[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES2077070T3 - Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable. - Google Patents

Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable.

Info

Publication number
ES2077070T3
ES2077070T3 ES90909403T ES90909403T ES2077070T3 ES 2077070 T3 ES2077070 T3 ES 2077070T3 ES 90909403 T ES90909403 T ES 90909403T ES 90909403 T ES90909403 T ES 90909403T ES 2077070 T3 ES2077070 T3 ES 2077070T3
Authority
ES
Spain
Prior art keywords
production
alkynyladenosine
derivative
synthesis
alkylyledenosine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909403T
Other languages
English (en)
Inventor
Toyofumi Yamaguchi
Takanori Miyashita
Shinji Sakata
Toichi Abiru
Akira Matsuda
Tohru Ueda
Kentaro Kogi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toa Eiyo Ltd
Yamasa Shoyu KK
Original Assignee
Toa Eiyo Ltd
Yamasa Shoyu KK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toa Eiyo Ltd, Yamasa Shoyu KK filed Critical Toa Eiyo Ltd
Application granted granted Critical
Publication of ES2077070T3 publication Critical patent/ES2077070T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Ladders (AREA)

Abstract

UN NUEVO COMPUESTO DE LA FORMULA (I), DONDE A REPRESENTA UN GRUPO VIVO, UTIL COMO INTERMEDIARIO PARA LA SINTESIS DE 2-ALKINILADENOSINA; PRODUCCION DE DICHO COMPUESTO; PRODUCCION DE 2-ALKINILADENOSINA EN LA (IV), DONDE A = NH SUB 2 DEL COMPUESTO; 2-ALKINILADENOSINA DERIVADA DE LA FORMULA (V), DONDE A = NHR SUB 4; Y CONSERVACION DE 2-ALKINILADENOSINA EN FORMA DE DICHO DERIVADO. EN LA FORMULA ANTERIOR,R ELEVADO 1 A R ELEVADO 4 REPRESENTAN CADA PARTICULA DE HIDROGENO O UN GRUPO DE PROTECCION, Y N ES UN NUMERO ENTERO DE 1 A 15, SIEMPRE QUE SE EXCLUYAN LOS ATOMOS DE HIDROGENO R ELEVADO 1 A R ELEVADO 4.
ES90909403T 1989-06-20 1990-06-20 Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable. Expired - Lifetime ES2077070T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15751789 1989-06-20
JP472790 1990-01-13

Publications (1)

Publication Number Publication Date
ES2077070T3 true ES2077070T3 (es) 1995-11-16

Family

ID=26338545

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909403T Expired - Lifetime ES2077070T3 (es) 1989-06-20 1990-06-20 Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable.

Country Status (8)

Country Link
US (2) US5283327A (es)
EP (1) EP0429681B1 (es)
KR (1) KR920700218A (es)
AT (1) ATE127472T1 (es)
CA (1) CA2035038C (es)
DE (1) DE69022176T2 (es)
ES (1) ES2077070T3 (es)
WO (1) WO1990015812A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5189027A (en) 1990-11-30 1993-02-23 Yamasa Shoyu Kabushiki Kaisha 2-substituted adenosine derivatives and pharmaceutical compositions for circulatory diseases
JP2740362B2 (ja) * 1991-02-12 1998-04-15 ヤマサ醤油株式会社 安定な固体状２‐オクチニルアデノシンおよびその製造法
KR100668006B1 (ko) * 1999-02-01 2007-01-15 유니버시티 오브 버지니아 페이턴트 파운데이션 염증 반응을 치료하기 위한 조성물
US6214807B1 (en) * 1999-06-22 2001-04-10 Cv Therapeutics, Inc. C-pyrazole 2A A receptor agonists
USRE47351E1 (en) 1999-06-22 2019-04-16 Gilead Sciences, Inc. 2-(N-pyrazolo)adenosines with application as adenosine A2A receptor agonists
US6403567B1 (en) 1999-06-22 2002-06-11 Cv Therapeutics, Inc. N-pyrazole A2A adenosine receptor agonists
US6180615B1 (en) * 1999-06-22 2001-01-30 Cv Therapeutics, Inc. Propargyl phenyl ether A2A receptor agonists
CA2439222C (en) 2000-02-23 2009-07-14 Cv Therapeutics, Inc. Identification of partial agonists of the a2a adenosine receptor
US8470801B2 (en) 2002-07-29 2013-06-25 Gilead Sciences, Inc. Myocardial perfusion imaging methods and compositions
US20050020915A1 (en) * 2002-07-29 2005-01-27 Cv Therapeutics, Inc. Myocardial perfusion imaging methods and compositions
KR20050026546A (ko) * 2002-07-29 2005-03-15 씨브이 쎄러퓨틱스, 인코포레이티드 Ａ2ａ 수용체 작용제를 이용한 심근 관류 조영
RU2007114908A (ru) * 2004-10-20 2008-10-27 Си Ви ТЕРАПЬЮСи Ви ТЕРАПЬЮТИКСИКС Применение агонистов аденозиновых рецепторов a2a
PT1989214T (pt) 2006-02-03 2016-09-22 Gilead Sciences Inc Processo para preparar um agonista de recetor de adenosina a2a e polimorfos do mesmo
EP2068850A1 (en) * 2006-06-22 2009-06-17 Cv Therapeutics, Inc. Use of a2a adenosine receptor agonists in the treatment of ischemia
MX2009002299A (es) * 2006-09-01 2009-03-20 Cv Therapeutics Inc Metodos y composiciones para incrementar la tolerancia del paciente durante metodos de formacion de imagenes del miocardio.
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
EP2066232A1 (en) * 2006-09-29 2009-06-10 Cv Therapeutics, Inc. Methods for myocardial imaging in patients having a history of pulmonary disease
CA2673653A1 (en) * 2007-01-03 2008-07-17 Cv Therapeutics, Inc. Myocardial perfusion imaging
CA2737077A1 (en) * 2008-09-29 2010-04-01 Gilead Sciences, Inc. Combinations of a rate control agent and an a-2-alpha receptor antagonist for use in multidetector computed tomography methods
US9822141B2 (en) 2012-08-01 2017-11-21 Lewis And Clark Pharmaceuticals, Inc. N-alkyl 2-(disubstituted)alkynyladenosine-5-uronamides as A2A agonists
CN104582709A (zh) 2012-08-01 2015-04-29 路易斯与克拉克药品公司 作为a2a激动剂的n-烷基2-(双取代的)炔基腺苷-5’-糖醛酰胺

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6299395A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd ２−アルキニルアデノシンおよび抗高血圧剤
WO1990005526A1 (en) * 1988-11-15 1990-05-31 Yamasa Shoyu Kabushiki Kaisha Agent for treatment and prophylaxis of ischemic disease of heart or brain

Also Published As

Publication number Publication date
EP0429681A4 (en) 1992-03-11
ATE127472T1 (de) 1995-09-15
EP0429681B1 (en) 1995-09-06
EP0429681A1 (en) 1991-06-05
DE69022176D1 (de) 1995-10-12
US5283327A (en) 1994-02-01
WO1990015812A1 (fr) 1990-12-27
CA2035038C (en) 1998-12-29
KR920700218A (ko) 1992-02-19
DE69022176T2 (de) 1996-02-15
CA2035038A1 (en) 1990-12-21
US5459254A (en) 1995-10-17

Similar Documents

Publication Publication Date Title
ES2077070T3 (es) Intermedio de sintesis de 2-alquiniladenosina, produccion de dicho intermedio, produccion de 2-alquiniladenosina a partir de dicho intermedio, y derivado de 2-alquiniladenosina estable.
ES2194986T3 (es) Compuestos de carbonil-piperazinilo y piperidinilo que inhiben la farnesil-protein-transferasa.
KR950702221A (ko) 폴리와 그의 생산방법(poly(3-hydroxyalk anoates) and process for the production thereof)
ATE152113T1 (de) Vanadium komplexe, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten
EA199800768A1 (ru) Новые производные эритромицина, способ их получения и их применение в качестве медикаментов
FR2678930B1 (fr) Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.
DK0519673T3 (da) Præparat indeholdende dioxabicyclo{3,3,0}octanderivat
AU1739092A (en) 1-methylcarbapenem derivatives, their preparation and their use as antibiotics
ZA9410181B (en) Arylacetic acid derivatives.
GR3019351T3 (en) Diaminoethylene compounds
CA2021733A1 (en) Azole-substituted cycloalkanol derivative, a process to produce the same and a use of the derivative as an agricultural and horticultural fungicide
ATE191915T1 (de) Herstellung von borester
DK0601191T3 (da) Hidtil ukendt tetracyklisk forbindelse
ZA891434B (en) Azolylmethyloxiranes and fungicides containing these compounds
ATE148128T1 (de) Anthracyclinglycosid-derivate und verfahren zu ihrer herstellung
FI951588A0 (fi) Öljykoostumuksia
ATE88471T1 (de) Azolylmethylcyloalkyloxirane, ihre herstellung und verwendung als pflanzenschutzmittel.
ATE102955T1 (de) Zyklisches tetrapeptid und verfahren zu dessen herstellung.
ATE92073T1 (de) Phosphorsaeurediester und salze davon.
DK0538517T3 (da) Nye organo-tinforbindelser med antitumoraktivitet og antitumormidler
FI960588A (fi) Mikrobisideina käytettäviä tiokarbamoyyliyhdisteitä
MY104689A (en) Amine salts of 1,4,2-oxazaphospholidine-4-acetic acid, 2-alkoxy-2-oxides.
EP0623608A4 (en) BENZOPYRANE DERIVATIVES, THE PRODUCTION THEREOF AND THE MEDICINAL PRODUCTS CONTAINING IT AS ACTIVE INGREDIENTS.
IT1261662B (it) Derivati xantonici, loro preparazione ed attivita'
EP0404936A4 (en) Preparation of vitamin d 2? and vitamin d 3?, or active vitamin d 2? and active vitamin d 3?, or their derivatives

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 429681

Country of ref document: ES