ES2114183T3 - Anticuerpo para el tratamiento de la diabetes dependiente de la insulina. - Google Patents
Anticuerpo para el tratamiento de la diabetes dependiente de la insulina.Info
- Publication number
- ES2114183T3 ES2114183T3 ES94909584T ES94909584T ES2114183T3 ES 2114183 T3 ES2114183 T3 ES 2114183T3 ES 94909584 T ES94909584 T ES 94909584T ES 94909584 T ES94909584 T ES 94909584T ES 2114183 T3 ES2114183 T3 ES 2114183T3
- Authority
- ES
- Spain
- Prior art keywords
- antibody
- insulin dependent
- treatment
- dependent diabetes
- diabetes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70542—CD106
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
SE PRESENTA UN METODO PARA LA PREVENCION DE LA DIABETES DEPENDIENTE DE LA INSULINA (DE TIPO I). EL METODO COMPRENDE LA ADMINISTRACION DE UN ANTICUERPO, POLIPEPTIDO U OTRA MOLECULA QUE RECONOZCA EL VLA4.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2933093A | 1993-02-09 | 1993-02-09 | |
US29330 | 1993-02-09 | ||
PCT/US1994/001456 WO1994017828A2 (en) | 1993-02-09 | 1994-02-09 | Treatment for insulin dependent diabetes |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2114183T3 true ES2114183T3 (es) | 1998-05-16 |
ES2114183T5 ES2114183T5 (es) | 2006-06-16 |
Family
ID=21848497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94909584T Expired - Lifetime ES2114183T5 (es) | 1993-02-09 | 1994-02-09 | Anticuerpo para el tratamiento de la diabetes dependiente de la insulina. |
Country Status (13)
Country | Link |
---|---|
US (2) | US5888507A (es) |
EP (1) | EP0682529B2 (es) |
JP (1) | JP3593343B2 (es) |
AT (1) | ATE161730T1 (es) |
AU (1) | AU687790B2 (es) |
CA (1) | CA2155303C (es) |
DE (1) | DE69407758T3 (es) |
DK (1) | DK0682529T4 (es) |
ES (1) | ES2114183T5 (es) |
GR (1) | GR3026531T3 (es) |
HK (1) | HK1008731A1 (es) |
NZ (1) | NZ262615A (es) |
WO (1) | WO1994017828A2 (es) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3731892B2 (ja) | 1992-11-13 | 2006-01-05 | ボード オブ リージェンツ オブ ユニバーシティ オブ ワシントン | 造血幹細胞の末梢化 |
ATE182625T1 (de) | 1993-01-12 | 1999-08-15 | Biogen Inc | Rekombinante anti-vla4 antikörpermoleküle |
WO1994017828A2 (en) * | 1993-02-09 | 1994-08-18 | Biogen, Inc. | Treatment for insulin dependent diabetes |
US5677291A (en) * | 1993-12-10 | 1997-10-14 | Hoechst Marion Roussel, Inc. | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols |
US5750336A (en) * | 1994-02-10 | 1998-05-12 | The Salk Institute For Biological Studies | Assays for the identification of compounds which inhibit activation of cAMP and mitogen responsive genes |
US6551593B1 (en) | 1995-02-10 | 2003-04-22 | Millennium Pharmaceuticals, Inc. | Treatment of Inflammatory bowel disease by inhibiting binding and/or signalling through α 4 β 7 and its ligands and madcam |
US7803904B2 (en) | 1995-09-01 | 2010-09-28 | Millennium Pharmaceuticals, Inc. | Mucosal vascular addressing and uses thereof |
US5608095A (en) * | 1996-04-30 | 1997-03-04 | Hoechst Marion Roussel, Inc. | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents |
US5795876A (en) * | 1996-04-30 | 1998-08-18 | Hoechst Marion Rousssel, Inc. | Method of inhibiting vascular cell adhesion molecule-1 and treating chronic inflammatory diseases with 2, 6-di-alkyl-4-silyl-phenols |
US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
US6114572A (en) * | 1996-11-20 | 2000-09-05 | Hoechst Marion Roussel, Inc. | Substituted phenols and thiophenols useful as antioxidant agents |
JP2001515360A (ja) * | 1997-04-18 | 2001-09-18 | バイオジェン,インコーポレイテッド | ▲II▼型TGF−βレセプター/免疫グロブリン定常領域融合タンパク質 |
US6121463A (en) * | 1997-06-24 | 2000-09-19 | Hoechst Marion Roussel, Inc. | Alkyl-4-silylheterocyclic phenols and thiophenols useful as antioxidant agents |
US6133467A (en) * | 1997-06-25 | 2000-10-17 | Hoechst Marion Roussel, Inc. | 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol |
DE19741235A1 (de) | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19741873A1 (de) * | 1997-09-23 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
DE19751251A1 (de) | 1997-11-19 | 1999-05-20 | Hoechst Marion Roussel De Gmbh | Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate |
DE19821483A1 (de) | 1998-05-14 | 1999-11-18 | Hoechst Marion Roussel De Gmbh | Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
US7618630B2 (en) | 1998-09-14 | 2009-11-17 | Board Of Regents, The University Of Texas System | Methods of treating multiple myeloma and myeloma-induced bone resorption using integrin antagonists |
PL203114B1 (pl) | 1998-09-14 | 2009-08-31 | Regents Board Of | Zastosowania przeciwciała przeciw VLA-4 lub jego fragmentu wiążącego antygen, przeciwciała przeciw integrynie alfa-4/beta7 lub jego fragmentu wiążącego antygen lub przeciwciała przeciw VCAM-1 lub jego fragmentu wiążącego antygen, zastosowania rozpuszczalnych polipeptydów VLA-4 lub VCAM-1, które antagonizują interakcję VLA-4/VCAM-1 |
US6110109A (en) * | 1999-03-26 | 2000-08-29 | Biosignia, Inc. | System and method for predicting disease onset |
DK1173201T3 (da) | 1999-04-22 | 2005-09-12 | Biogen Idec Inc | Fremgangsmåde til behandling af fibrose ved anvendelse af en antagonist af integrin-alfa-4-underenheden |
DE19922462A1 (de) | 1999-05-17 | 2000-11-23 | Aventis Pharma Gmbh | Spiro-imidazolidinderivate, ihre Herstellung ihre Verwendung und sie enthaltende pharmazeutische Präparate |
EA011384B1 (ru) | 1999-06-01 | 2009-02-27 | Байоджен Айдек Ма Инк. | Способ лечения воспалительного заболевания |
JP4975922B2 (ja) * | 1999-09-14 | 2012-07-11 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 1つ以上のインテグリンアンタゴニストを使用する慢性腎不全の治療 |
CA2392615A1 (en) | 1999-12-06 | 2001-06-07 | The General Hospital Corporation | Pancreatic stem cells and their use in transplantation |
US20060115473A1 (en) * | 2000-12-14 | 2006-06-01 | Biogen Idec Ma Inc., A Massachusetts Corporation | Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists |
DK2140881T3 (da) | 1999-12-16 | 2013-05-06 | Biogen Idec Inc | Fremgangsmåder til behandling af iskæmisk eller hæmoragisk læsion i centralnervesystemet ved anvendelse af anti-alpha-4-integrin-antagonister |
JP3459609B2 (ja) * | 2000-03-17 | 2003-10-20 | 三洋電機株式会社 | ライトキャッシュ回路、ライトキャッシュ回路を備えた記録装置、およびライトキャッシュ方法 |
US20010046496A1 (en) * | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
DE10111877A1 (de) | 2001-03-10 | 2002-09-12 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
ATE471344T1 (de) | 2001-04-13 | 2010-07-15 | Biogen Idec Inc | Antikörper gegen vla-1 |
DE10137595A1 (de) | 2001-08-01 | 2003-02-13 | Aventis Pharma Gmbh | Neue Imidazolidinderivate, ihre Herstellung und ihre Verwendung |
FR2849598B1 (fr) * | 2003-01-07 | 2006-09-22 | Merck Sante Sas | Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans |
JP2006516624A (ja) | 2003-01-24 | 2006-07-06 | エラン ファーマシューティカルズ,インコーポレイテッド | 脱髄疾患および麻痺のための組成物ならびに再有髄化剤を投与することによるそれらの治療 |
US7419666B1 (en) | 2004-02-23 | 2008-09-02 | Massachusetts Eye And Ear Infirmary | Treatment of ocular disorders |
CA2478458A1 (en) * | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
JP2008520717A (ja) | 2004-11-19 | 2008-06-19 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 多発性硬化症についての処置 |
WO2006060787A2 (en) * | 2004-12-03 | 2006-06-08 | Biogen Idec Ma Inc. | Delaying or preventing onset of multiple sclerosis |
DK3264094T3 (da) | 2005-04-04 | 2020-11-23 | Biogen Ma Inc | Fremgangsmåder til evaluering af en immunrespons på et terapeutisk middel |
EP1948691A1 (en) * | 2005-11-17 | 2008-07-30 | Millennium Pharmaceuticals, Inc. | HUMANIZED IMMUNOGLOBULIN REACTIVE WITH a4ß7INTEGRIN |
BRPI0712607A8 (pt) | 2006-05-25 | 2019-06-04 | Biogen Idec Inc | métodos de tratamento de acidente vascular cerebral |
AR067011A1 (es) | 2007-06-14 | 2009-09-30 | Biogen Idec Inc | Formulaciones de anticuerpos |
WO2009038684A1 (en) | 2007-09-14 | 2009-03-26 | Biogen Idec Ma Inc. | Compositions and methods for the treatment of progressive multifocal leukoencephalopathy (pml) |
EP2315779A2 (en) | 2008-07-09 | 2011-05-04 | Biogen Idec MA Inc. | Compositions comprising antibodies to lingo or fragments thereof |
CA2758548A1 (en) * | 2009-04-17 | 2010-10-21 | Biogen Idec Ma Inc. | Compositions and methods to treat acute myelogenous leukemia |
US20120258093A1 (en) | 2009-08-20 | 2012-10-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vla-4 as a biomarker for prognosis and target for therapy in duchenne muscular dystrophy |
US9377458B2 (en) | 2009-10-11 | 2016-06-28 | Biogen Ma Inc. | Anti-VLA-4 related assays |
SG10201502967RA (en) | 2010-04-16 | 2015-05-28 | Biogen Ma Inc | Anti-vla-4 antibodies |
WO2012061074A1 (en) | 2010-10-25 | 2012-05-10 | Elan Pharmaceuticals, Inc. | METHODS FOR DETERMINING DIFFERENCES IN ALPHA-4 INTEGRIN ACTIVITY BY CORRELATING DIFFERENCES IN sVCAM AND/OR sMAdCAM LEVELS |
UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
EP4378959A3 (en) | 2011-05-02 | 2024-09-04 | Millennium Pharmaceuticals, Inc. | Formulation for anti-alpha4beta7 antibody |
ES2732243T3 (es) | 2012-02-16 | 2019-11-21 | Santarus Inc | Composiciones farmacéuticas de anticuerpos ANTI-VLA1 (CD49A) |
LT2828284T (lt) | 2012-03-20 | 2019-08-26 | Biogen Ma Inc. | Jcv neutralizuonatys antikūnai |
US9717453B2 (en) | 2012-04-20 | 2017-08-01 | Biogen Idec Ma Inc. | Cognitive composite parameters and uses thereof for evaluating multiple sclerosis |
NZ702178A (en) | 2012-05-14 | 2017-01-27 | Biogen Ma Inc | Lingo-2 antagonists for treatment of conditions involving motor neurons |
US8735359B2 (en) * | 2012-05-24 | 2014-05-27 | Orban Biotech Llc | Combinations of modalities for the treatment of diabetes |
EP2883177A1 (en) | 2012-08-13 | 2015-06-17 | Biogen Idec MA Inc. | Disease progression parameters and uses thereof for evaluating multiple sclerosis |
KR20210063443A (ko) | 2012-10-09 | 2021-06-01 | 바이오젠 엠에이 인코포레이티드 | 탈수초성 질환의 치료를 위한 복합 요법 및 용도 |
WO2015063604A2 (en) | 2013-11-01 | 2015-05-07 | Imberti Luisa | BIOMARKERS PREDICTIVE OF THERAPEUTIC RESPONSIVENESS TO IFNβ AND USES THEREOF |
JP2018504400A (ja) | 2015-01-08 | 2018-02-15 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | Lingo‐1拮抗薬及び脱髄障害の治療のための使用 |
WO2016197009A1 (en) | 2015-06-05 | 2016-12-08 | Vertex Pharmaceuticals Incorporated | Triazoles for the treatment of demyelinating diseases |
AU2017297404A1 (en) | 2016-07-13 | 2019-01-24 | Biogen Ma Inc. | Dosage regimens of LINGO-1 antagonists and uses for treatment of demyelinating disorders |
WO2018045162A1 (en) | 2016-09-01 | 2018-03-08 | Biogen Ma Inc. | Biomarkers predictive of primary progressive multiple sclerosis and uses thereof |
WO2018106641A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Pyrazoles for the treatment of demyelinating diseases |
WO2018106646A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Aminotriazoles for the treatment of demyelinating diseases |
WO2018106643A1 (en) | 2016-12-06 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Heterocyclic azoles for the treatment of demyelinating diseases |
WO2018140510A1 (en) | 2017-01-25 | 2018-08-02 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
US12037398B2 (en) | 2018-06-04 | 2024-07-16 | Biogen Ma Inc. | Anti-VLA-4 antibodies having reduced effector function |
KR20210136063A (ko) | 2019-03-11 | 2021-11-16 | 바이오젠 엠에이 인코포레이티드 | 항-lingo-1 항체를 포함하는 약제학적 조성물 |
WO2022162164A1 (en) | 2021-01-29 | 2022-08-04 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of assessing the risk of developing progressive multifocal leukoencephalopathy in patients treated with vla-4 antagonists |
Family Cites Families (20)
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---|---|---|---|---|
NZ215865A (en) * | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
US5053393A (en) * | 1988-07-20 | 1991-10-01 | Monsanto Company | Novel platelet-aggregation inhibitor |
US4879313A (en) * | 1988-07-20 | 1989-11-07 | Mosanto Company | Novel platelet-aggregation inhibitors |
ATE142505T1 (de) * | 1988-11-14 | 1996-09-15 | Brigham & Womens Hospital | Antikörper, spezifisch gegen elam-1 sowie deren verwendung |
US5225538A (en) * | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
US5272263A (en) * | 1989-04-28 | 1993-12-21 | Biogen, Inc. | DNA sequences encoding vascular cell adhesion molecules (VCAMS) |
US5217870A (en) * | 1989-04-28 | 1993-06-08 | Biogen, Inc. | Monoclonal antibodies against CDX |
US5061693A (en) * | 1989-07-28 | 1991-10-29 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
IL95501A (en) † | 1989-09-01 | 1997-04-15 | Hutchinson Fred Cancer Res | Inhibition by antibodies of lymphocyte adherence to vascular endothelium utilizing an extracellular matrix receptor-ligand interaction, and pharmaceutical compositions containing said antibodies |
US4952562A (en) * | 1989-09-29 | 1990-08-28 | Rorer Pharmaceutical Corporation | Anti-thrombotic peptides and pseudopeptides |
US5053392A (en) * | 1989-12-01 | 1991-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Novel arginine, glycine, aspartic acid derivatives as platelet-aggregation inhibitors |
US5260277A (en) * | 1990-09-10 | 1993-11-09 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
WO1993008823A1 (en) * | 1991-11-06 | 1993-05-13 | Tanabe Seiyaku Co., Ltd. | Guanidinyl and related cell adhesion modulation compounds |
DE69309044T3 (de) * | 1992-01-13 | 2004-12-23 | Biogen, Inc., Cambridge | Behandlung von asthma |
EP0625912B1 (en) * | 1992-02-12 | 1997-04-16 | Biogen, Inc. | Treatment for inflammatory bowel disease |
JP3731892B2 (ja) * | 1992-11-13 | 2006-01-05 | ボード オブ リージェンツ オブ ユニバーシティ オブ ワシントン | 造血幹細胞の末梢化 |
US5591719A (en) * | 1992-12-10 | 1997-01-07 | Regents Of The University Of Minnesota | Method for treating acute and chronic inflammatory disorders using polypeptides with fibronectin activity |
ATE182625T1 (de) * | 1993-01-12 | 1999-08-15 | Biogen Inc | Rekombinante anti-vla4 antikörpermoleküle |
WO1994017828A2 (en) * | 1993-02-09 | 1994-08-18 | Biogen, Inc. | Treatment for insulin dependent diabetes |
KR100367948B1 (ko) * | 1994-01-25 | 2003-07-12 | 엘란 파마슈티칼스, 인크. | 백혈구부착분자vla-4에대한인체화된항체 |
-
1994
- 1994-02-09 WO PCT/US1994/001456 patent/WO1994017828A2/en active IP Right Grant
- 1994-02-09 AU AU62379/94A patent/AU687790B2/en not_active Ceased
- 1994-02-09 DK DK94909584T patent/DK0682529T4/da active
- 1994-02-09 DE DE69407758T patent/DE69407758T3/de not_active Expired - Lifetime
- 1994-02-09 ES ES94909584T patent/ES2114183T5/es not_active Expired - Lifetime
- 1994-02-09 NZ NZ262615A patent/NZ262615A/en not_active IP Right Cessation
- 1994-02-09 JP JP51833394A patent/JP3593343B2/ja not_active Expired - Fee Related
- 1994-02-09 EP EP94909584A patent/EP0682529B2/en not_active Expired - Lifetime
- 1994-02-09 AT AT94909584T patent/ATE161730T1/de active
- 1994-02-09 CA CA2155303A patent/CA2155303C/en not_active Expired - Fee Related
-
1995
- 1995-05-22 US US08/447,118 patent/US5888507A/en not_active Expired - Lifetime
-
1998
- 1998-04-03 GR GR980400715T patent/GR3026531T3/el unknown
- 1998-07-06 HK HK98108899A patent/HK1008731A1/xx not_active IP Right Cessation
-
2005
- 2005-04-11 US US11/103,362 patent/US20050208053A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU687790B2 (en) | 1998-03-05 |
DK0682529T4 (da) | 2006-05-15 |
DE69407758T3 (de) | 2007-05-24 |
EP0682529A1 (en) | 1995-11-22 |
AU6237994A (en) | 1994-08-29 |
NZ262615A (en) | 1996-02-27 |
CA2155303C (en) | 2010-04-20 |
JPH08508719A (ja) | 1996-09-17 |
HK1008731A1 (en) | 1999-05-14 |
US5888507A (en) | 1999-03-30 |
EP0682529B1 (en) | 1998-01-07 |
JP3593343B2 (ja) | 2004-11-24 |
DE69407758T2 (de) | 1998-08-27 |
GR3026531T3 (en) | 1998-07-31 |
EP0682529B2 (en) | 2005-12-28 |
WO1994017828A3 (en) | 1994-10-13 |
WO1994017828A2 (en) | 1994-08-18 |
DK0682529T3 (da) | 1998-09-07 |
DE69407758D1 (de) | 1998-02-12 |
US20050208053A1 (en) | 2005-09-22 |
ES2114183T5 (es) | 2006-06-16 |
CA2155303A1 (en) | 1994-08-18 |
ATE161730T1 (de) | 1998-01-15 |
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