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ES2055651A1 - Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles. - Google Patents

Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.

Info

Publication number
ES2055651A1
ES2055651A1 ES09201513A ES9201513A ES2055651A1 ES 2055651 A1 ES2055651 A1 ES 2055651A1 ES 09201513 A ES09201513 A ES 09201513A ES 9201513 A ES9201513 A ES 9201513A ES 2055651 A1 ES2055651 A1 ES 2055651A1
Authority
ES
Spain
Prior art keywords
group
atom
hydrogen
alkenyl
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09201513A
Other languages
English (en)
Other versions
ES2055651B1 (es
Inventor
Ges Josep Maria Caldero
Rovira Anna Bosch
Acin Joan Roca
Barjoan Pere Dalmases
Olondriz Francisco Marquillas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vita Invest SA
Original Assignee
Vita Invest SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vita Invest SA filed Critical Vita Invest SA
Priority to ES09201513A priority Critical patent/ES2055651B1/es
Priority to EP19930500092 priority patent/EP0580539A3/en
Priority to NO932375A priority patent/NO932375L/no
Priority to AU41643/93A priority patent/AU4164393A/en
Priority to US08/087,004 priority patent/US5331005A/en
Priority to CA002100034A priority patent/CA2100034A1/en
Priority to ZA934868A priority patent/ZA934868B/xx
Priority to HU9302078A priority patent/HUT70183A/hu
Priority to KR1019930013533A priority patent/KR940005475A/ko
Priority to JP5178724A priority patent/JPH06179651A/ja
Priority to FI933276A priority patent/FI933276A/fi
Publication of ES2055651A1 publication Critical patent/ES2055651A1/es
Application granted granted Critical
Publication of ES2055651B1 publication Critical patent/ES2055651B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE NUEVAS AMIDINAS DERIVADAS DE 3-AMINO ETILINDOLES DE FORMULA (I), Y SUS SALES FISIOLOGICAMENTE ACEPTABLES (RSI1 SC = H, ALQUILO O ALQUENILO; RSI2 SC = H, ALQUILO, ALQUENILO, ARILO, ARIL-ALQUILO O CICLOALQUILO; RSI3 SC Y RSI4 SC = H, O ALQUILO, Y RSI5 SC = H, ALQUILO, ALQUENILO O ALQUINILO, EVENTUALMENTE SUSTITUIDO, Y CON RSI4 SC Y EL NITROGENO PUEDE FORMAR UN HETEROCICLO); ESTA BASADO EN UNA OPERACION QUE SE INDICA: A) REACCION DE UNA AMINA (IV) CON UNA CARBOXAMIDA (V) FORMULA O B) REACCION DE UN COMPUESTO (IX) CON UNA AMINA (X). FORMULA ESTOS PRODUCTOS SE UTILIZAN PARA EL TRATAMIENTO Y LA PREVENCION DE LA MIGRAÑA.
ES09201513A 1992-07-20 1992-07-20 Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles. Expired - Fee Related ES2055651B1 (es)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ES09201513A ES2055651B1 (es) 1992-07-20 1992-07-20 Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
EP19930500092 EP0580539A3 (en) 1992-07-20 1993-06-24 Amidines derived from 3-aminoethyl indoles for the treatment of migraines
NO932375A NO932375L (no) 1992-07-20 1993-06-29 Amidiner avledet fra 3-aminoetyl og fremgangsmaate for deres fremstilling
AU41643/93A AU4164393A (en) 1992-07-20 1993-06-30 Amidines derived from 3-aminoethyl indoles and process for the preparation thereof
CA002100034A CA2100034A1 (en) 1992-07-20 1993-07-07 Amidines derived from 3-aminoethyl indoles and process for the preparation thereof
ZA934868A ZA934868B (en) 1992-07-20 1993-07-07 Amidines derived from 3-aminoethyl indoles and process for the preparation thereof
US08/087,004 US5331005A (en) 1992-07-20 1993-07-07 Amidines derived from 3-aminoethyl indoles and process for the preparation thereof
HU9302078A HUT70183A (en) 1992-07-20 1993-07-19 Amidines derivated from 3-(amino-ethyl)-indoles, process for producing thereof and pharmaceutical compositions comprising them
KR1019930013533A KR940005475A (ko) 1992-07-20 1993-07-19 3- 아미노에틸 인돌로부터 유도되는 아미딘 및 이의 제조방법
JP5178724A JPH06179651A (ja) 1992-07-20 1993-07-20 ３−アミノエチルインドール類から誘導されるアミジン類およびその製造方法
FI933276A FI933276A (fi) 1992-07-20 1993-07-20 Amidiner avledda fraon 3-aminoetylindoler och foerfarande foer deras framstaellning

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09201513A ES2055651B1 (es) 1992-07-20 1992-07-20 Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.

Publications (2)

Publication Number Publication Date
ES2055651A1 true ES2055651A1 (es) 1994-08-16
ES2055651B1 ES2055651B1 (es) 1995-03-01

Family

ID=8277714

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09201513A Expired - Fee Related ES2055651B1 (es) 1992-07-20 1992-07-20 Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.

Country Status (11)

Country Link
US (1) US5331005A (es)
EP (1) EP0580539A3 (es)
JP (1) JPH06179651A (es)
KR (1) KR940005475A (es)
AU (1) AU4164393A (es)
CA (1) CA2100034A1 (es)
ES (1) ES2055651B1 (es)
FI (1) FI933276A (es)
HU (1) HUT70183A (es)
NO (1) NO932375L (es)
ZA (1) ZA934868B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
KR20020080732A (ko) * 2001-04-17 2002-10-26 김연욱 연수기
KR100496125B1 (ko) * 2002-12-13 2005-06-16 신희승 누수 감시 시스템
ATE489138T1 (de) 2005-04-13 2010-12-15 Neuraxon Inc Substituierte indolverbindungen mit nos-hemmender aktivität
EP2010527B1 (en) * 2006-04-13 2013-08-14 Neuraxon Inc. 1,5 and 3,6- substituted indole compounds having nos inhibitory activity
CA2705833A1 (en) * 2007-11-16 2009-05-22 Subhash C. Annedi 3,5-substituted indole compounds having nos and norepinephrine reuptake inhibitory activity
US20090163451A1 (en) * 2007-11-16 2009-06-25 Frank Porreca Methods for treating visceral pain
WO2009062319A1 (en) * 2007-11-16 2009-05-22 Neuraxon, Inc. Indole compounds and methods for treating visceral pain

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8407473A1 (es) * 1982-06-07 1984-10-01 Glaxo Group Ltd "un procedimiento para la preparacion de derivados del indol"
EP0145459A2 (en) * 1983-12-06 1985-06-19 Glaxo Group Limited Process for the production of chemical compounds
ES8801204A1 (es) * 1984-08-01 1987-12-16 Glaxo Group Ltd Un procedimiento para la preparacion de derivados de indol

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI753673A (es) * 1975-01-15 1976-07-16 Merck & Co Inc
GB8332435D0 (en) * 1983-12-06 1984-01-11 Glaxo Group Ltd Chemical compounds
GB2162522B (en) * 1984-08-01 1988-02-24 Glaxo Group Ltd An indole derivative

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES8407473A1 (es) * 1982-06-07 1984-10-01 Glaxo Group Ltd "un procedimiento para la preparacion de derivados del indol"
ES8601880A1 (es) * 1982-06-07 1985-11-16 Glaxo Group Ltd Un procedimiento para la preparacion de derivados del indol
ES8609247A1 (es) * 1982-06-07 1986-07-16 Glaxo Group Ltd Un procedimiento para la preparacion de derivados del indol
EP0145459A2 (en) * 1983-12-06 1985-06-19 Glaxo Group Limited Process for the production of chemical compounds
ES8801204A1 (es) * 1984-08-01 1987-12-16 Glaxo Group Ltd Un procedimiento para la preparacion de derivados de indol

Also Published As

Publication number Publication date
KR940005475A (ko) 1994-03-21
EP0580539A3 (en) 1994-05-18
NO932375D0 (no) 1993-06-29
HUT70183A (en) 1995-09-28
FI933276A0 (fi) 1993-07-20
JPH06179651A (ja) 1994-06-28
CA2100034A1 (en) 1994-01-21
HU9302078D0 (en) 1993-10-28
FI933276A (fi) 1994-01-21
US5331005A (en) 1994-07-19
EP0580539A2 (en) 1994-01-26
ES2055651B1 (es) 1995-03-01
NO932375L (no) 1994-01-21
AU4164393A (en) 1994-01-27
ZA934868B (en) 1994-02-04

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960722