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ES2065336T3 - Peptidos terapeuticos. - Google Patents

Peptidos terapeuticos.

Info

Publication number
ES2065336T3
ES2065336T3 ES88308916T ES88308916T ES2065336T3 ES 2065336 T3 ES2065336 T3 ES 2065336T3 ES 88308916 T ES88308916 T ES 88308916T ES 88308916 T ES88308916 T ES 88308916T ES 2065336 T3 ES2065336 T3 ES 2065336T3
Authority
ES
Spain
Prior art keywords
naturally occurring
peptide
bombesin
analog
peptide bond
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88308916T
Other languages
English (en)
Inventor
David H Coy
Jacques-Pierre Moreau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Tulane University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tulane University filed Critical Tulane University
Application granted granted Critical
Publication of ES2065336T3 publication Critical patent/ES2065336T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C07K7/086—Bombesin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN PEPTIDO LINEAL QUE ES UN ANALOGO DE LA BOMBESINA BIOLOGICAMENTE ACTIVO, QUE OCURRE NATURALMENTE QUE TIENE UN SITIO ACTIVO Y UN SITIO DE UNION RESPONSABLE DE LA UNION DE LA BOMBESINA AL RECEPTOR DE LA CELULA BLANCO, DIVISION DEL PEPTIDO LAZO EN EL SITIO ACTIVO DEL PEPTIDO QUE OCURRE NATURALMENTE SIENDO INNECESARIO PARA LA ACTIVIDAD BIOLOGICA IN VIVO. EL ANALOGO TIENE UN LAZO NO - PEPTIDO A CAMBIO DE UN PEPTIDO LAZO ENTRE UN AMINOACIDO DEL SITIO ACTIVO Y UN AMINOACIDO ADYACENTE, Y TIENE EL MISMO SITIO DE UNION QUE EL PEPTIDO QUE OCURRE NATURALMENTE, ASI QUE EL ANALOGO, ES CAPAZ DE ACTUAR COMO INHIBIDOR COMPETITIVO DE LA BOMBESINA QUE OCURRE NATURALMENTE POR UNION AL RECEPTOR, Y POR VIRTUAL DEL LAZO NO - PEPTIDO, FALTA DE EXHIBIR LA ACTIVIDAD IN VIVO DE LA BOMBESINA QUE OCURRE NATURALMENTE.
ES88308916T 1987-09-24 1988-09-26 Peptidos terapeuticos. Expired - Lifetime ES2065336T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10057187A 1987-09-24 1987-09-24

Publications (1)

Publication Number Publication Date
ES2065336T3 true ES2065336T3 (es) 1995-02-16

Family

ID=22280431

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88308916T Expired - Lifetime ES2065336T3 (es) 1987-09-24 1988-09-26 Peptidos terapeuticos.

Country Status (9)

Country Link
EP (1) EP0309297B1 (es)
JP (1) JP2795449B2 (es)
AT (1) ATE113961T1 (es)
DE (1) DE3852086T2 (es)
DK (1) DK249489A (es)
ES (1) ES2065336T3 (es)
FI (1) FI100719B (es)
NO (1) NO178306C (es)
WO (1) WO1989002897A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084555A (en) * 1989-08-21 1992-01-28 The Administrators Of The Tulane Educational Fund An octapeptide bombesin analog
US5877277A (en) * 1987-09-24 1999-03-02 Biomeasure, Inc. Octapeptide bombesin analogs
AU618029B2 (en) * 1987-11-02 1991-12-12 Imperial Chemical Industries Plc Polypeptide compounds
GB8808768D0 (en) * 1988-04-14 1988-05-18 Erba Carlo Spa Peptide ligands for bombesin receptors
GB8813356D0 (en) * 1988-06-06 1988-07-13 Ici Plc Polypeptide compounds
GB2231051B (en) * 1989-05-05 1992-12-16 Erba Carlo Spa Bombesin antagonists
WO1991006563A1 (en) * 1989-11-06 1991-05-16 Farmitalia Carlo Erba S.R.L. Reduced irreversible bombesin antagonists
NZ236114A (en) * 1989-11-22 1993-04-28 Merrell Dow Pharma Peptide antagonists of bombesin and of gastrin releasing peptide, and pharmaceutical compositions
US5834433A (en) * 1990-07-26 1998-11-10 Merrell Pharmaceuticals Inc. Compounds and pharmaceutical uses of peptides of bombesin and GRP
ZA915740B (en) * 1990-07-26 1992-05-27 Merrell Dow Pharma Peptides
US5369094A (en) * 1990-11-29 1994-11-29 The Administrators Of The Tulane Educational Fund Polypeptide bombesin antagonists
US5244883A (en) * 1990-11-29 1993-09-14 The Administrators Of The Tulane Educational Fund Nonapeptide bombesin antagonists
ATE156492T1 (de) * 1991-05-23 1997-08-15 Merrell Pharma Inc Bombesinanaloge
NZ246815A (en) * 1992-02-07 1996-02-27 Merrell Dow Pharma Phenylalanine analogs of bombesin and compositions thereof
US6156725A (en) * 1996-08-16 2000-12-05 National Institute Of Immunology Drug for the treatment of cancer
US6492330B1 (en) 1996-08-16 2002-12-10 National Institute Of Immunology Antiangiogenic drugs
EP0835662B1 (en) * 1996-10-08 2001-11-14 National Institute of Immunology A drug for the treatment of cancer
ES2304345T3 (es) 1999-03-29 2008-10-16 THE PROCTER & GAMBLE COMPANY Ligandos del receptor de melanocortina.
US6316414B1 (en) 2000-07-31 2001-11-13 Dabur Research Foundation Somatostatin analogs for the treatment of cancer
US7922998B2 (en) 2003-01-13 2011-04-12 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US8420050B2 (en) 2003-01-13 2013-04-16 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7611692B2 (en) 2003-01-13 2009-11-03 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7850947B2 (en) 2003-01-13 2010-12-14 Bracco Imaging S.P.A. Gastrin releasing peptide compounds
US7226577B2 (en) 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
KR100817232B1 (ko) 2003-04-22 2008-03-27 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. 펩타이드 벡터
US20080293680A1 (en) * 2005-08-03 2008-11-27 Stefan Peters Substituted Ethane-1,2-Diamines for the Treatment of Alzheimer's Disease II
CA2662449A1 (en) * 2006-09-08 2008-03-13 Bayer Schering Pharma Aktiengesellschaft Compounds and methods for 18f labeled agents
CN107446053A (zh) 2008-06-12 2017-12-08 益普生生物创新有限公司 癌症的抑制
KR101642363B1 (ko) 2008-06-12 2016-07-25 입센 바이오이노베이션 리미티드 신경내분비계 질환의 억제
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
EP2198878A1 (en) 2008-12-18 2010-06-23 University Of Miami Polypeptide bombesin antagonists

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207311A (en) 1977-07-18 1980-06-10 The Salk Institute For Biological Studies Peptides having analgesic and thermoregulative properties

Also Published As

Publication number Publication date
FI892507A0 (fi) 1989-05-23
EP0309297A3 (en) 1990-07-04
DK249489D0 (da) 1989-05-23
AU622123B2 (en) 1992-04-02
FI892507A (fi) 1989-05-23
DE3852086T2 (de) 1995-05-18
ATE113961T1 (de) 1994-11-15
NO178306C (no) 1996-02-28
DE3852086D1 (de) 1994-12-15
WO1989002897A1 (en) 1989-04-06
EP0309297B1 (en) 1994-11-09
NO178306B (no) 1995-11-20
EP0309297A2 (en) 1989-03-29
AU2710288A (en) 1989-04-18
FI100719B (fi) 1998-02-13
NO892060D0 (no) 1989-05-23
JP2795449B2 (ja) 1998-09-10
JPH02502016A (ja) 1990-07-05
DK249489A (da) 1989-07-20
NO892060L (no) 1989-07-21

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