DE60000978D1 - 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose - Google Patents
22r-hydroxycholesta-8,14-diene derivate zur hemmung der meioseInfo
- Publication number
- DE60000978D1 DE60000978D1 DE60000978T DE60000978T DE60000978D1 DE 60000978 D1 DE60000978 D1 DE 60000978D1 DE 60000978 T DE60000978 T DE 60000978T DE 60000978 T DE60000978 T DE 60000978T DE 60000978 D1 DE60000978 D1 DE 60000978D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- hydrogen
- hydroxycholesta
- meiose
- inhibiting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000002401 inhibitory effect Effects 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000021121 meiosis Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Gynecology & Obstetrics (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99200680 | 1999-03-09 | ||
| PCT/EP2000/001780 WO2000053618A1 (en) | 1999-03-09 | 2000-03-03 | 22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60000978D1 true DE60000978D1 (de) | 2003-01-23 |
| DE60000978T2 DE60000978T2 (de) | 2003-07-17 |
Family
ID=8239958
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60000978T Expired - Fee Related DE60000978T2 (de) | 1999-03-09 | 2000-03-03 | 22r-hydroxycholesta-8,14-diene derivate zur hemmung der meiose |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6518262B1 (de) |
| EP (1) | EP1163258B1 (de) |
| JP (1) | JP2002539134A (de) |
| AT (1) | ATE229538T1 (de) |
| AU (1) | AU3285000A (de) |
| DE (1) | DE60000978T2 (de) |
| DK (1) | DK1163258T3 (de) |
| ES (1) | ES2188515T3 (de) |
| WO (1) | WO2000053618A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE246703T1 (de) * | 1999-04-06 | 2003-08-15 | Akzo Nobel Nv | Oral wirksame 7-alpha-alkyl androgene |
| GB9930533D0 (en) * | 1999-12-23 | 2000-02-16 | Mitsubishi Tokyo Pharm Inc | Nucleic acid delivery |
| JP2003529378A (ja) * | 2000-04-06 | 2003-10-07 | ノボ ノルディスク アクティーゼルスカブ | 卵母細胞の細胞質および核成熟の体外成熟方法 |
| WO2005020928A2 (en) | 2003-08-29 | 2005-03-10 | The Regents Of The University Of California | Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins |
| US9670244B2 (en) | 2006-02-27 | 2017-06-06 | The Regents Of The University Of California | Oxysterol compounds and the hedgehog pathway |
| CN101951915A (zh) | 2007-12-03 | 2011-01-19 | 加利福尼亚大学董事会 | 用于刺猬蛋白信号、骨诱导、抗脂肪形成和wnt信号的激活的氧固醇 |
| CA2872751A1 (en) | 2012-05-07 | 2013-11-14 | The Regents Of The University Of California | Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis |
| JP2016517888A (ja) | 2013-05-02 | 2016-06-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 骨選択的骨形成のオキシステロール骨標的薬剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1113086A (en) * | 1977-08-29 | 1981-11-24 | Robert J. Chorvat | 25-alkylcholesterol derivatives |
| US5716777A (en) * | 1994-06-23 | 1998-02-10 | Novo Nordisk A/S | Regulation of meiosis using sterols |
| BR9607673A (pt) * | 1995-03-06 | 1998-06-16 | Novo Nordisk As | Processo para estimular a meiose de uma célula germinativa e uso de um composto que causa o acúmulo de uma substância endógena ativadora de meiose |
| HUP9904616A3 (en) * | 1996-12-20 | 2001-02-28 | Novo Nordisk As | Meiosis regulating cholestane-derivatives |
-
2000
- 2000-03-03 AT AT00910752T patent/ATE229538T1/de not_active IP Right Cessation
- 2000-03-03 DE DE60000978T patent/DE60000978T2/de not_active Expired - Fee Related
- 2000-03-03 DK DK00910752T patent/DK1163258T3/da active
- 2000-03-03 EP EP00910752A patent/EP1163258B1/de not_active Expired - Lifetime
- 2000-03-03 ES ES00910752T patent/ES2188515T3/es not_active Expired - Lifetime
- 2000-03-03 AU AU32850/00A patent/AU3285000A/en not_active Abandoned
- 2000-03-03 WO PCT/EP2000/001780 patent/WO2000053618A1/en active IP Right Grant
- 2000-03-03 US US09/914,061 patent/US6518262B1/en not_active Expired - Fee Related
- 2000-03-03 JP JP2000604053A patent/JP2002539134A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU3285000A (en) | 2000-09-28 |
| DK1163258T3 (da) | 2003-03-31 |
| ES2188515T3 (es) | 2003-07-01 |
| EP1163258B1 (de) | 2002-12-11 |
| ATE229538T1 (de) | 2002-12-15 |
| US6518262B1 (en) | 2003-02-11 |
| WO2000053618A1 (en) | 2000-09-14 |
| JP2002539134A (ja) | 2002-11-19 |
| DE60000978T2 (de) | 2003-07-17 |
| EP1163258A1 (de) | 2001-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: N.V. ORGANON, OSS, NL |
|
| 8339 | Ceased/non-payment of the annual fee |