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ES2081636T3 - Preparacion de piperidinas sustituidas. - Google Patents

Preparacion de piperidinas sustituidas.

Info

Publication number
ES2081636T3
ES2081636T3 ES92925298T ES92925298T ES2081636T3 ES 2081636 T3 ES2081636 T3 ES 2081636T3 ES 92925298 T ES92925298 T ES 92925298T ES 92925298 T ES92925298 T ES 92925298T ES 2081636 T3 ES2081636 T3 ES 2081636T3
Authority
ES
Spain
Prior art keywords
preparation
substituted piperidines
processes
novel
piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92925298T
Other languages
English (en)
Inventor
Dennis Michael Godek
Sally Gut Ruggeri
Terry Jay Rosen
Lewin T Wint
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2081636T3 publication Critical patent/ES2081636T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE DESCRIBEN NUEVOS PROCESOS PARA LA PREPARACION Y RESOLUCION DE PIPERIDINAS SUSTITUIDAS DE FORMULA (I) EN DONDE R1 Y R2 SE DEFINEN COMO SE INDICA EN LA MEMORIA, Y COMPUESTOS RELACIONADOS, ASI COMO NUEVOS PRODUCTOS INTERMEDIOS USADOS EN TALES PROCESOS.
ES92925298T 1991-11-27 1992-11-24 Preparacion de piperidinas sustituidas. Expired - Lifetime ES2081636T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/800,667 US5364943A (en) 1991-11-27 1991-11-27 Preparation of substituted piperidines

Publications (1)

Publication Number Publication Date
ES2081636T3 true ES2081636T3 (es) 1996-03-16

Family

ID=25179032

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92925298T Expired - Lifetime ES2081636T3 (es) 1991-11-27 1992-11-24 Preparacion de piperidinas sustituidas.

Country Status (19)

Country Link
US (2) US5364943A (es)
EP (1) EP0619806B1 (es)
JP (1) JP2587903B2 (es)
KR (1) KR0150254B1 (es)
AT (1) ATE132487T1 (es)
AU (1) AU670765B2 (es)
BR (1) BR9206823A (es)
CA (1) CA2124083C (es)
CZ (1) CZ292947B6 (es)
DE (1) DE69207429T2 (es)
DK (1) DK0619806T3 (es)
ES (1) ES2081636T3 (es)
FI (1) FI107049B (es)
GR (1) GR3018679T3 (es)
HU (1) HUT70514A (es)
NO (1) NO300970B1 (es)
PL (1) PL173659B1 (es)
RU (1) RU2081112C1 (es)
WO (1) WO1993011110A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003445A1 (en) * 1992-08-04 1994-02-17 Pfizer Inc. 3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists
CA2162400A1 (en) * 1993-05-28 1994-12-08 William M. Snyder Process for preparing and resolving 2-phenyl-3-aminopiperidine
GB9317987D0 (en) * 1993-08-26 1993-10-13 Glaxo Group Ltd Chemical compounds
TW340842B (en) * 1995-08-24 1998-09-21 Pfizer Substituted benzylaminopiperidine compounds
PT780375E (pt) 1995-12-21 2002-12-31 Pfizer 3-¬(benzilo substituido em 5)amino|-2-phenilpiperidinas como antagonistas da substancia p
US5922898A (en) * 1997-04-08 1999-07-13 Catalytica Pharmaceuticals, Inc. Process for preparing biaryl compounds
US6194599B1 (en) 1997-04-08 2001-02-27 Catalytica, Inc. Process for preparing biaryl compounds
NZ329807A (en) * 1997-04-23 2000-07-28 Pfizer NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome
CA2291734A1 (en) 1997-06-27 1999-01-07 Merck Sharp & Dohme Limited Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents
DE19824470A1 (de) * 1998-05-30 1999-12-02 Boehringer Ingelheim Pharma Neue Neurokininantagonisten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE60014216T2 (de) 1999-02-24 2006-03-02 F. Hoffmann-La Roche Ag 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten
RS49964B (sr) * 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
US6962999B2 (en) * 2001-07-25 2005-11-08 Pharmacore, Inc. Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
US6911544B2 (en) * 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
US7105467B2 (en) * 2003-07-08 2006-09-12 Pharmacore, Inc. Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
TWI280239B (en) 2003-07-15 2007-05-01 Hoffmann La Roche Process for preparation of pyridine derivatives
US7105707B2 (en) * 2003-12-17 2006-09-12 Pharmacore, Inc. Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
JP5523706B2 (ja) 2005-09-23 2014-06-18 エフ．ホフマン−ラ ロシュ アーゲー 新規投薬配合物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560510A (en) * 1969-03-05 1971-02-02 Aldrich Chem Co Inc 2-benzhydrylquinuclidines
CA1160229A (en) * 1979-03-13 1984-01-10 Pieter T. Haken Pyridyliminomethylbenzene derivatives
GB2056974B (en) * 1979-07-19 1984-02-29 Shell Int Research Heterocyclic acylamino compounds having fungicidal herbicidal and plant-growth regulating properties
CA1231710A (en) * 1979-07-19 1988-01-19 Haken Pieter Ten Heterocyclic compounds having fungicidal, herbicidal and plant-growth regulating properties
GB2067187B (en) * 1979-12-07 1983-11-30 Cosmos Enterprise Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US4552960A (en) * 1983-06-20 1985-11-12 Eli Lilly And Company Fungicidal amines
US4680283A (en) * 1984-09-26 1987-07-14 Merck & Co., Inc. Analogs of substance P and eledoisin
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
WO1991009844A1 (en) * 1990-01-04 1991-07-11 Pfizer Inc. Substance p antagonists
EP0532515B1 (en) * 1990-05-31 1996-10-23 Pfizer Inc. Preparation of substituted piperidines
US5138060A (en) * 1991-01-03 1992-08-11 Pfizer Inc. Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
CA2100163A1 (en) * 1991-01-10 1992-07-11 John A. Lowe, Iii N-alkyl quinuclidinium salts
CA2106200C (en) * 1991-03-26 1996-11-19 Terry J. Rosen Stereoselective preparation of substituted piperidines
ES2092113T3 (es) * 1991-06-20 1996-11-16 Pfizer Derivados fluoroalcoxibencilamino de heterociclos que contienen nitrogeno.
TW202432B (es) * 1991-06-21 1993-03-21 Pfizer

Also Published As

Publication number Publication date
US5663349A (en) 1997-09-02
EP0619806A1 (en) 1994-10-19
DE69207429T2 (de) 1996-05-15
FI942457A0 (fi) 1994-05-26
HU9401584D0 (en) 1994-08-29
CZ130094A3 (en) 1995-11-15
JPH06510795A (ja) 1994-12-01
HUT70514A (en) 1995-10-30
KR0150254B1 (ko) 1998-10-15
BR9206823A (pt) 1995-04-25
NO941958L (no) 1994-05-26
DK0619806T3 (da) 1996-02-05
NO941958D0 (no) 1994-05-26
CZ292947B6 (cs) 2004-01-14
WO1993011110A1 (en) 1993-06-10
DE69207429D1 (de) 1996-02-15
AU670765B2 (en) 1996-08-01
RU2081112C1 (ru) 1997-06-10
FI107049B (fi) 2001-05-31
US5364943A (en) 1994-11-15
FI942457A (fi) 1994-05-26
NO300970B1 (no) 1997-08-25
AU3140893A (en) 1993-06-28
PL173659B1 (pl) 1998-04-30
CA2124083C (en) 2001-08-14
JP2587903B2 (ja) 1997-03-05
ATE132487T1 (de) 1996-01-15
EP0619806B1 (en) 1996-01-03
GR3018679T3 (en) 1996-04-30
CA2124083A1 (en) 1993-06-10

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