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ES2031529T3 - Procedimiento de preparacion de sistemas coloidales dispersables de una substancia bajo la forma de nanocapsulas. - Google Patents

Procedimiento de preparacion de sistemas coloidales dispersables de una substancia bajo la forma de nanocapsulas.

Info

Publication number
ES2031529T3
ES2031529T3 ES198787402998T ES87402998T ES2031529T3 ES 2031529 T3 ES2031529 T3 ES 2031529T3 ES 198787402998 T ES198787402998 T ES 198787402998T ES 87402998 T ES87402998 T ES 87402998T ES 2031529 T3 ES2031529 T3 ES 2031529T3
Authority
ES
Spain
Prior art keywords
substance
nanocapsules
solvents
solvent
mixture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787402998T
Other languages
English (en)
Inventor
Hatem Fessi
Francis Puisieux
Jean-Philippe Devissaguet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of ES2031529T3 publication Critical patent/ES2031529T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicinal Preparation (AREA)
  • Colloid Chemistry (AREA)

Abstract

EL PROCEDIMIENTO SEGUN LA INVENCION SE CARACTERIZA PORQUE: (1) SE PREPARA UNA FASE LIQUIDA CONSTITUIDA ESENCIALMENTE POR UNA DISOLUCION DE UNA SUSTANCIA A EN UN DISOLVENTE O EN UNA MEZCLA DE DISOLVENTES QUE CONTIENEN LA SUSTANCIA B EN DISOLUCION O EN DISPERSION. (2) SE PREPARA UNA SEGUNDA FASE LIQUIDA CONSTITUIDA ESENCIALMENTE POR UN NO DISOLVENTE O UNA MEZCLA DE NO DISOLVENTES DE LAS SUSTANCIAS A Y B, Y ADICION DE UNO O VARIOS TENSIOACTIVOS, SIENDO EL DISOLVENTE O LA MEZCLA DE DISOLVENTES DE LA PRIMERA FASE MISCIBLES EN TODAS PROPORCIONES EN EL NO DISOLVENTE O MEZCLA DE NO DISOLVENTES DE LA SEGUNDA FASE. (3) SE AÑADE, BAJO AGITACION MODERADA, LA PRIMERA Y SEGUNDA FASE CON OBJETO DE OBTENER UNA SUSPENSION COLOIDAL DE NANOCAPSULAS, CUYA PARED ESTA CONSTITUIDA POR LA SUSTANCIA A Y CUYO NUCLEO ESTA CONSTITUIDO POR LA SUSTANCIA B. (3) SI SE DESEA, SE ELIMINA TODO O PARTE DEL DISOLVENTE O DE LA MEZCLA DE DISOLVENTES Y DE NO DISOLVENTE O MEZCLA DE NO DISOLVENTES, CON OBJETO DE OBTENER UNA SUSPENSION COLOIDAL DE CONCENTRACION DESEADA EN NANOCAPSULAS O PARA OBTENER, DESPUES DE ADICION DE SUSTANCIAS ESTABILIZANTES, UN POLVO DE NANOCAPSULAS. APLICACIONES: QUIMICA, BIOQUIMICA, FARMACIA, MEDICINA.
ES198787402998T 1986-12-31 1987-12-28 Procedimiento de preparacion de sistemas coloidales dispersables de una substancia bajo la forma de nanocapsulas. Expired - Lifetime ES2031529T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8618444A FR2608942B1 (fr) 1986-12-31 1986-12-31 Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules

Publications (1)

Publication Number Publication Date
ES2031529T3 true ES2031529T3 (es) 1992-12-16

Family

ID=9342495

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198787402998T Expired - Lifetime ES2031529T3 (es) 1986-12-31 1987-12-28 Procedimiento de preparacion de sistemas coloidales dispersables de una substancia bajo la forma de nanocapsulas.

Country Status (9)

Country Link
US (1) US5049322A (es)
EP (1) EP0274961B1 (es)
JP (1) JPH0693998B2 (es)
AT (1) ATE74025T1 (es)
CA (1) CA1293170C (es)
DE (1) DE3777793D1 (es)
ES (1) ES2031529T3 (es)
FR (1) FR2608942B1 (es)
GR (1) GR3004198T3 (es)

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EP0274961A1 (fr) 1988-07-20
JPH0693998B2 (ja) 1994-11-24
US5049322A (en) 1991-09-17
GR3004198T3 (es) 1993-03-31
JPS63232840A (ja) 1988-09-28
FR2608942A1 (fr) 1988-07-01
ATE74025T1 (de) 1992-04-15
FR2608942B1 (fr) 1991-01-11
EP0274961B1 (fr) 1992-03-25
CA1293170C (en) 1991-12-17

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