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EP0618927A4 - Cytokines dotees d'un residu de cysteine non apparie et leurs produits de conjugaison. - Google Patents

Cytokines dotees d'un residu de cysteine non apparie et leurs produits de conjugaison.

Info

Publication number
EP0618927A4
EP0618927A4 EP93901259A EP93901259A EP0618927A4 EP 0618927 A4 EP0618927 A4 EP 0618927A4 EP 93901259 A EP93901259 A EP 93901259A EP 93901259 A EP93901259 A EP 93901259A EP 0618927 A4 EP0618927 A4 EP 0618927A4
Authority
EP
European Patent Office
Prior art keywords
conjugates
cytokines
cysteine residue
unpaired cysteine
unpaired
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93901259A
Other languages
German (de)
English (en)
Other versions
EP0618927A1 (fr
Inventor
Tse Wen Chang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanox Inc
Original Assignee
Tanox Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanox Inc filed Critical Tanox Inc
Publication of EP0618927A1 publication Critical patent/EP0618927A1/fr
Publication of EP0618927A4 publication Critical patent/EP0618927A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • A61K38/212IFN-alpha
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/555Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
    • A61K47/557Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells the modifying agent being biotin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/555Interferons [IFN]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
EP93901259A 1991-12-10 1992-12-10 Cytokines dotees d'un residu de cysteine non apparie et leurs produits de conjugaison. Withdrawn EP0618927A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80545291A 1991-12-10 1991-12-10
US805452 1991-12-10
PCT/US1992/010889 WO1993012142A1 (fr) 1991-12-10 1992-12-10 Cytokines dotees d'un residu de cysteine non apparie et leurs produits de conjugaison

Publications (2)

Publication Number Publication Date
EP0618927A1 EP0618927A1 (fr) 1994-10-12
EP0618927A4 true EP0618927A4 (fr) 1995-05-24

Family

ID=25191607

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93901259A Withdrawn EP0618927A4 (fr) 1991-12-10 1992-12-10 Cytokines dotees d'un residu de cysteine non apparie et leurs produits de conjugaison.

Country Status (5)

Country Link
EP (1) EP0618927A4 (fr)
JP (1) JP2704214B2 (fr)
AU (1) AU666914B2 (fr)
CA (1) CA2124672A1 (fr)
WO (1) WO1993012142A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165458A (en) * 1997-12-26 2000-12-26 Pharmaderm Laboratories Ltd. Composition and method for dermal and transdermal administration of a cytokine
CA2374050A1 (fr) * 1999-05-20 2000-11-30 Scios Inc. Dimeres, facteurs de croissance de l'endothelium vasculaire
WO2000071713A1 (fr) 1999-05-20 2000-11-30 Scios Inc. Variants du facteur de croissance endotheliale
DE10144252A1 (de) * 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanopartikel mit daran immobilisiertem biologisch aktivem TNF
GB0123262D0 (en) * 2001-09-27 2001-11-21 Adprotech Ltd Polymeric compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0105777A1 (fr) * 1982-09-22 1984-04-18 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Lipopeptides, leur obtention et leur application comme émulsifiants
EP0236987A2 (fr) * 1986-03-10 1987-09-16 F. Hoffmann-La Roche Ag Protéines chimiquement modifiées et leur production
EP0354992A2 (fr) * 1988-07-08 1990-02-21 Yeda Research And Development Company Limited Conjugués de VIP et de ses fragments actifs avec des portions hydrophobiques et des préparations pour l'utilisation dans le traitement de l'impuissance masculine
WO1990012874A2 (fr) * 1989-04-21 1990-11-01 Genetics Institute, Inc. Variantes de polypeptides par addition de cysteine, et leurs modifications chimiques
EP0441765A1 (fr) * 1990-02-09 1991-08-14 Washington University Substrats nouveaux pour enzymes à base d'analogues d'acides gras
WO1991012229A1 (fr) * 1990-02-12 1991-08-22 National Research Council Of Canada Procede de preparation de derives acyles de composes acylables
EP0458064A2 (fr) * 1990-05-04 1991-11-27 American Cyanamid Company Stabilisation de la somatotropine et autres protéines à travers une modification des résidus de cystéine

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0105777A1 (fr) * 1982-09-22 1984-04-18 Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) Lipopeptides, leur obtention et leur application comme émulsifiants
EP0236987A2 (fr) * 1986-03-10 1987-09-16 F. Hoffmann-La Roche Ag Protéines chimiquement modifiées et leur production
EP0354992A2 (fr) * 1988-07-08 1990-02-21 Yeda Research And Development Company Limited Conjugués de VIP et de ses fragments actifs avec des portions hydrophobiques et des préparations pour l'utilisation dans le traitement de l'impuissance masculine
WO1990012874A2 (fr) * 1989-04-21 1990-11-01 Genetics Institute, Inc. Variantes de polypeptides par addition de cysteine, et leurs modifications chimiques
EP0441765A1 (fr) * 1990-02-09 1991-08-14 Washington University Substrats nouveaux pour enzymes à base d'analogues d'acides gras
WO1991012229A1 (fr) * 1990-02-12 1991-08-22 National Research Council Of Canada Procede de preparation de derives acyles de composes acylables
EP0458064A2 (fr) * 1990-05-04 1991-11-27 American Cyanamid Company Stabilisation de la somatotropine et autres protéines à travers une modification des résidus de cystéine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9312142A1 *
WILCOX ET AL: "THE MAJORITY OF CELLULAR FATTY ACID ACYLATED PROTEINS ARE LOCALIZED TO THE CYTOPLASMIC SURFACE OF THE PLASMA MEMBRANE", BIOCHEMISTRY, vol. 26, 1987, WASHINGTON D.C.,USA, pages 1029 - 1036 *

Also Published As

Publication number Publication date
JP2704214B2 (ja) 1998-01-26
WO1993012142A1 (fr) 1993-06-24
AU666914B2 (en) 1996-02-29
AU3323593A (en) 1993-07-19
CA2124672A1 (fr) 1993-06-24
EP0618927A1 (fr) 1994-10-12
JPH07502508A (ja) 1995-03-16

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Legal Events

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