EP1003444A1 - Extenseur microporeux et dispositif d'implantation - Google Patents
Extenseur microporeux et dispositif d'implantationInfo
- Publication number
- EP1003444A1 EP1003444A1 EP98943181A EP98943181A EP1003444A1 EP 1003444 A1 EP1003444 A1 EP 1003444A1 EP 98943181 A EP98943181 A EP 98943181A EP 98943181 A EP98943181 A EP 98943181A EP 1003444 A1 EP1003444 A1 EP 1003444A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- stent
- balloon
- recited
- supporting structure
- catheter body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/9522—Means for mounting a stent or stent-graft onto or into a placement instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91558—Adjacent bands being connected to each other connected peak to peak
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
Definitions
- This invention relates generally to intraluminal stent implants for restoring and maintaining the patency of a body lumen, and their insertion devices, and more particularly to a uniformly expandable and flexible stent for restoring and maintaining the patency of a vascular conduit and an associated insertion device.
- Stents are commonly used to restore and maintain the patency of a damaged, injured or otherwise restricted body conduit or passageway.
- stents are commonly used to treat stenosis, stricture, and aneurisms, as well as other conditions.
- Stents which are also commonly known as endoprostetheses, are typically placed within the body passageway through a mechanical transluminal implantation procedure.
- a surgical stent implantation device is percutaneously inserted within the body passageway to reinforce collapsing, partially occluded, weakened or abnormally dilated sections of the conduit. This procedure is commonly performed within the vascular system where a stent may be used to restore the patency of an artery or other blood vessel.
- stents may also be used within the urinary tract, the bial tract and the intestinal tract among other body passageways and conduits.
- stents are often used in the treatment of diseased and damaged arteries and vessels.
- a stent may be used to repair or restore the patency in the artery or other blood vessel after angioplasty treatments.
- the angioplasty treatments are commonly used to compress obstructing material within a vessel into the vessel walls, or otherwise remove the obstructing material from the vessels walls to restore normal blood flow.
- the angioplasty device must first be removed and then the stent implantation device percutaneously inserted into the afflicted artery or vessel.
- the time required to remove the angioplasty device, as well as the time to insert the stent implantation device can be quite long and must generally be done sequentially. This requires additional surgery time from both the patient as well as the operating team. The desirability and benefits of reducing surgery time are well known.
- the need to immediately implant a stent may be critical.
- Stent/grafts have the advantage of almost fully covering the injured section of vessel wall with an outer covering which can stop blood leaks out of an injured vessel. Stent/grafts also reduce restenosis and the in-growth of obstructing tissue by preventing its growth past the sealing covering.
- Stent/grafts are necessarily small in diameter to enable passage through the vascular system without damaging vessel walls during placement and implantation.
- the stent supporting structure must also be very flexible to pass through the winding vascular system, yet structurally strong enough to support the vessel or other passageway without collapse.
- the stent should also be expandable so that it may be delivered in a reduced diameter state while on a small diameter catheter shaft and then expanded in-situ to support the vessel or other body passageway.
- the present stent/graft devices have a limited ability to expand.
- the outer covering must also be quite flexible and expandable and may limit the ability of the stent structure to expand.
- a stent or stent/graft which is uniformly expandable and which minimizes any high areas of stress on the outer covering during flexing and expansion, as well as for such a stent which is inexpensive and simple to install.
- a surgical device which can perform angioplasty and implant a stent within the same operation and without removing the angioplasty device. Such a surgical device should be inexpensive and operate similarly to existing angioplasty and stent implantation devices.
- the present invention overcomes the aforementioned problems by providing a stent which transfers a uniform axial and radial stress on an encircling polymer coating as the stent or graft is expanded and implanted within a body lumen.
- a stent having a supporting structure which radially expands uniformly from a contracted condition to an expanded condition, the stress imparted into the surrounding coating is evenly distributed. This even distribution of stress allows the use of a less flexible or stronger coating while reducing the concern for tearing or other damage.
- the term "stent” shall mean endoprostheses, and shall include stents structures and stent/grafts.
- the present invention also satisfies the need for a stent having sufficient longitudinal strength to retain its implanted shape and support the polymer coating while remaining sufficiently flexible to be maneuvered into and through a tortuous body passageway.
- a stent supporting structure having a plurality of uniformly expandable cylindrical bands
- the present stent remains longitudinally flexible and supportive of the polymer coating.
- the longitudinal strength and memory are increased. Positioning each circumferential set of linking members in quadrature positions furthers increases the longitudinal strength and memory while yielding high flexibility.
- the present invention also satisfies the need for a stent delivery and implantation device which can also be used to perform angioplasty procedures.
- a surgeon can effectively perform angioplasty and implant the supportive stent in a single procedure and using the single device. This eliminates the time, cost and unnecessary risk of removing the angioplasty device from the passageway and reinserting a prior art style stent deployment device.
- the present invention is generally directed to a flexible stent which may be placed within a vascular conduit and is radially expandable from a contracted condition to an expanded condition.
- the stent includes a tubular supporting structure which has a longitudinal axis that extends between a proximal end and a distal end.
- the supporting structure is formed from a plurality of spaced apart flexible cylindrical bands that extend around the longitudinal axis.
- Each of the cylindrical bands comprises a continuous and repeating pattern and is formed in a partially expanded condition.
- Each of the repeating patterns includes a straight section which leads into a proximal curved section having a first radius of curvature.
- This proximal curved section is in turn coupled to a second straight section which in turn leads into a distal curved section having a second radius of curvature.
- the repeating pattern of the cylindrical bands is configured such that each of the relatively independent cylindrical bands expands uniformly from the contracted condition to the expanded condition .
- a porous surface surrounds and encapsulates at least a portion of the supporting structure between the proximal end and the distal end.
- the porous surface is made from a thin coating of an expandable polymer which includes a plurality of spaced apart micropores. The coating is formulated and configured to expand along with the supporting structure and also support tissue within the passageway.
- the flexible stent further includes a pair of spaced apart interconnecting members or links which extend between and interconnect each pair of adjacent cylindrical bands.
- the interconnecting members are diametrically opposed between adjacent cylindrical bands.
- the spaced apart interconnecting members between successive pairs of adjacent cylindrical bands are rotated 90 degrees about the longitudinal axis relative to adjacent interconnecting members.
- Each of the interconnecting members extends between and interconnects one of the proximal curved sections on a first cylindrical band to an adjacent distal curved section on a second and adjacent cylindrical band.
- the present invention is also directed to a balloon catheter and stent implantation device for inserting and implanting a stent having an expandable supporting structure within a vascular or other body conduit.
- the balloon catheter device includes a tubular catheter body which has a longitudinal axis that extends between a proximal end and a distal end.
- the tubular body also contains a longitudinal lumen which extends distally from the proximal end.
- An elongate inner member may be disposed coaxially within the catheter body for slidably supporting a catheter guidewire.
- An expandable balloon is disposed coaxially about the catheter body adjacent the distal end.
- the balloon includes an outer balloon surface and an inner balloon surface defining a balloon chamber.
- the balloon chamber is fluidly connected to the lumen extending through the catheter body and is expandable between an inflated condition and a deflated condition through passage of a fluid or gas therethrough.
- An independent outer sleeve is slidably supported on the catheter body.
- the outer sleeve includes a proximal sleeve end which extends distally to a distal sleeve tip.
- the distal sleeve tip is configured to engage with a stent inserted over the catheter body and to move the stent distally along the catheter body to a deployment position over the balloon.
- the distal sleeve tip includes an engagement groove for retaining a proximal end of said stent.
- the distal sleeve tip may be coupled to an integral retaining tube which surrounds and retains the stent against the catheter body.
- An actuating mechanism is coupled to the proximal end of the elongate catheter body.
- the actuating mechanism includes an actuating shaft which has a proximal shaft end that is coupled to an actuating handle and a distal shaft end which is coupled to the outer sleeve.
- the shaft is slidable along the catheter body for slidably moving the outer sleeve along the catheter body between a proximal sleeve position and a distal sleeve position.
- the shaft travel is limited by a mechanical stop which prevents the outer sleeve from moving distally beyond the balloon.
- the outer sleeve and the stent are moved distally along the catheter body until the outer sleeve reaches the distal sleeve position and the stent is positioned over the deflated balloon.
- the balloon catheter device includes an angioplasty balloon.
- the angioplasty balloon is configured for both performing angioplasty within the vascular conduit and for receiving and implanting the stent.
- the balloon catheter device eliminates the time, cost and unnecessary risk of removing the angioplasty device and reinserting a prior art style stent deployment device when implantation of a stent is desired.
- the balloon catheter and stent delivery device includes a stent having an expandable supporting structure, such as the stent of the present invention.
- the stent is fitted over the catheter body and is slidably supported on the catheter body.
- a preferred method for implanting a radially expandable stent within a vascular conduit or other body passageway comprises the steps of providing a balloon catheter stent delivery device which includes a tubular catheter body supporting an expandable balloon as previously described. An expandable stent, as previously described is also provided.
- the method includes the step of placing the stent over the catheter body.
- the stent After the stent is placed on the catheter body, it is compressed around the body to minimize its overall outer diameter.
- the catheter body, including the stent, is then inserted into the vascular conduit or other passageway of the patient and the balloon is directed to a desired location within the passageway.
- the actuating mechanism is actuated to move the outer sleeve distally along the catheter body such that the stent is pushed over and onto the deflated balloon.
- the balloon is then inflated to the expand the stent to the expanded condition within the passageway.
- the balloon is the deflated and the balloon catheter and stent delivery device is withdrawn and removed from the patient.
- the balloon is an angioplasty balloon.
- the method includes the steps of inflating and deflating the balloon to perform angioplasty within the vascular conduit prior to the step of actuating the actuating mechanism to move the stent.
- FIG. 1 is a partial cross-sectional view of a stent and a balloon catheter stent delivery device of the present invention shown being inserted within a patient;
- FIG. 2 is an enlarged side view, in isolation, of the stent of FIG. 1;
- FIG. 3 is a cross-sectional view of the stent of FIG. 2 taken along lines 3-3;
- FIG. 4 is a side view of an alternative embodiment of a supporting structure according to the principles of the present invention.
- FIG. 5 is a cross-sectional view of the supporting structure of FIG. 4, taken along lines 5-5;
- FIG. 6 is a partial side view of a second alternative embodiment of the supporting structure according to the principles of the present invention.
- FIG. 7 is a perspective view of the balloon catheter and stent device of FIG. 1;
- FIG. 8 is an elevational side view of a compression device for use in compressing the stent of the present invention over a catheter device
- FIG. 9 is an expanded and partial-elevational side view showing a stent of the present invention compressed on a portion of a balloon catheter device
- FIG. 10 is a cross-sectional view of the stent and balloon catheter device of FIG. 9 taken along lines 10-10.
- a radially expandable stent and a balloon catheter and stent delivery device according to the principles of the present invention are illustrated in Figure 1 and designated by the reference numerals 10 and 12, respectively.
- the stent 10 is mounted on the balloon catheter device 12 for insertion within a body passageway 14 of a patient (not shown).
- the body passageway 14 may include most any body passageway, including a vascular conduit such as an artery, a vessel or a vein.
- the stent 10 may also include a stent/graft or similar tubular intraluminal prosthetic or endoprostheses device.
- the stent 10 includes a flexible and tubular supporting structure 18.
- the supporting structure 18 has a longitudinal axis 20 which extends between a proximal end 22 and a distal end 24.
- the supporting structure 18 is formed from a plurality of spaced apart and relatively independent flexible cylindric bands 26. Each of these cylindrical bands 26 extends around the longitudinal axis 20 and is radially expandable from a contracted condition 28 to an expanded condition 30.
- Each of the cylindrical bands 26 is formed from a continuous and repeating pattern 32.
- this repeating pattern 32 sequentially and circumferentially includes a straight section 34 which leads into a proximal curved section 36 having a first radius of curvature 38.
- the proximal curved section 36 in turn, leads into a second straight section 40 which is itself joined to a distal curved section 42 having a second radius of curvature 44.
- the proximal curved section 36 and the distal curved section 42 may have a uniform curve or bend to facilitate the uniform radial expansion of the cylindrical band 26 from the contracted condition 28 to the expanded condition 30.
- the first radii of curvature 38 and the second radius of curvature 44 are the same, however, differing radii of curvature may also be used.
- the sections 34, 36, 40 and 42 of the supporting structure 18 each have a cross section 46 which is preferably rectangular shaped with rounded corners, as best illustrated in Figure 5.
- the cross section 46 of the supporting structure 18 and particularly, the individual sections 34, 36, 38 and 42 may also be formed into other shapes, such as circular, ellipse, oval, or egg, for example.
- At least one linking member 48 may be provided between at least one pair of adjacent cylindrical bands 26.
- the linking member 48 may extend between and interconnect the two adjacent cylindrical bands 26.
- each pair of adjacent cylindrical bands 26 is interconnected with a plurality or group of linking members 48 which are spaced apart around their circumferences.
- Each of the linking members 48 may extend and interconnect the proximal curved section 36 on a first cylindrical band 52 to the adjacent distal curved section 42 on a second and adjacent cylindrical band 56 as best illustrated in Figures 4 and 6.
- Successive pairs of adjacent cylindrical bands 26 may be interconnected with a set of linking members 48 with adjacent sets of linking members 48 indexed or rotated relative to the longitudinal axis 20. This indexing alters the positions of the linking members 48 between each successive pair of cylindrical bands 26 relative to adjacent pairs of linking members 48, thus improving the flexibility of the stent 10 while maximizing structural strength and memory.
- two linking members 48 are positioned between each pair of adjacent cylindrical bands 26 as described above.
- the linking members may be straight links which are generally parallel with the longitudinal axis 20.
- Each set of the two linking members 48 are equally spaced apart around the circumference of the adjacent cylindrical bands 26.
- the linking members 48 are diametrically opposed between each pair of adjacent cylindrical bands 26 (preferably 180 degrees apart).
- each set of the linking members 48 between successive pairs of adjacent cylindrical bands 26 is rotated 90 degrees about the longitudinal axis 20 relative to the adjacent pair of linking members 48.
- the linking members 48 may have a sinusoidal-shape 57, as best illustrated in Figure 6.
- This type of link structure 57 may be preferred where it is desired to maintain a strongly bent shape retention characteristic or memory from the insertion and deployment procedure, while allowing for substantial flexing properties as the stent 10 is being inserted through the vascular conduit or other passageway 14.
- the linking members 48 provide structural strength to the stent 10 as well as modifying its overall flexibility. Varying the number, placement, shape and size of the linking members 48 will particularly increase or decrease the flexibility of the stent 10 along the longitudinal axis 20. This flexibility is important because the stent 10 must flex when mounted on the shaft of the catheter delivery device 12 as the shaft is advanced through the vascular system and into a desired location. Further, the desired location where the stent 10 is to be implanted may be a complex curve or alternatively may be a straight segment. Thus, the desired flexibility of the stent 10 may be tailored to the specific application.
- maximum flexibility may typically be achieved by eliminating the linking members 48 altogether.
- a potential disadvantage for some applications will be that the stent 10 will have a lack of memory and want to return to a neutral position after being flexed, rather than maintaining a bent shape into which it has been conformed by the catheter delivery device 12 during the insertion procedure.
- maximum flexibility may be advantageous, if for example, the stent 10 is desired to flex with the vessel during the expansions and contractions of the heart.
- the selection of the number, placement, shape and size of the linking members 48 may be tailored for each specific application.
- the stent supporting structure 18 may be machined from a section of surgical grade tubing material. Machining may include laser machining or even chemical machining, including chemical etching.
- the supporting structure 18 may also be fabricated from a continuous or alternatively, discrete segments of a metal wire which are formed into a plurality of columns of the repeating pattern 32, as is best illustrated in Figure 4.
- the formed wire may be shaped into the cylindrical bands 26 by bending the wire over forming mandrels and welding or otherwise connecting the wires to form the continuous cylindrical bands 26.
- the supporting structure 18 is preferably constructed in an intermediate expanded condition.
- the supporting structure 18 is preferably constructed using tubing or a mandrel or similar device having a cross sectional diameter greater than the diameter of the structure in the contracted state 28 but smaller than the diameter of the structure in its expanded state 30. Constructing the supporting structure 18 with an intermediate expanded state allows more uniform expansion to the expanded state 30 as well as more uniform compression to the contracted state 28.
- the supporting structure 18 and particularly, the tubing material may be constructed from a surgical grade metal tubing such as a stainless steel or tantalum hypotube. However, other materials may also be used and may include: platinum, titanium, nitinol, or even a high strength polymer or other plastic.
- the structural support 18 is made from a 315L stainless steel hypotube, of approximately 0.5 to approximately 3.0 mm diameter and a wall thickness of between approximately .001 to approximately .005 inches.
- a self-expanding spring material may also be used.
- the stent supporting structure 18 may be further processed after machining, welding or any other fabrication step to eliminate any rough surfaces or sharp corners. This processing step may also be used to shape the cross section 46 of the sections 34, 36, 40 and 42. Processing may include sand blasting, chemical deburring, etching or any other similar process.
- a portion of the stent supporting structure 18 may be encapsulated with a thin flexible coating or covering 58, as illustrated in Figures 2 and 3.
- the thin coating 58 includes a plurality of spaced apart micropores 60.
- the coating 58 may be made from a polymer, such as a bio-compatible polyurethane, however, any bio-compatible and flexible material may be used.
- the coating 58 is formulated and applied to the supporting structure 18 such that it is expandable with the supporting structure 18.
- the coating 58 may also be used as a carrier for supporting therapeutic agents and drugs.
- a suitable coating mixture for dipping and forming the coating 58 may be formulated by dissolving a medical grade aliphatic polyurethane such as Tecoflex 5680, manufactured by Thermedics Co of Woburn, Massachusetts, in pyrolidone solvent at approximately 3% solids by weight.
- a medical grade aliphatic polyurethane such as Tecoflex 5680, manufactured by Thermedics Co of Woburn, Massachusetts
- pyrolidone solvent at approximately 3% solids by weight.
- suitable polymers, including polymers containing a therapeutic drug, which may be used as the coating material 58 are described in U.S. Patent No. 5,591,227, and issued to Dinh, which is herein expressly and fully incorporated by reference.
- a suitable polyurethane is also described in U.S. Patent Serial No. 4,873,308, which is also herein expressly incorporated by reference.
- Suitable solvents may include, for example, tetrahydrofuran, methylene chloride, trichlorome
- the thin coating 58 may be formed on the supporting structure 18 by dipping the supporting structure 18 into a suitable biocompatible synthetic or naturally-occurring coating material 58, such as the polymer materials described above and which has been dissolved in a compatible solvent.
- the stent supporting structure 18 may be secured by at least one of the proximal or distal ends 22 and 24.
- a mask may be used to prevent the coating 58 from being applied to specific locations on the supporting structure 18.
- the stent 10 is configured having the proximal end 22 and the distal end 24 free from the encapsulating coating 58. Thus, the mask may be placed over the proximal and distal ends 22 and 24 and anywhere else that the coating 58 is not desired.
- the supporting structure 18 may then be dipped into the polymer and solvent mixture to coat and encapsulate the unmasked portion. Multiple dips or other applications of the polymer and solvent may be required to achieve the desired coating thickness. The number of dips required may vary depending on the viscosity of the polymer and solvent mix and the size of the supporting structure 18. Preferably, the coating 58 may have a wall thickness of approximately .001-.015 inches. The mask may then be removed.
- the stent supporting structure 18 may be placed over a separate holding structure which has an outer cylindrical surface.
- a holding structure may simply be a dowel type pin, but preferably includes an outer surface made from a non stick material such as a Teflon.
- the holding structure and attached supporting structure 18 may then be advanced through a tube coating machine for application of the coating 58.
- the use of a supporting member and a tube coating machine is generally described in U.S. Patent No. 4,356,218, issued to Chiu et al., and herein expressly and fully incorporated by reference.
- the coating 58 may also be used and may include folding a semi-solid layer of the coating 58 around the supporting structure 18, or shrinking a polymer tube over the supporting structure 18.
- soluble particles such as sugar or salt may be added to the solution of polymer and solvent. The particles are preferable maintained suspended by continuous stirring or mixing.
- the stent 10 may be dipped in water or other solvent to dissolve the particles from the polymer matrix, leaving the micropores 60.
- the micropores 60 may be created or formed using any method as is commonly known in the fabrication of polymer coatings and stents.
- the micropores 60 may be from a few microns in diameter to the approximate size of sand grains, however, larger as well as smaller sized micropores 60 are contemplated and may be used.
- the supporting structure 18, and preferably, only the portion of the supporting structure 18 which is not encapsulated by the thin coating 58, may be further processed to form a porous exterior surface 62.
- the supporting structure 18 may be coated with microbeads or similar particles to create the porous exterior surface 62.
- U.S. Patent Serial No. 4,101,984, issued to MacGregor discloses suitable microbeads and methods of processing to attach these microbeads to a structure, and is herein expressly and fully incorporated by reference.
- the porous exterior surface 62 renders the exposed portions of the supporting structure 18, such as the proximal and distal ends 22 and 24, more biocompatible by promoting tissue in-growth while reducing the formation of blood clots.
- the balloon catheter and stent delivery device 12 may be used to insert a radially expandable tubular stent and particularly, the stent 10 of the present invention, within the body passageway 14 and deliver it to the desired location.
- the balloon catheter device 12 includes an elongate tubular catheter body 64 which has a longitudinal catheter axis 66 extending between a proximal catheter end 68 and a distal catheter end 70.
- the catheter body 64 may contain an internal longitudinal lumen which extends distally from the proximal catheter end 68.
- An elongate inner member may be disposed coaxially within the catheter body 64 for slidably supporting a catheter guidewire.
- An expandable balloon 72 is disposed coaxially about the catheter body
- the balloon 72 includes an outer balloon surface 74 and an inner balloon surface which defines an interior balloon chamber.
- the balloon chamber may be fluidly connected to a lumen 73 which extends longitudinally through the catheter body 64. A fluid or a gas may then be passed through the lumen 73 to inflate and deflate the balloon 72 between an inflated condition and a deflated condition.
- the balloon 72 is configured to receive the tubular stent 10 when in the deflated condition, as best illustrated in Figure 7.
- the stent 10 may be inserted over the deflated balloon 72 or alternatively over the catheter body 64 where it may be later moved over the deflated balloon 72.
- the balloon 72 may then be inflated or otherwise expanded such that the stent 10 is radially expanded within the bodily passageway 14.
- the balloon 72 is a high pressure dilation balloon.
- the balloon 72 may be an angioplasty balloon.
- the angioplasty balloon 72 is preferably configured for both performing angioplasty within the body passageway 14 which may be a vascular conduit and for receiving and implanting the stent 10.
- the outer surface 74 of the angioplasty balloon 72 may expand uniformly parallel to the catheter longitudinal axis 66 such that the stent 10 may be uniformly expanded in the radial direction.
- An independent outer sleeve 76 is movably mounted on the catheter body 64.
- the outer sleeve 76 is slidably supported along the longitudinal length of the catheter body 64 and may have a cross section which slidably mates over the cross section of the catheter body 64.
- the outer sleeve 76 includes a proximal sleeve end 78 which extends distally along the catheter body 64 to a distal sleeve tip 80.
- the distal sleeve tip 80 may be configured to engage with a stent 10 that has been inserted over and onto the catheter body 64 and to move the stent 10 distally along the catheter body 64 to a deployment position over the balloon 72.
- the outer sleeve 76 may be constructed from a plastic, such as an extrudable or moldable polymer. However, other materials may also be used.
- the distal sleeve tip 80 may include an engagement device 82 for receiving and retaining the stent 10 against the catheter body 64.
- the engagement device 82 may be a circumferential groove or even a series of grooves or depressions formed within the distal sleeve tip 80.
- This engagement groove 82 is used to receive and retain or cup the stent proximal end 22 while the stent 10 is moved distally along the catheter body 64.
- the engagement groove 82 may be particularly useful to retain or cup the plurality of stent tips 25 (proximal curved sections 36) on the stent proximal end 22 and prevent them from being bent inwardly or outwardly relative to the catheter body 64 during insertion and deployment.
- the engagement device 82 may include an integral retaining tube which is coupled to the distal sleeve tip 80.
- the integral retaining tube 82 may be preferable when inserting and deploying a stent 10 having a supporting structure 18 made from a self expanding material.
- the integral retaining tube 82 may be moved over the stent 10 after placement on the catheter body 64 to maintain the stent 10 in the contracted condition 28.
- the retaining tube type of engagement device 82 may include a slidable or removable sheath which is placed over the stent 10 and coupled to the outer sleeve 76. Once the stent 10 has been moved or slid into position over the balloon 72, the retaining tube type of engagement device 82 may be removed.
- Removal may be accomplished by inflating the balloon 72 to rupture the engagement device 82.
- removal may be accomplished by tearing and removing the tube 82 during proximal pullback of the outer sleeve 76 while holding the stent 10 with the balloon 72.
- a tether or other retaining strap may be attached to the retaining tube type of engagement device 82 and also secured to the balloon catheter device 12 to ensure its removal from the body passageway 14.
- the retaining tube device 82 may also include an integral, tear-away strap which is attached to the outer sleeve 76. In this configuration, pulling proximally on the outer sleeve 76 after positioning the stent 10 over the balloon 72 may cause the tube device 82 to tear along it's longitudinal axis, thus releasing the stent 10.
- An actuating mechanism 84 may be coupled to the catheter proximal end 68 for use in moving the outer sleeve 76 along the catheter body 64 between a proximal sleeve position 86 and a distal sleeve position 88.
- the actuating mechanism 84 may also be coupled to a hub 90, such as a tri-furcated hub or similar device, which may be directly attached to catheter proximal end 68.
- the actuating mechanism 84 may be configured to include an actuating shaft 92 which may be generally parallel to, and slidable along or alternatively within, the catheter body 64.
- the actuating shaft 92 may include a proximal shaft end 94 which is connected to an actuating handle 96 or other grip and a distal shaft end 98 which is coupled to the outer sleeve 76.
- An intermediate coupling 99 or pusher sleeve may be used to couple the shaft 92 to the outer sleeve 76.
- the shaft 92 is slidable by moving the handle 96 relative to the catheter body 64 to slidably move the outer sleeve 76 between the proximal sleeve position 86 and the distal sleeve position 88.
- the actuating shaft 92 may be constructed from a stainless steel wire or other high strength and flexible material such as nininol, a liquid crystal polymer, or even Marlex. However, other materials may also be used. Movement of the handle 96 or even the shaft 92 relative to catheter body 64 may be limited by a mechanical stop 100 which prevents the outer sleeve 76 from moving the stent 10 distally beyond the balloon 72.
- the outer sleeve 76 and the stent 10 are moved distally along the catheter body 64 until the outer sleeve 76 reaches the distal sleeve position 88 and the stent 10 is positioned over the deflated balloon 72.
- the mechanical stop 100 may include limiting the length of the shaft 92 or the travel of the handle 96.
- a marking or indicator may also be placed on the shaft 92 or even the catheter device 12 to indicate the location of the outer sleeve 76 and thus the stent 10 relative to the proximal and distal sleeve positions 86 and
- a method of using a stent delivery device, such as the balloon catheter device 12 of the present invention to insert and implant a radially expandable stent, such as the stent 10 of the present invention, into a desired location 16 within a body passageway 14 will be described.
- the method which restores or otherwise improves the patency of a body lumen, includes the step of providing a balloon catheter stent delivery device, such as the balloon catheter device 12 previously described.
- a radially expandable stent such as the stent 10 to the present invention is provided.
- the stent 10 is placed over the catheter body 64 and adjacent the outer sleeve 76.
- the stent 10 may then be compressed on the catheter body 64.
- This step of compressing the stent 10 onto the catheter body 64 may be accomplished using a conical compression fixture 102 , as best illustrated in Figure 8.
- the stent 10 is compressed snugly against the catheter body 64 such that it does not freely move, but is generally freely movable when pushed by the outer sleeve 76.
- Figure 9 shows the stent 10 compressed about the catheter body 64.
- the actual step of compression may be accomplished by sliding a flexible tube 104 over the partially expanded stent 10, as best illustrated in Figure 8.
- the tube 104 and the contained stent 10 may then be slid or otherwise moved through the enlarged open end 106 of the conical compression fixture 102 and drawn through its gradually decreasing diameter such that the stent 10 is compressed against the catheter body 64.
- the flexible tube 104 may then be removed from the catheter body 64 and the stent 10.
- the flexible tube 104 comprises an elastomeric and preferably a fluropolymer sleeve or similar material tube.
- the step of compressing may also include the step of applying a tube or sheath, such as the retaining tube type engagement device 82 about the compressed stent 10.
- Alternative methods of compressing the stent 10 over the catheter body 64 may also be used and may include stent crimping tools or even manual crimping.
- the polymer coating 58 over the unsupported regions 45 within the supporting structure 18 is preferably smoothly displaced towards the longitudinal axis 20 of the stent 10, as best illustrated in Figure 10. These openings or unsupported regions 45 become smaller as the cylindrical bands 26 are uniformly circumferentially compressed about the catheter body 64.
- the resulting displacement of the thin polymer coating 58 creates a series of axially oriented ridges 108 of the polymer coating 58. These ridges 108 may be further compressed upon contact with the catheter body 64 to clamp and secure the stent 10 in a fixed location on the catheter body 64.
- the catheter body 64 may be inserted into the body passageway 14 of the patient.
- the catheter body 64 and particularly, the balloon 72 are placed at the desired location 16 within the passageway 14.
- the balloon 72 which is preferably an angioplasty balloon as previously described may be inflated to dilate the body passageway 14 and more preferably, to perform angioplasty.
- the balloon 72 may be further inflated and deflated along with any other desired angioplasty techniques as are known in the art of angioplasty.
- the balloon 72 is deflated and the actuating mechanism 84 is actuated to move the outer sleeve 76 and the adjacent stent 10 distally along the catheter body 64.
- the actuating mechanism 84 is advanced, or otherwise actuated, a predetermined distance such that the stent 10 is pushed over and centrally located on top of the deflated balloon 72.
- the balloon 72 is inflated to uniformly and smoothly expand the supporting structure 18 and the surrounding polymer coating 58.
- the stent 10 is expanded into the expanded state 30 and implanted within the body passageway 14 to support the dilated passageway 14.
- the balloon 72 may then be deflated and the balloon catheter device 12 withdrawn from the patient.
- various modifications can be made to the various embodiments of the present invention herein disclosed without departing from the spirit and scope thereof.
- various sizes of the stent and the balloon catheter and delivery device are contemplated as well as various types of construction materials.
- various modifications may be made in the configuration of the parts and their interaction. Therefore, the above description should not be construed as limiting the invention, but merely as an exemplification of preferred embodiments thereof. Those of skill in the art will envision other modifications within the scope and spirit of the present invention as defined by the claims appended hereto.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Veterinary Medicine (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Prostheses (AREA)
Abstract
L'invention concerne un extenseur (10) à déploiement radial et un dispositif d'insertion (12) servant à implanter l'extenseur à l'intérieur d'une lumière du corps telle qu'une artère. L'extenseur est constitué de plusieurs bandes cylindriques extensibles (26) qui soutiennent un revêtement microporeux environnant (58). Chacune des bandes cylindriques est formée de plusieurs sections ondulées (42), configurées pour se déployer de manière uniforme et exercer une contrainte uniforme sur le revêtement environnant. Plusieurs éléments de connexion (48) relient chaque paire de bandes cylindriques adjacentes, orientées en quadrature autour de chaque circonférence et par rapport à chaque paire successive de bandes cylindriques adjacentes. Le dispositif d'insertion de l'extenseur comprend un cathéter à ballonnet (12) destiné à effectuer l'angioplastie et à implanter l'extenseur. Le cathéter comprend un corps de cathéter (64) muni à son extrémité distale d'un ballonnet d'angioplastie (72). Une gaine extérieure (76), installée coulissante sur le corps de cathéter, sert à rendre l'extenseur à destination et à le monter sur le ballonnet une fois l'angioplastie terminée. L'invention concerne également un procédé d'utilisation de ce dispositif pour cathéter à ballonnet.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90771397A | 1997-08-08 | 1997-08-08 | |
US907713 | 1997-08-08 | ||
PCT/US1998/016514 WO1999007308A1 (fr) | 1997-08-08 | 1998-08-07 | Extenseur microporeux et dispositif d'implantation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1003444A1 true EP1003444A1 (fr) | 2000-05-31 |
EP1003444A4 EP1003444A4 (fr) | 2004-07-28 |
Family
ID=25424526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP98943181A Withdrawn EP1003444A4 (fr) | 1997-08-08 | 1998-08-07 | Extenseur microporeux et dispositif d'implantation |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1003444A4 (fr) |
JP (1) | JP2001513359A (fr) |
AU (1) | AU741328B2 (fr) |
WO (1) | WO1999007308A1 (fr) |
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US6755856B2 (en) | 1998-09-05 | 2004-06-29 | Abbott Laboratories Vascular Enterprises Limited | Methods and apparatus for stenting comprising enhanced embolic protection, coupled with improved protection against restenosis and thrombus formation |
US6312463B1 (en) * | 2000-02-01 | 2001-11-06 | Endotex Interventional Systems, Inc. | Micro-porous mesh stent with hybrid structure |
US6939376B2 (en) | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7682387B2 (en) | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
DE60226236T3 (de) | 2002-09-20 | 2011-12-15 | Abbott Laboratories Vascular Enterprises Ltd. | Mit einer rauhen Oberfläche versehener Stent und sein Herstellungsverfahren |
US11259945B2 (en) | 2003-09-03 | 2022-03-01 | Bolton Medical, Inc. | Dual capture device for stent graft delivery system and method for capturing a stent graft |
US7763063B2 (en) | 2003-09-03 | 2010-07-27 | Bolton Medical, Inc. | Self-aligning stent graft delivery system, kit, and method |
US7901451B2 (en) | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7491225B2 (en) * | 2005-02-16 | 2009-02-17 | Boston Scientific Scimed, Inc. | System and method for deploying a drug-eluting external body and tissue scaffold |
US20080097591A1 (en) | 2006-10-20 | 2008-04-24 | Biosensors International Group | Drug-delivery endovascular stent and method of use |
US20080103584A1 (en) | 2006-10-25 | 2008-05-01 | Biosensors International Group | Temporal Intraluminal Stent, Methods of Making and Using |
US9387100B2 (en) * | 2007-01-08 | 2016-07-12 | Cardinal Health Switzerland GmbH | Intraluminal medical device having variable axial flexibility about the circumference of the device |
US8128679B2 (en) | 2007-05-23 | 2012-03-06 | Abbott Laboratories Vascular Enterprises Limited | Flexible stent with torque-absorbing connectors |
WO2009065087A1 (fr) | 2007-11-14 | 2009-05-22 | Biosensors International Group, Ltd. | Appareil et procédé de revêtement automatisé |
US8920488B2 (en) | 2007-12-20 | 2014-12-30 | Abbott Laboratories Vascular Enterprises Limited | Endoprosthesis having a stable architecture |
CN104688385B (zh) | 2008-06-30 | 2018-01-26 | 波顿医疗公司 | 用于腹主动脉瘤的系统和方法 |
CN102413794B (zh) | 2009-03-13 | 2017-02-08 | 波顿医疗公司 | 用于在手术部位部署腔内假体的系统和方法 |
JP6118961B2 (ja) * | 2012-09-14 | 2017-04-26 | 株式会社国際電気通信基礎技術研究所 | パワーアシストロボット |
WO2014087414A1 (fr) | 2012-12-03 | 2014-06-12 | Amrita Vishwa Vidya Peetham University | Endoprothèse cardiovasculaire à base de titane métallique avec une surface nanostructurée et procédé pour la fabriquer |
US9439751B2 (en) | 2013-03-15 | 2016-09-13 | Bolton Medical, Inc. | Hemostasis valve and delivery systems |
CN103479453A (zh) * | 2013-10-14 | 2014-01-01 | 黄景陶 | 一种精确定位人体管腔支架置入器 |
WO2018050916A1 (fr) | 2016-09-19 | 2018-03-22 | Biotronik Ag | Endoprothèses vasculaires à élution de médicament exemptes de polymère |
KR20190078904A (ko) | 2017-12-27 | 2019-07-05 | 부산대학교 산학협력단 | 조영제와 생분해성 고분자를 유효성분으로 포함하는 생분해성 스텐트 및 이의 제조방법 |
KR102221074B1 (ko) | 2018-12-24 | 2021-03-02 | 부산대학교 산학협력단 | 생분해성 고분자 및 니티놀을 포함하는 스텐트 및 이의 제조방법 |
US12023265B2 (en) | 2019-01-16 | 2024-07-02 | Boston Scientific Scimed, Inc. | Stent including anti-migration capabilities |
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CA1322628C (fr) * | 1988-10-04 | 1993-10-05 | Richard A. Schatz | Greffon vasculaire intraluminal |
US5123917A (en) * | 1990-04-27 | 1992-06-23 | Lee Peter Y | Expandable intraluminal vascular graft |
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US5599352A (en) | 1992-03-19 | 1997-02-04 | Medtronic, Inc. | Method of making a drug eluting stent |
US5449377A (en) * | 1992-03-24 | 1995-09-12 | Angeion Corporation | Overcharged final countershock for an implantable cardioverter defibrillator and method |
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1998
- 1998-08-07 EP EP98943181A patent/EP1003444A4/fr not_active Withdrawn
- 1998-08-07 JP JP2000506906A patent/JP2001513359A/ja active Pending
- 1998-08-07 AU AU91030/98A patent/AU741328B2/en not_active Ceased
- 1998-08-07 WO PCT/US1998/016514 patent/WO1999007308A1/fr not_active Application Discontinuation
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WO1995005132A1 (fr) * | 1993-08-18 | 1995-02-23 | W.L. Gore & Associates, Inc. | Greffon endoluminal servant d'extenseur |
EP0686379A2 (fr) * | 1994-06-08 | 1995-12-13 | Cardiovascular Concepts, Inc. | Appareil pour la pose d'une greffe endoluminale |
Non-Patent Citations (1)
Title |
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Also Published As
Publication number | Publication date |
---|---|
AU741328B2 (en) | 2001-11-29 |
JP2001513359A (ja) | 2001-09-04 |
WO1999007308A1 (fr) | 1999-02-18 |
EP1003444A4 (fr) | 2004-07-28 |
AU9103098A (en) | 1999-03-01 |
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