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EP3394068A4 - Tdo2-inhibitoren - Google Patents

Tdo2-inhibitoren Download PDF

Info

Publication number
EP3394068A4
EP3394068A4 EP16877789.4A EP16877789A EP3394068A4 EP 3394068 A4 EP3394068 A4 EP 3394068A4 EP 16877789 A EP16877789 A EP 16877789A EP 3394068 A4 EP3394068 A4 EP 3394068A4
Authority
EP
European Patent Office
Prior art keywords
tdo2 inhibitors
tdo2
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP16877789.4A
Other languages
English (en)
French (fr)
Other versions
EP3394068A1 (de
EP3394068B1 (de
Inventor
Xingyu LIN
Po-Wai Yuen
Rohan Mendonca
Brendan PARR
Richard Pastor
Zhonghua Pei
Lewis Gazzard
Firoz Jaipuri
Sanjeev Kumar
Xiaokai Li
Roheeth PAVANA
Hima Potturi
Venkata Velvadapu
Jesse Waldo
Zuhui ZHANG
Guosheng Wu
Benjamin Douglas Sellers
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Lumos Pharma Inc
Original Assignee
Genentech Inc
NewLink Genetics Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc, NewLink Genetics Corp filed Critical Genentech Inc
Publication of EP3394068A1 publication Critical patent/EP3394068A1/de
Publication of EP3394068A4 publication Critical patent/EP3394068A4/de
Application granted granted Critical
Publication of EP3394068B1 publication Critical patent/EP3394068B1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EP16877789.4A 2015-12-24 2016-12-23 Tdo2-inhibitoren Active EP3394068B1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2015098685 2015-12-24
CN2016103358 2016-10-26
CN2016106624 2016-11-21
PCT/CN2016/111730 WO2017107979A1 (en) 2015-12-24 2016-12-23 Tdo2 inhibitors

Publications (3)

Publication Number Publication Date
EP3394068A1 EP3394068A1 (de) 2018-10-31
EP3394068A4 true EP3394068A4 (de) 2019-07-03
EP3394068B1 EP3394068B1 (de) 2024-09-11

Family

ID=59089083

Family Applications (1)

Application Number Title Priority Date Filing Date
EP16877789.4A Active EP3394068B1 (de) 2015-12-24 2016-12-23 Tdo2-inhibitoren

Country Status (6)

Country Link
US (2) US10800780B2 (de)
EP (1) EP3394068B1 (de)
JP (1) JP7227005B2 (de)
CN (2) CN115010712A (de)
TW (1) TW201730190A (de)
WO (1) WO2017107979A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2016250976B2 (en) * 2015-04-21 2020-02-27 Jiangsu Hengrui Medicine Co., Ltd. Imidazo isoindole derivative, preparation method therefor and medical use thereof
CN115010712A (zh) * 2015-12-24 2022-09-06 基因泰克公司 Tdo2抑制剂
EP3645533A1 (de) * 2017-06-28 2020-05-06 Genentech, Inc. Tdo2- und ido1-inhibitoren
PT3752501T (pt) 2018-02-13 2023-07-12 Gilead Sciences Inc Inibidores de pd-1/pd-l1
CN112041311B (zh) 2018-04-19 2023-10-03 吉利德科学公司 Pd-1/pd-l1抑制剂
BR112020022088A8 (pt) 2018-05-01 2023-02-07 Merck Sharp & Dohme Moduladores alostéricos de espiropiperidina de receptores nicotínicos de acetilcolina
GB201809050D0 (en) 2018-06-01 2018-07-18 E Therapeutics Plc Modulators of tryptophan catabolism
SI3820572T1 (sl) 2018-07-13 2023-12-29 Gilead Sciences, Inc. Inhibitorji pd-1/pd-l1
KR102635333B1 (ko) 2018-10-24 2024-02-15 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
EP3835432A1 (de) 2019-12-10 2021-06-16 Deutsches Krebsforschungszentrum, Stiftung des öffentlichen Rechts Interleukin-4-induziertes gen 1 (il4i1) und zugehörige metabolite als biomarker für krebs
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016165613A1 (en) * 2015-04-12 2016-10-20 Hangzhou Innogate Pharma Co., Ltd. Heterocycles useful as ido and tdo inhibitors
WO2016169421A1 (zh) * 2015-04-21 2016-10-27 江苏恒瑞医药股份有限公司 咪唑并异吲哚类衍生物、其制备方法及其在医药上的应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5807892A (en) 1994-09-30 1998-09-15 Alcon Laboratories, Inc. Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension
AU1628699A (en) 1997-12-05 1999-06-28 Medical College Of Georgia Research Institute, Inc. High-affinity tryptophan transporter
WO2003087347A1 (en) 2002-04-12 2003-10-23 Medical College Of Georgia Research Institute, Inc. Antigen-presenting cell populations and their use as reagents for enhancing or reducing immune tolerance
US8008281B2 (en) 2003-03-27 2011-08-30 Lankenau Institute For Medical Research Methods for the treatment of cancer
DE102007020493A1 (de) 2007-04-30 2008-11-06 Grünenthal GmbH Substituierte Amid-Derivate
US10047066B2 (en) 2007-11-30 2018-08-14 Newlink Genetics Corporation IDO inhibitors
WO2009132238A2 (en) 2008-04-24 2009-10-29 Newlink Genetics Ido inhibitors
WO2011056652A1 (en) 2009-10-28 2011-05-12 Newlink Genetics Imidazole derivatives as ido inhibitors
JP2012037986A (ja) 2010-08-04 2012-02-23 Canon Inc 画像形成装置及びその制御方法と画像形成システム
NO2694640T3 (de) * 2011-04-15 2018-03-17
US9617272B2 (en) 2013-03-14 2017-04-11 Newlink Genetics Corporation Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization
EP2883681B1 (de) * 2013-12-16 2018-09-12 Discma AG Vielzahl von Behältern und Verpackung mit einer Vielzahl von Behältern
GB201322673D0 (en) 2013-12-20 2014-02-05 Tpp Global Dev Ltd Screening method
US10167257B2 (en) * 2014-04-04 2019-01-01 Iomet Pharma Ltd. Indole derivatives for use in medicine
GB201418300D0 (en) 2014-10-15 2014-11-26 Redx Pharma Ltd Compounds
CN105037371A (zh) * 2015-06-30 2015-11-11 西华大学 一种氘代的吲哚胺-2,3-双加氧酶抑制剂
CN106478634B (zh) * 2015-09-01 2020-05-22 尚华医药科技(江西)有限公司 稠合咪唑化合物、其制备方法、药物组合物和用途
CN115010712A (zh) * 2015-12-24 2022-09-06 基因泰克公司 Tdo2抑制剂
EP3645533A1 (de) * 2017-06-28 2020-05-06 Genentech, Inc. Tdo2- und ido1-inhibitoren

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016165613A1 (en) * 2015-04-12 2016-10-20 Hangzhou Innogate Pharma Co., Ltd. Heterocycles useful as ido and tdo inhibitors
WO2016169421A1 (zh) * 2015-04-21 2016-10-27 江苏恒瑞医药股份有限公司 咪唑并异吲哚类衍生物、其制备方法及其在医药上的应用
EP3287461A1 (de) * 2015-04-21 2018-02-28 Jiangsu Hengrui Medicine Co., Ltd. Imidazo-isoindol-derivat, herstellungsverfahren dafür und medizinische verwendung davon

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO2017107979A1 *

Also Published As

Publication number Publication date
US20190016726A1 (en) 2019-01-17
US20220306635A1 (en) 2022-09-29
CN115010712A (zh) 2022-09-06
US10800780B2 (en) 2020-10-13
EP3394068A1 (de) 2018-10-31
WO2017107979A1 (en) 2017-06-29
CN110072864B (zh) 2022-05-27
TW201730190A (zh) 2017-09-01
EP3394068B1 (de) 2024-09-11
JP7227005B2 (ja) 2023-02-21
JP2019504039A (ja) 2019-02-14
CN110072864A (zh) 2019-07-30

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