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EP1173145A1 - Composition pour soins cosmetiques et dermatologiques de la peau - Google Patents

Composition pour soins cosmetiques et dermatologiques de la peau

Info

Publication number
EP1173145A1
EP1173145A1 EP00910486A EP00910486A EP1173145A1 EP 1173145 A1 EP1173145 A1 EP 1173145A1 EP 00910486 A EP00910486 A EP 00910486A EP 00910486 A EP00910486 A EP 00910486A EP 1173145 A1 EP1173145 A1 EP 1173145A1
Authority
EP
European Patent Office
Prior art keywords
skin
composition according
weight
composition
proteinase inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP00910486A
Other languages
German (de)
English (en)
Inventor
Roland Jermann
Thomas Schreier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM Nutritional Products AG
Original Assignee
Pentapharm AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pentapharm AG filed Critical Pentapharm AG
Publication of EP1173145A1 publication Critical patent/EP1173145A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/001—Preparations for care of the lips

Definitions

  • composition for cosmetic and dermatological care of the skin Composition for cosmetic and dermatological care of the skin
  • the present invention relates to a composition for cosmetic and dermatological care of the skin, this composition containing at least one oxidoreductase and at least one proteinase inhibitor.
  • the compositions according to the invention can be present, for example, as a cream, lotion, emulsion, gel, powder, plaster or in another suitable form.
  • the task of the skin as an organ enveloping the organism consists in sealing and mediating functions against the environment.
  • Various biochemical and bio-physical systems serve to maintain the integrity of this exposed organ.
  • an immune system protects the skin from damage caused by pathogenic microorganisms
  • the melanin-forming system regulates pigmentation and protects the skin from radiation damage
  • a lipid system produces lipid micelles that contain the transdermal water loss
  • regulated keratin synthesis provides the mechanically resistant horny layer.
  • the systems mentioned are based on complex chemical processes, the course of which is kept in motion by enzymes and regulated by enzyme inhibitors. Even a slight inhibition or disinhibition of these biochemical systems manifests itself in noticeable changes in the skin.
  • the visible and tangible condition of the skin is, however, a yardstick for beauty, health and youth; Preserving it is a general goal of nourishing cosmetics.
  • the human skin usually reacts to exogenous, ie external stress factors such as UV radiation, ozone or other harmful substances present in the air (environmental pollution) with slight or severe irritation. nen.
  • the skin is damaged by the released in irritation reactions of oxygen radicals and non-spe ⁇ -specific proteases.
  • this can have a negative effect on the appearance or the elasticity or the barrier functions of the skin.
  • excess mobilized body proteinases such as tryptases, elastases, collagenases and cathepsins, can attack the skin and in particular its structural proteins such as collagen and elastin.
  • EP 0 532 465 discloses the use of selected protein fractions obtained from legume seeds as a proteinase inhibitor for the cosmetic and dermatological care of the skin and for the treatment of inflammatory skin diseases.
  • a combination of an oxidoreductase together with a proteinase inhibitor is excellent for the cosmetic and dermatological care of the skin and for the treatment of inflammatory skin diseases and in particular for protection against damage to the skin by pollutants in the atmosphere, such as ozone and nitrogen oxides , Dust particles etc., as well as UV rays and detergents, is suitable, the protection against the damage caused by ozone being in the foreground.
  • pollutants in the atmosphere such as ozone and nitrogen oxides , Dust particles etc., as well as UV rays and detergents
  • the combination of a biotechnologically produced, purified oxidoreductase with a proteinase inhibitor, preferably a proteinase inhibitor obtained from legume seeds and containing selected protein fractions, is particularly suitable.
  • the present invention relates to a composition which is suitable for the cosmetic and dermatological care of the skin, in particular for protecting the skin against damage caused by an increased ozone concentration in the atmosphere and its subsequent reactions, characterized in that this composition comprises at least one oxidoreductase and contains at least one proteinase inhibitor.
  • the present invention also relates to the use of a composition which contains at least one oxidoreductase and at least one proteinase inhibitor for the cosmetic and dermatological care of the skin and for the treatment of inflammatory skin reactions, in particular for protection against damage to the skin by pollutants in the atmosphere (ozone , Nitrogen oxides, dust particles etc.), UV rays and detergents.
  • pollutants in the atmosphere ozone , Nitrogen oxides, dust particles etc.
  • the invention further relates to a preparation which is preferably a cream, lotion, emulsion, a gel, powder, plaster or another suitable cosmetic form of application which contains a composition according to the invention.
  • the weight ratio of the oxidoreductase to the proteinase inhibitor is generally preferably in the range from 20: 1 to 1:20, preferably in the range from 10: 1 to 1:10 and in particular from 6: 1 to 1: 6.
  • the substances according to the invention are expediently used in a skin-friendly vehicle, for example as a cream, lotion, gel, face mask, powder or plaster.
  • the acid value is preferably in the pH range from 5.5 to 9.
  • the finished preparations generally contain 0.001 to 1% by weight, preferably 0.01 to 0.5% by weight, preferably 0.05 to 0.5% by weight , the composition according to the invention as dry matter, calculated on the total weight (100% by weight) of the finished product.
  • the preparations can also contain larger amounts, for example up to about 2.5% by weight, preferably 0.001 to 2.2% by weight, calculated on the total weight of the finished product.
  • the upper limit is not critical.
  • plasters for transdermal application of a preparation according to the invention can contain up to 10% by weight, preferably up to 5% by weight, of the composition according to the invention (always calculated as dry matter) calculated on the total weight (100% by weight) of the patch -Finished preparation included.
  • the composition preferably contains the proteinase inhibitor in an amount of at least 0.005% by weight, preferably at least 0.01% by weight, calculated on the total weight of the composition.
  • stable active ingredient concentrates which contain the combination according to the invention of at least one oxidoreductase and at least one proteinase inhibitor, with an active ingredient content as dry substance of 0.01 to 10 wt. %, preferably from 0.1% by weight to 5% by weight, can be prepared by dissolving the combination of active substances according to the invention in water and with the addition of a water-soluble preservative, such as, for example, methyl p-oxybenzoate, to prevent microbial growth Growth and one polyhydric alcohol, such as ethylene glycol or propylene glycol, to stabilize the active ingredient.
  • a water-soluble preservative such as, for example, methyl p-oxybenzoate
  • polyhydric alcohol such as ethylene glycol or propylene glycol
  • Oxidoreductases used according to the invention are able to intercept or neutralize free oxygen radicals.
  • Oxidoreductases are preferably produced biotechnologically. This production is known per se and, for example, in Appl. Microbiol. Biotechnol. (1987) 26, pp. 531-536.
  • Oxidoreductases are, for example, lactoperoxidase, glutathione oxidase, glutathione reductase, glutathione peroxidase, superoxide dismutase, thiol oxidase, peroxidase, thioredoxin reductase, cytochrome c reductase, cytochrome oxidase. Lactoperoxidase, glutathione peroxidase and superoxide dismutase are preferred.
  • the proteinase inhibitor to be used according to the invention is capable of rendering non-specific proteinases ineffective.
  • the proteinase inhibitor to be used according to the invention is preferably a protein fraction containing at least one protein which a) was isolated from legume seeds, and b) at least one band in polyacrylamide gel electrophoresis with sodium dodecyl sulfate, c) molecular weights in the range from 3,000 to 30 minutes. 000 g / mol, d) a total nitrogen content of 14% to 20% and
  • Proteins or proteinase inhibitors to be used according to the invention are preferably produced from legume seeds, for example from bean species, such as, for example, Phaseolus angularis, Phaseolus lunatus, Phaseolus aureus, Phaseolus vulgaris, Phaseolus coccineus, Phaseolus limensis, from pea species such as, for example, La thyrus odora tus, from soybeans Glycine max and Glvcine hispida, from peanut Arachis hypogaea and from seeds of tropical legumes of the genera Cajanus, Dolichus, Vigna and Vi cia. Protein fractions which have been produced from legume seeds soya or lima beans are preferred.
  • composition according to the invention is preferably used in day creams, after-sun creams, in products for the treatment of dry, poorly elastic skin, for skin which is sensitive to harmful substances of the environment, such as, for example, ozone, or also for the regenerative treatment of tired, aging or stressed skin, used.
  • composition according to the invention is preferably produced on an aqueous basis and can contain further additives such as solvents, preservatives, buffers, antioxidants and / or dyes.
  • additives are known per se and are listed, for example, in the CTFA Dictionary.
  • Preferred solvents are, for example, polyglycols or polyalcohols, preferably glycerol.
  • Preferred preservatives are, for example, phenoxyethanol, methylparaben, propylparaben, ethylparaben or butylparaben, such as are commercially available, for example, as a mixture under the brand name Phenonip®.
  • Other additives are known to the person skilled in the art.
  • composition according to the invention can also be combined with active ingredients, such as sunscreens, moisturizers, skin-revitalizing active ingredients, barrier agents and / or self-tanners.
  • active ingredients such as sunscreens, moisturizers, skin-revitalizing active ingredients, barrier agents and / or self-tanners.
  • active ingredients are known per se.
  • Sunscreens include octyl methoxycinnamate, butyl methoxydibenzoylmethane, benzophenone, titanium dioxide, zinc oxide, and related compounds.
  • Humectants are, for example, glycosammoglycans, hyaluronic acid and other polysaccharides, proteins and protein hydrolysates such as collagen, elastm, wheat protein hydrolysates and similar compounds, urea, glycols and polyglycols.
  • Skin revitalizing active ingredients include vitamins, alpha-hydroxy acids, amino acids and related compounds.
  • Barriers are, for example, ceramides, free fatty acids, sterols, triglycerides.
  • Self-tanning agents are, for example, dihydroxyacetone or erythrulose.
  • Preparation of a make-up lotion a) The additives of the substances listed in Table 1 under A) are heated in a mixer to 70 ° C. and mixed well. The substances listed in Table 1 above under B) are then mixed in a mixer at a temperature of 75 ° C. b) The mixture of components B) is then slowly added to mixture A with stirring at 70 ° C. and, after the addition has ended, cooled to 50 ° C., homogenized and then cooled to 30 ° C. Then the dye is added and stirred cold. You get a make-up lotion with a very good effect.
  • phase A) The components of phase A) are mixed and heated to 70 ° C. while mixing.
  • the components of phase B) are heated to 75 ° C.
  • phase B) is added to the mixture of phase A) obtained with stirring.
  • the mixture is then cooled to 50 ° C., homogenized and further cooled to 30 ° C.
  • Preparation of a regenerative gel a) Components 2 to 6 of phase A) are dissolved in water. Components 7 and 8 of phase B) are added to thicken and neutralize the mixture obtained, a gel being obtained.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composition convenant pour les soins cosmétiques et dermatologiques de la peau, en particulier pour la protéger contre toute atteinte résultant d'une concentration élevée en ozone dans l'atmosphère, caractérisée en ce qu'elle renferme au moins une oxydoréductase et au moins un inhibiteur de protéinase, et en ce que le rapport pondéral oxydoréductase/inhibiteur de protéinase est compris de préférence entre 20 : 1 et 1 : 20, avantageusement entre 10 : 1 et 1 : 10 et, plus particulièrement, entre 6 : 1 et 1 : 6.
EP00910486A 1999-03-31 2000-03-30 Composition pour soins cosmetiques et dermatologiques de la peau Withdrawn EP1173145A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH61599 1999-03-31
CH61599 1999-03-31
PCT/CH2000/000184 WO2000059462A1 (fr) 1999-03-31 2000-03-30 Composition pour soins cosmetiques et dermatologiques de la peau

Publications (1)

Publication Number Publication Date
EP1173145A1 true EP1173145A1 (fr) 2002-01-23

Family

ID=4191128

Family Applications (1)

Application Number Title Priority Date Filing Date
EP00910486A Withdrawn EP1173145A1 (fr) 1999-03-31 2000-03-30 Composition pour soins cosmetiques et dermatologiques de la peau

Country Status (6)

Country Link
EP (1) EP1173145A1 (fr)
JP (1) JP2002541082A (fr)
KR (1) KR20010102559A (fr)
CN (1) CN1345224A (fr)
AU (1) AU3270200A (fr)
WO (1) WO2000059462A1 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811226B1 (fr) * 2000-06-05 2003-06-20 Clarins Laboratoires S A S Composition cosmetique hydratante comprenant un inhibiteur de trypsine vegetal
EP1281392A1 (fr) * 2001-08-02 2003-02-05 Cognis France S.A. Compositions cosmétiques et/ou pharmaceutiques contenant des extraits de plantes
EP1310261A1 (fr) 2001-11-09 2003-05-14 Cognis France S.A. Utilisation d'un extrait de Vigna aconitifolia dans une composition cosmétique et/ou dermopharmaceutique
KR100471372B1 (ko) * 2001-12-04 2005-03-08 주식회사 태평양 피부 탄력 향상용 화장료 조성물
WO2005084612A1 (fr) * 2004-02-24 2005-09-15 Fengming Liu Utilisation des inhibiteurs de l'elastase
KR101123654B1 (ko) * 2004-05-06 2012-03-20 주식회사 래디안 대기오염물질에 의한 피부 손상 방지용의 항산화성 화장료
US20060110815A1 (en) 2004-10-13 2006-05-25 Gruber James V Personal care composition containing ozone-stressed yeast lysates
CN101083973B (zh) * 2004-12-07 2011-06-29 捷通国际有限公司 使用具有抗氧化性质的芳香物清除氧化的氮和氧物质的方法
JP4160964B2 (ja) 2005-04-01 2008-10-08 株式会社ファンケル スイートピー抽出物含有化粧料
CH696659A9 (it) * 2007-01-04 2007-11-15 Labo Cosprophar Ag Composizione cosmetica per il trattamento e/o la prevenzione delle smagllature della pelle
TW200846017A (en) * 2007-04-03 2008-12-01 Fancl Corp Apoptosis inhibitory agent
CN115778837B (zh) * 2022-11-21 2024-04-02 安徽品赫生物科技有限公司 一种协同增效的亮肤修护冻干粉及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2049728A1 (fr) * 1990-08-24 1992-02-25 Kenji Kitamura Composition de lavage capable de prevenir et d'ameliorer les irritations de la peau
ES2179038T3 (es) * 1991-09-13 2003-01-16 Pentapharm Ag Fraccion porteinica para el tratamiento cosmetico y dermatologico de la piel.
WO1994021222A1 (fr) * 1993-03-15 1994-09-29 Nurture, Inc. Lotion antisolaire contenant des particules proteiniques emulsifiantes et sa preparation
FR2714599B1 (fr) * 1993-12-30 1996-02-09 Oreal Composition pour lutter contre le vieillissement, agissant siimultanément sur les couches superficielles et profondes de la peau, son utilisation.
FR2746316B1 (fr) * 1996-03-19 1998-06-12 Guerlain Nouvelles compositions cosmetologiques ou dermatologiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO0059462A1 *

Also Published As

Publication number Publication date
KR20010102559A (ko) 2001-11-15
JP2002541082A (ja) 2002-12-03
WO2000059462A1 (fr) 2000-10-12
AU3270200A (en) 2000-10-23
CN1345224A (zh) 2002-04-17

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