ATE108787T1 - Nervenschützende 3-piperidino-4- hydroxychromanderivate. - Google Patents

Nervenschützende 3-piperidino-4- hydroxychromanderivate.

Info

Publication number: ATE108787T1
Authority: AT; Austria
Prior art keywords: piperidino; nervous; hydroxychroman; hydroxychroman derivatives; derivatives
Prior art date: 1990-02-06

Application number

AT91300549T

Other languages

English (en)

Inventor

Todd William Butler

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-06

Filing date

1991-01-24

Publication date

1994-08-15

1991-01-24 Application filed by Pfizer filed Critical Pfizer

1994-08-15 Application granted granted Critical

1994-08-15 Publication of ATE108787T1 publication Critical patent/ATE108787T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT91300549T 1990-02-06 1991-01-24 Nervenschützende 3-piperidino-4- hydroxychromanderivate. ATE108787T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1990/000674 WO1991012005A1 (en)	1990-02-06	1990-02-06	Neuroprotective 3-piperidino-4-hydroxychroman derivatives and analogs

Publications (1)

Publication Number	Publication Date
ATE108787T1 true ATE108787T1 (de)	1994-08-15

Family

ID=22220666

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91300549T ATE108787T1 (de)	1990-02-06	1991-01-24	Nervenschützende 3-piperidino-4- hydroxychromanderivate.

Country Status (29)

Country	Link
US (1)	US5356905A (de)
EP (1)	EP0441506B1 (de)
JP (1)	JPH0768214B2 (de)
KR (1)	KR930011041B1 (de)
CN (1)	CN1029960C (de)
AT (1)	ATE108787T1 (de)
AU (1)	AU626490B2 (de)
BR (1)	BR9100490A (de)
CA (1)	CA2035653C (de)
CZ (1)	CZ286218B6 (de)
DE (2)	DE69102893T4 (de)
DK (1)	DK0441506T3 (de)
EG (1)	EG19643A (de)
ES (1)	ES2056571T3 (de)
FI (1)	FI94957C (de)
HU (1)	HU222726B1 (de)
IE (1)	IE63836B1 (de)
IL (1)	IL97100A (de)
MX (1)	MX24433A (de)
MY (1)	MY105293A (de)
NO (1)	NO178399C (de)
NZ (1)	NZ237025A (de)
PH (1)	PH31061A (de)
PL (1)	PL164866B1 (de)
PT (1)	PT96664B (de)
RU (1)	RU2099339C1 (de)
SK (1)	SK281729B6 (de)
WO (1)	WO1991012005A1 (de)
ZA (1)	ZA91830B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5594007A (en) *	1991-04-18	1997-01-14	Pfizer Inc.	Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
DE9290042U1 (de) *	1991-04-18	1993-12-16	Pfizer Inc., New York, N.Y.	Pro-Arzneimittelester von phenolischen 2-Piperidino-1-alkanolen
US5436255A (en) *	1992-07-23	1995-07-25	Pfizer Inc.	Method of treating diseases susceptable to treatment by blocking NMDA-receptors
US5498610A (en) *	1992-11-06	1996-03-12	Pfizer Inc.	Neuroprotective indolone and related derivatives
CA2182101C (en) *	1994-01-31	1999-08-03	Todd W. Butler	Neuroprotective compounds
KR100224961B1 (ko) *	1994-08-18	1999-10-15	디. 제이. 우드	신경보호성 3-(피페리디닐-1)-크로만-4,7-디올 및 1-(4-하이드로페닐)-2-(피페리디닐-1)-알칸올 유도체
ES2211904T3 (es)	1995-05-26	2004-07-16	Pfizer Inc.	Combinaciones para el tratamiento del parkinsonismo que contienen antagonistas selectivos de nmda.
TW498067B (en) *	1996-07-19	2002-08-11	Hoffmann La Roche	4-hydroxy-piperidine derivatives
US6495561B2 (en)	1999-10-29	2002-12-17	Merck & Co., Inc.	2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6369076B1 (en)	1999-10-29	2002-04-09	Merck & Co. Inc.	5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6316474B1 (en)	1999-10-29	2001-11-13	Merck & Co., Inc.	2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6476041B1 (en)	1999-10-29	2002-11-05	Merck & Co., Inc.	1,4 substituted piperidinyl NMDA/NR2B antagonists
US6432976B1 (en)	1999-10-29	2002-08-13	Merck & Co., Inc.	8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6380205B1 (en)	1999-10-29	2002-04-30	Merck & Co., Inc.	2-cyclohexyl quinazoline NMDA/NR2B antagonists
WO2001030330A2 (en)	1999-10-29	2001-05-03	Merck Sharp & Dohme Limited	Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6489477B1 (en)	1999-10-29	2002-12-03	Merck & Co., Inc.	2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6291499B1 (en)	1999-10-29	2001-09-18	Merck & Co., Inc.	2-cyclohexyl benzimidazole NMDA/NR2B antagonists
IL145209A0 (en)	2000-09-06	2002-06-30	Pfizer Prod Inc	Pharmaceutical combinations for the treatment of stroke and traumatic brain injury
EP1674087A1 (de)	2000-10-02	2006-06-28	Pfizer Products Inc.	Prophylaktische Verwendung von N-Methyl-D-Aspartat Rezeptor (NMDA) Antagonisten
AU2002252053B2 (en)	2001-02-23	2006-09-14	Merck & Co., Inc.	N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists
WO2002080928A1 (en)	2001-04-03	2002-10-17	Merck & Co., Inc.	N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
WO2005034878A2 (en) *	2003-10-08	2005-04-21	President And Fellows Of Harvard College	Pyrovalerone analogs and therapeutic uses thereof
CA2547283C (en) *	2003-11-26	2010-11-09	Pfizer Products Inc.	Aminopyrazole derivatives as gsk-3 inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3294804A (en) *	1961-01-27	1966-12-27	Sterling Drug Inc	1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine
FR5733M (de) *	1966-09-27	1968-01-22
GB1495526A (en) *	1974-05-31	1977-12-21	Beecham Group Ltd	Chroman derivatives
DE2507782A1 (de) *	1975-02-22	1976-09-02	Merck Patent Gmbh	Tetralon- und indanon-derivate sowie verfahren zu ihrer herstellung
US4016281A (en) *	1975-02-22	1977-04-05	Merck Patent Gesellschaft Mit Beschrankter Haftung	Tetralone and indanone compounds
ATE23718T1 (de) *	1981-09-25	1986-12-15	Beecham Group Plc	Benzopyran-verbindungen mit pharmazeutischer wirkung.
EP0093534A1 (de) *	1982-04-28	1983-11-09	Beecham Group Plc	Chromanolen
GB8308064D0 (en) *	1983-03-24	1983-05-05	Beecham Group Plc	Active compounds

1990
- 1990-02-06 WO PCT/US1990/000674 patent/WO1991012005A1/en active IP Right Grant
- 1990-02-06 US US07/916,130 patent/US5356905A/en not_active Expired - Lifetime
- 1990-02-06 MX MX2443391A patent/MX24433A/es unknown
- 1990-02-06 HU HU9202568A patent/HU222726B1/hu active IP Right Grant
- 1990-02-06 RU SU5053040/04A patent/RU2099339C1/ru not_active IP Right Cessation
1991
- 1991-01-21 PH PH41875A patent/PH31061A/en unknown
- 1991-01-24 EP EP91300549A patent/EP0441506B1/de not_active Expired - Lifetime
- 1991-01-24 ES ES91300549T patent/ES2056571T3/es not_active Expired - Lifetime
- 1991-01-24 DE DE69102893A patent/DE69102893T4/de not_active Expired - Fee Related
- 1991-01-24 AT AT91300549T patent/ATE108787T1/de not_active IP Right Cessation
- 1991-01-24 DK DK91300549.2T patent/DK0441506T3/da active
- 1991-01-30 IL IL9710091A patent/IL97100A/en not_active IP Right Cessation
- 1991-02-01 CZ CS1991250A patent/CZ286218B6/cs not_active IP Right Cessation
- 1991-02-01 SK SK250-91A patent/SK281729B6/sk unknown
- 1991-02-04 PT PT96664A patent/PT96664B/pt not_active IP Right Cessation
- 1991-02-04 CA CA002035653A patent/CA2035653C/en not_active Expired - Fee Related
- 1991-02-04 PL PL91288949A patent/PL164866B1/pl not_active IP Right Cessation
- 1991-02-05 MY MYPI91000171A patent/MY105293A/en unknown
- 1991-02-05 IE IE37291A patent/IE63836B1/en not_active IP Right Cessation
- 1991-02-05 AU AU70293/91A patent/AU626490B2/en not_active Ceased
- 1991-02-05 ZA ZA91830A patent/ZA91830B/xx unknown
- 1991-02-05 CN CN91100705A patent/CN1029960C/zh not_active Expired - Fee Related
- 1991-02-05 JP JP3014569A patent/JPH0768214B2/ja not_active Expired - Fee Related
- 1991-02-05 NZ NZ237025A patent/NZ237025A/en unknown
- 1991-02-06 BR BR919100490A patent/BR9100490A/pt not_active Application Discontinuation
- 1991-02-06 DE DE9101346U patent/DE9101346U1/de not_active Expired - Lifetime
- 1991-02-06 KR KR1019910002022A patent/KR930011041B1/ko not_active IP Right Cessation
- 1991-02-06 EG EG7291A patent/EG19643A/xx active
1992
- 1992-08-05 NO NO923081A patent/NO178399C/no not_active IP Right Cessation
- 1992-08-05 FI FI923527A patent/FI94957C/fi active

Also Published As

Publication number	Publication date
KR910015568A (ko)	1991-09-30
NO178399B (no)	1995-12-11
JPH0768214B2 (ja)	1995-07-26
CN1053923A (zh)	1991-08-21
RU2099339C1 (ru)	1997-12-20
CN1029960C (zh)	1995-10-11
ZA91830B (en)	1992-09-30
NO923081L (no)	1992-08-05
NO178399C (no)	1996-03-20
DE69102893T4 (de)	1995-08-10
AU7029391A (en)	1991-09-05
EG19643A (en)	1995-09-30
NZ237025A (en)	1992-11-25
IL97100A (en)	1996-06-18
MY105293A (en)	1994-09-30
AU626490B2 (en)	1992-07-30
CA2035653A1 (en)	1991-08-07
PL164866B1 (pl)	1994-10-31
EP0441506A2 (de)	1991-08-14
CA2035653C (en)	1999-12-21
FI923527A0 (fi)	1992-08-05
IE63836B1 (en)	1995-06-14
FI94957C (fi)	1995-11-27
KR930011041B1 (ko)	1993-11-20
IE910372A1 (en)	1991-08-14
DE69102893T2 (de)	1994-11-03
BR9100490A (pt)	1991-10-29
CS25091A3 (en)	1991-09-15
PH31061A (en)	1998-02-05
US5356905A (en)	1994-10-18
PT96664A (pt)	1991-10-31
PT96664B (pt)	1998-07-31
HU222726B1 (hu)	2003-09-29
DK0441506T3 (da)	1994-09-05
WO1991012005A1 (en)	1991-08-22
DE9101346U1 (de)	1991-06-06
MX24433A (es)	1993-05-01
FI923527A (fi)	1992-08-05
DE69102893D1 (de)	1994-08-25
PL288949A1 (en)	1991-07-29
FI94957B (fi)	1995-08-15
SK281729B6 (sk)	2001-07-10
IL97100A0 (en)	1992-03-29
EP0441506A3 (en)	1991-11-21
CZ286218B6 (cs)	2000-02-16
ES2056571T3 (es)	1994-10-01
EP0441506B1 (de)	1994-07-20
NO923081D0 (no)	1992-08-05
JPH04211058A (ja)	1992-08-03

Publication	Publication Date	Title
ATE108787T1 (de)	1994-08-15	Nervenschützende 3-piperidino-4- hydroxychromanderivate.
MX9800867A (es)	1998-04-30	Halogenobencimidazoles y su empleo como microbicidas.
EP0513387A4 (en)	1993-04-21	Active oxygen inhibitor
MX9700273A (es)	1997-05-31	Benzamidinas sustituidas, su preparacion y empleo como sustancias medicamentosas.
GR69233B (de)	1982-05-10
ATE414094T1 (de)	2008-11-15	Zuckerverbindungen
HU9301931D0 (en)	1993-12-28	Process for the production of azabicyclo [2.2.2] octane-3-imines and thereof inrtermediers
EP0432841A3 (en)	1992-01-29	Spiro-indoline-oxazine compounds with photochromatic and photosensitizing characteristics and the process for their preparation
HUT62581A (en)	1993-05-28	Process for producing pipeidine derivatives and pharmaceutical compositions comprising such compounds
JPS557820A (en)	1980-01-21	Modifiing method of synthetic polymer
EP0500952A4 (en)	1993-03-10	Process for producing nitrogenous heterocycle
JPS5319392A (en)	1978-02-22	Polyamino cyclic polysaccharide compounds and their preparation
CA2055174A1 (en)	1992-05-14	Process for the synthesis of alpha-((dialkylamino) substituted-methylene)-beta-oxo-(substituted) propanenitriles
ES8606368A1 (es)	1986-04-01	Un procedimiento para producir un derivado de bencil-fosfi- nato etilico
JPS5368790A (en)	1978-06-19	Preparation of 1-(2'-tetrahydrofuryl)-5-fluorouracil
JPS5318313A (en)	1978-02-20	Encoding system
IT1240644B (it)	1993-12-17	Derivati polifosfazenici contenenti gruppi azobenzenici atti all' impiego come materiali a caratteristiche fotocromiche
ES459898A1 (es)	1978-11-16	Un procedimiento para la preparacion de acido 6,11-dihidro- dibenzo (b. e.) tiepin-11-on-3-acetico.
ES482948A1 (es)	1980-09-01	Un procedimiento para la preparacion de derivados de oxadia-zolotriazona
HRPK920279B1 (en)	2001-06-30	Masterbatch for pvc mass dyeing
JPS5422353A (en)	1979-02-20	2-chloro-2-cyano-7-alkylidene-bicyclo(2,2,1)-5-heptene and its preparation
ES410007A1 (es)	1975-12-01	Un procedimiento para la preparacion de 1-etil-1-alcoxicar-bonil-etil-1, 2, 3, 4, 6, 6, 12, 12b-octahidro-indol-(2, 3- a) quinolicinas.
MY124079A (en)	2006-06-30	Process for producing 1, 2-dimethyl-3-hydroxypyrid-4- one
ES461209A1 (es)	1978-05-01	Nuevo procedimiento para la preparacion de un derivado ben- cilico.
JPS5439088A (en)	1979-03-24	Novel antibacterial agents

Legal Events

Date	Code	Title	Description
2007-10-15	REN	Ceased due to non-payment of the annual fee