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ES2079183T3 - Formas de dosificacion oral de liberacion retardada para el tratamiento de trastornos intestinales. - Google Patents

Formas de dosificacion oral de liberacion retardada para el tratamiento de trastornos intestinales.

Info

Publication number
ES2079183T3
ES2079183T3 ES92905384T ES92905384T ES2079183T3 ES 2079183 T3 ES2079183 T3 ES 2079183T3 ES 92905384 T ES92905384 T ES 92905384T ES 92905384 T ES92905384 T ES 92905384T ES 2079183 T3 ES2079183 T3 ES 2079183T3
Authority
ES
Spain
Prior art keywords
pct
granules
drug
coated
meth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92905384T
Other languages
English (en)
Inventor
John Rhodes
Brian Kenneth Evans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tillotts Pharma AG
Original Assignee
Tillotts Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tillotts Pharma AG filed Critical Tillotts Pharma AG
Application granted granted Critical
Publication of ES2079183T3 publication Critical patent/ES2079183T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

UNA FORMA DE DOSIFICACION FARMACEUTICA ORALMENTE ADMINISTRABLE, PARA ADMINISTRAR SELECTIVAMENTE UNA MEDICINA AL INTESTINO, COMPRENDE UNA PLURALIDAD DE GRANULOS ENTERICOS REVESTIDOS, CONTENIDOS EN UNA CAPSULA ENTERICAMENTE REVESTIDA, QUE LIBERA LOS GRANULOS EN EL INTESTINO DELGADO. LOS GRANULOS ESTAN PREFERENTEMENTE REVESTIDOS CON UN REVESTIMIENTO QUE PERMANECE INTACTO HASTA QUE LOS GRANULOS HAN ALCANZADO POR LO MENOS EL ILEON, Y DESPUES PROPORCIONAR UNA LIBERACION SOSTENIDA DE LA MEDICINA EN EL COLON. SE SELECCIONAN PRODUCTOS ADECUADOS DE REVESTIMIENTO DE LA GAMA EUDRAGIT DE POLIMEROS DE ACIDO DE (METH)ACRILATO Y (METH)ACRILICO. LA INVENCION TIENE APLICACION ESPECIFICA EN MEDICINAS TOPICAMENTE ACTIVAS, TALES COMO ESTEROIDES TOPICAMENTE ACTIVOS, SALES DE BISMUTO Y COMPLEJOS Y, ESPECIALMENTE, ACIDO 5
ES92905384T 1991-02-22 1992-02-21 Formas de dosificacion oral de liberacion retardada para el tratamiento de trastornos intestinales. Expired - Lifetime ES2079183T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9103795A GB2253346A (en) 1991-02-22 1991-02-22 Delayed release oral dosage forms for treatment of intestinal disorders

Publications (1)

Publication Number Publication Date
ES2079183T3 true ES2079183T3 (es) 1996-01-01

Family

ID=10690451

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92905384T Expired - Lifetime ES2079183T3 (es) 1991-02-22 1992-02-21 Formas de dosificacion oral de liberacion retardada para el tratamiento de trastornos intestinales.

Country Status (23)

Country Link
US (1) US5401512A (es)
EP (1) EP0572486B1 (es)
JP (1) JP2958116B2 (es)
KR (1) KR100220322B1 (es)
AT (1) ATE129893T1 (es)
AU (1) AU652032B2 (es)
CA (1) CA2104686C (es)
CZ (1) CZ281792B6 (es)
DE (1) DE69205971T2 (es)
DK (1) DK0572486T3 (es)
ES (1) ES2079183T3 (es)
FI (1) FI105255B (es)
GB (1) GB2253346A (es)
GE (1) GEP19971086B (es)
GR (1) GR3018455T3 (es)
HU (1) HU219449B (es)
IE (1) IE74225B1 (es)
IL (1) IL101036A (es)
IN (1) IN179089B (es)
NO (1) NO307405B1 (es)
NZ (1) NZ241687A (es)
WO (1) WO1992014452A1 (es)
YU (1) YU17892A (es)

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US5260071A (en) * 1989-12-18 1993-11-09 Lemelson Jerome H Drug units and methods for using same
JPH064531B2 (ja) * 1990-06-04 1994-01-19 アイセロ化学株式会社 大腸崩壊性硬質カプセル

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GR3018455T3 (en) 1996-03-31
GB9103795D0 (en) 1991-04-10
FI933680A (fi) 1993-08-20
YU17892A (sh) 1994-12-28
IL101036A (en) 1996-05-14
NO932979L (no) 1993-08-20
JPH06505246A (ja) 1994-06-16
CA2104686C (en) 2000-05-02
IE920548A1 (en) 1992-08-26
AU652032B2 (en) 1994-08-11
HU9302379D0 (en) 1993-11-29
HUT65914A (en) 1994-07-28
GEP19971086B (en) 1997-12-02
NZ241687A (en) 1993-09-27
AU1279592A (en) 1992-09-15
DE69205971T2 (de) 1996-04-11
IE74225B1 (en) 1997-07-16
JP2958116B2 (ja) 1999-10-06
US5401512A (en) 1995-03-28
IL101036A0 (en) 1992-11-15
NO932979D0 (no) 1993-08-20
ATE129893T1 (de) 1995-11-15
IN179089B (es) 1997-08-23
NO307405B1 (no) 2000-04-03
FI105255B (fi) 2000-07-14
KR100220322B1 (ko) 1999-09-15
CZ162693A3 (en) 1994-10-19
CZ281792B6 (cs) 1997-01-15
FI933680A0 (fi) 1993-08-20
CA2104686A1 (en) 1992-08-23
DE69205971D1 (de) 1995-12-14
DK0572486T3 (da) 1995-12-11
EP0572486A1 (en) 1993-12-08
WO1992014452A1 (en) 1992-09-03
KR930702963A (ko) 1993-11-29
EP0572486B1 (en) 1995-11-08
HU219449B (hu) 2001-04-28
GB2253346A (en) 1992-09-09

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