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ES2070921T3 - Procedimiento de preparacion de una fraccion concentrada de factor viia y su aplicacion a titulo de medicamento. - Google Patents

Procedimiento de preparacion de una fraccion concentrada de factor viia y su aplicacion a titulo de medicamento.

Info

Publication number
ES2070921T3
ES2070921T3 ES89401605T ES89401605T ES2070921T3 ES 2070921 T3 ES2070921 T3 ES 2070921T3 ES 89401605 T ES89401605 T ES 89401605T ES 89401605 T ES89401605 T ES 89401605T ES 2070921 T3 ES2070921 T3 ES 2070921T3
Authority
ES
Spain
Prior art keywords
fraction
preparing
procedure
application
factor viia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89401605T
Other languages
English (en)
Inventor
Jacques Chabbat
Lucette Pejaudier
Marion Steinbuch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FOND NAT TRANSFUSION SANGUINE
Original Assignee
FOND NAT TRANSFUSION SANGUINE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FOND NAT TRANSFUSION SANGUINE filed Critical FOND NAT TRANSFUSION SANGUINE
Application granted granted Critical
Publication of ES2070921T3 publication Critical patent/ES2070921T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UNA FRACCION RICA EN FACTOR VIIA CARACTERIZADA EN QUE: SE HACE ABSORBER EL PRECLUIDO DEL PPSB POR UN ABSORBENTE CON UNA AFINIDAD SELECTIVA PARA LAS PROTEINAS FIJANDOSE AL CA ELEGIDO ENTRE LAS SALES DE METAL DIVALENTE INSOLUBLE EN AGUA; SE ELUYEN LAS PROTEINAS FIJADAS POR ADICION DE UN TAMPON CON SALES SOLUBLES CAPACES DE DESPLAZAR LAS PROTEINAS FIJADAS; SE RECUPERA EL ELUYENTE CONCENTRADO EN FACTOR VIIA.
ES89401605T 1988-06-09 1989-06-09 Procedimiento de preparacion de una fraccion concentrada de factor viia y su aplicacion a titulo de medicamento. Expired - Lifetime ES2070921T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8807687A FR2632524B1 (fr) 1988-06-09 1988-06-09 Procede de preparation d'une fraction concentree en facteur viia et son application a titre de medicament

Publications (1)

Publication Number Publication Date
ES2070921T3 true ES2070921T3 (es) 1995-06-16

Family

ID=9367108

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89401605T Expired - Lifetime ES2070921T3 (es) 1988-06-09 1989-06-09 Procedimiento de preparacion de una fraccion concentrada de factor viia y su aplicacion a titulo de medicamento.

Country Status (7)

Country Link
EP (1) EP0346241B1 (es)
JP (1) JPH02504587A (es)
AT (1) ATE119196T1 (es)
DE (1) DE68921371T2 (es)
ES (1) ES2070921T3 (es)
FR (1) FR2632524B1 (es)
WO (1) WO1989012097A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2965069B2 (ja) * 1989-01-13 1999-10-18 吉富製薬株式会社 蛋白質含有組成物の製造方法
FR2684999A1 (fr) * 1991-12-16 1993-06-18 Aquitaine Dev Transf Sanguine Procede de fabrication d'un concentre de facteur vii active de haute purete essentiellement depourvu des facteurs vitamine k dependants et des facteurs viiic et viiicag.
DE19538716A1 (de) * 1995-10-18 1997-04-24 Behringwerke Ag Verfahren zur Quantifizierung von aktiviertem Gerinnungsfaktor VII (FVIIa)
DE19531637A1 (de) * 1995-08-28 1997-03-06 Immuno Ag Pharmazeutische Zusammensetzung zur Behandlung von Blutgerinnungsstörugnen, Verfahren zur Herstellung derselben und deren Verwendung
DE19538715A1 (de) * 1995-10-18 1997-04-30 Behringwerke Ag Verfahren zur Reinigung von Faktor VII und aktiviertem Faktor VII
FR2894831B1 (fr) 2005-12-16 2008-02-15 Lab Francais Du Fractionnement Colle biologique exempte de thrombine et son utilisation comme medicament.
ES2257225B1 (es) * 2006-02-17 2007-03-16 Grifols, S.A Preparacion terapeutica de fviia de muy alta pureza y metodo para su obtencion.
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
FR2901796A1 (fr) * 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
FR2904558B1 (fr) * 2006-08-01 2008-10-17 Lab Francais Du Fractionnement "composition de facteur vii recombinant ou transgenique, presentant majoritairement des formes glycanniques biantennees, bisialylees et non fucosylees"
FR2942231B1 (fr) 2009-02-19 2015-03-20 Lfb Biotechnologies Acides nucleiques se liant specifiquement au facteur vii/viia humain, et utilisations
FR2946348B1 (fr) * 2009-06-05 2011-08-05 Lab Francais Du Fractionnement Procede de preparation d'une composition de complexe prothrombique a haut degre de purete
AU2011343813B2 (en) 2010-12-15 2015-05-21 Takeda Pharmaceutical Company Limited Eluate collection using conductivity gradient
EP2687595B1 (en) 2012-07-19 2018-05-30 Laboratoire Français du Fractionnement et des Biotechnologies Method for purifying transgenic factor VII
US20150344863A1 (en) * 2012-12-24 2015-12-03 Bayer Healthcare Llc Short-acting factor vii polypeptides
FR3011250A1 (fr) 2013-09-30 2015-04-03 Lab Francais Du Fractionnement Acides nucleiques se liant specifiquement au facteur ix/ixa humain, et utilisations
RU2559576C1 (ru) * 2014-06-09 2015-08-10 Федеральное государственное бюджетное учреждение Гематологический научный центр Министерства здравоохранения РФ Способ получения вирусбезопасного полного протромбинового комплекса

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4382083A (en) * 1981-06-25 1983-05-03 Baxter Travenol Laboratories, Inc. Therapeutic method for treating blood-clotting defects with factor VIIa
US4470979A (en) * 1982-09-17 1984-09-11 Janssen Pharmaceutica N.V. Chemical sterilization of insects with salicylanilides
US4470969A (en) * 1983-12-02 1984-09-11 Miles Laboratories, Inc. Process for producing a concentrate of coagulation factors VII and VIIa
US4473553A (en) * 1983-12-02 1984-09-25 Miles Laboratories, Inc. Process for producing a lipoprotein-poor concentrate of coagulation factors VII and VIIa
US4637932A (en) * 1984-10-15 1987-01-20 Miles Laboratories, Inc. Process for producing a concentrate enriched in coagulation factors VII and VIIa

Also Published As

Publication number Publication date
FR2632524B1 (fr) 1992-03-13
EP0346241A1 (fr) 1989-12-13
FR2632524A1 (fr) 1989-12-15
ATE119196T1 (de) 1995-03-15
DE68921371D1 (de) 1995-04-06
DE68921371T2 (de) 1996-01-04
WO1989012097A1 (fr) 1989-12-14
EP0346241B1 (fr) 1995-03-01
JPH02504587A (ja) 1990-12-27

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