[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

ES2056571T3 - Derivados de 3-piperidino-4-hidroxicromano neuroprotectores. - Google Patents

Derivados de 3-piperidino-4-hidroxicromano neuroprotectores.

Info

Publication number
ES2056571T3
ES2056571T3 ES91300549T ES91300549T ES2056571T3 ES 2056571 T3 ES2056571 T3 ES 2056571T3 ES 91300549 T ES91300549 T ES 91300549T ES 91300549 T ES91300549 T ES 91300549T ES 2056571 T3 ES2056571 T3 ES 2056571T3
Authority
ES
Spain
Prior art keywords
hydroxychromane
neuroprotectors
piperidine
derivatives
redn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91300549T
Other languages
English (en)
Inventor
Todd William Butler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of ES2056571T3 publication Critical patent/ES2056571T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SON DERIVADOS DEL 3-PIPERIDINO-1-CROMANOL Y ANALOGOS DE FORMULA EN DONDE A Y B SI VAN JUNTOS SON -CH SUB 2CH SUB 2 VAN SEPARADOS CADA UNO ES UN H, X ES CH SUB 2 O O, X ELEVADO A 1 ES UN H O UN OH, Z ES UN H, F, CL, BR O OH, Z ELEVADO A 1 ES UN H, F, CL, BR, O UN ALKILO (C SUB 1-C SUB 3), N ES 0 O 1 M ES 0 O UN NUMERO ENTERO DE 1 A 6, COMPUESTOS FARMACOLOGICOS DERIVADOS DE LOS MISMOS, METODOS PARA TRATAR LAS ALTERACIONES DEL SNC CON LOS MISMOS, Y SUSTANCIAS INTERMEDIAS UTILES EN LA PREPARACION DE DICHOS COMPUESTOS.
ES91300549T 1990-02-06 1991-01-24 Derivados de 3-piperidino-4-hidroxicromano neuroprotectores. Expired - Lifetime ES2056571T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1990/000674 WO1991012005A1 (en) 1990-02-06 1990-02-06 Neuroprotective 3-piperidino-4-hydroxychroman derivatives and analogs

Publications (1)

Publication Number Publication Date
ES2056571T3 true ES2056571T3 (es) 1994-10-01

Family

ID=22220666

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91300549T Expired - Lifetime ES2056571T3 (es) 1990-02-06 1991-01-24 Derivados de 3-piperidino-4-hidroxicromano neuroprotectores.

Country Status (29)

Country Link
US (1) US5356905A (es)
EP (1) EP0441506B1 (es)
JP (1) JPH0768214B2 (es)
KR (1) KR930011041B1 (es)
CN (1) CN1029960C (es)
AT (1) ATE108787T1 (es)
AU (1) AU626490B2 (es)
BR (1) BR9100490A (es)
CA (1) CA2035653C (es)
CZ (1) CZ286218B6 (es)
DE (2) DE69102893T4 (es)
DK (1) DK0441506T3 (es)
EG (1) EG19643A (es)
ES (1) ES2056571T3 (es)
FI (1) FI94957C (es)
HU (1) HU222726B1 (es)
IE (1) IE63836B1 (es)
IL (1) IL97100A (es)
MX (1) MX24433A (es)
MY (1) MY105293A (es)
NO (1) NO178399C (es)
NZ (1) NZ237025A (es)
PH (1) PH31061A (es)
PL (1) PL164866B1 (es)
PT (1) PT96664B (es)
RU (1) RU2099339C1 (es)
SK (1) SK281729B6 (es)
WO (1) WO1991012005A1 (es)
ZA (1) ZA91830B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594007A (en) * 1991-04-18 1997-01-14 Pfizer Inc. Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
DE9290042U1 (de) * 1991-04-18 1993-12-16 Pfizer Inc., New York, N.Y. Pro-Arzneimittelester von phenolischen 2-Piperidino-1-alkanolen
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
CA2182101C (en) * 1994-01-31 1999-08-03 Todd W. Butler Neuroprotective compounds
KR100224961B1 (ko) * 1994-08-18 1999-10-15 디. 제이. 우드 신경보호성 3-(피페리디닐-1)-크로만-4,7-디올 및 1-(4-하이드로페닐)-2-(피페리디닐-1)-알칸올 유도체
ES2211904T3 (es) 1995-05-26 2004-07-16 Pfizer Inc. Combinaciones para el tratamiento del parkinsonismo que contienen antagonistas selectivos de nmda.
TW498067B (en) * 1996-07-19 2002-08-11 Hoffmann La Roche 4-hydroxy-piperidine derivatives
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
WO2001030330A2 (en) 1999-10-29 2001-05-03 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
IL145209A0 (en) 2000-09-06 2002-06-30 Pfizer Prod Inc Pharmaceutical combinations for the treatment of stroke and traumatic brain injury
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
AU2002252053B2 (en) 2001-02-23 2006-09-14 Merck & Co., Inc. N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
WO2002080928A1 (en) 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
WO2005034878A2 (en) * 2003-10-08 2005-04-21 President And Fellows Of Harvard College Pyrovalerone analogs and therapeutic uses thereof
CA2547283C (en) * 2003-11-26 2010-11-09 Pfizer Products Inc. Aminopyrazole derivatives as gsk-3 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294804A (en) * 1961-01-27 1966-12-27 Sterling Drug Inc 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine
FR5733M (es) * 1966-09-27 1968-01-22
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
DE2507782A1 (de) * 1975-02-22 1976-09-02 Merck Patent Gmbh Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung
US4016281A (en) * 1975-02-22 1977-04-05 Merck Patent Gesellschaft Mit Beschrankter Haftung Tetralone and indanone compounds
ATE23718T1 (de) * 1981-09-25 1986-12-15 Beecham Group Plc Benzopyran-verbindungen mit pharmazeutischer wirkung.
EP0093534A1 (en) * 1982-04-28 1983-11-09 Beecham Group Plc Novel chromanols
GB8308064D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds

Also Published As

Publication number Publication date
KR910015568A (ko) 1991-09-30
NO178399B (no) 1995-12-11
JPH0768214B2 (ja) 1995-07-26
CN1053923A (zh) 1991-08-21
RU2099339C1 (ru) 1997-12-20
CN1029960C (zh) 1995-10-11
ZA91830B (en) 1992-09-30
NO923081L (no) 1992-08-05
NO178399C (no) 1996-03-20
DE69102893T4 (de) 1995-08-10
AU7029391A (en) 1991-09-05
EG19643A (en) 1995-09-30
NZ237025A (en) 1992-11-25
IL97100A (en) 1996-06-18
MY105293A (en) 1994-09-30
AU626490B2 (en) 1992-07-30
CA2035653A1 (en) 1991-08-07
PL164866B1 (pl) 1994-10-31
EP0441506A2 (en) 1991-08-14
CA2035653C (en) 1999-12-21
FI923527A0 (fi) 1992-08-05
IE63836B1 (en) 1995-06-14
ATE108787T1 (de) 1994-08-15
FI94957C (fi) 1995-11-27
KR930011041B1 (ko) 1993-11-20
IE910372A1 (en) 1991-08-14
DE69102893T2 (de) 1994-11-03
BR9100490A (pt) 1991-10-29
CS25091A3 (en) 1991-09-15
PH31061A (en) 1998-02-05
US5356905A (en) 1994-10-18
PT96664A (pt) 1991-10-31
PT96664B (pt) 1998-07-31
HU222726B1 (hu) 2003-09-29
DK0441506T3 (da) 1994-09-05
WO1991012005A1 (en) 1991-08-22
DE9101346U1 (de) 1991-06-06
MX24433A (es) 1993-05-01
FI923527A (fi) 1992-08-05
DE69102893D1 (de) 1994-08-25
PL288949A1 (en) 1991-07-29
FI94957B (fi) 1995-08-15
SK281729B6 (sk) 2001-07-10
IL97100A0 (en) 1992-03-29
EP0441506A3 (en) 1991-11-21
CZ286218B6 (cs) 2000-02-16
EP0441506B1 (en) 1994-07-20
NO923081D0 (no) 1992-08-05
JPH04211058A (ja) 1992-08-03

Similar Documents

Publication Publication Date Title
ES2056571T3 (es) Derivados de 3-piperidino-4-hidroxicromano neuroprotectores.
MX9800867A (es) Halogenobencimidazoles y su empleo como microbicidas.
EP0513387A4 (en) Active oxygen inhibitor
DE69637747D1 (de) Zuckerverbindungen
WO1999009965A3 (en) Anti-inflammatory agent
TR199801474T2 (xx) 2, 4-Diamino-1, 3, 5-Triazin, �retim y�ntemleri.
CA2014490A1 (en) Diaminoethylene compounds
HU9301931D0 (en) Process for the production of azabicyclo [2.2.2] octane-3-imines and thereof inrtermediers
EP0432841A3 (en) Spiro-indoline-oxazine compounds with photochromatic and photosensitizing characteristics and the process for their preparation
HUT62581A (en) Process for producing pipeidine derivatives and pharmaceutical compositions comprising such compounds
AU7206898A (en) Method for producing 1,3-di-substituted 2-nitroguanidines
EP0500952A4 (en) Process for producing nitrogenous heterocycle
JPS5319392A (en) Polyamino cyclic polysaccharide compounds and their preparation
CA2055174A1 (en) Process for the synthesis of alpha-((dialkylamino) substituted-methylene)-beta-oxo-(substituted) propanenitriles
IT1240644B (it) Derivati polifosfazenici contenenti gruppi azobenzenici atti all&#39; impiego come materiali a caratteristiche fotocromiche
HRPK920279B1 (en) Masterbatch for pvc mass dyeing
ES8606368A1 (es) Un procedimiento para producir un derivado de bencil-fosfi- nato etilico
ES459898A1 (es) Un procedimiento para la preparacion de acido 6,11-dihidro- dibenzo (b. e.) tiepin-11-on-3-acetico.
JPS5368790A (en) Preparation of 1-(2&#39;-tetrahydrofuryl)-5-fluorouracil
JPS5318313A (en) Encoding system
ES8305333A1 (es) &#34;procedimiento para la preparacion de nuevas sulfiminas&#34;.
MY124079A (en) Process for producing 1, 2-dimethyl-3-hydroxypyrid-4- one
JPS5382795A (en) Novel penicillin derivs., their phermaceutivals and process for theirpreparation
JPS5439088A (en) Novel antibacterial agents
JPS52143287A (en) Mocrobial production of b-methyl-l-norleucine

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 441506

Country of ref document: ES