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ES2054177T3 - Derivados disubstituidos del acido (quinolin-2-il-metoxi)fenilacetico. - Google Patents

Derivados disubstituidos del acido (quinolin-2-il-metoxi)fenilacetico.

Info

Publication number
ES2054177T3
ES2054177T3 ES90115444T ES90115444T ES2054177T3 ES 2054177 T3 ES2054177 T3 ES 2054177T3 ES 90115444 T ES90115444 T ES 90115444T ES 90115444 T ES90115444 T ES 90115444T ES 2054177 T3 ES2054177 T3 ES 2054177T3
Authority
ES
Spain
Prior art keywords
quinolin
phenylacetic acid
metoxi
disubstituted
disubstituted derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90115444T
Other languages
English (en)
Inventor
Klaus Dr Mohrs
Siegfried Dr Raddatz
Romanis Fruchtmann
Christian Dr Kohlsdorfer
Reiner Prof Muller-Peddinghaus
Pia Dr Theisen-Popp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Application granted granted Critical
Publication of ES2054177T3 publication Critical patent/ES2054177T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Detergent Compositions (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

EL INVENTO SE REFIERE A UN DERIVADO DE ACIDO (QUINOLINA-2-ILO-METOXI) FENILACETICO DISUSTITUIDO, QUE SE EMPLEA COMO MATERIA ACTIVA EN MEDICAMENTEOS Y SE OBTIENE A TRAVES DE LA REDUCCION DE CETOESTERES DISUSTITUIDOS MEDIANTE REACTIVOS GRIGNARD Y EL TRATAMIENTO DEL COMPUESTO OBTENIDO EN LA ETAPA DE REDUCCION CON TIOLENO.
ES90115444T 1989-08-24 1990-08-11 Derivados disubstituidos del acido (quinolin-2-il-metoxi)fenilacetico. Expired - Lifetime ES2054177T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3927931A DE3927931A1 (de) 1989-08-24 1989-08-24 Disubstituierte (chinolin-2-yl-methoxy)phenylessigsaeure-derivate

Publications (1)

Publication Number Publication Date
ES2054177T3 true ES2054177T3 (es) 1994-08-01

Family

ID=6387762

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90115444T Expired - Lifetime ES2054177T3 (es) 1989-08-24 1990-08-11 Derivados disubstituidos del acido (quinolin-2-il-metoxi)fenilacetico.

Country Status (20)

Country Link
US (1) US5126354A (es)
EP (1) EP0414078B1 (es)
JP (1) JPH0390063A (es)
KR (1) KR910004570A (es)
CN (1) CN1049657A (es)
AT (1) ATE106395T1 (es)
AU (1) AU632845B2 (es)
CA (1) CA2023776A1 (es)
DD (1) DD298921A5 (es)
DE (2) DE3927931A1 (es)
DK (1) DK0414078T3 (es)
ES (1) ES2054177T3 (es)
FI (1) FI904158A0 (es)
HU (1) HU208960B (es)
IE (1) IE903072A1 (es)
IL (1) IL95443A (es)
NZ (1) NZ234995A (es)
PH (1) PH27287A (es)
PT (1) PT95071A (es)
ZA (1) ZA906706B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204358A (en) * 1987-11-25 1993-04-20 Merck Frosst Canada, Inc. Hetaryl styryl quinolines as leukotriene inhibitors
DE3900261A1 (de) * 1988-05-31 1989-12-07 Bayer Ag Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
DE3916663A1 (de) * 1989-05-23 1990-11-29 Bayer Ag Substituierte (chinolin-2-yl-methoxy)phenyl-acyl-sulfonamide und -cyanamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3927930A1 (de) * 1989-08-24 1991-02-28 Bayer Ag Cyclisch substituierte (chinolin-2-yl-methoxy)phenyl-essig-saeure-derivate
US5021576A (en) * 1989-10-27 1991-06-04 American Home Products Corporation 2-Anilino phenylacetic acid derivatives
US5304563A (en) * 1991-02-22 1994-04-19 Bayer Aktiengesellschaft 2-substituted quinolines, and their use in medicaments
DE4105551A1 (de) * 1991-02-22 1992-08-27 Bayer Ag 2-substituierte chinoline, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE4128681A1 (de) * 1991-08-29 1993-03-04 Bayer Ag Substituierte mandelsaeurederivate, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
CA2092152A1 (en) * 1992-03-23 1993-09-24 Azuma Igarashi Phenoxyacetic acid compounds and medical preparations containing them
DE4219765A1 (de) * 1992-06-17 1993-12-23 Bayer Ag Substituierte (Benzothiazolyl- und Chinoxalyl-methoxy)phenylessigsäurederivate
DE4226519A1 (de) * 1992-08-11 1994-02-17 Bayer Ag 3-Substituierte Chinolylmethoxy-phenylessigsäurederivate
DE4443892A1 (de) * 1994-12-09 1996-06-13 Bayer Ag 4-(Chinolin-2-yl-methoxy)-phenyl-essigsäurederivate
DE4443891A1 (de) 1994-12-09 1996-06-13 Bayer Ag Heterocyclisch substituierte Oxy-phenyl-(phenyl)glycinolamide
PA8619901A1 (es) 2003-12-12 2005-11-25 Wyeth Corp Quinolinas utiles en el tratamiento de enfermedades cardiovasculares
JP2010511632A (ja) 2006-11-30 2010-04-15 アミラ ファーマシューティカルス，インコーポレーテッド ５−リポキシゲナーゼ活性化タンパク質インヒビターおよび一酸化窒素モジュレーターを含んでいる組成物および治療法
ES2878405T3 (es) 2014-02-04 2021-11-18 Bioscience Pharma Partners Llc Uso de inhibidores de flap para reducir la lesión mediada por neuroinflamación en el sistema nervioso central

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2046979B (en) * 1979-04-17 1983-05-18 Burroughs Corp Recording and replay apparatus employing rotary media
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US4661499A (en) * 1985-06-18 1987-04-28 Merck Frosst Canada, Inc. 2-[(substituted)-phenoxymethyl]quinolines
DE3814504A1 (de) * 1988-04-29 1989-11-09 Bayer Ag (alpha)-substituierte 4-(chinolin-2-yl-methoxy)phenylessigsaeuren und -ester, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3900261A1 (de) * 1988-05-31 1989-12-07 Bayer Ag Substituierte 4-(chinolin-2-yl-methoxy) phenyl-essigsaeure-derivate
EP0349062A1 (en) * 1988-06-27 1990-01-03 Merck Frosst Canada Inc. Quinoline ether alkanoic acid
DE3927369A1 (de) * 1989-08-19 1991-02-21 Bayer Ag Substituierte n-(chinolin-2-yl-methoxy)benzyl-sulfonyl-harnstoffe
DE3927930A1 (de) * 1989-08-24 1991-02-28 Bayer Ag Cyclisch substituierte (chinolin-2-yl-methoxy)phenyl-essig-saeure-derivate

Also Published As

Publication number Publication date
DE3927931A1 (de) 1991-02-28
PT95071A (pt) 1991-04-18
ZA906706B (en) 1991-06-26
DE59005899D1 (de) 1994-07-07
US5126354A (en) 1992-06-30
PH27287A (en) 1993-05-04
EP0414078A2 (de) 1991-02-27
IL95443A (en) 1994-06-24
CA2023776A1 (en) 1991-02-25
HU208960B (en) 1994-02-28
DD298921A5 (de) 1992-03-19
JPH0390063A (ja) 1991-04-16
FI904158A0 (fi) 1990-08-22
EP0414078A3 (en) 1992-03-11
NZ234995A (en) 1991-12-23
KR910004570A (ko) 1991-03-28
HUT54989A (en) 1991-04-29
IL95443A0 (en) 1991-06-30
ATE106395T1 (de) 1994-06-15
EP0414078B1 (de) 1994-06-01
DK0414078T3 (da) 1994-08-15
AU632845B2 (en) 1993-01-14
HU905304D0 (en) 1991-02-28
CN1049657A (zh) 1991-03-06
AU6108590A (en) 1991-02-28
IE903072A1 (en) 1991-02-27

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