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ES2619371T3 - Remodelación y glucoconjugación del Factor IX - Google Patents

Remodelación y glucoconjugación del Factor IX Download PDF

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Publication number
ES2619371T3
ES2619371T3 ES10184886T ES10184886T ES2619371T3 ES 2619371 T3 ES2619371 T3 ES 2619371T3 ES 10184886 T ES10184886 T ES 10184886T ES 10184886 T ES10184886 T ES 10184886T ES 2619371 T3 ES2619371 T3 ES 2619371T3
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ES
Spain
Prior art keywords
factor
group
glucoconjugation
remodeling
intact
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES10184886T
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English (en)
Inventor
Shawn De Frees
David Zopf
Caryn Bowe
David Hakes
Xi Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
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Novo Nordisk AS
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Publication date
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Publication of ES2619371T3 publication Critical patent/ES2619371T3/es
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
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Abstract

Un conjugado covalente entre un Factor IX y un grupo modificador que altera una propiedad de dicho Factor IX, en el que dicho grupo modificador está unido por enlace covalente a dicho Factor IX en un resto glucosilo o de aminoácido preseleccionado de dicho péptido mediante un grupo de enlace glucosilo intacto, en el que dicho grupo modificador comprende poli(etilenglicol), y en el dicho grupo de enlace glucosilo intacto es un residuo de ácido siálico.
ES10184886T 2001-10-10 2002-10-09 Remodelación y glucoconjugación del Factor IX Expired - Lifetime ES2619371T3 (es)

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US32852301P 2001-10-10 2001-10-10
US34469201P 2001-10-19 2001-10-19
US33423301P 2001-11-28 2001-11-28
US33430101P 2001-11-28 2001-11-28
US38729202P 2002-06-07 2002-06-07
US39177702P 2002-06-25 2002-06-25
US39659402P 2002-07-17 2002-07-17
US40424902P 2002-08-16 2002-08-16
US40752702P 2002-08-28 2002-08-28

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ES10012536.8T Expired - Lifetime ES2556338T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de péptidos
ES10012798T Expired - Lifetime ES2561985T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de anticuerpos
ES10012938.6T Expired - Lifetime ES2516041T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de la hormona del crecimiento humano (hGH)
ES10012794.3T Expired - Lifetime ES2538342T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de la hormona estimuladora del folículo (FSH)
ES10012939.4T Expired - Lifetime ES2466024T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de factor de crecimiento de fibroblastos (FGF)
ES09000818.6T Expired - Lifetime ES2606840T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de factor estimulante de colonias de granulocitos (G-CSF)
ES02795509T Expired - Lifetime ES2411007T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de péptidos
ES10184886T Expired - Lifetime ES2619371T3 (es) 2001-10-10 2002-10-09 Remodelación y glucoconjugación del Factor IX
ES09151346.5T Expired - Lifetime ES2564688T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de poli(éter) a eritropoyetina

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ES10012536.8T Expired - Lifetime ES2556338T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de péptidos
ES10012798T Expired - Lifetime ES2561985T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de anticuerpos
ES10012938.6T Expired - Lifetime ES2516041T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de la hormona del crecimiento humano (hGH)
ES10012794.3T Expired - Lifetime ES2538342T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de la hormona estimuladora del folículo (FSH)
ES10012939.4T Expired - Lifetime ES2466024T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de factor de crecimiento de fibroblastos (FGF)
ES09000818.6T Expired - Lifetime ES2606840T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de factor estimulante de colonias de granulocitos (G-CSF)
ES02795509T Expired - Lifetime ES2411007T3 (es) 2001-10-10 2002-10-09 Remodelación y glicoconjugación de péptidos

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JP3894776B2 (ja) 2001-11-09 2007-03-22 富士通メディアデバイス株式会社 吐出装置および吐出方法
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