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ES2052449A1 - Nuevo procedimiento para la preparacion del apovincaminato de etilo. - Google Patents

Nuevo procedimiento para la preparacion del apovincaminato de etilo.

Info

Publication number
ES2052449A1
ES2052449A1 ES09202595A ES9202595A ES2052449A1 ES 2052449 A1 ES2052449 A1 ES 2052449A1 ES 09202595 A ES09202595 A ES 09202595A ES 9202595 A ES9202595 A ES 9202595A ES 2052449 A1 ES2052449 A1 ES 2052449A1
Authority
ES
Spain
Prior art keywords
apovincaminoate
ethyl
preparation
new procedure
geriatrics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09202595A
Other languages
English (en)
Other versions
ES2052449B1 (es
Inventor
Mondelo Fernando Calvo
Ferrero M Teresa Manresa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Covex SA
Original Assignee
Covex SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Covex SA filed Critical Covex SA
Priority to ES9202595A priority Critical patent/ES2052449B1/es
Priority to HU9301983A priority patent/HU209927B/hu
Priority to CZ138493A priority patent/CZ279608B6/cs
Priority to PL29969293A priority patent/PL171090B1/pl
Priority to SK756-93A priority patent/SK278851B6/sk
Priority to RO9301002A priority patent/RO110500B1/ro
Priority to BG97969A priority patent/BG61305B1/bg
Publication of ES2052449A1 publication Critical patent/ES2052449A1/es
Application granted granted Critical
Publication of ES2052449B1 publication Critical patent/ES2052449B1/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NUEVO PROCEDIMIENTO PARA LA PREPARACION DEL APOVINCAMINATO DE ETILO. COMPRENDE: HACER REACCIONAR ACIDO APOVINCAMINICO (II) CON ETANOLEN PRESENCIA DE UN CATALIZADOR DE FORMULA (III) EN LA QUE X = -OCH3, -COCH3, -NO2, -CH3 Y -CN. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO POLAR, EN PRESENCIA DE UNA BASE ORGANICA Y A TEMPERATURA AMBIENTE. EL APOVINCAMINATO DE ETILO (I) TIENE APLICACION EN EL TRATAMIENTO DE LOS TRASTORNOS CEREBRALES Y EN GERIATRIA.
ES9202595A 1992-12-22 1992-12-22 Nuevo procedimiento para la preparacion del apovincaminato de etilo. Expired - Lifetime ES2052449B1 (es)

Priority Applications (7)

Application Number Priority Date Filing Date Title
ES9202595A ES2052449B1 (es) 1992-12-22 1992-12-22 Nuevo procedimiento para la preparacion del apovincaminato de etilo.
HU9301983A HU209927B (en) 1992-12-22 1993-07-09 Process for the preparation of ethyl apovincaminate
CZ138493A CZ279608B6 (cs) 1992-12-22 1993-07-12 Způsob výroby ethylapovincaminatu
PL29969293A PL171090B1 (pl) 1992-12-22 1993-07-15 Sposób wytwarzania apowinkaminianu etylu(© ) Pierwszenstwo:22.12.1992,E S ,9202595 PL
SK756-93A SK278851B6 (sk) 1992-12-22 1993-07-16 Spôsob výroby etylapovincaminátu
RO9301002A RO110500B1 (ro) 1992-12-22 1993-07-16 Procedeu pentru prepararea apovincaminatului de etil
BG97969A BG61305B1 (bg) 1992-12-22 1993-07-20 нов метод за получаване на етилов аповинкаминат

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9202595A ES2052449B1 (es) 1992-12-22 1992-12-22 Nuevo procedimiento para la preparacion del apovincaminato de etilo.

Publications (2)

Publication Number Publication Date
ES2052449A1 true ES2052449A1 (es) 1994-07-01
ES2052449B1 ES2052449B1 (es) 1995-02-16

Family

ID=8279195

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9202595A Expired - Lifetime ES2052449B1 (es) 1992-12-22 1992-12-22 Nuevo procedimiento para la preparacion del apovincaminato de etilo.

Country Status (7)

Country Link
BG (1) BG61305B1 (es)
CZ (1) CZ279608B6 (es)
ES (1) ES2052449B1 (es)
HU (1) HU209927B (es)
PL (1) PL171090B1 (es)
RO (1) RO110500B1 (es)
SK (1) SK278851B6 (es)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021923A1 (fr) * 1979-06-22 1981-01-07 Synthelabo Procédé de préparation de dérivés vincaminiques et dérivés vincaminiques
FR2472571A1 (fr) * 1979-12-28 1981-07-03 Richter Gedeon Vegyeszet Procede pour la preparation de derives d'esters halogeno-vincaminiques et halogeno-apovincaminiques
FR2489824A1 (fr) * 1980-09-10 1982-03-12 Richter Gedeon Vegyeszet Procede pour la preparation d'esters d'acide apovincaminique et produits ainsi obtenus
ES8400746A1 (es) * 1981-10-16 1983-11-01 Elmu Sa Procedimiento de obtencion de un ester del acido apovincami-nico
ES8604956A1 (es) * 1985-11-20 1986-03-16 Covex Sa Procedimiento de obtencion del ester etilico del acido apo- vincaminico
CH676002A5 (en) * 1986-05-23 1990-11-30 Arysearch Arylan Ag Ethyl apo:vincaminate prepn. - by esterification of vincamine with ethanol in presence of alkali metal followed by saponification

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0021923A1 (fr) * 1979-06-22 1981-01-07 Synthelabo Procédé de préparation de dérivés vincaminiques et dérivés vincaminiques
FR2472571A1 (fr) * 1979-12-28 1981-07-03 Richter Gedeon Vegyeszet Procede pour la preparation de derives d'esters halogeno-vincaminiques et halogeno-apovincaminiques
FR2489824A1 (fr) * 1980-09-10 1982-03-12 Richter Gedeon Vegyeszet Procede pour la preparation d'esters d'acide apovincaminique et produits ainsi obtenus
ES8400746A1 (es) * 1981-10-16 1983-11-01 Elmu Sa Procedimiento de obtencion de un ester del acido apovincami-nico
ES8604956A1 (es) * 1985-11-20 1986-03-16 Covex Sa Procedimiento de obtencion del ester etilico del acido apo- vincaminico
CH676002A5 (en) * 1986-05-23 1990-11-30 Arysearch Arylan Ag Ethyl apo:vincaminate prepn. - by esterification of vincamine with ethanol in presence of alkali metal followed by saponification

Also Published As

Publication number Publication date
ES2052449B1 (es) 1995-02-16
HU209927B (en) 1994-12-28
HU9301983D0 (en) 1993-09-28
PL299692A1 (en) 1994-06-27
RO110500B1 (ro) 1996-01-30
SK278851B6 (sk) 1998-04-08
BG61305B1 (bg) 1997-05-30
SK75693A3 (en) 1994-11-09
CZ138493A3 (en) 1995-05-17
BG97969A (bg) 1994-04-29
CZ279608B6 (cs) 1995-05-17
HUT65826A (en) 1994-07-28
PL171090B1 (pl) 1997-03-28

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