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ES2147601T3 - Procedimiento para la preparacion de 3-amino-2-cloro-4-alquil-piridinas o 3-amino-2-cloro-4-cicloalquil-piridinas. - Google Patents

Procedimiento para la preparacion de 3-amino-2-cloro-4-alquil-piridinas o 3-amino-2-cloro-4-cicloalquil-piridinas.

Info

Publication number
ES2147601T3
ES2147601T3 ES95902106T ES95902106T ES2147601T3 ES 2147601 T3 ES2147601 T3 ES 2147601T3 ES 95902106 T ES95902106 T ES 95902106T ES 95902106 T ES95902106 T ES 95902106T ES 2147601 T3 ES2147601 T3 ES 2147601T3
Authority
ES
Spain
Prior art keywords
amino
piridines
chlorine
alkyl
pct
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95902106T
Other languages
English (en)
Inventor
Heinrich Schneider
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
BOEHRINGER INGELHEIM PHARMA
Boehringer Ingelheim Pharma GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BOEHRINGER INGELHEIM PHARMA, Boehringer Ingelheim Pharma GmbH and Co KG filed Critical BOEHRINGER INGELHEIM PHARMA
Application granted granted Critical
Publication of ES2147601T3 publication Critical patent/ES2147601T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN NUEVO PROCESO PARA LA ELABORACION DE 3 - AMINO - 2 - CLORO - 4 - ALQUIL O - 4 - ARIL PIRIDINA EN UNA ESCALA COMERCIAL TECNICA.
ES95902106T 1993-12-02 1994-12-01 Procedimiento para la preparacion de 3-amino-2-cloro-4-alquil-piridinas o 3-amino-2-cloro-4-cicloalquil-piridinas. Expired - Lifetime ES2147601T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4341033 1993-12-02

Publications (1)

Publication Number Publication Date
ES2147601T3 true ES2147601T3 (es) 2000-09-16

Family

ID=6503969

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95902106T Expired - Lifetime ES2147601T3 (es) 1993-12-02 1994-12-01 Procedimiento para la preparacion de 3-amino-2-cloro-4-alquil-piridinas o 3-amino-2-cloro-4-cicloalquil-piridinas.

Country Status (11)

Country Link
US (1) US5686618A (es)
EP (1) EP0682655B1 (es)
JP (1) JP3516454B2 (es)
AT (1) ATE192437T1 (es)
CA (1) CA2155214C (es)
DE (2) DE59409324D1 (es)
DK (1) DK0682655T3 (es)
ES (1) ES2147601T3 (es)
GR (1) GR3034079T3 (es)
PT (1) PT682655E (es)
WO (1) WO1995015314A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535310A (ja) * 1999-01-22 2002-10-22 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド アセトン及びエチルシアノアセテートからの３‐アミノ−２−クロロ−４‐メチルピリジンの合成
CA2318441A1 (en) * 1999-01-22 2000-07-27 Boehringer Ingelheim Pharmaceuticals, Inc. Synthesis of 3-amino-2-chloro-4-methylpyridine from malononitrile and acetone
US6399781B1 (en) 2000-10-10 2002-06-04 Boehringer Ingelheim Chemicals, Inc. Process for making 3-amino-2-chloro-4-methylpyridine
CN114835714A (zh) * 2022-04-01 2022-08-02 上海蓝乐鸟实业有限公司 一种托法替尼的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5200522A (en) * 1991-06-11 1993-04-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for preparing 3-amino-2-chloro-4-alkylpyridines
DE69215346T2 (de) * 1991-06-11 1997-04-30 Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Conn. Verfahren zur herstellung von 3-amino-2-chloro-4-alkylpyridinen

Also Published As

Publication number Publication date
JP3516454B2 (ja) 2004-04-05
DE59409324D1 (de) 2000-06-08
WO1995015314A1 (de) 1995-06-08
CA2155214A1 (en) 1995-06-08
JPH08506361A (ja) 1996-07-09
US5686618A (en) 1997-11-11
EP0682655B1 (de) 2000-05-03
DK0682655T3 (da) 2000-08-07
PT682655E (pt) 2000-08-31
ATE192437T1 (de) 2000-05-15
GR3034079T3 (en) 2000-11-30
DE4442808A1 (de) 1995-06-08
CA2155214C (en) 2005-03-29
EP0682655A1 (de) 1995-11-22

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