EP0618927A4 - Cytokines with an unpaired cysteine residue and conjugates thereof. - Google Patents

Cytokines with an unpaired cysteine residue and conjugates thereof.

Info

Publication number: EP0618927A4
Authority: EP; European Patent Office
Prior art keywords: conjugates; cytokines; cysteine residue; unpaired cysteine; unpaired
Prior art date: 1991-12-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP93901259A

Other languages

German (de)

French (fr)

Other versions

EP0618927A1 (en

Inventor

Tse Wen Chang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Tanox Inc

Original Assignee

Tanox Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-10

Filing date

1992-12-10

Publication date

1995-05-24

1992-12-10 Application filed by Tanox Inc filed Critical Tanox Inc

1994-10-12 Publication of EP0618927A1 publication Critical patent/EP0618927A1/en

1995-05-24 Publication of EP0618927A4 publication Critical patent/EP0618927A4/en

Status Withdrawn legal-status Critical Current

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
- A61K47/557—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells the modifying agent being biotin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

EP93901259A 1991-12-10 1992-12-10 Cytokines with an unpaired cysteine residue and conjugates thereof. Withdrawn EP0618927A4 (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US80545291A	1991-12-10	1991-12-10
US805452		1991-12-10
PCT/US1992/010889 WO1993012142A1 (en)	1991-12-10	1992-12-10	Cytokines with an unpaired cysteine residue and conjugates thereof

Publications (2)

Publication Number	Publication Date
EP0618927A1 EP0618927A1 (en)	1994-10-12
EP0618927A4 true EP0618927A4 (en)	1995-05-24

Family

ID=25191607

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP93901259A Withdrawn EP0618927A4 (en)	1991-12-10	1992-12-10	Cytokines with an unpaired cysteine residue and conjugates thereof.

Country Status (5)

Country	Link
EP (1)	EP0618927A4 (en)
JP (1)	JP2704214B2 (en)
AU (1)	AU666914B2 (en)
CA (1)	CA2124672A1 (en)
WO (1)	WO1993012142A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6165458A (en) *	1997-12-26	2000-12-26	Pharmaderm Laboratories Ltd.	Composition and method for dermal and transdermal administration of a cytokine
JP2003500053A (en) *	1999-05-20	2003-01-07	サイオス，インコーポレーテッド	Vascular endothelial growth factor dimer
AU5023300A (en)	1999-05-20	2000-12-12	Scios Inc.	Vascular endothelial growth factor variants
DE10144252A1 (en)	2001-08-31	2003-03-27	Fraunhofer Ges Forschung	Nanoparticles with biologically active TNF immobilized on them
GB0123262D0 (en) *	2001-09-27	2001-11-21	Adprotech Ltd	Polymeric compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0105777A1 (en) *	1982-09-22	1984-04-18	Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)	Lipopeptides, their manufacture and use as emulsifiers
EP0236987A2 (en) *	1986-03-10	1987-09-16	F. Hoffmann-La Roche Ag	Chemically modified protein and production thereof
EP0354992A2 (en) *	1988-07-08	1990-02-21	Yeda Research And Development Company Limited	Conjugates of VIP and active fragments thereof with hydrophobic moieties and topical compositions for use in the treatment of male impotence
WO1990012874A2 (en) *	1989-04-21	1990-11-01	Genetics Institute, Inc.	Cysteine added variants of polypeptides and chemical modifications thereof
EP0441765A1 (en) *	1990-02-09	1991-08-14	Washington University	Novel fatty acid analog enzyme substrates
WO1991012229A1 (en) *	1990-02-12	1991-08-22	National Research Council Of Canada	Process for preparing acyl derivatives of acylatable compounds
EP0458064A2 (en) *	1990-05-04	1991-11-27	American Cyanamid Company	Stabilization of somatotropins and other proteins by modification of cysteine residues

1992
- 1992-12-10 EP EP93901259A patent/EP0618927A4/en not_active Withdrawn
- 1992-12-10 JP JP5511163A patent/JP2704214B2/en not_active Expired - Lifetime
- 1992-12-10 AU AU33235/93A patent/AU666914B2/en not_active Ceased
- 1992-12-10 WO PCT/US1992/010889 patent/WO1993012142A1/en not_active Application Discontinuation
- 1992-12-10 CA CA002124672A patent/CA2124672A1/en not_active Abandoned

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0105777A1 (en) *	1982-09-22	1984-04-18	Etablissement Public dit: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)	Lipopeptides, their manufacture and use as emulsifiers
EP0236987A2 (en) *	1986-03-10	1987-09-16	F. Hoffmann-La Roche Ag	Chemically modified protein and production thereof
EP0354992A2 (en) *	1988-07-08	1990-02-21	Yeda Research And Development Company Limited	Conjugates of VIP and active fragments thereof with hydrophobic moieties and topical compositions for use in the treatment of male impotence
WO1990012874A2 (en) *	1989-04-21	1990-11-01	Genetics Institute, Inc.	Cysteine added variants of polypeptides and chemical modifications thereof
EP0441765A1 (en) *	1990-02-09	1991-08-14	Washington University	Novel fatty acid analog enzyme substrates
WO1991012229A1 (en) *	1990-02-12	1991-08-22	National Research Council Of Canada	Process for preparing acyl derivatives of acylatable compounds
EP0458064A2 (en) *	1990-05-04	1991-11-27	American Cyanamid Company	Stabilization of somatotropins and other proteins by modification of cysteine residues

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of WO9312142A1 *
WILCOX ET AL: "THE MAJORITY OF CELLULAR FATTY ACID ACYLATED PROTEINS ARE LOCALIZED TO THE CYTOPLASMIC SURFACE OF THE PLASMA MEMBRANE", BIOCHEMISTRY, vol. 26, 1987, WASHINGTON D.C.,USA, pages 1029 - 1036 *

Also Published As

Publication number	Publication date
WO1993012142A1 (en)	1993-06-24
AU3323593A (en)	1993-07-19
CA2124672A1 (en)	1993-06-24
JPH07502508A (en)	1995-03-16
AU666914B2 (en)	1996-02-29
EP0618927A1 (en)	1994-10-12
JP2704214B2 (en)	1998-01-26

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Legal Events

Date	Code	Title	Description
1994-08-26	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1994-10-12	17P	Request for examination filed	Effective date: 19940708
1994-10-12	AK	Designated contracting states	Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1995-05-24	A4	Supplementary search report drawn up and despatched	Effective date: 19950406
1995-05-24	AK	Designated contracting states	Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE
1998-12-30	17Q	First examination report despatched	Effective date: 19981116
1999-08-06	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN
1999-09-22	18D	Application deemed to be withdrawn	Effective date: 19990327