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EP3675728A4 - System and method for detecting and monitoring blast exposure using magnetic resonance spectroscopy (mrs) - Google Patents

System and method for detecting and monitoring blast exposure using magnetic resonance spectroscopy (mrs) Download PDF

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Publication number
EP3675728A4
EP3675728A4 EP18851200.8A EP18851200A EP3675728A4 EP 3675728 A4 EP3675728 A4 EP 3675728A4 EP 18851200 A EP18851200 A EP 18851200A EP 3675728 A4 EP3675728 A4 EP 3675728A4
Authority
EP
European Patent Office
Prior art keywords
mrs
detecting
magnetic resonance
resonance spectroscopy
blast exposure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP18851200.8A
Other languages
German (de)
French (fr)
Other versions
EP3675728A1 (en
Inventor
Carolyn Mountford
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Datchem
Original Assignee
Translational Research Institute Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Translational Research Institute Pty Ltd filed Critical Translational Research Institute Pty Ltd
Publication of EP3675728A1 publication Critical patent/EP3675728A1/en
Publication of EP3675728A4 publication Critical patent/EP3675728A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room
    • A61B5/004—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part
    • A61B5/0042—Features or image-related aspects of imaging apparatus, e.g. for MRI, optical tomography or impedance tomography apparatus; Arrangements of imaging apparatus in a room adapted for image acquisition of a particular organ or body part for the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/16—Devices for psychotechnics; Testing reaction times ; Devices for evaluating the psychological state
    • A61B5/165—Evaluating the state of mind, e.g. depression, anxiety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/4064—Evaluating the brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4076—Diagnosing or monitoring particular conditions of the nervous system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
    • G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4842—Monitoring progression or stage of a disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4625—Processing of acquired signals, e.g. elimination of phase errors, baseline fitting, chemometric analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46—NMR spectroscopy
    • G01R33/4633—Sequences for multi-dimensional NMR
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Physiology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Psychology (AREA)
  • Educational Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Developmental Disabilities (AREA)
  • Social Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
EP18851200.8A 2017-09-01 2018-08-31 System and method for detecting and monitoring blast exposure using magnetic resonance spectroscopy (mrs) Withdrawn EP3675728A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762553502P 2017-09-01 2017-09-01
PCT/IB2018/056683 WO2019043648A1 (en) 2017-09-01 2018-08-31 System and method for detecting and monitoring blast exposure using magnetic resonance spectroscopy (mrs)

Publications (2)

Publication Number Publication Date
EP3675728A1 EP3675728A1 (en) 2020-07-08
EP3675728A4 true EP3675728A4 (en) 2021-05-19

Family

ID=65525141

Family Applications (1)

Application Number Title Priority Date Filing Date
EP18851200.8A Withdrawn EP3675728A4 (en) 2017-09-01 2018-08-31 System and method for detecting and monitoring blast exposure using magnetic resonance spectroscopy (mrs)

Country Status (3)

Country Link
EP (1) EP3675728A4 (en)
AU (1) AU2018326834A1 (en)
WO (1) WO2019043648A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019365585A1 (en) * 2018-10-24 2021-05-27 Translational Research Institute Pty Ltd Method and system for monitoring the progress of treatment of an individual having acute pain, chronic pain, acute stress disorder, blast exposure or ptsd using spectral data of the brain

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1949123A2 (en) * 2005-10-18 2008-07-30 Cambridge Enterprise Limited Methods and biomarkers for diagnosing and monitoring psychotic disorders
US20090247860A1 (en) * 2007-10-25 2009-10-01 Research Foundation Of State University Of New York Spectral biomarker and algorithm for the identification and detection of neural stem and progenitor cells and their use in studying mammalian brains
WO2012071584A2 (en) * 2010-11-26 2012-05-31 Brigham And Women's Hospital, Inc. Method for assessing repetitive head injuries with tow-dimensional magnetic resonance spectorscopy
WO2015171870A1 (en) * 2014-05-07 2015-11-12 University Of Utah Research Foundation Diagnosis of affective disorders using magnetic resonance spectroscopy neuroimaging
US20160377639A1 (en) * 2015-06-27 2016-12-29 William Beaumont Hospital Methods for detecting, diagnosing and treating traumatic brain injury
WO2017042635A1 (en) * 2015-09-10 2017-03-16 Translational Research Institute System and method for detecting and monitoring post traumatic stress disorder (ptsd) using magnetic resonance spectroscopy (mrs)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GALLOWAY GRAHAM J. ET AL: "NEURO 2D CORRELATED SPECTROSCOPY IDENTIFIES NEURO DEREGULATION IN SOLDIERS EXPOSED TO BLAST PRIOR TO DISCERNIBLE CHANGES BY CONVENTIONAL IMAGING", INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE, ISMRM, 2030 ADDISON STREET, 7TH FLOOR, BERKELEY, CA 94704 USA, no. 5651, 7 April 2017 (2017-04-07), XP040693218 *
KONTOS ANTHONY P. ET AL: "Clinical and Magnetic Resonance Spectroscopic Imaging Findings in Veterans With Blast Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder", MILITARY MEDICINE, vol. 182, no. S1, 1 March 2017 (2017-03-01), US, pages 99 - 104, XP055792311, ISSN: 0026-4075, Retrieved from the Internet <URL:https://watermark.silverchair.com/milmed-d-16-00177.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAtQwggLQBgkqhkiG9w0BBwagggLBMIICvQIBADCCArYGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMR2VFVgriVkPGkcPtAgEQgIIChwRkcHlVYYltu3LxkTZ_BvnQg0QEzmxAWGpFZ4adzb16vd8RzzgvTm7SgD9jBkzogVvReXdX55YqJU0Bdw> DOI: 10.7205/MILMED-D-16-00177 *
LANEROLLE NIHAL C. ET AL: "Concussive brain injury from explosive blast", ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, vol. 1, no. 9, 30 September 2014 (2014-09-30), GB, pages 692 - 702, XP055792398, ISSN: 2328-9503, Retrieved from the Internet <URL:https://onlinelibrary.wiley.com/doi/full-xml/10.1002/acn3.98> DOI: 10.1002/acn3.98 *
MOUNTFORD CAROLYN: "MRS as a Biomarker for Brain Disease", INTERNATIONAL SOCIETY FOR MAGNETIC RESONANCE IN MEDICINE, ISMRM, 2030 ADDISON STREET, 7TH FLOOR, BERKELEY, CA 94704 USA, no. 8059, 7 April 2017 (2017-04-07), XP040693436 *

Also Published As

Publication number Publication date
AU2018326834A8 (en) 2022-02-17
AU2018326834A1 (en) 2020-03-05
WO2019043648A1 (en) 2019-03-07
EP3675728A1 (en) 2020-07-08

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