[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES2167745T3 - Suspensiones acuosas de esteres de acidos grasos de 9-hidroxi-risperidona. - Google Patents

Suspensiones acuosas de esteres de acidos grasos de 9-hidroxi-risperidona.

Info

Publication number
ES2167745T3
ES2167745T3 ES97923912T ES97923912T ES2167745T3 ES 2167745 T3 ES2167745 T3 ES 2167745T3 ES 97923912 T ES97923912 T ES 97923912T ES 97923912 T ES97923912 T ES 97923912T ES 2167745 T3 ES2167745 T3 ES 2167745T3
Authority
ES
Spain
Prior art keywords
composition
risperidona
esteres
hidroxi
fatty acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97923912T
Other languages
English (en)
Inventor
Marc Karel Jozef Francois
Roger Carolus August Embrechts
Herman Karel Borghijs
Johan Monbaliu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8224016&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2167745(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2167745T3 publication Critical patent/ES2167745T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UNA COMPOSICION FARMACEUTICA ADECUADA COMO FORMULACION DE BASE PARA LA ADMINISTRACION POR INYECCION, VIA INTRAMUSCULAR O SUBCUTANEA. DICHA COMPOSICION COMPRENDE: (1) COMO INGREDIENTE ACTIVO, UNA CANTIDAD TERAPEUTICAMENTE EFECTIVA DE UN ESTER DE ACIDO GRASO DE 9 HIDROXIRISPERIDONA O UNA SAL O UN ESTEREOISOMERO O UNA MEZCLA ESTEROISOMERICA DE ESTOS Y (2) UN TRANSPORTADOR FARMACEUTICAMENTE ACEPTABLE, SIENDO ESTE ULTIMO AGUA, EN EL QUE VA SUSPENDIDO DICHO INGREDIENTE ACTIVO. TAMBIEN SE DESCRIBE UN PROCEDIMIENTO DE PREPARACION DE DICHA COMPOSICION. LA INVENCION SE REFIERE ADEMAS AL USO DE DICHA COMPOSICION COMO MEDICAMENTO EN EL TRATAMIENTO DE LA ESQUIZOFRENIA, PSICOSIS NO ESQUIZOFRENICA, PERTURBACIONES DE LA CONDUCTA ASOCIADAS CON TRASTORNOS NEURODEGENERATIVOS, POR EJEMPLO EN LA DEMENCIA, PERTURBACIONES DE LA CONDUCTA EN RETRASO MENTAL Y AUTISMO, MANIA BIPOLAR, DEPRESION, Y ANSIEDAD.
ES97923912T 1996-05-20 1997-05-12 Suspensiones acuosas de esteres de acidos grasos de 9-hidroxi-risperidona. Expired - Lifetime ES2167745T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96201429 1996-05-20

Publications (1)

Publication Number Publication Date
ES2167745T3 true ES2167745T3 (es) 2002-05-16

Family

ID=8224016

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97923912T Expired - Lifetime ES2167745T3 (es) 1996-05-20 1997-05-12 Suspensiones acuosas de esteres de acidos grasos de 9-hidroxi-risperidona.

Country Status (38)

Country Link
US (1) US6077843A (es)
EP (1) EP0904081B1 (es)
JP (1) JP3274687B2 (es)
KR (1) KR100358373B1 (es)
CN (1) CN1093762C (es)
AR (1) AR007194A1 (es)
AT (1) ATE208619T1 (es)
AU (1) AU715572B2 (es)
BG (1) BG62684B1 (es)
BR (1) BR9706824B8 (es)
CA (1) CA2236691C (es)
CY (2) CY2270B1 (es)
CZ (1) CZ291284B6 (es)
DE (2) DE122011100027I1 (es)
DK (1) DK0904081T3 (es)
EA (1) EA000536B1 (es)
EE (1) EE03594B1 (es)
ES (1) ES2167745T3 (es)
FR (1) FR11C0035I2 (es)
HK (1) HK1017852A1 (es)
HR (1) HRP970276B1 (es)
HU (2) HU224025B1 (es)
ID (1) ID16927A (es)
IL (1) IL124551A (es)
LU (1) LU91842I2 (es)
MX (1) MX9804816A (es)
MY (1) MY126302A (es)
NO (2) NO315931B1 (es)
NZ (1) NZ330369A (es)
PL (1) PL188309B1 (es)
PT (1) PT904081E (es)
SI (1) SI0904081T1 (es)
SK (1) SK284013B6 (es)
TR (1) TR199800923T2 (es)
TW (1) TW487572B (es)
UA (1) UA61898C2 (es)
WO (1) WO1997044039A1 (es)
ZA (1) ZA974331B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2245252A1 (es) * 2004-06-15 2005-12-16 Farmalider, S.A. Solucion acuosa de risperidona para administracion oral.

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA72189C2 (uk) * 1997-11-17 2005-02-15 Янссен Фармацевтика Н.В. Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот
DE69917000T2 (de) * 1998-02-25 2005-04-21 Abbott Lab Butorphanol enthaltende formulierungen mit verzögerter freisetzung
WO2000010572A1 (en) * 1998-08-18 2000-03-02 Sepracor Inc. Use of hydroxyrisperidone for the manufacture of a medicament for the treatment and prevention of psychoses, emesis and symptoms of withdrawal from alcohol and nicotine
SK288541B6 (sk) 1999-03-31 2018-03-05 Janssen Pharmaceutica N. V. Predželatínovaný škrob v hydrofilnej formulácii s riadeným uvoľňovaním
US6495164B1 (en) 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
CA2419314C (en) * 2000-08-14 2006-07-11 Teva Pharmaceutical Industries Ltd. Preparation of risperidone
US7666445B2 (en) * 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
GB0216416D0 (en) * 2002-07-15 2002-08-21 Novartis Ag Organic compounds
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
ES2293039T3 (es) * 2002-07-29 2008-03-16 Alza Corporation Procedimiento y formas de dosificacion para el suministro controlado de paliperidona.
GB0322994D0 (en) * 2003-10-01 2003-11-05 Novartis Ag Organic compounds
AU2004285448C1 (en) 2003-10-23 2021-08-19 Otsuka Pharmaceutical Co., Ltd. Controlled release sterile injectable aripiprazole formulation and method
US8329203B2 (en) * 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
CA2553254C (en) * 2004-01-12 2013-12-17 The Trustees Of The University Of Pennsylvania Long-term delivery formulations and methods of use thereof
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
CN101163702B (zh) 2005-04-25 2011-09-07 詹森药业有限公司 制备无菌的3-[2-[4-(6-氟-1,2-苯并异唑-3-基)-1-哌啶基]乙基]-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并[1,2-a]嘧啶-4-酮棕榈酸酯的方法
PL116330U1 (en) * 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
PT2359808E (pt) 2006-08-09 2013-08-28 Intarcia Therapeutics Inc Sistemas de entrega osmótica e montagens de pistão
US8314110B2 (en) * 2007-04-19 2012-11-20 Youxin Li Compounds for treating mental disorders, and preparation and uses thereof
RU2440097C2 (ru) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Способ лечения диабета ii типа и ожирения, осмотическое устройство для доставки и способ его изготовления
US20090076035A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched paliperidone
RS61765B1 (sr) * 2007-12-19 2021-05-31 Janssen Pharmaceutica Nv Režim doziranja povezan sa dugodelujućim injektabilnim estrima paliperidona
WO2009089076A2 (en) * 2008-01-10 2009-07-16 Teva Pharmaceutical Industries Ltd. Processes for the preparation and purification of paliperidone palmitate
US8343140B2 (en) 2008-02-13 2013-01-01 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
WO2010028257A1 (en) 2008-09-04 2010-03-11 Amylin Pharmaceuticals, Inc. Sustained release formulations using non-aqueous carriers
EP3323423B1 (en) 2009-09-28 2020-06-17 Intarcia Therapeutics, Inc Rapid establishment and/or termination of substantial steady-state drug delivery
JP2013509435A (ja) 2009-10-30 2013-03-14 ヤンセン ファーマシューティカ エヌ．ベー． 長時間作用型注入可能パリペリドンエステルに関連した投与レジメン
WO2011074017A1 (en) * 2009-12-17 2011-06-23 Alkem Laboratories Ltd. A novel process for the preparation of paliperidone
TWI577377B (zh) 2010-09-16 2017-04-11 Ｖｉｉｖ醫療保健公司 醫藥組合物
CN107625728A (zh) 2010-10-18 2018-01-26 大日本住友制药株式会社 注射用缓释制剂
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
PL2683717T3 (pl) 2011-05-31 2016-11-30 Wytwarzanie 3-[2-[4-((6-fluoro-1,2-benzoizoksazol-3-ilo)-1-piperydynylo)-6,7,8,9-tetrahydro-9- hydroksy-2-metylo-4H-pirydo[1,2-a]pirymidyn-4-onu (paliperydonu) i palmitynianu paliperydonu
WO2013046225A2 (en) * 2011-08-10 2013-04-04 Glenmark Generics Limited Process for the preparation of paliperidone palmitate
CN102993200B (zh) * 2011-09-10 2016-02-03 鲁翠涛 帕潘立酮氨基酸酯及其制备方法
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
US10525057B2 (en) 2013-09-24 2020-01-07 Otsuka Pharmaceutical Co., Ltd. Method of providing aripiprazole to patients having impaired CYP2D6 or CYP3A4 enzyme function
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
HUE049485T2 (hu) 2015-04-07 2020-09-28 Janssen Pharmaceuticals Inc Adagolási rend hosszan ható, injektálható paliperidon-észterek beadásának elmaradása esetén
JP6993235B2 (ja) 2015-06-03 2022-01-13 インターシア セラピューティクス，インコーポレイティド インプラントの設置及び撤去システム
BR112018073511A2 (pt) 2016-05-16 2019-03-26 Intarcia Therapeutics, Inc. polipeptídeos seletivos do receptor de glucagon e métodos de uso dos mesmos
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
MX2023006368A (es) 2020-11-30 2023-08-07 Janssen Pharmaceutica Nv Regimenes de dosificacion asociados con formulaciones inyectables de paliperidona de liberacion prolongada.
PL4025187T3 (pl) 2020-11-30 2024-04-29 Janssen Pharmaceutica Nv Schematy dawkowania związane z formulacjami paliperydonu do wstrzykiwania o przedłużonym uwalnianiu
WO2022112367A1 (en) 2020-11-30 2022-06-02 Janssen Pharmaceutica Nv Methods for ensuring resuspension of paliperidone palmitate formulations
DK4025188T3 (da) 2020-11-30 2024-03-04 Janssen Pharmaceutica Nv Doseringsregimer associeret med injicerbare paliperidonformuleringer med forlænget frigivelse
HUP2100259A1 (hu) 2021-07-07 2023-01-28 Richter Gedeon Nyrt Cariprazine tartalmú szabályozott hatóanyag-leadású injekciós készítmények
EP4137136A1 (en) 2021-08-20 2023-02-22 Janssen Pharmaceutica NV Dosing regimens associated with extended release paliperidone injectable formulations

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
US5254556A (en) * 1988-11-07 1993-10-19 Janssen Pharmaceutica N.V. 3-piperidinyl-1,2-benzisoxazoles
TW376319B (en) * 1993-04-28 1999-12-11 Janssen Pharmaceutica Nv Pharmaceutical composition containing risperidone pamoate and having a long acting activity for treating psychoses induced by the release of dopamine
EP0729357B1 (en) * 1993-11-19 2005-02-02 Janssen Pharmaceutica N.V. Microencapsulated 1,2-benzazoles
CA2474701C (en) * 1993-11-19 2009-01-27 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradeable microparticles containing a biologically active agent
US5650173A (en) * 1993-11-19 1997-07-22 Alkermes Controlled Therapeutics Inc. Ii Preparation of biodegradable microparticles containing a biologically active agent
KR100304179B1 (ko) * 1995-06-06 2001-11-22 게리 디. 스트리트, 스티븐 엘. 네스비트 항정신병제로서의벤즈이속사졸및인다졸유도체,이의제조방법및이를함유하는약제학적조성물
US5792477A (en) * 1996-05-07 1998-08-11 Alkermes Controlled Therapeutics, Inc. Ii Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2245252A1 (es) * 2004-06-15 2005-12-16 Farmalider, S.A. Solucion acuosa de risperidona para administracion oral.
WO2005123085A1 (es) * 2004-06-15 2005-12-29 Farmalider, S.A. Solución acuosa de risperidona para administración oral

Also Published As

Publication number Publication date
BG102443A (en) 1999-06-30
HUP9901319A2 (hu) 1999-08-30
CY2011011I2 (el) 2016-12-14
CN1093762C (zh) 2002-11-06
EE9800136A (et) 1998-10-15
EA000536B1 (ru) 1999-10-28
HUP9901319A3 (en) 1999-11-29
HRP970276B1 (en) 2002-04-30
NZ330369A (en) 2000-04-28
PL327995A1 (en) 1999-01-04
FR11C0035I2 (fr) 2013-08-16
LU91842I2 (fr) 2011-09-20
JP3274687B2 (ja) 2002-04-15
CZ291284B6 (cs) 2003-01-15
DK0904081T3 (da) 2002-02-25
SK62098A3 (en) 2000-04-10
SI0904081T1 (en) 2002-04-30
NO2011015I1 (no) 2011-09-19
IL124551A (en) 2001-08-26
EE03594B1 (et) 2002-02-15
NO2011015I2 (no) 2013-03-11
KR19990067603A (ko) 1999-08-25
WO1997044039A1 (en) 1997-11-27
TW487572B (en) 2002-05-21
MX9804816A (es) 1998-10-31
FR11C0035I1 (es) 2011-07-10
HU224025B1 (hu) 2005-05-30
IL124551A0 (en) 1998-12-06
US6077843A (en) 2000-06-20
ZA974331B (en) 1998-11-19
TR199800923T2 (xx) 1999-09-21
PL188309B1 (pl) 2005-01-31
PT904081E (pt) 2002-04-29
HRP970276A2 (en) 1998-04-30
NO981984L (no) 1998-11-19
NO981984D0 (no) 1998-04-30
HUS1100013I1 (hu) 2017-03-28
CY2011011I1 (el) 2016-12-14
KR100358373B1 (ko) 2003-02-11
AR007194A1 (es) 1999-10-13
DE69708284T2 (de) 2002-07-25
SK284013B6 (sk) 2004-08-03
DE122011100027I1 (de) 2011-11-17
DE69708284D1 (de) 2001-12-20
CY2270B1 (en) 2003-07-04
EP0904081B1 (en) 2001-11-14
JP2000513718A (ja) 2000-10-17
ID16927A (id) 1997-11-20
CA2236691C (en) 2007-01-02
NO315931B1 (no) 2003-11-17
AU715572B2 (en) 2000-02-03
BR9706824B8 (pt) 2015-02-18
HK1017852A1 (en) 1999-12-03
UA61898C2 (en) 2003-12-15
CA2236691A1 (en) 1997-11-27
BG62684B1 (bg) 2000-05-31
CN1206347A (zh) 1999-01-27
EP0904081A1 (en) 1999-03-31
AU2955997A (en) 1997-12-09
CZ140198A3 (cs) 1999-04-14
EA199800531A1 (ru) 1998-12-24
ATE208619T1 (de) 2001-11-15
MY126302A (en) 2006-09-29
BR9706824A (pt) 1999-03-23

Similar Documents

Publication Publication Date Title
ES2167745T3 (es) Suspensiones acuosas de esteres de acidos grasos de 9-hidroxi-risperidona.
EA200000541A1 (ru) Водные суспензии субмикронных 9-гидроксирисперидоновых сложных эфиров жирных кислот
ES2058109T3 (es) Un procedimiento para la preparacion de una composicion farmaceutica antimicrobiana topica.
BR9809655A (pt) Uso de derivados do ácido fumárico
SE8503664L (sv) Ett system for tillforsel av lekemedel
BR0209320A (pt) ésteres de uridina farmaceuticamente ativos
ES2185758T3 (es) Utilizacion de esteres grasos etoxilados como compuestos auto-emulsionables.
GT199800150A (es) Derivados de resorcinol.
HUP0101580A2 (hu) Gélesedő gyógyászati készítmények
KR100397034B1 (ko) 비강투여용비무기식염용액
BRPI0107731B8 (pt) método para purificar daptomicina
KR960700062A (ko) 산성 pH에서의 안정성을 개선시키기 위해 변형된 올리고누클레오티드(OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACIC pH)
BR9812553A (pt) Formulação medicamentosa com liberação de substância ativa controlada
IL97796A0 (en) Pharmaceutical compositions containing n-alkylated 1,4-dihydropyridine-dicarboxylic acid esters,certain such compounds and their preparation
WO1987004926A3 (en) Method of modifying the lipid structure of cell membranes and pharmaceutical compositions for use therein
AR004625A1 (es) Composicion de un oseo activo que comprende una sustancia de un oseo activo y un carrier bilogico de dicha sustancia,composicion farmaceutica que comprende dicha composicion de un oseo-activo,y uso de dicha composicion para la preparacion de un medicamento
ES2093782T3 (es) Piridazindionas y su uso en el tratamiento de trastornos neurologicos.
AR005102A1 (es) Compuestos derivados de octahidro-pirrolo [1,2-a]-pirazina 2,7-sustituidos, composiciones farmaceuticas y uso de dichos compuestos para la fabricacion deun medicamento.
IT1253832B (it) Derivati di gangliosidi
WO2001018031A3 (en) Peptides and pharmaceutical compositions comprising same
JPH0366618A (ja) 薬学的配合物
MX9300057A (es) Ester especial del acido 1,4-dihidropiridin-3,5-dicarboxilico y procedimiento para su obtencion.
US4837203A (en) Pharmacologically active compounds and use
KR870700024A (ko) 약, 비타민 또는 왁진의 근육내 주사용 제제
AU7338587A (en) Pharmaceutical compositions of furosemide, piretanide or lemidosul in a fatty acid alkanolamide base