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EP0593464A4 - Benzoic acid derivatives. - Google Patents

Benzoic acid derivatives.

Info

Publication number
EP0593464A4
EP0593464A4 EP19910911699 EP91911699A EP0593464A4 EP 0593464 A4 EP0593464 A4 EP 0593464A4 EP 19910911699 EP19910911699 EP 19910911699 EP 91911699 A EP91911699 A EP 91911699A EP 0593464 A4 EP0593464 A4 EP 0593464A4
Authority
EP
European Patent Office
Prior art keywords
benzoic acid
acid derivatives
derivatives
benzoic
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP19910911699
Other languages
German (de)
French (fr)
Other versions
EP0593464A1 (en
Inventor
Robert A Daines
William Dennis Kingsbury
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0593464A4 publication Critical patent/EP0593464A4/en
Publication of EP0593464A1 publication Critical patent/EP0593464A1/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EP91911699A 1990-06-07 1991-05-31 BENZOIC ACID DERIVATIVES and their use as LTB4 inhibitors Ceased EP0593464A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53439790A 1990-06-07 1990-06-07
US534397 1990-06-07
PCT/US1991/003772 WO1991018601A1 (en) 1990-06-07 1991-05-31 Benzoic acid derivatives

Publications (2)

Publication Number Publication Date
EP0593464A4 true EP0593464A4 (en) 1993-02-12
EP0593464A1 EP0593464A1 (en) 1994-04-27

Family

ID=24129867

Family Applications (1)

Application Number Title Priority Date Filing Date
EP91911699A Ceased EP0593464A1 (en) 1990-06-07 1991-05-31 BENZOIC ACID DERIVATIVES and their use as LTB4 inhibitors

Country Status (17)

Country Link
EP (1) EP0593464A1 (en)
JP (1) JPH07116150B2 (en)
KR (1) KR930700102A (en)
CN (1) CN1058015A (en)
AU (1) AU655428B2 (en)
CA (1) CA2083957A1 (en)
FI (1) FI925545A0 (en)
HU (1) HUT64747A (en)
IL (1) IL98387A0 (en)
MA (1) MA22195A1 (en)
MX (1) MX26167A (en)
NZ (1) NZ238426A (en)
PL (1) PL290587A1 (en)
PT (1) PT97913A (en)
TW (1) TW221809B (en)
WO (1) WO1991018601A1 (en)
ZA (1) ZA914322B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993006085A1 (en) * 1991-09-19 1993-04-01 Smithkline Beecham Corporation Pyridine compounds for treating leukotriene-related diseases
CN1095713A (en) * 1992-06-30 1994-11-30 史密丝克莱恩比彻姆公司 Make the method for some thioether
IL106156A0 (en) * 1992-06-30 1993-10-20 Smithkline Beecham Corp Pyridinyl compounds
DE4224402A1 (en) * 1992-07-21 1994-01-27 Schering Ag New pyridine derivatives with leukotriene-B¶4¶ antagonistic effects
GR1001409B (en) * 1992-10-15 1993-11-30 Smithkline Beecham Corp Compounds for the treatment of diseases associated with leukotrienes.
ES2065234B1 (en) * 1992-10-27 1995-09-01 Smithkline Beecham Corp COMPOUNDS TO TREAT DISEASES RELATED TO LEUCOTRENEES.
US5643914A (en) * 1993-03-02 1997-07-01 Smithkline Beecham Corporation Pharmaceutical pyridine compounds
US5929096A (en) * 1996-02-29 1999-07-27 Smithkline Beecham Corporation Method for treating atopic dermatitis and contact dermatitis
EP0942903A1 (en) 1996-09-26 1999-09-22 Novartis AG Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity
DK2520654T3 (en) 2003-08-26 2017-05-01 Univ Colorado Regents Inhibitors of serine protease activity and their use in methods and compositions for the treatment of bacterial infections
WO2019244464A1 (en) * 2018-06-22 2019-12-26 パナソニック株式会社 Organic salt, hydroxy-radical sensor including same, and detection medium

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4056619A (en) * 1975-09-08 1977-11-01 Warner-Lambert Company 1-Substituted-2-(2-pyridinyl)ethanone N-oxides

Also Published As

Publication number Publication date
EP0593464A1 (en) 1994-04-27
AU655428B2 (en) 1994-12-22
ZA914322B (en) 1992-06-24
CA2083957A1 (en) 1991-12-08
NZ238426A (en) 1994-11-25
HUT64747A (en) 1994-02-28
MX26167A (en) 1994-02-28
TW221809B (en) 1994-03-21
MA22195A1 (en) 1992-04-01
AU8189691A (en) 1991-12-31
KR930700102A (en) 1993-03-13
FI925545A (en) 1992-12-07
HU9203867D0 (en) 1993-03-29
WO1991018601A1 (en) 1991-12-12
PL290587A1 (en) 1992-08-24
JPH05507492A (en) 1993-10-28
IL98387A0 (en) 1992-07-15
CN1058015A (en) 1992-01-22
JPH07116150B2 (en) 1995-12-13
FI925545A0 (en) 1992-12-07
PT97913A (en) 1992-03-31

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19921204

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

17Q First examination report despatched

Effective date: 19950911

GRAG Despatch of communication of intention to grant

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Effective date: 19960913