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DE3780819D1 - Quaternaere derivate von noroxymorphon zur behandlung von uebelkeit und erbrechen. - Google Patents

Quaternaere derivate von noroxymorphon zur behandlung von uebelkeit und erbrechen.

Info

Publication number
DE3780819D1
DE3780819D1 DE8787307999T DE3780819T DE3780819D1 DE 3780819 D1 DE3780819 D1 DE 3780819D1 DE 8787307999 T DE8787307999 T DE 8787307999T DE 3780819 T DE3780819 T DE 3780819T DE 3780819 D1 DE3780819 D1 DE 3780819D1
Authority
DE
Germany
Prior art keywords
nausea
quaternaere
noroxymorphone
vomiting
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787307999T
Other languages
English (en)
Other versions
DE3780819T2 (de
Inventor
Leon I Goldberg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Chicago
Original Assignee
University of Chicago
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Chicago filed Critical University of Chicago
Publication of DE3780819D1 publication Critical patent/DE3780819D1/de
Application granted granted Critical
Publication of DE3780819T2 publication Critical patent/DE3780819T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8787307999T 1987-09-10 1987-09-10 Quaternaere derivate von noroxymorphon zur behandlung von uebelkeit und erbrechen. Expired - Lifetime DE3780819T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87307999A EP0306575B1 (de) 1987-09-10 1987-09-10 Quaternäre Derivate von Noroxymorphon zur Behandlung von Übelkeit und Erbrechen

Publications (2)

Publication Number Publication Date
DE3780819D1 true DE3780819D1 (de) 1992-09-03
DE3780819T2 DE3780819T2 (de) 1993-01-14

Family

ID=8198027

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787307999T Expired - Lifetime DE3780819T2 (de) 1987-09-10 1987-09-10 Quaternaere derivate von noroxymorphon zur behandlung von uebelkeit und erbrechen.

Country Status (5)

Country Link
EP (1) EP0306575B1 (de)
AT (1) ATE78687T1 (de)
DE (1) DE3780819T2 (de)
ES (1) ES2051742T3 (de)
GR (1) GR3005834T3 (de)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7563899B2 (en) 2005-05-25 2009-07-21 Progenics Pharmaceuticals, Inc. (S)-N-methylnaltrexone
US7674904B2 (en) 2005-05-25 2010-03-09 Progenics Pharmaceuticals, Inc. Synthesis of R-N-methylnaltrexone

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274591B1 (en) * 1997-11-03 2001-08-14 Joseph F. Foss Use of methylnaltrexone and related compounds
AU2003272642B2 (en) * 2002-09-25 2009-07-09 Euro-Celtique S.A. N-substituted hydromorphones and the use thereof
PL2368553T3 (pl) 2003-04-08 2015-05-29 Progenics Pharm Inc Preparaty farmaceutyczne zawierające metylonaltrekson
CN104248763A (zh) 2005-03-07 2014-12-31 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
EP2139890B1 (de) 2007-03-29 2014-06-25 Wyeth LLC Peripherer opioid-rezeptor antagonisten und verwendungen davon
TWI466671B (zh) 2007-03-29 2015-01-01 Progenics Pharm Inc 末梢性類鴉片受體拮抗劑及其用途
CA2945356C (en) 2007-03-29 2021-03-23 Progenics Pharmaceuticals, Inc. (r)-n-methylnaltrexone bromide and pharmaceutical compostitions therof useful as peripheral .mu. opioid receptor antagonist
JP5358587B2 (ja) 2008-02-06 2013-12-04 プロジェニックス・ファーマシューティカルス・インコーポレイテッド （ｒ），（ｒ）−２，２’−ビス−メチルナルトレキソンの製造及び用途
JP5647098B2 (ja) 2008-03-21 2014-12-24 ザ ユニヴァーシティー オヴ シカゴ オピオイド拮抗薬とｍＴＯＲ阻害薬を用いた治療
CA2676881C (en) 2008-09-30 2017-04-25 Wyeth Peripheral opioid receptor antagonists and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1202148A (en) * 1968-03-06 1970-08-12 Sankyo Co Pharmaceutical compositions
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
US4466968A (en) * 1980-11-24 1984-08-21 Dermall, Ltd. Method for prophylaxis or treatment of emesis and nausea
JPS59500418A (ja) * 1982-03-16 1984-03-15 ザ　ロツクフエラ−　ユニバ−シテイ 胃腸能動作用障害を回復する方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7563899B2 (en) 2005-05-25 2009-07-21 Progenics Pharmaceuticals, Inc. (S)-N-methylnaltrexone
US7674904B2 (en) 2005-05-25 2010-03-09 Progenics Pharmaceuticals, Inc. Synthesis of R-N-methylnaltrexone

Also Published As

Publication number Publication date
ATE78687T1 (de) 1992-08-15
ES2051742T3 (es) 1994-07-01
EP0306575B1 (de) 1992-07-29
EP0306575A1 (de) 1989-03-15
DE3780819T2 (de) 1993-01-14
GR3005834T3 (de) 1993-06-07

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