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IT1253832B - Derivati di gangliosidi - Google Patents

Derivati di gangliosidi

Info

Publication number
IT1253832B
IT1253832B ITPD910139A ITPD910139A IT1253832B IT 1253832 B IT1253832 B IT 1253832B IT PD910139 A ITPD910139 A IT PD910139A IT PD910139 A ITPD910139 A IT PD910139A IT 1253832 B IT1253832 B IT 1253832B
Authority
IT
Italy
Prior art keywords
gangliosides
acyl
lyso
pharmaceutical preparations
groups
Prior art date
Application number
ITPD910139A
Other languages
English (en)
Inventor
Gino Toffano
Aurelio Romeo
Alberta Leon
Original Assignee
Fidia Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fidia Spa filed Critical Fidia Spa
Publication of ITPD910139A0 publication Critical patent/ITPD910139A0/it
Priority to ITPD910139A priority Critical patent/IT1253832B/it
Priority to US07/922,383 priority patent/US5350841A/en
Priority to PT100756A priority patent/PT100756B/pt
Priority to EP92917164A priority patent/EP0599908B1/en
Priority to AT92917164T priority patent/ATE150028T1/de
Priority to DE69218222T priority patent/DE69218222T2/de
Priority to JP5503281A priority patent/JPH06509350A/ja
Priority to AU24265/92A priority patent/AU2426592A/en
Priority to PCT/EP1992/001776 priority patent/WO1993003049A1/en
Priority to ES92917164T priority patent/ES2100360T3/es
Publication of ITPD910139A1 publication Critical patent/ITPD910139A1/it
Application granted granted Critical
Publication of IT1253832B publication Critical patent/IT1253832B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invenzione riguarda dei nuovi derivati di gangliosidi e più precisamente delle carbossilamidi dei gruppi sialici dei gangliosidi, e di gangliosidi semisintetici scelti dal gruppo formato dagli N-acil-N-liso-gangliosidi, N'-acil-N'-liso-gangliosidi, N, N'-diacil-N, N'-di-lios-gangliosidi in cui i gruppi N e N'-acilici derivano da acidi della serie alifatica, in cui il gruppo amidico deriva da un aminoacido di natura alifatica con funzione acida carbossilica o solfonica, e i loro sali.L'invenzione comprende pure delle preparazioni farmaceutiche comprendenti i suddetti composti come ingredienti attivi, e l'uso terapeutico dei nuovi prodotti e delle relative preparazioni farmaceutiche.
ITPD910139A 1991-08-01 1991-08-01 Derivati di gangliosidi IT1253832B (it)

Priority Applications (10)

Application Number Priority Date Filing Date Title
ITPD910139A IT1253832B (it) 1991-08-01 1991-08-01 Derivati di gangliosidi
US07/922,383 US5350841A (en) 1991-08-01 1992-07-31 Ganglioside derivatives
PT100756A PT100756B (pt) 1991-08-01 1992-07-31 Novos derivados de gangliosidos, processo para a sua preparacao e composicoes farmaceuticas que os contem
AT92917164T ATE150028T1 (de) 1991-08-01 1992-08-01 Neue ganglioside-derivaten
EP92917164A EP0599908B1 (en) 1991-08-01 1992-08-01 New ganglioside derivatives
DE69218222T DE69218222T2 (de) 1991-08-01 1992-08-01 Neue ganglioside-derivaten
JP5503281A JPH06509350A (ja) 1991-08-01 1992-08-01 新規なガングリオシド誘導体
AU24265/92A AU2426592A (en) 1991-08-01 1992-08-01 New ganglioside derivatives
PCT/EP1992/001776 WO1993003049A1 (en) 1991-08-01 1992-08-01 New ganglioside derivatives
ES92917164T ES2100360T3 (es) 1991-08-01 1992-08-01 Nuevos derivados de gangliosidos.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITPD910139A IT1253832B (it) 1991-08-01 1991-08-01 Derivati di gangliosidi

Publications (3)

Publication Number Publication Date
ITPD910139A0 ITPD910139A0 (it) 1991-08-01
ITPD910139A1 ITPD910139A1 (it) 1993-02-01
IT1253832B true IT1253832B (it) 1995-08-29

Family

ID=11389659

Family Applications (1)

Application Number Title Priority Date Filing Date
ITPD910139A IT1253832B (it) 1991-08-01 1991-08-01 Derivati di gangliosidi

Country Status (10)

Country Link
US (1) US5350841A (it)
EP (1) EP0599908B1 (it)
JP (1) JPH06509350A (it)
AT (1) ATE150028T1 (it)
AU (1) AU2426592A (it)
DE (1) DE69218222T2 (it)
ES (1) ES2100360T3 (it)
IT (1) IT1253832B (it)
PT (1) PT100756B (it)
WO (1) WO1993003049A1 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407072B1 (en) * 1988-12-02 2002-06-18 Fidia S.P.A. Lysoganglioside derivatives
IT1232175B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Analoghi semisintetici di gangliosidi
IT1254280B (it) * 1992-03-13 1995-09-14 Fidia Spa Composizioni farmaceutiche comprendenti monosialoganglioside gm1 o un suo derivato atte al trattamento della malattia di parkinson
US5795869A (en) * 1993-03-04 1998-08-18 Fidia S.P.A. Sulfated lyso-ganglioside derivatives
IT1267955B1 (it) * 1993-03-04 1997-02-18 Fidia S P A In Amministrazione Derivati solfatati dei lisogangliosidi
IT1267956B1 (it) * 1993-03-04 1997-02-18 Fidia S P A In Amministrazione Derivati o-solfatati di gangliosidi e lisogangliosidi
US5849717A (en) * 1993-03-04 1998-12-15 Fidia S.P.A. O-sulfated gangliosides and lyso-ganglioside derivatives
EP0812855B1 (en) * 1995-12-18 2001-08-08 Daikin Industries, Limited Fluorinated ganglioside gm3 analogues and intermediates therefor
MXPA04001831A (es) 2001-08-29 2004-07-08 Neose Technologies Inc Nuevos derivados sinteticos de gangliosidos y composiciones de los mismos.
NZ542148A (en) 2003-03-06 2008-05-30 Neose Technologies Inc Methods and compositions for the enzymatic synthesis of gangliosides
EP2410846B1 (en) 2009-03-25 2016-09-07 Seneb Biosciences, Inc. Glycolipids as treatment for disease
WO2023102665A1 (en) * 2021-12-09 2023-06-15 The Governors Of The University Of Alberta Cellular and tissue clearance of misfolded proteins and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1199116B (it) * 1984-07-03 1988-12-30 Fidia Farmaceutici Derivati di gangliosidi
IT1235161B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisogangliosidi
IT1232175B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Analoghi semisintetici di gangliosidi
IT1232176B (it) * 1989-07-27 1992-01-25 Fidia Farmaceutici Derivati di-lisogangliosidi
IT1238346B (it) * 1989-11-14 1993-07-13 Gangliosidi modificati e loro derivati funzionali.

Also Published As

Publication number Publication date
ATE150028T1 (de) 1997-03-15
US5350841A (en) 1994-09-27
PT100756A (pt) 1993-09-30
AU2426592A (en) 1993-03-02
EP0599908A1 (en) 1994-06-08
ITPD910139A0 (it) 1991-08-01
EP0599908B1 (en) 1997-03-12
PT100756B (pt) 1999-10-29
ITPD910139A1 (it) 1993-02-01
DE69218222T2 (de) 1997-10-09
DE69218222D1 (de) 1997-04-17
ES2100360T3 (es) 1997-06-16
JPH06509350A (ja) 1994-10-20
WO1993003049A1 (en) 1993-02-18

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19980515