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ES2160600T3 - Activacion transcutanea in vivo de agentes fotosensibles en la sangre. - Google Patents

Activacion transcutanea in vivo de agentes fotosensibles en la sangre.

Info

Publication number
ES2160600T3
ES2160600T3 ES93918860T ES93918860T ES2160600T3 ES 2160600 T3 ES2160600 T3 ES 2160600T3 ES 93918860 T ES93918860 T ES 93918860T ES 93918860 T ES93918860 T ES 93918860T ES 2160600 T3 ES2160600 T3 ES 2160600T3
Authority
ES
Spain
Prior art keywords
cells
objective
photosensible
animal
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93918860T
Other languages
English (en)
Inventor
Anna M Richter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novelion Therapeutics Inc
Original Assignee
Quadra Logic Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quadra Logic Technologies Inc filed Critical Quadra Logic Technologies Inc
Application granted granted Critical
Publication of ES2160600T3 publication Critical patent/ES2160600T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Radiation-Therapy Devices (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN METODO QUE DESTRUYE O DAÑA CELULAS OBJETIVO QUE TIENEN UN AGENTE FOTOSENSIBLE ACUMULADO SELECTIVAMENTE. LAS CELULAS OBJETIVOS ESTAN EN LA CORRIENTE SANGUINEA DE UN ANIMAL INTEGRO, CUYA CORRIENTE SANGUINEA Y ANIMAL CONTIENEN ADICIONALMENTE CELULAS DISTINTAS A LAS OBJETIVO. SE APLICA TRANSCUTANEAMENTE RADIACION A AL MENOS UNA PORCION DEL ANIMAL INTEGRO CON UNA INTENSIDAD EFECTIVA PARA DAÑAR O DESTRUIR SELECTIVAMENTE LAS CELULAS OBJETIVO Y PARA DEJAR LAS CELULAS DISTINTAS A LAS OBJETIVO RELATIVAMENTE NO DAÑADAS. LAS CELULAS OBJETIVO INCLUYEN CELULAS DE LEUCEMIA, CELULAS QUE CONTIENEN VIRUS, CELULAS QUE CONTIENEN PARASITO, Y MICROORGANISMOS TALES COMO BACTERIAS, PARASITOS Y VIRUS LIBRES.
ES93918860T 1992-09-21 1993-09-20 Activacion transcutanea in vivo de agentes fotosensibles en la sangre. Expired - Lifetime ES2160600T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US94811392A 1992-09-21 1992-09-21

Publications (1)

Publication Number Publication Date
ES2160600T3 true ES2160600T3 (es) 2001-11-16

Family

ID=25487290

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93918860T Expired - Lifetime ES2160600T3 (es) 1992-09-21 1993-09-20 Activacion transcutanea in vivo de agentes fotosensibles en la sangre.

Country Status (21)

Country Link
US (2) US5484803A (es)
EP (1) EP0660712B1 (es)
JP (2) JP3598306B2 (es)
AT (1) ATE201596T1 (es)
AU (1) AU681088B2 (es)
CA (1) CA2144327C (es)
DE (1) DE69330277T2 (es)
DK (1) DK0660712T3 (es)
ES (1) ES2160600T3 (es)
FI (1) FI951295A (es)
GR (1) GR3036479T3 (es)
HU (1) HU220251B (es)
IL (1) IL107035A (es)
NO (1) NO951066L (es)
NZ (1) NZ255302A (es)
PL (1) PL308116A1 (es)
PT (1) PT660712E (es)
SK (1) SK35295A3 (es)
TW (1) TW241204B (es)
WO (1) WO1994006424A1 (es)
ZA (1) ZA936968B (es)

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US6710066B2 (en) * 1989-07-28 2004-03-23 Queen's University At Kingston Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
US5955490A (en) * 1989-07-28 1999-09-21 Queen's University At Kingston Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
US5587490A (en) * 1990-04-16 1996-12-24 Credit Managers Association Of California Method of inactivation of viral and bacterial blood contaminants
US5798238A (en) * 1990-04-16 1998-08-25 Baxter International Inc. Method of inactivation of viral and bacterial blood contaminants with quinolines as photosensitizer
US20040110819A1 (en) * 1991-10-28 2004-06-10 Queen's University At Kingston Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
AU679016B2 (en) * 1992-11-20 1997-06-19 University Of British Columbia, The Method of activating photosensitive agents
WO1996039188A1 (en) * 1995-06-05 1996-12-12 Queen's University At Kingston Photochemotherapeutic method using 5-aminolevulinic acid and other precursors of endogenous porphyrins
US6008211A (en) * 1995-07-27 1999-12-28 Pdt Pharmaceuticals, Inc. Photoactivatable compounds comprising benzochlorin and furocoumarin
CA2236873A1 (en) * 1995-11-06 1997-05-15 New York Blood Center, Inc. Viral inactivation treatment of red blood cells using phthalocyanines and red light
US5895786A (en) * 1996-05-08 1999-04-20 New York Blood Center, Inc. Method for treating viral infections
US6159733A (en) * 1996-06-20 2000-12-12 New York Blood Center, Inc. Method for photoinactivating malignant cells
US5922278A (en) † 1996-11-19 1999-07-13 Baxter International Inc. Method and apparatus for inactivating contaminants in biological fluid
US5742380A (en) * 1996-12-31 1998-04-21 Ronn Avigdor M Plasma assay spectrometer
US6103706A (en) * 1997-04-29 2000-08-15 New York Blood Center, Inc. Methods for treating viral infections
US6010890A (en) * 1997-04-29 2000-01-04 New York Blood Center, Inc. Method for viral inactivation and compositions for use in same
US5856566A (en) 1997-09-02 1999-01-05 Dusa Pharmaceuticals, Inc. Sterilized 5-aminolevulinic acid
US6159178A (en) 1998-01-23 2000-12-12 Heartport, Inc. Methods and devices for occluding the ascending aorta and maintaining circulation of oxygenated blood in the patient when the patient's heart is arrested
US6096066A (en) * 1998-09-11 2000-08-01 Light Sciences Limited Partnership Conformal patch for administering light therapy to subcutaneous tumors
US6183773B1 (en) 1999-01-04 2001-02-06 The General Hospital Corporation Targeting of sebaceous follicles as a treatment of sebaceous gland disorders
CA2356532A1 (en) * 1999-01-15 2000-07-20 Light Sciences Corporation Noninvasive vascular therapy
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
ATE234114T1 (de) * 1999-01-15 2003-03-15 Light Sciences Corp Therapeutische zusammensetzungen fur knochenstoffwechselstörungen oder knochenmetastasen enthaltend einen photosensitizer und ein bisphosphonat
US6454789B1 (en) * 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
US6376483B1 (en) 1999-05-27 2002-04-23 Miravant Pharmaceuticals, Inc. Bacteriochlorins and bacteriopurpurins useful as photoselective compounds for photodynamic therapy and a process for their production
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
DE19960705A1 (de) * 1999-12-16 2001-06-21 Laser & Med Tech Gmbh Verfahren und Vorrichtung zur Herstellung eines autologen Immunisierungsimpfstoffes gegen Krebserkrankungen (Tumorvakzine)
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US7166719B2 (en) 2002-06-27 2007-01-23 Health Research, Inc. Fluorinated photosensitizers related to chlorins and bacteriochlorins for photodynamic therapy
EP1267935A2 (en) * 2000-01-12 2003-01-02 Light Sciences Corporation Novel treatment for eye disease
KR100365151B1 (ko) * 2000-05-08 2003-02-11 김형락 어류 병원성 세균과 바이러스의 감염 예방 및 치료를 위한δ-아미노레불린산의 신규한 용도
DE10034673C1 (de) 2000-07-17 2002-04-25 Medac Klinische Spezialpraep Dermales Applikationssystem für Aminolävulinsäure und seine Verwendung
EP2248536A3 (en) 2000-12-14 2010-12-08 The General Hospital Corporation doing business as Massachusetts General Hospital Topical Aminolevulinic acid-photodynamic therapy for acne vulgaris
AU2001291260A1 (en) 2000-08-16 2002-02-25 The General Hospital Corporation D/B/A Massachusetts General Hospital Topical aminolevulinic acid-photodynamic therapy for acne vulgaris
US7498029B2 (en) * 2001-05-01 2009-03-03 The General Hospital Corporation Photoimmunotherapies for cancer using combination therapies
AU2002327180A1 (en) * 2001-06-04 2003-01-21 The General Hospital Corporation Detection and therapy of vulnerable plaque with photodynamic compounds
DE10162712A1 (de) * 2001-12-19 2003-07-17 Blutspendienst Der Landesverba Verfahren zur Inaktivierung von Bakterien und Leukozyten in Blut oder Blutprodukten
WO2003061696A2 (en) * 2002-01-23 2003-07-31 Light Sciences Corporation Systems and methods for photodynamic therapy
US7053210B2 (en) 2002-07-02 2006-05-30 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
US7659301B2 (en) * 2003-04-15 2010-02-09 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US20070020272A1 (en) * 2003-04-30 2007-01-25 Tayyaba Hasan Indirectly linked photosensitizer immunoconjugates, processes for the production thereof and methods of use thereof
JP2007500227A (ja) * 2003-05-29 2007-01-11 ミトス・ファーマシューティカルズ・インコーポレーテッド 光増感剤及び音増感剤と関連してのニトロキシドの使用方法
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Also Published As

Publication number Publication date
SK35295A3 (en) 1996-05-08
CA2144327A1 (en) 1994-03-31
NO951066L (no) 1995-05-19
FI951295A0 (fi) 1995-03-20
DE69330277D1 (de) 2001-07-05
AU681088B2 (en) 1997-08-21
JP2001316288A (ja) 2001-11-13
JP3598306B2 (ja) 2004-12-08
US5736563A (en) 1998-04-07
DE69330277T2 (de) 2002-04-18
NZ255302A (en) 2001-04-27
IL107035A0 (en) 1993-12-28
IL107035A (en) 1998-12-27
ATE201596T1 (de) 2001-06-15
PL308116A1 (en) 1995-07-24
EP0660712B1 (en) 2001-05-30
HUT70966A (en) 1995-11-28
WO1994006424A1 (en) 1994-03-31
FI951295A (fi) 1995-05-17
HU220251B (hu) 2001-11-28
NO951066D0 (no) 1995-03-20
ZA936968B (en) 1994-04-12
GR3036479T3 (en) 2001-11-30
TW241204B (es) 1995-02-21
DK0660712T3 (da) 2001-08-27
PT660712E (pt) 2001-11-30
CA2144327C (en) 2002-08-06
EP0660712A1 (en) 1995-07-05
JPH08501301A (ja) 1996-02-13
US5484803A (en) 1996-01-16
AU4940593A (en) 1994-04-12

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