[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES2033575B1 - Procedimiento para la resolucion de derivados de acido 3-(4-sustituido-fenil)-glicidico. - Google Patents

Procedimiento para la resolucion de derivados de acido 3-(4-sustituido-fenil)-glicidico.

Info

Publication number
ES2033575B1
ES2033575B1 ES919101192A ES9101192A ES2033575B1 ES 2033575 B1 ES2033575 B1 ES 2033575B1 ES 919101192 A ES919101192 A ES 919101192A ES 9101192 A ES9101192 A ES 9101192A ES 2033575 B1 ES2033575 B1 ES 2033575B1
Authority
ES
Spain
Prior art keywords
compounds
procedure
formula
resolution
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES919101192A
Other languages
English (en)
Other versions
ES2033575A1 (es
Inventor
Claudio Giordano
Roberto Casagrande
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon Group SpA
Zambon SpA
Original Assignee
Zambon Group SpA
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Group SpA, Zambon SpA filed Critical Zambon Group SpA
Publication of ES2033575A1 publication Critical patent/ES2033575A1/es
Application granted granted Critical
Publication of ES2033575B1 publication Critical patent/ES2033575B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA RESOLUCION CINETICA DE MEZCLAS ENANTIOMERICAS CIS O TRANS DE LOS COMPUESTOS DE FORMULA (III-A), EN DONDE R3 REPRESENTA UN ALCOXI C1-18 LINEAL O RAMIFICADO, UN BENCILOXILO O UN GRUPO AMINO, MONO O DIALQUILAMINO, EN DONDE LA FRACCION ALQUILO TIENE 1-6 ATOMOS DE CARBONO; X REPRESENTA UN METOXI O GRUPO TRANSFORMABLE EN MEYOXI ELEGIDO ENTRE EL GRUPO FORMADO POR HIDROXI E HIDROXI PROTEGIDO COMO BENCILOXI. EL PROCEDIMIENTO CONSISTE EN HACER REACCIONAR LA MEZCLA RACEMICA DE COMPUESTOS DE FORMULA (III-A), CON UN TIOFENOL DE FORMULA (II-A). LA REACCION SE REALIZA EN PRESENCIA DE UNA CANTIDAD CATALITICA DE UNA AMINA TERCIARIA OPTICAMENTE ACTIVA, EN UN DISOLVENTE INERTE, Y A TEMPERATURA ENTRE -20 C Y +30 C. ESTOS COMPUESTOS SE UTILIZAN COMO INTERMEDIARIOS EN LA PREPARACION DE COMPUESTOS ACTIVOS SOBRE EL SISTEMA CARDIOVASCULAR.
ES919101192A 1990-05-17 1991-05-16 Procedimiento para la resolucion de derivados de acido 3-(4-sustituido-fenil)-glicidico. Expired - Fee Related ES2033575B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20349A IT1240651B (it) 1990-05-17 1990-05-17 Processo per la risoluzione di derivati glicidici

Publications (2)

Publication Number Publication Date
ES2033575A1 ES2033575A1 (es) 1993-03-16
ES2033575B1 true ES2033575B1 (es) 1994-02-01

Family

ID=11165943

Family Applications (1)

Application Number Title Priority Date Filing Date
ES919101192A Expired - Fee Related ES2033575B1 (es) 1990-05-17 1991-05-16 Procedimiento para la resolucion de derivados de acido 3-(4-sustituido-fenil)-glicidico.

Country Status (13)

Country Link
US (1) US5198557A (es)
JP (1) JP3122953B2 (es)
AT (1) AT401055B (es)
BE (1) BE1004850A3 (es)
CA (1) CA2041305C (es)
CH (1) CH682075A5 (es)
DE (1) DE4115698C2 (es)
ES (1) ES2033575B1 (es)
FR (1) FR2662161B1 (es)
GB (1) GB2244055B (es)
IT (1) IT1240651B (es)
NL (1) NL194273C (es)
SE (1) SE509298C2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2658513B1 (fr) * 1990-02-21 1994-02-04 Rhone Poulenc Sante Procede de preparation de l'acide cis-beta-phenylglycidique-(2r,3r).
IT1249777B (it) * 1990-05-17 1995-03-18 Zambon Spa Processo per la preparazione di intermedi per la sintesi del diltiazem
DE4209497A1 (de) * 1992-03-24 1993-09-30 Basf Ag Verfahren zur Herstellung von chlorsubstituierten olefinischen Verbindungen
US6262278B1 (en) 1995-03-14 2001-07-17 President And Fellows Of Harvard College Stereoselective ring opening reactions
SG72731A1 (en) * 1996-03-15 2000-05-23 Nabe Seiyaku Co Ltd Process for preparing optically active trans-3-phenylglycidamide compounds
US6562967B2 (en) * 2000-07-31 2003-05-13 Brandeis University Kinetic resolutions of chiral 2-and-3-substituted carboxylic acids
KR100799789B1 (ko) * 2000-07-31 2008-01-31 브랜데이스 유니버시티 키랄 2- 및 3-치환된 카르복실산의 속도론적 분할
US7531662B2 (en) * 2003-06-11 2009-05-12 Brandeis University Cinchona-alkaloid-based catalysts, and asymmetric alcoholysis of cyclic anhydrides using them

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1236467A (en) * 1967-10-28 1971-06-23 Tanabe Seiyaku Co Benzothiazepine derivatives
EP0059335B1 (en) * 1981-02-27 1985-05-15 Tanabe Seiyaku Co., Ltd. Novel process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester
SE449611B (sv) * 1982-07-09 1987-05-11 Tanabe Seiyaku Co Sett att framstella 1,5-bensotiazepinderivat
IT1152721B (it) * 1982-10-15 1987-01-07 Luso Farmaco Inst Risoluzione ottica dell'acido dl-alfa-2-idrossi-3-(4-metossifenil)-3-(2-amminofeniltio)propionico
US4567175A (en) * 1983-06-03 1986-01-28 Tanabe Seiyaku Co., Ltd. 8-Chloro-1,5-benzothiazepine derivatives
JPS6013775A (ja) * 1983-07-05 1985-01-24 Sawai Seiyaku Kk 光学活性３−（ｐ−アルコキシフエニル）グリシツド酸アルカリ金属塩の製造法
JPS6013776A (ja) * 1983-07-05 1985-01-24 Sawai Seiyaku Kk 光学活性３−（ｐ−アルコキシフエニル）グリシツド酸誘導体の製造法
US4594342A (en) * 1984-04-10 1986-06-10 Tanabe Seiyaku Co., Ltd. 1,5-benzothiazepine derivative
GB2167063A (en) * 1984-11-17 1986-05-21 Tanabe Seiyaku Co 6 or 9-chloro-1, 5-benzothiazepine derivatives
EP0320532A1 (en) * 1986-07-15 1989-06-21 Nihon Iyakuhin Kogyo Co., Ltd. Novel optically active carboxylic acid derivative l-lysine salt and process for production thereof
IT1217988B (it) * 1988-01-28 1990-03-30 Ind Chimica Profarmaco Spa Procedimento per la risoluzione ottica di un pacemo
US4996352A (en) * 1988-05-10 1991-02-26 Hoffmann-La Roche Inc. Enantiomers of β-[(2-amino-1-naphthalenyl) thiol]-α-hydroxy-4-methoxybenzene propanoic acid
US4864058A (en) * 1988-05-10 1989-09-05 Hoffmann-La Roche Inc. Process for making optically active naphtho[1,2-b][1,4]thiazepin-4(5H)-ones
US4885375A (en) * 1988-05-18 1989-12-05 Marion Laboratories, Inc. Resolution of 3-(4-methoxyphenyl)glycidic acid with in situ conversion to alkyl esters
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
FR2637285B1 (fr) * 1988-10-03 1991-04-12 Synthelabo Procede de preparation de derives de l'acide propionique et produits obtenus
DE69002924T2 (de) * 1989-06-30 1993-12-23 Richter Gedeon Vegyeszet Verfahren zur resolution von threo-3-[(2-aminophenyl)-thio]-2-hydroxy-3-(4-methoxy-phenyl)propionsäure.

Also Published As

Publication number Publication date
ATA99691A (de) 1995-10-15
AT401055B (de) 1996-06-25
FR2662161A1 (fr) 1991-11-22
NL9100853A (nl) 1991-12-16
GB2244055B (en) 1993-09-22
IT1240651B (it) 1993-12-17
GB9108741D0 (en) 1991-06-12
US5198557A (en) 1993-03-30
BE1004850A3 (fr) 1993-02-09
CA2041305C (en) 2000-12-12
IT9020349A0 (it) 1990-05-17
DE4115698A1 (de) 1991-11-21
IT9020349A1 (it) 1991-11-17
SE9101483D0 (sv) 1991-05-16
CH682075A5 (es) 1993-07-15
NL194273C (nl) 2001-11-05
JPH0616652A (ja) 1994-01-25
FR2662161B1 (fr) 1993-08-06
DE4115698C2 (de) 2001-08-23
GB2244055A (en) 1991-11-20
ES2033575A1 (es) 1993-03-16
SE9101483L (sv) 1991-11-18
JP3122953B2 (ja) 2001-01-09
SE509298C2 (sv) 1999-01-11
NL194273B (nl) 2001-07-02
CA2041305A1 (en) 1991-11-18

Similar Documents

Publication Publication Date Title
ES2005745A6 (es) Un procedimiento para preparar arilpiperindionas.
ES2033575B1 (es) Procedimiento para la resolucion de derivados de acido 3-(4-sustituido-fenil)-glicidico.
PH14502A (en) Aluminum-modified silica and its uses as catalyst
KR880005129A (ko) 신규 화합물
ES430116A1 (es) Un procedimiento mejorado para la preparacion de cefalexinay sales no toxicas y farmaceuticamente aceptables de la mis-ma.
ES445348A1 (es) Un procedimiento para preparar compuestos de 3-aciloximetil-cefem.
BR8306183A (pt) Processo para preparar um composto pesticida,composicao pesticida e processo de combater pragas
EP1010701A4 (en) PROCESS FOR THE PREPARATION OF 3-CEPHEM COMPOUNDS
ES431673A1 (es) Un procedimiento para la preparacion de compuestos de 7- acilamido-7-metoxi-cefalosporina.
PE24898A1 (es) Procedimiento para preparar dioxoazabiciclohexanos
ATE20742T1 (de) Verfahren zur herstellung von pyrazin-derivaten.
ES447615A1 (es) Un procedimiento para obtener compuesto de cefalosporina.
MX173989B (es) Procedimiento para la preparacion de derivados de acido glutarico
JPS5583727A (en) Purification of ortho ester
KR880701723A (ko) 세팔로스코린 유도체의 신규한 제조방법
MX3019E (es) PROCEDIMIENTO MEJORADO PARA PRODUCIR PIRIMIDO - [ 4 , 5 - b ] QUINOLIN - 4 ( 3 H ) - ON - 2 - CARBOXILATOS DE ALQUILO
JPS5620552A (en) Novel basic compound and its preparation
JPS5620545A (en) Preparation of half ester
BR0116146A (pt) Processo para preparação de ácidos formilfenilborÈnicos
JPS5653652A (en) Preparation of indole or indole derivative
JPS57212172A (en) Preparation of cyanuric halide derivative
JPS54148743A (en) Production of methoclopramide
ES8100243A1 (es) Un procedimiento para la preparacion de derivados de acido tro-clorocitrico
JPS5259140A (en) Process for preparation of optical active organic thiophosphoric acid
KR920007967A (ko) 케탈의 연속 제조방법

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050517