[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES2067159T3 - Proceso para la preparacion de nitrilos. - Google Patents

Proceso para la preparacion de nitrilos.

Info

Publication number
ES2067159T3
ES2067159T3 ES91307184T ES91307184T ES2067159T3 ES 2067159 T3 ES2067159 T3 ES 2067159T3 ES 91307184 T ES91307184 T ES 91307184T ES 91307184 T ES91307184 T ES 91307184T ES 2067159 T3 ES2067159 T3 ES 2067159T3
Authority
ES
Spain
Prior art keywords
novel
certain
defined hereinafter
formula
biphenylcarbonitriles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91307184T
Other languages
English (en)
Inventor
David Anthony Roberts
Simon Thomas Russell
John David Pittam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10680408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2067159(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ES2067159T3 publication Critical patent/ES2067159T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Turning (AREA)
  • Glass Compositions (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Air Bags (AREA)
  • Electrotherapy Devices (AREA)

Abstract

LA INVENCION PROPORCIONA UN PROCESO NOVEDOSO PARA LA FABRICACION DE BIFENILCARBONITRILOS DE FORMULA III, COMO SE DESCRIBE MAS ADELANTE, LOS CUALES SON UTILES PARA LA PRODUCCION DE CIERTOS CONOCIDOS DERIVADOS DE IMIDAZOL Y CIERTOS NUEVOS DERIVADOS DE QUINOLINA QUE TIENEN UNA ACTIVIDAD INHIBIDORA ANGIOTENSINA II. EL PROCESO ENVUELVE UNA REACCION DE CATALISIS CON PALADIO O NICKEL DE UN COMPUESTO DE BORO DE FORMULA II CON UN NITRILO DE FORMULA III, EN DONDE LAS VARIABLES L ELEVADO 1, L (AL CUADRADO) , Q ELEVADO 1, Y Q (AL CUADRADO) TIENEN VARIOS SIGNIFICADOS DEFINIDOS MAS ADELANTE. ALGUNOS DE LOS BIFENILCARBONITRILOS SON NOVEDOSOS Y SON PROPORCIONADOS COMO UNA CARACTERISTICA MAS DE LA INVENCION. LA INVENCION TAMBIEN SE PROPORCIONA UN NUEVO PROCESO PARA LA PRODUCCION LOS CONOCIDOS Y NUEVOS INHIBIDORES DE ANGIOTENSINA II DE FORMULA VI Y VII COMO SE DEFINEN MAS ADELANTE.
ES91307184T 1990-08-09 1991-08-05 Proceso para la preparacion de nitrilos. Expired - Lifetime ES2067159T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909017482A GB9017482D0 (en) 1990-08-09 1990-08-09 Manufacturing process

Publications (1)

Publication Number Publication Date
ES2067159T3 true ES2067159T3 (es) 1995-03-16

Family

ID=10680408

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91307184T Expired - Lifetime ES2067159T3 (es) 1990-08-09 1991-08-05 Proceso para la preparacion de nitrilos.

Country Status (23)

Country Link
EP (1) EP0470795B2 (es)
JP (1) JP3001298B2 (es)
KR (1) KR920004337A (es)
CN (1) CN1059516A (es)
AT (1) ATE117672T1 (es)
AU (1) AU646473B2 (es)
CA (1) CA2047369A1 (es)
CS (1) CS241391A3 (es)
DE (1) DE69106977T3 (es)
ES (1) ES2067159T3 (es)
FI (1) FI913640A (es)
GB (2) GB9017482D0 (es)
HU (1) HU207841B (es)
IL (1) IL98862A0 (es)
NO (1) NO174502B (es)
NZ (1) NZ239026A (es)
PL (1) PL291370A1 (es)
PT (1) PT98608A (es)
RU (1) RU2026285C1 (es)
TW (1) TW198710B (es)
YU (1) YU137891A (es)
ZA (1) ZA915566B (es)
ZW (1) ZW9591A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BG92674A (bg) * 1989-08-11 1993-12-24 David Roberts Метод за получаване на производни на хинолина
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
FR2688507B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Derives de l'acide tetrazolylbenzeneboronique, leur preparation et leur utilisation comme intermediaires de synthese.
FR2689887B1 (fr) * 1992-04-13 1995-06-23 Sanofi Elf Procede de preparation d'un derive de biphenyle.
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
DE4423061C1 (de) * 1994-07-01 1996-01-18 Hoechst Ag Verfahren zur Herstellung von Biphenylen mit Palladacyclen als Katalysatoren
DE4426671A1 (de) * 1994-07-28 1996-02-01 Hoechst Ag Verfahren zur Kreuzkupplung von aromatischen Borverbindungen mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten
KR100354802B1 (ko) * 1994-10-20 2002-12-26 한국화학연구원 테트라졸유도체의제조방법
JP2928982B2 (ja) 1994-10-27 1999-08-03 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造法
DE19620023C2 (de) * 1996-05-17 2001-03-08 Celanese Chem Europe Gmbh Verfahren zur Herstellung von Phosphinat- oder Phosphonatgruppen enthaltenden tertiären Phosphanen und neue Phosphinatgruppen enthaltende tertiäre Phosphane
US6194599B1 (en) 1997-04-08 2001-02-27 Catalytica, Inc. Process for preparing biaryl compounds
US5922898A (en) * 1997-04-08 1999-07-13 Catalytica Pharmaceuticals, Inc. Process for preparing biaryl compounds
EP1064243B1 (en) 1998-03-18 2002-10-23 Ciba SC Holding AG Coupling reactions with palladium catalysts
US6962999B2 (en) 2001-07-25 2005-11-08 Pharmacore, Inc. Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
DE10211597A1 (de) 2002-03-15 2003-10-02 Merck Patent Gmbh Verfahren zur Herstellung von Ringverbindungen
CA2482857A1 (en) 2002-04-29 2003-11-13 Teva Pharmaceutical Industries Ltd. Processes for preparing losartan and losartan potassium
WO2003106406A1 (ja) 2002-06-12 2003-12-24 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造方法
US7105467B2 (en) 2003-07-08 2006-09-12 Pharmacore, Inc. Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
US7105707B2 (en) 2003-12-17 2006-09-12 Pharmacore, Inc. Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
JP2006151946A (ja) * 2004-04-30 2006-06-15 Konishi Kagaku Ind Co Ltd ジアリール誘導体の製造方法
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US20100120694A1 (en) 2008-06-04 2010-05-13 Synergy Pharmaceuticals, Inc. Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
ES2534557T3 (es) * 2009-08-31 2015-04-24 Bayer Intellectual Property Gmbh Procedimiento de tetraarilborato para la preparación de bifenilos sustituidos
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
EP3004138B1 (en) 2013-06-05 2024-03-13 Bausch Health Ireland Limited Ultra-pure agonists of guanylate cyclase c, method of making and using same
JP5975081B2 (ja) * 2013-09-30 2016-08-23 ダイキン工業株式会社 含フッ素ビアリール化合物の製造方法
KR101512729B1 (ko) 2014-01-17 2015-04-17 에프케이엔지니어링 주식회사 화장로
AU2022380979A1 (en) 2021-11-02 2024-06-06 Flare Therapeutics Inc. Pparg inverse agonists and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
WO1989003821A1 (en) * 1987-10-19 1989-05-05 The Secretary Of State For Defence In Her Britanni Laterally cyano- and fluoro-substituted terphenyls
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
BG92674A (bg) * 1989-08-11 1993-12-24 David Roberts Метод за получаване на производни на хинолина

Also Published As

Publication number Publication date
TW198710B (es) 1993-01-21
HU912481D0 (en) 1991-12-30
GB9115244D0 (en) 1991-08-28
NO913086L (no) 1992-02-10
RU2026285C1 (ru) 1995-01-09
FI913640A0 (fi) 1991-07-30
EP0470795B2 (en) 2001-02-21
FI913640A (fi) 1992-02-10
CA2047369A1 (en) 1992-02-10
HU207841B (en) 1993-06-28
AU8043691A (en) 1992-02-13
NO174502B (no) 1994-02-07
DE69106977T2 (de) 1995-05-24
JP3001298B2 (ja) 2000-01-24
JPH04253949A (ja) 1992-09-09
YU137891A (sh) 1994-06-10
DE69106977D1 (de) 1995-03-09
GB9017482D0 (en) 1990-09-26
NO913086D0 (no) 1991-08-08
PL291370A1 (en) 1992-11-16
IL98862A0 (en) 1992-07-15
ATE117672T1 (de) 1995-02-15
KR920004337A (ko) 1992-03-27
EP0470795B1 (en) 1995-01-25
ZW9591A1 (en) 1992-06-10
NO174502C (es) 1994-05-18
PT98608A (pt) 1992-06-30
DE69106977T3 (de) 2001-07-19
CN1059516A (zh) 1992-03-18
EP0470795A1 (en) 1992-02-12
AU646473B2 (en) 1994-02-24
ZA915566B (en) 1992-04-29
NZ239026A (en) 1993-12-23
CS241391A3 (en) 1992-03-18
HUT59662A (en) 1992-06-29

Similar Documents

Publication Publication Date Title
ES2067159T3 (es) Proceso para la preparacion de nitrilos.
TR200800474T2 (tr) Florfenikole aracı maddelerin hazırlanmasına ilişkin işlem.
DE69532634D1 (de) Zwischenprodukte für die herstellung von pharmazeutischem camptothecin
MX9307810A (es) Heterociclicos no aromaticos sustituidos con aminometileno.
NO303574B1 (no) Ny fremgangsmÕte for fremstilling av 9-amino-6-demetyl-6-deoksytetracykliner
DK356285D0 (da) Nyt mellemprodukt og fremgangsmaade til fremstilling heraf
ES2070660A1 (es) Un procedimiento para la preparacion de 2,5-damino-3-hidroxihexanos sustituidos, utiles como inhibidores de proteasas retrovirales.
ATE21105T1 (de) 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
ATE183993T1 (de) Zwischenprodukte für die herstellung einer substituierten 2,5-diamino-3-hydroxyhexan.
ATE43834T1 (de) Antimikrobiell wirksame substanzen, ihre herstellung und ihre verwendung.
DK539589D0 (da) Fremgangsmaade til fremstilling af 3-oxo-4-azasteroider
DK0503453T3 (da) Fremgangsmåde til fremstilling af cephalosporiner og mellemprodukter i denne fremgangsmåde
ES2113975T3 (es) Azida de tri-alquil superior-estaño y su uso.
ES543154A0 (es) Metodo de preparar un derivado de acido b-carbolin-3-carbo- xilico
ES2145920T3 (es) Procedimiento de produccion de derivado de alcoxiiminoacetamida.
ATE245147T1 (de) Substituierte aminochinazolinon (thion) derivate
ES2053707T3 (es) Procedimiento para la preparacion de amidas de acidos 3,3-diaril-acrilicos.
DK159432C (da) Fremgangsmaade til fremstilling af 4-amino-5-dialkoxymethylpyrimidinderivater
EA199800722A1 (ru) Способ получения 2-(тиозамещенных)-4-галогенацетофенонов

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 470795

Country of ref document: ES