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ES2042493T3 - Nuevos derivados de antraciclina, sus usos como agente antitumoral y la produccion de los mismos. - Google Patents

Nuevos derivados de antraciclina, sus usos como agente antitumoral y la produccion de los mismos.

Info

Publication number
ES2042493T3
ES2042493T3 ES86117662T ES86117662T ES2042493T3 ES 2042493 T3 ES2042493 T3 ES 2042493T3 ES 86117662 T ES86117662 T ES 86117662T ES 86117662 T ES86117662 T ES 86117662T ES 2042493 T3 ES2042493 T3 ES 2042493T3
Authority
ES
Spain
Prior art keywords
anthracicline
production
new derivatives
didesoxi
antitumoral agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES86117662T
Other languages
English (en)
Inventor
Hamao Umezawa
Sumio Umezawa
Tsutomu Tsuchiya
Tomio Takeuchi
Yasushi Takagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of ES2042493T3 publication Critical patent/ES2042493T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)

Abstract

COMO NUEVOS DERIVADOS DE ANTRACICLINA SE PRESENTAN AHORA LA 7O-(2,6-DIDESOXI-2-FLUORO-O-L-TALOPIRANOSIL)-DAUNOMICINONA Y LA 7-O-(2,6-DIDESOXI-2-FLUORO-O-L-TALOPIRANOSIL)-ADRIAMICINONA QUE SON UTILES COMO AGENTES ANTITUMORES ASI COMO AGENTES ANTIBACTERIANOS. BREVEMENTE, ESTOS NUEVOS COMPUESTOS SE PUEDEN PRODUCIR A BASE DE CONDENSAR UN HALURO DE 2,6-DIDESOXI-2-FLUOROO-L-TALOPIRANISILO CON EL GRUPO 7-HIDROXILO DE LA DAUNOMICINONA O LA ADRIAMICINONA.
ES86117662T 1985-12-18 1986-12-18 Nuevos derivados de antraciclina, sus usos como agente antitumoral y la produccion de los mismos. Expired - Lifetime ES2042493T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP60282798A JPH0631298B2 (ja) 1985-12-18 1985-12-18 新規アンスラサイクリン誘導体，抗腫瘍剤，及び製造法

Publications (1)

Publication Number Publication Date
ES2042493T3 true ES2042493T3 (es) 1993-12-16

Family

ID=17657227

Family Applications (1)

Application Number Title Priority Date Filing Date
ES86117662T Expired - Lifetime ES2042493T3 (es) 1985-12-18 1986-12-18 Nuevos derivados de antraciclina, sus usos como agente antitumoral y la produccion de los mismos.

Country Status (6)

Country Link
EP (1) EP0230013B1 (es)
JP (1) JPH0631298B2 (es)
KR (1) KR940004075B1 (es)
CA (1) CA1294957C (es)
DE (1) DE3685743T2 (es)
ES (1) ES2042493T3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0660189B2 (ja) * 1986-01-22 1994-08-10 財団法人微生物化学研究会 ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノ−ス又はその誘導体とその製造法
EP0335369A3 (en) * 1988-03-29 1990-03-28 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai New anthracycline derivatives and processes for the preparation of the same
US5220001A (en) * 1989-10-25 1993-06-15 Zaidan Hojim Biseibutsu Dong-A Pharm Co. Anthracycline glycoside derivatives
KR100211417B1 (ko) * 1990-11-30 1999-10-01 유충식 L-탈로피라노시드 유도체 및 그의 제조방법
EP0643069B1 (en) * 1991-11-14 1997-03-05 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 2'-deoxy-2'-fluorocoformycin and stereoisomers thereof
CA2185247A1 (en) * 1994-03-11 1995-09-14 Tomio Takeuchi Novel anthracycline derivatives containing trifluoromethylated sugar unit
CA2184956A1 (en) * 1995-09-08 1997-03-09 Tomio Takeuchi Fluorine-containing anthracycline derivatives having hydroxyl group(s) mono- or di-o-aminoalkanoylated in the sugar moiety thereof
CN107056868A (zh) * 2017-03-24 2017-08-18 昆明理工大学 思茅藤孕甾烷糖苷类化合物及其应用

Also Published As

Publication number Publication date
KR940004075B1 (ko) 1994-05-11
DE3685743T2 (de) 1993-02-04
JPH0631298B2 (ja) 1994-04-27
EP0230013B1 (en) 1992-06-17
JPS62145097A (ja) 1987-06-29
EP0230013A1 (en) 1987-07-29
DE3685743D1 (de) 1992-07-23
CA1294957C (en) 1992-01-28
KR870006078A (ko) 1987-07-09

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