, halogen, lower alkoxy, nitro or amino; the reaction being carried out in an anhydrous solvent. (Machine-translation by Google Translate, not legally binding)
ES432131A 1973-11-14 1974-11-13 Esters and carbamates of aminoalkanols Expired ES432131A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB5275073 1973-11-14
GB3231874A GB1434826A (en) 1973-11-14 1974-07-22 Esters and carbamates of aminoalkanols

Publications (1)

Publication Number Publication Date
ES432131A1 true ES432131A1 (en) 1977-03-01

Family

ID=26261313

Family Applications (1)

Application Number Title Priority Date Filing Date
ES432131A Expired ES432131A1 (en) 1973-11-14 1974-11-13 Esters and carbamates of aminoalkanols

Country Status (2)

Country Link
ES (1) ES432131A1 (en)
GB (1) GB1434826A (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2588556B1 (en) * 1985-10-11 1988-01-08 Sanofi Sa NAPHTHALENE DERIVATIVES SUBSTITUTED BY AN ALCANOL (OMEGA-AMINO) GROUP WITH ANTIMICROBIAL ACTIVITY, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM
FR2593499B1 (en) * 1986-01-30 1988-08-12 Jouveinal Sa AMINOALCOOLS, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS, ESPECIALLY IN THERAPEUTICS
FR2613719B1 (en) * 1987-04-10 1991-03-22 Sanofi Sa AROMATIC DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTIMICROBIALS
US5142094A (en) * 1989-11-06 1992-08-25 Warner-Lambert Company Aryl substituted carbamate derivatives which are acat inhibitors
US5087726A (en) * 1990-02-13 1992-02-11 Warner-Lambert Company Carbamate ACAT inhibitors
FR2690917B1 (en) * 1992-05-05 1994-06-17 Jouveinal Inst Rech AMINOESTERS, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS.
US5472970A (en) * 1992-05-05 1995-12-05 Institut De Recherche Jouveinal S.A. Allylaminoesters and their application in therapeutics
FR2711137B1 (en) * 1993-10-15 1995-12-15 Irj Allylaminoesters, their preparation process and their therapeutic application.
KR100197892B1 (en) * 1994-09-09 1999-06-15 남창우 Novel phenylalkylaminoalcohol carbamates and process for preparing the same
DE4443892A1 (en) * 1994-12-09 1996-06-13 Bayer Ag 4- (Quinolin-2-yl-methoxy) phenyl acetic acid derivatives
KR0173863B1 (en) * 1995-04-10 1999-04-01 조규향 O-carbamoyl-phenylalanineol compounds having substituents on phenyl, pharmaceutically useful salts thereof, and preparation methods thereof
FR2765218B1 (en) * 1997-06-30 1999-08-13 Jouveinal Inst Rech 2 (METHYLAMINO-2-PHENYL-N- BUTYL) 3,4,5-TRIMETHOXYBENZOATE (S), ITS APPLICATION TO THE TREATMENT OF CHRONIC PAIN
FR2927076B1 (en) 2008-01-31 2010-03-26 Oroxcell 2-AMINO-2-PHENYL-ALKANOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2948660B1 (en) * 2009-07-30 2011-08-19 Oroxcell 2-AMINO-2-PHENYL-ALKANOL DERIVATIVES, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CN102276487B (en) * 2011-06-29 2013-06-12 岳阳亚王精细化工有限公司 Preparation method of trimebutine
CN103896782B (en) * 2012-12-26 2015-10-28 北京奥得赛化学股份有限公司 The method of preparation 2-(N, N-dimethylamino)-2 phenylbutanol
WO2015132733A1 (en) * 2014-03-05 2015-09-11 Universita' Degli Studi Di Pavia Use of arylalkanolamines as sigma-1 receptor antagonists
CN105037139B (en) * 2015-07-07 2018-04-17 浙江博聚新材料有限公司 A kind of 2 phenylpropionic acid preparation methods
RU2752086C1 (en) * 2020-04-27 2021-07-22 Общество С Ограниченной Ответственностью "Валента-Интеллект" New [2-(dimethylamino)-2-phenylbutyl]-3,4,5-trimetoxybenzoate 4-methyl-2h-chromen-2-on-7-ilsulphate compound and application thereof

Also Published As

Publication number Publication date
GB1434826A (en) 1976-05-05

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