EP4223874A3 - Human anti-il-33 neutralizing monoclonal antibody - Google Patents

Human anti-il-33 neutralizing monoclonal antibody Download PDF

Info

Publication number: EP4223874A3
Authority: EP; European Patent Office
Prior art keywords: amino acid; acid sequences; human anti; neutralizing monoclonal; monoclonal antibody
Prior art date: 2013-12-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

EP23166641.3A

Other languages

German (de)

English (en)

French (fr)

Other versions

EP4223874A2 (en

Inventor

Yasuhiro Fujino

Tsutomu Yoshikawa

Hiroshi Ochi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mitsubishi Tanabe Pharma Corp

Original Assignee

Mitsubishi Tanabe Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-12-26

Filing date

2014-12-26

Publication date

2023-09-27

2014-12-26 Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp

2023-08-09 Publication of EP4223874A2 publication Critical patent/EP4223874A2/en

2023-09-27 Publication of EP4223874A3 publication Critical patent/EP4223874A3/en

Status Pending legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Pulmonology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Dermatology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Neurology (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

EP23166641.3A 2013-12-26 2014-12-26 Human anti-il-33 neutralizing monoclonal antibody Pending EP4223874A3 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2013270551		2013-12-26
JP2014078223		2014-04-04
EP14873812.3A EP3088517B1 (en)	2013-12-26	2014-12-26	Human anti-il-33 neutralizing monoclonal antibody
PCT/JP2014/084695 WO2015099175A1 (ja)	2013-12-26	2014-12-26	ヒト抗ｉｌ－３３中和モノクローナル抗体

Related Parent Applications (2)

Application Number	Title	Priority Date	Filing Date
EP14873812.3A Division-Into EP3088517B1 (en)	2013-12-26	2014-12-26	Human anti-il-33 neutralizing monoclonal antibody
EP14873812.3A Division EP3088517B1 (en)	2013-12-26	2014-12-26	Human anti-il-33 neutralizing monoclonal antibody

Publications (2)

Publication Number	Publication Date
EP4223874A2 EP4223874A2 (en)	2023-08-09
EP4223874A3 true EP4223874A3 (en)	2023-09-27

Family

ID=53479013

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
EP23166641.3A Pending EP4223874A3 (en)	2013-12-26	2014-12-26	Human anti-il-33 neutralizing monoclonal antibody
EP14873812.3A Active EP3088517B1 (en)	2013-12-26	2014-12-26	Human anti-il-33 neutralizing monoclonal antibody

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
EP14873812.3A Active EP3088517B1 (en)	2013-12-26	2014-12-26	Human anti-il-33 neutralizing monoclonal antibody

Country Status (19)

Country	Link
US (4)	US9758578B2 (es)
EP (2)	EP4223874A3 (es)
JP (5)	JP6159419B2 (es)
KR (1)	KR102400060B1 (es)
CN (2)	CN112079923A (es)
AU (1)	AU2014370883B2 (es)
BR (1)	BR112016013347B1 (es)
CA (2)	CA3190793A1 (es)
DK (1)	DK3088517T5 (es)
ES (1)	ES2963673T3 (es)
FI (1)	FI3088517T3 (es)
HU (1)	HUE064292T2 (es)
MX (1)	MX2016008472A (es)
PH (1)	PH12016501212B1 (es)
PL (1)	PL3088517T3 (es)
PT (1)	PT3088517T (es)
RU (1)	RU2709722C1 (es)
TW (1)	TWI563003B (es)
WO (1)	WO2015099175A1 (es)

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CN112079923A (zh)	2020-12-15
CN105980556B (zh)	2020-10-09
EP3088517A1 (en)	2016-11-02
US20160289322A1 (en)	2016-10-06
EP3088517B1 (en)	2023-11-01
TW201529601A (zh)	2015-08-01
US9758578B2 (en)	2017-09-12
DK3088517T5 (en)	2024-10-14
RU2709722C1 (ru)	2019-12-19
BR112016013347A8 (pt)	2018-04-17
JP2019142865A (ja)	2019-08-29
AU2014370883B2 (en)	2020-09-24
PL3088517T3 (pl)	2024-03-11
EP4223874A2 (en)	2023-08-09
US11725049B2 (en)	2023-08-15
ES2963673T3 (es)	2024-04-01
US20170283494A1 (en)	2017-10-05
BR112016013347A2 (pt)	2017-09-26
CN105980556A (zh)	2016-09-28
EP3088517A4 (en)	2017-11-08
MX2016008472A (es)	2016-10-28
PT3088517T (pt)	2023-11-29
CA2934933C (en)	2023-04-25
WO2015099175A1 (ja)	2015-07-02
JP6159419B2 (ja)	2017-07-05
JPWO2015099175A1 (ja)	2017-03-23
RU2016125489A (ru)	2017-12-28
CA3190793A1 (en)	2015-07-02
HUE064292T2 (hu)	2024-03-28
US20190330329A1 (en)	2019-10-31
PH12016501212B1 (en)	2016-08-15
BR112016013347B1 (pt)	2023-12-12
DK3088517T3 (en)	2023-12-04
US20240002495A1 (en)	2024-01-04
JP2021054855A (ja)	2021-04-08
JP2017186361A (ja)	2017-10-12
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JP6548696B2 (ja)	2019-07-24
CA2934933A1 (en)	2015-07-02
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