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ES381036A1 - Analgesic drugs based on N- (aroilalkil) n '- (alfanols) piperacinas and their derivatives, and procedure for their obtaination. (Machine-translation by Google Translate, not legally binding) - Google Patents

Analgesic drugs based on N- (aroilalkil) n '- (alfanols) piperacinas and their derivatives, and procedure for their obtaination. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES381036A1
ES381036A1 ES381036A ES381036A ES381036A1 ES 381036 A1 ES381036 A1 ES 381036A1 ES 381036 A ES381036 A ES 381036A ES 381036 A ES381036 A ES 381036A ES 381036 A1 ES381036 A1 ES 381036A1
Authority
ES
Spain
Prior art keywords
formula
phenyl group
compound
see formula
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES381036A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferlux SA
Original Assignee
Ferlux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferlux SA filed Critical Ferlux SA
Publication of ES381036A1 publication Critical patent/ES381036A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for obtaining analgesic drugs based on an active compound N (aroilalkil) N'(alkanol) piperazine, its addition salt with a mineral or organic acid, the expressed compound having the general formula: ** (See formula) ** where R designates a halogen or a lower alkoxy, R1 designates - either a hydrogen atom - either a -CO-R2 group wherein R2 can be a halogen-aryl or alkoxy aryl group, - well a group (see formula) where R3 and R4 are identical hydrogen atoms or lower alkyl groups, - either a phenyl group, a halogen-phenyl group, an alkyl phenyl group, n and n'designate integers, excluding the compound of formula I in which R is fluorine, R1 is hydrogen, n = 3 and n'= 2, in accordance with the procedure, R1 being hydrogen or a substituted or unsubstituted phenyl group, in an inert solvent and in the presence of an agent capable of fixing the formed acid, an aroyl alkyl halide of formula ** (See formula) ** where B and n have the same meanings as above, with respectively (a) an N (alkanol) piperazine of the formula ** (See formula) ** in order to form compound II (I with R1 = H) ** (See formula) ** or (b) with a compound of the formula ** (See formula) ** where Ar is a substituted or unsubstituted phenyl group, and then on collecting the expressed active compounds formed. (Machine-translation by Google Translate, not legally binding)
ES381036A 1969-06-03 1970-06-02 Analgesic drugs based on N- (aroilalkil) n '- (alfanols) piperacinas and their derivatives, and procedure for their obtaination. (Machine-translation by Google Translate, not legally binding) Expired ES381036A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR6918171A FR2047866B1 (en) 1969-06-03 1969-06-03

Publications (1)

Publication Number Publication Date
ES381036A1 true ES381036A1 (en) 1973-04-16

Family

ID=9035045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES381036A Expired ES381036A1 (en) 1969-06-03 1970-06-02 Analgesic drugs based on N- (aroilalkil) n '- (alfanols) piperacinas and their derivatives, and procedure for their obtaination. (Machine-translation by Google Translate, not legally binding)

Country Status (8)

Country Link
BE (1) BE751351A (en)
CH (1) CH522655A (en)
DE (1) DE2027054A1 (en)
ES (1) ES381036A1 (en)
FR (1) FR2047866B1 (en)
GB (1) GB1289227A (en)
LU (1) LU61040A1 (en)
NL (1) NL7007929A (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2145682C3 (en) * 1971-09-13 1975-09-04 Kali-Chemie Ag, 3000 Hannover 1,4-disubstituted piperazine derivatives and their acid addition compounds
US3969356A (en) * 1971-09-13 1976-07-13 Kali-Chemie Aktiengesellschaft N-[3-(p-f-benzoyl)-propyl]-N'-[2.(nitro,nitro-el, or methoxyphenyl)-ethyl]-p
FR2206088A1 (en) * 1972-11-14 1974-06-07 Synthelabo Analgesic piperazino butyrophenone ketals - prepd. by reaction of halo butyrophenone ketal with hydroxy alkyl piperazine
CH603611A5 (en) * 1973-03-12 1978-08-31 Kali Chemie Ag
CN1181065C (en) * 2002-05-08 2004-12-22 上海医药工业研究院 Aralkylformylalkyl piperazine derivative and its application as brain nerve protector

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1186495A (en) * 1968-02-20 1970-04-02 Delalande Sa 0-[3-(4-Fluorobenzoyl) Proplyl]-4-Substituted Piperazines, their Acid Addition Salts and their method of preparation

Also Published As

Publication number Publication date
CH522655A (en) 1972-06-30
LU61040A1 (en) 1972-03-22
BE751351A (en) 1970-12-02
FR2047866B1 (en) 1973-03-16
NL7007929A (en) 1970-12-07
DE2027054A1 (en) 1970-12-10
FR2047866A1 (en) 1971-03-19
GB1289227A (en) 1972-09-13

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