EP1017366A4 - SOLID COPARCIPITATES FOR IMPROVED BIOVERABILITY OF LIPOPHILIC SUBSTANCES - Google Patents
SOLID COPARCIPITATES FOR IMPROVED BIOVERABILITY OF LIPOPHILIC SUBSTANCESInfo
- Publication number
- EP1017366A4 EP1017366A4 EP97940639A EP97940639A EP1017366A4 EP 1017366 A4 EP1017366 A4 EP 1017366A4 EP 97940639 A EP97940639 A EP 97940639A EP 97940639 A EP97940639 A EP 97940639A EP 1017366 A4 EP1017366 A4 EP 1017366A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- coprecipitates
- solid
- lipophilic substances
- enhanced bioavailability
- bioavailability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL11917696A IL119176A (en) | 1996-09-01 | 1996-09-01 | Soluble coprecipitates for enhanced oral bioavailability of lipophilic substances |
| IL11917696 | 1996-09-01 | ||
| US833076 | 1997-04-02 | ||
| US08/833,076 US5891469A (en) | 1997-04-02 | 1997-04-02 | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
| PCT/US1997/015072 WO1998008490A1 (en) | 1996-09-01 | 1997-08-27 | Solid coprecipitates for enhanced bioavailability of lipophilic substances |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP1017366A1 EP1017366A1 (en) | 2000-07-12 |
| EP1017366A4 true EP1017366A4 (en) | 2006-03-22 |
Family
ID=26323300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP97940639A Withdrawn EP1017366A4 (en) | 1996-09-01 | 1997-08-27 | SOLID COPARCIPITATES FOR IMPROVED BIOVERABILITY OF LIPOPHILIC SUBSTANCES |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1017366A4 (ja) |
| JP (1) | JP2001523221A (ja) |
| AU (1) | AU730216B2 (ja) |
| CA (1) | CA2264718C (ja) |
| WO (1) | WO1998008490A1 (ja) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5891845A (en) * | 1997-11-21 | 1999-04-06 | Fuisz Technologies Ltd. | Drug delivery systems utilizing liquid crystal structures |
| IT1298731B1 (it) * | 1998-03-13 | 2000-02-02 | Recordati Chem Pharm | Composizioni farmaceutiche contenenti complessi di inclusione con melatonina |
| US6241969B1 (en) * | 1998-06-26 | 2001-06-05 | Elan Corporation Plc | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| US6200550B1 (en) * | 1998-12-11 | 2001-03-13 | Q-Pharma, Inc. | Oral care compositions comprising coenzyme Q10 |
| US20080070981A1 (en) | 2000-02-23 | 2008-03-20 | Henryk Borowy-Borowski | Water-soluble compositions of bioactive lipophilic compounds |
| US6045826A (en) * | 1999-04-02 | 2000-04-04 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
| US6632443B2 (en) * | 2000-02-23 | 2003-10-14 | National Research Council Of Canada | Water-soluble compositions of bioactive lipophilic compounds |
| AR025587A1 (es) | 1999-09-13 | 2002-12-04 | Hoffmann La Roche | Formulaciones en dispersion que contienen inhibidores de lipasa |
| CA2392810A1 (en) * | 1999-12-01 | 2001-06-07 | Natco Pharma Limited | A rapid acting freeze dired oral pharmaceutical composition for treating migraine |
| WO2001052826A2 (en) * | 2000-01-20 | 2001-07-26 | Supratek Pharma Inc. | Novel podophyllotoxin compositions |
| DE10046541A1 (de) | 2000-09-19 | 2002-03-28 | Knoll Ag | Mechanisch stabile darreichungsformen, enthaltend Ubichinone |
| AR033711A1 (es) * | 2001-05-09 | 2004-01-07 | Novartis Ag | Composiciones farmaceuticas |
| ES2266564T3 (es) | 2001-10-19 | 2007-03-01 | Isotechnika Inc. | Sintesis de analogos de cicloporinas. |
| FR2840614B1 (fr) * | 2002-06-07 | 2004-08-27 | Flamel Tech Sa | Polyaminoacides fonctionnalises par de l'alpha-tocopherol et leurs applications notamment therapeutiques |
| AU2002350719A1 (en) | 2002-11-29 | 2004-06-23 | Janssen Pharmaceutica N.V. | Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base |
| EP1592760A4 (en) | 2003-01-31 | 2009-08-12 | Smithkline Beecham Corp | AS FIXED DISPERSIONS, COMPOSITIONS |
| CN1758901B (zh) * | 2003-02-19 | 2010-04-28 | 生命周期药物公司 | 硅石或硅石衍生物作为吸附材料的用途 |
| US20050096365A1 (en) * | 2003-11-03 | 2005-05-05 | David Fikstad | Pharmaceutical compositions with synchronized solubilizer release |
| US20070149509A1 (en) * | 2003-12-18 | 2007-06-28 | Luca Barella | Use of vitamin e |
| ATE533473T1 (de) * | 2004-09-24 | 2011-12-15 | Boehringer Ingelheim Pharma | Neue klasse von surfuctantähnlichen materialien mit vitamin-e-tpgs und wasserlöslichem polymer |
| JP2008514714A (ja) * | 2004-09-30 | 2008-05-08 | イーストマン ケミカル カンパニー | 有意な流出阻害を示さない、親油性薬物を可溶化するビタミンｅｔｐｇｓ分子を含む医薬製剤及びこのような医薬製剤の使用 |
| US20060088591A1 (en) * | 2004-10-22 | 2006-04-27 | Jinghua Yuan | Tablets from a poorly compressible substance |
| US7446096B2 (en) * | 2005-12-19 | 2008-11-04 | Industrial Technology Research Institute | Glutathione based delivery system |
| US8067380B2 (en) | 2005-12-19 | 2011-11-29 | Industrial Technology Research Institute | Glutathione-based delivery system |
| WO2008007728A1 (fr) * | 2006-07-13 | 2008-01-17 | Kaneka Corporation | Préparation orale contenue dans une structure à membrane lipidique, et agent contre la fatigue comprenant une coenzyme comme ingrédient actif |
| PE20081506A1 (es) | 2006-12-12 | 2008-12-09 | Infinity Discovery Inc | Formulaciones de ansamicina |
| JP5437232B2 (ja) * | 2008-03-11 | 2014-03-12 | あすか製薬株式会社 | 固体分散体とその医薬組成物、並びにそれらの製造方法 |
| MX2010010050A (es) | 2008-03-20 | 2011-03-15 | Virun Inc Star | Emulsiones que incluyen un derivado de polietilen glicol de tocoferol. |
| US8765661B2 (en) | 2008-03-20 | 2014-07-01 | Virun, Inc. | Compositions containing non-polar compounds |
| AR075180A1 (es) * | 2009-01-29 | 2011-03-16 | Novartis Ag | Formulaciones orales solidas de una pirido-pirimidinona |
| JPWO2010092925A1 (ja) * | 2009-02-12 | 2012-08-16 | あすか製薬株式会社 | 固体分散体とその医薬組成物、並びにそれらの製造方法 |
| US8252821B2 (en) * | 2009-04-14 | 2012-08-28 | Bristol-Myers Squibb Company | Bioavailable capsule compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
| WO2011119228A1 (en) | 2010-03-23 | 2011-09-29 | Virun, Inc. | Nanoemulsion including sucrose fatty acid ester |
| US8741373B2 (en) | 2010-06-21 | 2014-06-03 | Virun, Inc. | Compositions containing non-polar compounds |
| ITMI20112042A1 (it) * | 2011-11-10 | 2013-05-11 | Eratech S R L | Polvere da ricostituire prima dell'uso comprendente melatonina e preparazione iniettabile ottenibile da tale polvere. |
| ITRM20120331A1 (it) | 2012-07-12 | 2014-01-13 | Guidotti & C Spa Labor | Composizioni pediatriche orali liquide contenenti nepadutant. |
| FR2999081B1 (fr) * | 2012-12-06 | 2015-02-27 | Hra Pharma Lab | Dispersion solide d'un modulateur selectif du recepteur a la progesterone |
| US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
| US9693574B2 (en) | 2013-08-08 | 2017-07-04 | Virun, Inc. | Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch |
| HUP1300647A2 (hu) * | 2013-11-12 | 2015-05-28 | Druggability Technologies Ip Holdco Jersey Ltd | Ciklosporin A és származékainak komplexei, elõállításuk és gyógyszerészeti kompozícióik |
| US11331279B2 (en) | 2014-05-29 | 2022-05-17 | Radius Pharmaceuticals, Inc. | Stable cannabinoid formulations |
| US11911361B2 (en) | 2014-05-29 | 2024-02-27 | Radius Pharmaceuticals, Inc. | Stable cannabinoid formulations |
| GB201410869D0 (en) * | 2014-06-18 | 2014-07-30 | Perioc Ltd | Novel pharmaceutical formulations and their use in the treatment of periodontal disease |
| US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
| US10016363B2 (en) | 2014-09-18 | 2018-07-10 | Virun, Inc. | Pre-spray emulsions and powders containing non-polar compounds |
| AU2016267585C1 (en) * | 2015-05-28 | 2023-02-16 | Fresh Cut Development, Llc | Stable cannabinoid formulations |
| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| MX2019007968A (es) * | 2017-01-03 | 2019-12-05 | Receptor Holdings Inc | Compuestos medicinales y suplementos nutricionales. |
| AU2018221739A1 (en) * | 2017-02-15 | 2019-08-29 | Molecular Infusions, Llc | Formulations |
| CN108245683B (zh) * | 2018-01-26 | 2020-02-14 | 华中科技大学 | 一种具有p-糖蛋白抑制功能的抗肿瘤前药及制备方法 |
| WO2021123949A1 (en) * | 2019-12-20 | 2021-06-24 | Idorsia Pharmaceuticals Ltd | Pharmaceutical compositions comprising n-[1-(5-cyano-pyridin-2-ylmethyl)-1h-pyrazol-3-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide |
| FI4076404T3 (fi) * | 2019-12-20 | 2024-01-31 | Intervet Int Bv | Farmaseuttinen pyratsolikoostumus |
| WO2021186001A1 (en) * | 2020-03-19 | 2021-09-23 | Ac Immune Sa | Dose treatments of tauopathies |
| IT202200002528A1 (it) * | 2022-02-11 | 2023-08-11 | Pierpaoli Exelyas S R L | Composizione comprendente melatonina ad alta biodisponibilità |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996036316A1 (en) * | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Self-emulsifying formulations of lipophilic drugs |
| US5583105A (en) * | 1994-11-21 | 1996-12-10 | Biogal Gyogyszerguar Rt | Oral pharmaceutical preparation |
| WO1997035587A1 (en) * | 1996-03-22 | 1997-10-02 | Glaxo Group Limited | Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3102078A (en) * | 1961-01-13 | 1963-08-27 | Eastman Kodak Co | Water-dispersible vitamin preparations |
| US3673163A (en) * | 1970-06-16 | 1972-06-27 | Lilly Co Eli | Pharmacological preparation containing an acronycine-polyvinylprrolidone coprecipitate |
| GB1579818A (en) * | 1977-06-07 | 1980-11-26 | Yamanouchi Pharma Co Ltd | Nifedipine-containing solid preparation composition |
| US4327080A (en) * | 1981-07-13 | 1982-04-27 | E. R. Squibb & Sons, Inc. | Novel Bendroflumethiazide formulations and method |
| US4758427A (en) * | 1985-08-08 | 1988-07-19 | Ciba-Geigy Corporation | Enhanced absorption of psychoactive 2-aryl-pyrazolo quinolines as a solid molecular dispersion in polyvinylpyrrolidone |
| US5179122A (en) * | 1991-02-11 | 1993-01-12 | Eastman Kodak Company | Nutritional supplement containing vitamin e |
| US5234696A (en) * | 1991-12-27 | 1993-08-10 | Abbott Laboratories | Method of producing tablets, tablets produced thereby, and method of treatment using same |
| IT1255792B (it) * | 1992-08-05 | 1995-11-16 | Bayer Italia Spa | Composizioni farmaceutiche per la somministrazione orale di diidropiridine in forma di bevanda |
| US5430021A (en) * | 1994-03-18 | 1995-07-04 | Pharmavene, Inc. | Hydrophobic drug delivery systems |
-
1997
- 1997-08-27 JP JP51187998A patent/JP2001523221A/ja not_active Ceased
- 1997-08-27 AU AU42373/97A patent/AU730216B2/en not_active Ceased
- 1997-08-27 CA CA002264718A patent/CA2264718C/en not_active Expired - Fee Related
- 1997-08-27 WO PCT/US1997/015072 patent/WO1998008490A1/en active Application Filing
- 1997-08-27 EP EP97940639A patent/EP1017366A4/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5583105A (en) * | 1994-11-21 | 1996-12-10 | Biogal Gyogyszerguar Rt | Oral pharmaceutical preparation |
| WO1996036316A1 (en) * | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Self-emulsifying formulations of lipophilic drugs |
| WO1997035587A1 (en) * | 1996-03-22 | 1997-10-02 | Glaxo Group Limited | Compositions comprising an hiv protease inhibitor such as vx 478 and a water soluble vitamin e compound such as vitamin e-tpgs |
Non-Patent Citations (1)
| Title |
|---|
| See also references of WO9808490A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001523221A (ja) | 2001-11-20 |
| EP1017366A1 (en) | 2000-07-12 |
| WO1998008490A1 (en) | 1998-03-05 |
| AU4237397A (en) | 1998-03-19 |
| CA2264718A1 (en) | 1998-03-05 |
| CA2264718C (en) | 2006-05-30 |
| AU730216B2 (en) | 2001-03-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| 17P | Request for examination filed |
Effective date: 19990331 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
| RAP1 | Party data changed (applicant data changed or rights of an application transferred) |
Owner name: PHARMOS CORPORATION |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20060203 |
|
| 17Q | First examination report despatched |
Effective date: 20060818 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 20081014 |