EP0422011A1

EP0422011A1 - Substances based on uracil-derivates for stimulating growth and reducing fat in animals

Info

Publication number: EP0422011A1
Application number: EP89905092A
Authority: EP
Inventors: Klaus Euler; Peter Lechtken; Lothar Franz; Peter Paul Hoppe; Franz-Josef Schoener
Original assignee: BASF SE
Current assignee: BASF SE
Priority date: 1988-05-05
Filing date: 1989-04-29
Publication date: 1991-04-17
Also published as: WO1989010701A1

Abstract

Lesdits produits servent également à améliorer l'assimilation de la nourriture et l'absorption des protéines chez les animaux. Ils contiennent au moins un dérivé d'uracil ou un sel physiologiquement toléré dudit dérivé.Said products also serve to improve the assimilation of food and the absorption of proteins in animals. They contain at least one uracil derivative or a physiologically tolerated salt of said derivative.

Description

Agents based on uracil derivatives for promoting growth and reducing fat in animals

description

The invention relates to an agent based on uracil derivatives and their use for promoting growth, increasing feed utilization and the amount of protein and for reducing fat in animals, in particular farm animals and pets.

The use of feed additives to achieve higher weight additions, improved feed utilization and reduced fat intake is already widely practiced in animal nutrition, especially when fattening pigs, cattle and poultry.

We have now found agents comprising at least one uraci 1 derivative of the general formula I,

in which A and B either represent a hydrogen atom or together form a bond,

D is oxygen or sulfur, the group = NCN or the group = NE, where E is a phenyl, benzyl, pyridyl, C ₁ -C ₄ -alkyl group or together with R ¹ the group - (CH ₂ ) _k N = , where k represents the number 2 or 3,

R ¹ if D is an oxygen atom:

a) a hydrogen atom or

b) a C ₁ -C ₆ alkyl group which is substituted by 1 to 3-fluorine, chlorine or bromine atoms, a hydroxy, a C ₁ -C ₃ alkoxy, a C ₂ -C ₄ alkanoyloxy, C ₁ -C ₃ alkylsulfonyloxy, an aminocarbonyloxy, a mono- or di (C ₁ -C ₃ alkyl) aminocarbonyloxy, a mercapto, a C ₁ -C ₃ alkyl mercapto, a phenylmercapto, a pyridylmercapto, pyridazinyl mercapto, pyrimidinyl mercapto, pyrazinyl mercapto or one Triazinyl mercapto group, a cyano, a carboxy, a (C ₁ -C ₄ -alkoxy) carbonyl group, a phenyl group which is formed by 1 to 2 C ₁ -C ₃ -alkyl radicals, 1 to 2 C ₁ -C ₃ -alkoxy radicals and / or 1 to 2 fluorine, chlorine or bromine atoms can be substituted, or an imidazolyl group, which can be substituted by 1 to 3 C ₁ -C ₃ alkyl groups, or a group of the formula Ia

in which the dashed line can mean an additional bond, R ^{6 is} a hydrogen atom, a C ₁ -C ₄ alkyl group which is optionally substituted by a phenyl radical, a C ₃ -C ₆ cycloalkyl group, a phenyl group which is optionally substituted by 1 or 2 C ₁ -C ₄ alkyl groups, 1 or 2 C ₁ -C ₄ alkoxy groups or 1 or 2 halogen atoms and / or may be substituted by a nitrile, nitro or trifluoromethyl group, or

is a group of the formula R ⁸ R ⁹ N-, in which R ^{8 is} a hydrogen atom or a phenyl group which is 1 to 2 times halogen atoms, C ₁ -C ₄ -alkyl radicals, C ₁ -C ₄ -alkoxy groups and / or a nitrile and / or nitro group can be substituted, R ^{9 represents} a C ₁ -C ₄ alkanoyl or benzoyl group. or R ⁸ and R ⁹ together with the nitrogen atom form a benzimidazol-2-one-1-yl group, R ^{7 can have the} same meanings as R ⁶ ,

and m represents 0, 1 or 2 or

a group of formula Ib

wherein R ^{10 is} a C ₁ -C ₃ hydrocarbon radical which may be substituted by a naphthyl radical or a phenyl radical, the phenyl radical optionally 1 to 2 halogen atoms, 1 to 2 C ₁ -C ₄ alkyl radicals, 1 to 2 C ₁ -C ₄ alkoxy or a trifluoromethyl, nitro, hydroxy, C ₁ -C ₄ alkanyl, (C ₁ -C ₅ alkoxy) carbonyl and / or cyano group, a naphthyl radical, one Phenyl radical, the 1 to 3 times by halogen atoms, C ₁ -C ₄ alkyl radicals, C ₁ -C ₄ alkoxy groups and / or one Trifluoromethyl or a C ₁ -C ₄ alkanoyl group can be substituted, or represents a δ-membered heteroaryl radical having 1 to 2 nitrogen atoms and p represents the number 2 or 3, or

a group of formula Ic, wherein R ^{11 is} a hydrogen atom, a C ₁ -C ₈ alkyl radical, optionally by a phenyl radical, the 1 to 2 C ₁ -C ₄ alkyl groups, 1 to 2 C ₁ -C ₄ alkoxy groups and / or 1 or 2 halogen atoms may contain, is substituted, a C ₃ -C ₁₂ cycloalkyl group which may be substituted by 1 to 3 methyl groups, a phenyl or benzyl radical, or a C7-C ₁₀ bicyclic or tricyclic alkyl radical which is substituted by 1 to 3 methyl radicals may be, or a benzo-fused C ₅ -C ₇ cycloalkyl group and R ^{12 represents} a hydrogen atom or a C ₁ -C ₈ alkyl radical, or

a group of formula Id,

wherein n is the number 1, 2 or 3 and the aromatic ring can be substituted by 1 to 2 halogen atoms, 1 to 2 C ₁ -C ₄ alkyl radicals or 1 to 2 C ₁ -C ₄ alkoxy radicals, or

a group of formula Ie, in which G represents oxygen or sulfur atom and the heterocyclic ring can be substituted by 1 to 2 C ₁ -C ₄ alkyl groups,

represents, or

represents a C2-C5 alkenyl group which may be substituted by 1 chlorine atom or a phenyl group, or d) represents a C ₃ -C ₆ alkynyl group or

e) represents a C ₃ -C ₆ cycloalkyl group which can be substituted by 1 to 2 C ₁ -C ₃ alkyl groups and / or 1 to 2 fluorine, chlorine or bromine atoms and / or by 1 phenyl group, or

f) represents a phenyl group which is represented by 1 to 2 C ₁ -C ₃ alkyl groups, 1 to 2 C ₁ -C ₃ alkoxy groups, 1 to 2 fluorine, chlorine or bromine atoms, an amino group, a mono- or di- C ₁ -C ₃ alkylamino group, a C ₂ -C ₄ alkanoylamino group, a carboxy group or a C ₁ -C ₄ alkoxycarbonyl group, or can be substituted

g) represents a pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group which is represented by 1 to 3 C ₁ -C ₃ -alkyl groups and / or a C ₁ -C ₃ -alkoxy group, a hydroxyl group, an amino group, a Mono- or di-C ₁ -C ₃ alkoxy group may be substituted, or

h) represents a 5-membered aromatic heterocyclic group which contains 1 oxygen, 1 sulfur and / or 1, 2 or 3 nitrogen atoms as heteroatoms and is optionally substituted by 1 to 3 C ₁ -C ₃ -alkyl groups, or

i) represents a C ₁ -C ₆ alkoxy group which is a C ₃ -C ₆ cycloalkyl group, one or two chlorine or bromine atoms, a C ₁ -C ₃ alkoxy group or a phenyl group which is substituted by 1 to 2 C ₁ - C ₃ alkyl, 1 to 2 C ₁ -C ₃ alkoxy, 1 to 2 fluorine, chlorine or bromine atoms, a trifluoromethyl radical or a nitro group may be substituted, or

j) represents a C ₃ -C ₆ alkenyloxy group which may be substituted by a phenyl group, or

k) represents a C ₃ -C ₆ alkynyloxy group which may be substituted by a phenyl radical, or

l) represents a C ₃ -C ₆ cycloalkyloxy group which is substituted by 1 to 2 C ₁ -C ₃ -

Alkyl groups and / or 1 to 2 chlorine or bromine atoms can be substituted, or

m) represents a phenoxy group which can be substituted by 1 to 2 C ₁ -C ₃ -alkyl radicals, 1 to 2 C ₁ -C ₃ -alkoxy groups, 1 to 2 fluorine or chlorine atoms or a nitro group, or n) represents a C ₁ -C ₃ alkyl mercapto group, or

o) the group R ¹³ R ¹⁴ N, where R ^{13 represents} a hydrogen atom, a C ₁ -C ₃ -alkyl, a C ₃ -C ₄ -alkenyl or a C ₃ -C ₄ -alkynyl group or a phenyl group and R * ^ represents a hydrogen atom or a C ₁ -C ₃ alkyl group, or

R ¹ , if D represents a sulfur atom,

represents a C ₁ -C ₄ alkylamino group or a di (C ₁ -C ₄ alkyl) amino group, or

R ¹ , if D represents the group = N-CN, represents a hydrogen atom, a Cχ-C4-alkyl group, a phenyl group, a C ₁ -C ₄ alkylamino or a di (C ₁ -C ₄ alkyl) amino group , or

R ¹ , if D represents the group = NE, a hydrogen atom, a C ₁ -C ₄ alkyl group, a phenyl group, a pyridinyl group, a C ₁ -C ₄ alkynylamino or a di (C ₁ -C ₄ -Alkyl) -amino group means

R ^{2 represents} a hydrogen atom or a C _1-3 alkyl group,

or R ¹ and R ² together form a C ₂ -C ₄ alkylidene group which can be substituted by 1 to 2 C _1-3 alkyl groups and / or a phenyl group,

R ³ and R ⁴ independently represent

a) a hydrogen atom or

b), a C ₁ -C ₆ alkyl group formed by 1 to 3-fluorine, chlorine or bromine atoms, a hydroxy, a C ₁ -C ₃ alkoxy, a C ₂ -C ₄ alkanoyloxy, a C ₁ -C ₃ alkylsulfonyloxy, an aminocarbonyloxy, a mono- or di (C ₁ -C ₃ alkyl) aminocarbonyloxy, a mercapto, a C ₁ -C ₃ alkyl mercapto, a phenyl mercapto , a pyridylmercapto, pyridazinyl-mercapto, pyrimidinylmercapto, pyrazinylmercapto or a triazinyl mercapto group, a cyano, a carboxy, a (C ₁ -C ₄ -alkoxy) carbonyl group, a phenyl group which can be substituted by 1 to 2 C ₁ -C ₃ -alkyl radicals, 1 to 2 C ₁ -C ₃ -alkoxy radicals and / or 1 to 2 fluorine, chlorine or bromine atoms, or an imidazolyl group which is substituted by 1 to 3 C ₁ -C ₃ -alkyl groups can be or a group of the formula If,

in which the dashed line can mean an additional bond, R6 is a hydrogen atom, a C ₁ -C ₄ alkyl group which is optionally substituted by a phenyl radical, a C ₃ -C ₆ cycloalkyl group, a phenyl group which is optionally substituted by 1 or 2 C ₁ C ₄ alkyl groups, 1 or 2 C ₁ C ₄ alkoxy groups or 1 or 2 halogen atoms and / or can be substituted by a nitrile, nitro or trifluoromethyl group, or

is a group of the formula R ⁸ R ⁹ N-, in which R ^{8 is} a hydrogen atom or a pfienyl group which is 1- to 2-fold by halogen atoms, C ₁ -C ₄ alkyl-restev C ₁ -C ₄ alkoxy groups and / or a nitrile and / or nitro group can be substituted, R ^{9 represents} a C ₁ -C ₄ alkanoyl or an 8enzimidazol-2-one-1-yl group, R ^{7 can have the} same meanings as R ⁶ ,

and m represents 0, 1 or 2 or

a group of the formula Ig,

wherein R ^{10 is} a C ₁ -C ₃ hydrocarbon radical which can be substituted by a naphthyl radical or a phenyl radical, the phenyl radical optionally 1 to 2 halogen atoms, 1 to 2 C ₁ -C ₄ alkyl radicals, 1 to 2 C ₁ -C ₄ alkoxy radicals or a trifluoromethyl, nitro, hydroxy, C ₁ -C ₄ alkanyl, (C ₁ -C ₅ alkoxy) carbonyl and / or cyano group, a naphthyl radical, a phenyl radical, which can be substituted 1 to 3 times by halogen atoms, C ₁ -C ₄ alkyl radicals, C ₁ -C ₄ alkoxy groups and / or a trifluoromethyl or a C ₁ -C ₄ alkanoyl group, or a 6-membered heteroaryl radical with 1 to 2 nitrogen atoms and p represents the number 2 or 3, or

a group of the formula Ih,

wherein R ^{11 is} a hydrogen atom, a C ₁ -C ₈ alkyl radical, optionally by a phenyl radical, the 1 to 2 C ₁ -C ₄ alkyl groups, 1 to 2 C ₁ -C ₄ alkoxy groups and / or 1 to Can contain 2 halogen atoms, is substituted, a C ₃ -C ₁₂ cycloalkyl group, which can be substituted by 1 to 3 methyl groups, a phenyl or benzyl radical, or a C ₇ -C ₁₀ bi or tricyclic alkyl radical, which is substituted by 1 to 3 Methyl radicals can be substituted, or a benzo-fused

C ₅ -C ₇ cycloalkyl group and R ^{12 represents} a hydrogen atom or a C ₁ -C ₈ alkyl radical, or

c) a C ₂ -C ₆ alkenyl group which can be substituted by 1 chlorine atom or a phenyl group, or

d) a C ₃ -C ₆ alkynyl group or

e) a C ₃ -C ₆ cycloalkyl group formed by 1 to 2 C ₁ -C ₃ alkyl groups and / or 1 to 2 fluorine, chlorine or bromine atoms and / or by

1 phenyl group may be substituted, or

f) a phenyl group substituted by 1 to 2 C ^* ι-C3 alkyl groups, 1 to 2 C ₁ -C ₃ alkoxy groups, 1 to 2 fluorine, chlorine or bromine atoms, an amino group, a mono- or di-C ₁ -C ₃ alkylamino group, a C ₂ -C ₄ alkanoylamino group, a carboxy group or a C ₁ -C ₄ alkoxycarbonyl group may be substituted, or g) a pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group formed by 1 to 3 C ₁ -C ₃ alkyl groups and / or a C ₁ -C ₃ alkoxy group, a hydroxy group, an amino group, a mono - Or di-C ₁ -C ₃ alkoxy group may be substituted, or

h) a 5-membered aromatic heterocyclic group which contains 1 oxygen, 1 sulfur and / or 1, 2 or 3 nitrogen atoms as hetero atoms and is optionally substituted by 1 to 3 C ₁ -C ₃ alkyl groups, or

i) a C ₁ -C ₆ alkoxy group which is a C ₃ -C ₆ cycloalkyl group, one or two chlorine or bromine atoms, a C ₁ -C ₃ alkoxy group or a phenyl group which is formed by 1 to 2 C ₁ -C ₃ alkyl, 1 to 2 C ₁ -C ₃ alkoxy, 1 to 2 fluorine, chlorine or bromine atoms, a trifluoromethyl radical or a nitro group may be substituted, or

j) a C ₃ -C ₆ alfcenyloxy group which may be substituted by a phenyl group, or

k) a C ₃ -C ₆ -alk.inyioxygruppe, which can be substituted by a phenyl radical, or

l) a C ₃ -C ₆ cycloalkyloxy group which can be substituted by 1 to 2 C ₁ -C ₃ alkyl groups and / or 1 to 2 chlorine or bromine atoms, or

m) a phenoxy group which can be substituted by 1 to 2 C ₁ -C ₃ alkyl radicals, 1 to 2 C ₁ -C ₃ alkoxy groups, 1 to 2 fluorine or chlorine atoms or a nitro group, or

n) a C ₁ -C ₃ alkyl mercapto group, or

o) the group R ¹³ R ¹⁴ N, where R ^{13 represents} a hydrogen atom, a C ₁ -C ₃ alkyl, a C ₃ -C ₄ alkenyl or a C ₃ -C ₄ alkynyl group or a phenyl group and R ^{14 represents} a hydrogen atom or a C ₁ -C ₃ alkyl group; and

R ⁵

a) a hydrogen atom

b) a C ₁ -C ₆ -alkyl group which can be substituted by 1-3 fluorine, chlorine or bromine atoms, a hydroxyl, a cyano or carboxy group, c) a halogen atom, or

d) a cyano, carboxy, nitro, nitroso, hydroxyl or amino group, which can be substituted by one or two C ₁ -C ₆ -alkyl radicals, optionally with a halogen atom or a hydroxyl group,

represents;

or a uracil derivative of the general formula II

in which A, B, D, R ³ , R ⁴ and R ^{5 have} the meanings given for formula I, and

R ^{15 represents} a hydrogen atom, a C _1-4 alkyl radical, a phenyl, a hydroxy, a C _1-4 alkoxy, a phenoxy group, the group

R ¹⁸ -NH-CH ₂ -CH (OH) -CH ₂ O-, in which R ^{18 represents} the isopropyl or tert-butyl group, a nitro, trifluoromethyl, carboxy, C ₁ -C ₄ alkoxycarbonyl- , Aminocarbonyl or cyano group, a fluorine, chlorine or bromine atom, an amino, C _1-4 alkylamino or di (C ₁ -C ₄ alkyl) amino group, a pyrrolidine, piperidine or morpholine radical, or the group -NH-CH ₂ -J, where J is a pyridyl, furyl, thienyl or phenyl radical, the phenyl radical being substituted by 1 to 3 radicals from the group halogen, hydroxy, C ₁ -C ₄ -alkoxy) carbonyl or C ₁ -C ₄ alkyl may be substituted, or a group -NHL, in which L is a 5- or 6-membered heterocyclic group, the 1 N, O or S atom and optionally 1 or 2 further N atoms means, the heterocyclic group being replaced by a radical from the group cyano, hydroxy, C ₁ -C ₄ -alkoxy, amino, C ₁ -C ₄ -alkylamino, di- (C ₁ -C ₄ -alkyl) - amino, (C ₁ -C ₄ alkoxy Jcarbonyl, aminocarbonyl or C ₁ -C ₄ alkanoyl or by 1 to 3 C ₁ -C ₄ alkyl groups, where one of these C ₁ -C ₄ alkyl groups can be substituted by a hydroxyl group or the radical R ¹⁹ R ²⁰ N, where R ¹⁹ and R ²⁰ independently of one another are hydrogen atoms, C ₁ -C ₄ alkyl radicals, Benzyl or phenethyl groups mean or the group R ¹⁹ R ²⁰ _{N represents} a pyrrolidine, piperidine or morpholine residue, may be substituted,

or a uracil derivative of the general formula III

in which R ³ , R ⁴ and R ⁵ , A and B have the meanings given above for i-ormel I,

X and Y independently of one another represent an N atom or a carbon atom which is substituted by a hydrogen atom or one of the radicals R ¹⁹ , R ²⁰ or R ²¹ , where

R ^{19 represents} a hydrogen atom, a C ₁ -C ₄ alkyl group, a C ₁ -C ₄ hydroxyalkyl group, a C ₁ -C ₄ alkanoyl, a hydroxycarbonyl, a (C ₁ -C ₄ alkoxy) carbonyl -, an aminocarbonyl, a cyano group or a group of the formula purple

means where

R ^{22 is} a C ₁ -C ₆ alkyl, a phenyl (C ₁ -C ₃ alkyl), a C ₁ -C ₄ alkanoyl, a benzoyl, a pyridinecarbonyl or a C ₁ -C ₄ -Alkylsulfonylgruppe means

R ^{23 represents} a hydrogen atom or a C ₁ -C ₆ alkyl group, or

R ²² and R ²³ together with the N atom to which they are attached represent a pyrrolidine, piperidine or piperazine residue which can be substituted by a phenyl group and / or a hydroxy group, R ^{24 represents} a C ₁ -C ₄ alkylidene group, and

R ²⁰ and R ²¹ independently of one another denote hydrogen atoms or C ₁ -C ₄ alkyl groups,

or the physiologically tolerable salts of the compounds of the general formulas I, II and III.

Preferred compounds for the agent according to the invention and the use according to the invention are uracil derivatives of the general formula I,

in the

A and B either each represent a hydrogen atom or together form a bond,

D represents an oxygen atom,

R ^{1 has} the following meanings: a) a hydrogen atom or

b) a C ₁ -C ₃ alkyl group which is substituted by a chlorine atom, a hydroxy, a methoxy, an acetoxy, a methylmercapto, a pyridiylmercapto, a cyano, a carboxy, a (C _1-4 Alkoxy) carbonyl or a phenyl group or a group of the formula Ia,

in which the dashed line can mean an additional bond, and R6 is a hydrogen atom, a methyl group, a phenyl group which may optionally be substituted by 1 or 2 methyl, methoxy groups or chlorine atoms, or a group of the formula R ⁸ R * ^ N means in which R ^{8 is} a hydrogen atom or a phenyl group and R ^* ^ is a propionyl or benzoyl group or R ⁸ and R ^* ^ together with the nitrogen atom is one Form benzimidazol-2-one-1-yl group, R ⁷ denotes a hydrogen atom, a methyl, a hydroxy, an acetyl, an ethoxycarbonyl or a cyano group,

m stands for 1 or

a group of formula Ib

wherein R ^{10 is} a benzyl, a naphthyl or a phenyl radical, which can be substituted 1 to 3 times by chlorine atoms, methyl and / or methoxy groups, or a pyridyl radical and

p represents the number 2, or

a group of formula Ic,

wherein R ^{11 is} a C ₁ -C ₃ -alkyl radical, which is optionally substituted by a phenyl radical, and R ^{12 represents} a hydrogen atom or a methyl radical, or

a group of formula Id,

where n is the number 2, or

a group of formula Ie, wherein G represents a hydrogen atom and the heterocyclic ring can be substituted by 1 to 2 C ₁ -C ₄ alkyl groups, or c) a C ₂ -C ₄ alkenyl group which can be substituted by a phenyl group, or

d) a C ₃ -C ₄ alkynyl group or

e) a C ₃ -C ₆ cycloalkyl group which can be substituted by 1 to 2 methyl groups and / or 1 to 2 chlorine atoms and / or a phenyl group, or

f) a phenyl group which can be substituted by 1 to 2 methyl groups, 1 to 2 methoxy groups, 1 to 2 chlorine atoms, a carboxy group or an ethoxycarbonyl group, or

g) a pyridyl group, which can be substituted by 1 to 3 methyl groups, or

h) a thiophenyl, furanyl, imidazolyl or oxazolyl group which is optionally substituted by 1 to 3 methyl groups, or

i) a C ₁ -C ₄ alkoxy group which can be substituted by a methoxy group or by a phenyl group, or

j) a C ₃ -C ₄ alkenyloxy group which may be substituted by a phenyl group, or

k) a C ₃ -C ₄ alkynyloxy group which may be substituted by a phenyl radical, or

l) a C ₃ -C ₆ cycloalkoxy group or

m) a phenoxy group or

n) a methyl merc apto group or

o) the group R ¹³ R ¹⁴ N-, where R ^{13 represents} a hydrogen atom, a methyl, an allyl or a propionyl group and R ^{14 represents} a hydrogen atom or a methyl group,

R ^{2 represents} a hydrogen atom

or R! and R ² together form a C2 ~ C4 alkylidene group, which can be substituted by 1 to 2 methyl groups, R ³ and R ⁴ independently represent

a) a hydrogen atom or

b) a C ₁ -C ₃ alkyl group which is substituted by a chlorine atom, a hydroxy, a methoxy, an acetoxy, a methylmercapto, a pyridiylmercapto, a cyano, a carboxy, a (C _1-4 Alkoxy) carbonyl or a phenyl group or a group of the formula If,

in which the dashed line can mean an additional bond, and R ^{6 is} a hydrogen atom, a methyl group, a phenyl group which may optionally be substituted by 1 or 2 methyl, methoxy groups or chlorine atoms, or a group of the formula R ⁸ R ⁹ N means in which R ^{8 represents} a hydrogen atom or a phenyl group and R ^{9 represents} a propionyl or benzoyl group or R ⁸ and R ⁹ together with the nitrogen atom form a benzimidazol-2-one-1-yl group, R ^{7 represents} a hydrogen atom, a Is methyl, a hydroxyl, an acetyl, an ethoxycarbonyl or a cyano group,

m stands for 1 or

a group of the formula Ig,

p represents the number 2, or a group of the formula Ih

wherein R ^{11 is} a C ₁ -C ₃ alkyl radical, which is optionally substituted by a phenyl radical, and R ^{12 represents} a hydrogen atom or a methyl radical, or

c) a C ₂ -C ₄ alkenyl group which can be substituted by a phenyl group, or

d) a C ₃ -C ₄ alkynyl group or

g) a pyridyl group, which can be substituted by 1 to 3 methyl groups, or

l) a C ₃ -C ₆ cycloalkoxy group or

m) a phenoxy group or

n) a methyl mercapto group or o) the group R ¹³ R ¹⁴ N-, where R ^{13 represents} a hydrogen atom, a methyl, an allyl or a propionyl group and R ^{14 represents} a hydrogen atom or a methyl group; and

R ⁵

a) a hydrogen atom

b) a C ₁ -C ₃ -alkyl group which can be terminally substituted by a fluorine, chlorine or bromine atom, a hydroxyl, a cyano or carboxy group,

c) a bromine or chlorine atom, or

d) a cyano, carboxy, nitro, nitroso, hydroxyl or amino group which can be substituted by one or two C ₁ -C ₃ with optionally terminal chlorine atoms or a hydroxyl group,

represents;

or a uracil derivative of the general formula II

in the

A and B either each represent a hydrogen atom or together form a bond,

D represents an oxygen atom,

R ³ and R ⁴ independently represent

a) a hydrogen atom or b) a C ₁ -C ₃ alkyl group which is substituted by a chlorine atom, a hydroxy, a methoxy, an acetoxy, a methylmercapto, a pyridiylmercapto, a cyano, a carboxy, a (C _1-4 Alkoxy) carbonyl or a phenyl group or a group of the formula If,

in which the dashed line can mean an additional bond, and R ^{6 is} a hydrogen atom, a methyl group, a phenyl group which may optionally be substituted by 1 or 2 methyl, methoxy groups or chlorine atoms, or a group of the formula R ⁸ R ⁹ N means in which R ^{8 represents} a hydrogen atom or a phenyl group and R ^{9 represents} a propionyl or benzoyl group or R ⁸ and R ⁹ together with the nitrogen atom form a benzimidazol-2-one-1-yl group, R ^{7 represents} a hydrogen atom, a Is methyl, a hydroxy, an acetyl, an ethoxycarbonyl or a cyano group,

m stands for 1, or

a group of the formula Ig,

p represents the number 2, or

a group of the formula Ih,

c) a C ₂ -C ₄ alkenyl group which can be substituted by a phenyl group, or d) a C ₃ -C ₄ alkynyl group or

g) a pyridyl group, which can be substituted by 1 to 3 methyl groups, or

l) a C ₃ -C ₆ cycloalkoxy group or

m) a phenoxy group or

n) a methyl mercapto group or

o) the group R ¹³ R ¹⁴ N-, where R ^{13 represents} a hydrogen atom, a methyl, an allyl or a propionyl group and R ^{14 represents} a hydrogen atom or a methyl group; and

_R 5

a) a hydrogen atom

c) a bromine or chlorine atom, or d) a cyano, carboxy, nitro, nitroso, hydroxyl or amino group which can be substituted by one or two C ₁ -C ₃ with optionally terminal chlorine atoms or a hydroxyl group,

5 represents; and

R ^{1 5}

a) a hydrogen atom

b) a C ₁ -C ₄ alkyl radical,

c) a cyano, carboxy or amino group, which can be substituted by optionally one to two C ₁ -C ₃ alkyl groups

d) a piperidine residue

e) the group NHCH ₂ J, where J is a pyridiyl, furyl, thionyl or phenyl radical,

f) the group NHL, in which L denotes a pyridyl or a thiazolyl radical, it being possible for the pyridyl or the thiazolyl radical to be substituted by 1-2 methyl groups,

represents;

o a uracil derivative of the general formula III

iin the

A and B either each represent a hydrogen atom or together form a bond,

D is an oxygen atom,

R ³ and R ⁴ independently represent

a) a hydrogen atom or a C ₁ -C ₃ -alkyl group which is formed by a chlorine atom, a hydroxy, a methoxy, an acetoxy, a methylmercapto, a pyridiylmercapto, a cyano, a carboxy, a (C _1-4 -alkoxy) carbonyl or a phenyl group or a group of the formula If,

m stands for 1 or

a group of the formula Ig,

p represents the number 2, or

a group of the formula Ih

wherein R ^{11 is} a C ₁ -C ₃ alkyl radical, which is optionally substituted by a phenyl radical, and R ^{12 represents} a hydrogen atom or a methyl radical, or c) a C ₂ -C ₄ alkenyl group which can be substituted by a phenyl group, or

d) a C ₃ -C ₄ ~ alkynyl group or

g) a pyridyl group, which can be substituted by 1 to 3 methyl groups, or

i) a C ₁ -C ₄ alkoxy group which can be substituted by a methoxy group or by a phenyl group,

l) a C ₃ -C ₆ cycloalkoxy group or

m) a phenoxy group or

n) a methyl mercapto group or

R ⁵

a) a hydrogen atom

b) a C ₁ -C ₃ -alkyl group which can be terminally substituted by a fluorine, chlorine or bromine atom, a hydroxyl, a cyano or carboxy group, c) a bromine or chlorine atom, or

represents;

and the rest

overall means: an imidazol-1-yl radical which can be substituted by 1-3 methyl groups or a hydroxymethyl group,

or a 1,2,4-triazol-1-yl radical, a pyrazol-1-yl radical, a pyrazol-1-yl radical or a pyrrol-1-yl radical which is substituted by a hydroxymethyl group, a formyl group , an acetyl group or a group of the formula purple,

may be substituted, in which R ²² denotes a C ₁ -C ₃ alkyl, a benzyl, a C ₁ -C ₄ alkanoyl or a benzoyl group,

R ^{23 represents} a hydrogen atom or a C ₁ -C ₆ alkyl group, or

R ²² and R ²³ together with the N atom represent a piperidine or piperazine residue which is substituted by a phenyl group,

R ^{24 represents} a C ₁ -C ₃ alkylidene group;

The agent according to the invention is preferably in the form of animal feed, drinking water for animals, additives for animal feed and drinking water or in the form of a premix. The invention also relates to the use of the uracil derivatives of the general formulas I, II and III for increasing performance in animal breeding, in particular for promoting growth, improving feed conversion, increasing the protein content and / or reducing the fat content in animals.

Manufacturing processes for the compounds used in the agent according to the invention are known and are described, for example, in the following references:

a) DE-B 834 105

b) E.C. Taylor and A. Mc Killop, J. Org. Chem. 30, 3153 (1965)

c) D.T. Hurst, An Introduction to the Chemistry and Biochemistry of Pyrimidines, Purines and Pteridines; Wiley (1980)

d) D.J. Brown, The Pyrimidines; Wiley (1962); Suppl. 1 (1970) Suppl. 2 (1985)

As far as the compounds of formulas I, II and III are known, they show cyctostatic, thyreostatic and diuretic effects in a known manner.

Such effects are e.g. described in

1) M. Negwer, Organic Chemical Drugs and their Synonyma, Akademie-Verlag, Berlin 1978

2) References a) to d) mentioned in the manufacturing process.

Surprisingly, it has now been found that the compounds of the general formulas I, II and III have a growth-promoting and fat-reducing effect.

The active ingredients can be used in all areas of animal breeding as a means of promoting and accelerating growth, improving feed conversion, reducing the amount of fat and increasing the amount of protein in healthy and sick animals.

The effectiveness of the active ingredients is largely independent of the type and gender of the animals. The active ingredients are particularly valuable in the rearing and keeping of young and fattening animals. As Animals in which the active ingredients can be used to promote and accelerate growth and to improve feed conversion include the following useful and ornamental animals:

Warm-blooded animals such as cattle, pigs, horses, sheep, goats, cats, dogs, rabbits, fur animals, e.g. Mink and chinchilla, poultry e.g. Chickens, geese, ducks, turkeys, pigeons, parrots and canaries and cold-blooded animals such as fish, e.g. Carp and reptiles, e.g. Snakes.

The dose of active substance which is administered to the animals in order to achieve the desired effect can be varied largely because of the favorable properties of the active substances. It is preferably about 0.01 to 100 mg of active ingredient / kg of feed, in particular 0.1 to 10 mg of active ingredient / kg of feed or drinking water. The duration of administration can range from a few hours or days to several years. The appropriate amount of the active ingredient and the appropriate duration of administration depend in particular on the type, age, gender, state of health and the type of keeping and feeding the animals and are easy to determine by any specialist.

The active substances are administered to the animals according to the usual methods. The method of administration depends in particular on the type, behavior and state of health of the animals. Thus, the administration can take place orally or parenterally once or several times a day at regular or irregular intervals. For reasons of expediency, oral administration is preferred in most cases, in particular in the rhythm of the food and / or drink intake of the animals.

The active ingredients can be used as a pure mixture or in formulated form, i.e. in a mixture with non-toxic inert carriers of any kind, e.g. with carriers and in formulations as are customary in nutritional preparations.

the active ingredients, optionally in formulated form, are administered together with pharmaceutical active ingredients, mineral salts, trace elements, vitamins, protein substances, fats, colorants and / or flavorings. Oral administration together with the feed and / or drinking water is recommended, the active ingredient being added to the total amount or only parts of the feed and / or drinking water as required.

The active ingredients are added to the feed and / or drinking water by conventional methods by simple mixing as a pure substance mixture, preferably in finely divided form or in formulated form in a mixture with edible non-toxic carriers, optionally in the form of a premix or a feed concentrate. The type of feed and its composition is irrelevant. All common or special feed compositions can be used, which preferably contain the usual balance of energy and building materials including vitamins and minerals necessary for a balanced diet. The feed can be composed, for example, of vegetable substances, for example hay, beets, cereals, grain by-products, animal substances, for example meat, fats, bone meal, fish products, vitamins, for example vitamin A, D complex and B complex, proteins, amino acids, for example DL-methionine and inorganic substances such as lime and table salt.

Feed concentrates contain the active substances in addition to edible substances, e.g. Rye flour, corn flour, soybean flour or lime, possibly with other nutrients and building materials, as well as proteins, mineral salts and vitamins. They can be produced using the usual mixing methods.

Preferably, in premixes and feed concentrates, the active ingredients can optionally also be covered by suitable agents covering their surface, e.g. protected from air, light and / or moisture with non-toxic waxes or gelatin.

The invention is illustrated in the following examples:

Example 1 Example of the composition of a chick rearing feed to which an active ingredient according to the invention is added:

Components corn-soy ration% barley-oat-tapioca ration%

Corn 48.0 Oats 20.00

Barley 10.0 24.49

Tapioca 13.00

Soybean meal 31.0 31.00

Soybean oil 3.0 5.00 Fish meal 2.9 3.00

Cefkaphos 1.76 1.76 carbon. Feed lime 1.2 1.20

Cattle salt 0.25 0.25

Trace element VM 0.025 0.025 Vitamin VM 0.025 0.025

Choline chloride 0.1 0.10

Methionine 0.15 0.15

Wheat semolina

100.00 100.00 Nutrient levels of corn soy, barley, oat tapioca

Ration ration

(Lufa Kiel) (calculated)

Crude protein: 21.8% 21.6%

Crude fat: 6.6%

Crude fiber: 3.3%

MJ ME: 12.4 12.3

EZG: 82.5

Ca: 1.1% 1.02%

P: 0.84% 0.88%

Na: 0.11% 0.15%

Lysine: 1.22% 0.51%

Methionine: 0.66% 0.51%

Example 2

Example of the composition of a pig rearing feed to which an active ingredient according to the invention is added:

Composition of the feed mixtures (g / kg)

Piglet rearing fattening pigs

Maize 350 300 Barley 153.3 270

Tapioca - 100

Oats - 100

Soybean meal 120 150

Fish meal - 40 wheat 100 -

Magermi Ichpulver 100 -

Wheat bran 80 4.65

Animal meal 40 -

Soybean oil 30 - Cefkaphos 6.83 11 kohlens. Feed lime 3.0 14.2

Cattle salt 2.79 1.3

Trace element VM 0.8 0.6

Vitamin VM 3.0 4.0 lysine 2.5 1.0

Methionine 1.0 2.0

Choline chloride 0.8 0.25

Cr ₂ O ₃ 1.0 1.0 The specified feed mixtures are preferably matched for rearing and fattening chicks or pigs, but they can also be used in the same or a similar composition for rearing and fattening other animals.

Several feed and metabolism studies were carried out with the active compounds according to the invention.

Example 3

Evaluation of test compounds as growth promoters and body fat reducing substances in animal nutrition - rat tests

a) Animal characteristics and feed

Rats, male, SPF-Wistar (Fa. Thomae) 300 animals / experiment {30 x 10) Weight at the start of the experiment: 55-65 g Weight at the end of the experiment: 185-220 g

Food: Diet for rats with the following composition:

salary

95% dry matter 5% crude ash 13, 8% crude protein 5.3% crude fat

Raw nutrients and vitamins

15.1% casein 10.0% sugar 3.0% cellulose 5.0% soybean oil

6.0% mineral VM 2.0% vitamin VM 0.2% methionine 58.7% corn starch 100%

b) treatment of animals

After arrival of the animals, these 3 days are adapted to the test conditions and then randomized. Randomization example

body weight

Group number mean standard deviation i 10 55.5 2.12

2 10 55.5 2.27

3 10 55.6 2.22

4 10 55.6 2.27

5 10 55.5 2.27

6 10 55.5 2.17

7 10 55.5 2.22

8 10 55.6 2.27

9 10 55.6 2.27

10 10 55.5 2.27

11 10 55.5 2.07

12 10 55.5 2.12

13 10 55.5 2.07

14 10 55.4 2.01

15 10 55.5 2.17

16 10 55.6 2.17

17 10 55.7 2.21

18 10 55.6 2.22

19 10 55.5 2.17

20 10 55.5 2.22

21 10 55.5 2.07

22 10 55.4 2.22

23 10 55.6 2.17

24 10 55.5 2.17

25 10 55.5 2.07

26 10 55.5 2.17

27 10 55.5 2.17

28 10 55.6 2.07

29 10 55.6 1.96

30 10 55.4 2.06

Total 300 55.5 2.06

Deleted 55 55.3 5.09

The subsequent test period is 21 days. The animals are fed ad libitum and / or rationed (1st week 90 g; 2nd week 110 g; 3rd week 130 g).

The animals are kept individually and weighed at weekly intervals.

After the end of the experiment, the rats are killed with CO ₂ . For whole-body analysis, the animals in an experimental group are autoclaved and then homogenized with a cutter. c) results

The data obtained are shown in a table below.

Claims

1. Means for increasing the performance in animal nutrition of cold-blooded and warm-blooded animals, containing at least either a uracil derivative of the general formula I,

in which A and B either each represent a hydrogen atom or together form a bond,

D is oxygen or sulfur, the group = NCN or the group = NE, where E is a phenyl, benzyl, pyridyl, C ₁ -C ₄ -alkyl group or together with fil the group - (CH ₂ ) _k N =, where k represents the number 2 or 3,

R ¹ if D is an oxygen atom:

a) a hydrogen atom or

b) a C ₁ -C ₆ alkyl group which is substituted by 1 to 3-fluorine, chlorine or bromine atoms, a hydroxy, a C ₁ -C ₃ alkoxy, a C ₂ -C ₄ alkanoyloxy, C ₁ -C ₃ alkylsulfonyloxy, an aminocarbonyloxy, a mono- or

Di (C ₁ -C ₃ alkyl) aminocarbonyloxy, a mercapto, a C ₁ -C ₃ alkyl mercapto, a phenylmercapto, a pyridylmercapto, pyridazinyl, mercapto, pyrimidinylmercapto, pyrazinylmercapto or one Triazinyl mercapto group, a cyano, a carboxy, a (C ₁ -C ₄ alkoxy) carbonyl group, a phenyl group which is formed by 1 to 2 C ₁ -C ₃ alkyl radicals, 1 to 2 C ₁ -C ₃ alkoxy radicals and / or 1 to 2 fluorine, chlorine or bromine atoms can be substituted, or an imidazolyl group which can be substituted by 1 to 3 C ₁ -C ₃ alkyl groups, or a group of formula Ia

m

is a group of the formula R ⁸ R ⁹ N-, in which R ^{8 is} a hydrogen atom or a phenyl group which is 1 to 2 times halogen atoms, C ₁ -C ₄ -alkyl radicals, C ₁ -C ₄ -alkoxy groups and / or a nitrile and / or nitro group can be substituted, R ^{9 represents} a C ₁ -C ₄ alkanoyl or benzoyl group or R ⁸ and R ⁹ together with the nitrogen atom form a benzimidazol-2-one-1-yl group, R ^{7 can have the} same meanings as R ⁶ ,

and m represents 0, 1 or 2, or

a group of formula Ib

wherein R ^{10 is} a C ₁ -C ₃ hydrocarbon radical which can be substituted by a naphthyl * radical or a phenyl radical, the phenyl radical optionally 1 to 2 halogen atoms, 1 to 2 C ₁ -C ₄ alkyl radicals, 1 to 2 C ₁ -C ₄ alkoxy or a trifluoromethyl, nitro, hydroxy, C ₁ -C ₄ alkanyl, (C ₁ -C ₅ alkoxy) carbonyl and / or cyano group, a naphthyl radical, one Phenyl radical which can be substituted 1 to 3 times by halogen atoms, C ₁ -C ₄ alkyl radicals, C ₁ -C ₄ alkoxy groups and / or a trifluoromethyl or a C ₁ -C ₄ alkanoyl group, or a 6- membered heteroaryl radical having 1 to 2 nitrogen atoms and p represents the number 2 or 3, or a group of formula Ic,

wherein R ^{11 is} a hydrogen atom, a C ₁ -C ₈ alkyl test, optionally by a phenyl radical, the 1 to 2 C ₁ -C ₄ alkyl groups, 1 to 2 C ₁ -C ₄ alkoxy groups and / or 1 or 2 halogen atoms may contain, is substituted, a C ₃ -C ₁₂ cycloalkyl group which can be substituted by 1 to 3 methyl groups, a phenyl or benzyl radical, or a C ₇ -C ₁₀ bicyclic or tricyclic alkyl radical which is substituted by 1 to 3 methyl radicals may be substituted, or a benzo-fused C ₅ -C ₇ cycloalkyl group and R ^{12 represents} a hydrogen atom or a C ₁ -C ₈ alkyl radical, or

a group of formula Id,

represents, or

c) denotes a C ₂ -C ₆ alkenyl group which can be substituted by 1 chlorine atom or a phenyl group, or

d) represents a C ₃ -C ₆ alkynyl group or

e) represents a C ₃ -C ₆ cycloalkyl group which can be substituted by 1 to 2 C ₁ -C ₃ alkyl groups and / or 1 to 2 fluorine, chlorine or bromine atoms and / or by 1 phenyl group, or f) represents a phenyl group which is represented by 1 to 2 C ₁ -C ₃ alkyl groups, 1 to 2 C ₁ -C ₃ alkoxy groups, 1 to 2 fluorine, chlorine or bromine atoms, an amino group, a mono- or di- C ₁ -C ₃ alkylamino group, a C ₂ -C ₄ alkanoylamino group, a carboxy group or a C ₁ -C ₄ alkoxycarbonyl group, or can be substituted

l) represents a C ₃ -C ₆ cycloalkyloxy group which can be substituted by 1 to 2 C ₁ -C ₃ alkyl groups and / or 1 to 2 chlorine or bromine atoms, or

m) represents a phenoxy group which can be substituted by 1 to 2 C ₁ -C ₃ -alkyl radicals, 1 to 2 C ₁ -C ₃ -alkoxy groups, 1 to 2 fluorine or chlorine atoms or a nitro group, or

n) represents a C ₁ -C ₃ alkyl mercapto group, or

σ) represents the group R ¹³ R ¹⁴ N, where R ^{13 represents} a hydrogen atom, a C ₁ -C ₃ alkyl, a C ₃ -C ₄ alkenyl or a C ₃ -C ₄ alkynyl group or a phenyl group and R ^{14 represents} a hydrogen atom or a C ₁ -C ₃ alkyl group, or R ¹ , if D represents a sulfur atom, denotes a C ₁ -C ₄ alkylamino group or a di (C ₁ -C ₄ alkyl) amino group, or

R ¹ , if D represents the group = N-CN, for a hydrogen atom, a C ₁ -C ₄ alkyl group, a phenyl group, a C ₁ -C ₄ alkyl amino or a di (C ₁ -C ₄ alkyl) ) amino group, or

R ¹ , if D represents the group = NE, a hydrogen atom, a C ₁ -C ₄ alkyl group, a phenyl group, a pyridinyl group, a C ₁ -C ₄ alkynylamino or a di (C ₁ -C ₄ alkyl) ) amino group means

R ^{2 represents} a hydrogen atom or a C _1-3 alkyl group,

R ³ and R ⁴ independently represent

a) a hydrogen atom or

b) a C ₁ -C ₆ alkyl group which is substituted by 1 to 3-fluorine, chlorine or bromine atoms, a hydroxy, a C ₁ -C ₃ alkoxy, a C ₂ -C ₄ alkanoyloxy, a C ₁ -C ₃ alkylsulfonyloxy, an aminocarbonyloxy, a mono- or di (C ₁ -C ₃ alkyl) aminocarbonyloxy, a mercapto, a C ₁ -C ₃ alkyl mercapto, a phenomercapto, a pyridylmercapto, pyridazinyl-mercapto, pyrimidinylmercapto, pyrazinylmercapto or a triazinyl mercapto group, a cyano, a carboxy, a (C ₁ -C ₄ -alkoxy) carbonyl group, a phenyl group which can be substituted by 1 to 2 C ₁ -C ₃ -alkyl radicals, 1 to 2 C ₁ -C ₃ -alkoxy radicals and / or 1 to 2 fluorine, chlorine or bromine atoms, or an imidazolyl group which is substituted by 1 to 3 C ₁ -C ₃ -alkyl groups can be or

a group of the formula If,

(If)

in which the dashed line can mean an additional bond, R *> a hydrogen atom, a C ₁ -C ₄ alkyl group which is optionally substituted by a phenyl radical, a C ₃ -C ₆ cycloalkyl group, a phenyl group which may optionally be substituted by 1 or 2 C ₁ C ₄ alkyl groups, 1 or 2 C ₁ C ₄ alkoxy groups or 1 or 2 halogen atoms and / or by a nitrile, nitro or trifluoromethyl group, or

is a group of the formula R ⁸ R ⁹ N-, in which R ^{8 is} a hydrogen atom or a phenyl group which is 1 to 2 times halogen atoms, C ₁ -C ₄ -alkyl radicals, C ₁ -C ₄ -alkoxy groups and / or a nitrile and / or nitro group can be substituted, R ^{9 represents} a C ₁ -C ₄ alkanoyl or a benzimidazol-2-one-1-yl group, R ^{7 can have the} same meanings as R ⁶ ,

and m represents 0, 1 or 2 or

a group of the formula Ig,

wherein R ^{10 is} a C ₁ -C ₃ hydrocarbon radical which can be substituted by a naphthyl radical or a phenyl radical, the phenyl radical optionally 1 to 2 halogen atoms, 1 to 2 C ₁ -C ₄ alkyl radicals, 1 to 2 C ₁ -C ₄ alkoxy radicals or a trifluoromethyl, nitro, hydroxy, C ₁ -C ₄ alkanyl, (Cι ~ C5-alkoxy) carbonyl and / or cyano group, a naphthyl radical, a phenyl radical, the 1st - Can be substituted up to 3 times by halogen atoms, C ₁ -C ₄ alkyl radicals, C ₁ -C ₄ alkoxy groups and / or a trifluoromethyl or a C ₁ -C ₄ alkanoyl group, or a 6-membered heteroaryl radical with 1 means up to 2 nitrogen atoms and p represents the number 2 or 3, or

a group of the formula Ih,

wherein RH is a hydrogen atom, a C ^* [-Cg-alkyl radical, optionally containing a phenyl radical, the 1 to 2 C ₁ -C ₄ alkyl groups, 1 to 2 C ₁ -C ₄ alkoxy groups and / or 1 to 2 halogen atoms can be substituted, a C3-Ci2-cycloalkyl group which can be substituted by 1 to 3 methyl groups, a phenyl or benzyl radical, or a C ₇ -C ₁₀ bicyclic or tricyclic alkyl radical, which can be substituted by 1 to 3 methyl radicals, or a benzo-fused C ₅ -C ₇ cycloalkyl group and R ^{12 represents} a hydrogen atom or a C ₁ -C ₆ alkyl radical , or

d) a C ₃ -C ₆ alkynyl group or

e) a C ₃ -C ₆ cycloalkyl group ,. by 1 to 2 C ₁ -C ₃ alkyl groups and / or 1 to 2 fluorine, chlorine or bromine atoms and / or by

1 phenyl group may be substituted, or

f) a phenyl group formed by 1 to 2 C ₁ -C ₃ alkyl groups, 1 to 2 C ₁ -C ₃ alkoxy groups, 1 to 2 fluorine, chlorine or bromine atoms, an amino group, a mono- or di-C ₁ -C ₃ alkylamino group, a C ₂ -C ₄ alkanoylamino group, a carboxy group or a C ₁ -C ₄ alkoxycarbonyl group may be substituted, or

g) a pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl or triazinyl group formed by 1 to 3 C ₁ -C ₃ alkyl groups and / or a C ₁ -C ₃ alkoxy group, a hydroxy group, an amino group, a mono - Or di-C ₁ -C ₃ alkoxy group may be substituted, or

i) a C ₁ -C ₆ alkoxy group which is a C ₃ -C ₆ cycloalkyl group, one or two chlorine or bromine atoms, a C ₁ -C ₃ alkoxy group or a phenyl group which is formed by 1 to 2 C _j ^ - Alkyl, 1 to 2 C ₁ -C ₃ alkoxy, 1 to 2 fluorine, chlorine or bromine atoms, a trifluoromethyl radical or a nitro group may be substituted, or

j) a C ₃ -C ₆ alkenyloxy group which may be substituted by a phenyl group, or

k) a C ₃ -C ₆ alkynyloxy group which may be substituted by a phenyl radical, or l) a C ₃ -C ₆ cycloalkyloxy group which can be substituted by 1 to 2 C ₁ -C ₃ alkyl groups and / or 1 to 2 chlorine or bromine atoms, or

n) a C ₁ -C ₃ alkyl mercapto group, or

R ⁵

a) a hydrogen atom

b) a C ₁ -C ₆ -alkyl group which can be substituted by 1-3 fluorine, chlorine or bromine atoms, a hydroxyl, a cyano or carboxy group,

c) a halogen atom, or

d) a cyano, carboxy, nitro, nitroso, hydroxyl or amino group, which may be substituted by one or two C ₁ -C ₆ -alkyl radicals with one

Halogen atom or a hydroxy group may be substituted,

represents;

or a uracil derivative of the general formula II

in which A, B, D, R3, R4- and R ^ have the meanings given for formula I, R ^{15 is} a hydrogen atom, a C _1-4 -alkyl radical, a phenyl, a hydroxyl, a C _1-4 -alkoxy or a phenoxy group, the group R ¹⁸ -NH-CH ₂ -CH (OH} -CH ₂ O-, in which R ^{18 is} the isopropyl or tert-butyl group, a nitro, trifluoromethyl, carboxy, C ₁ -C ₄ -alkoxycarbonyl, aminocarbonyl or cyano group, a fluorine or chlorine group - or bromine atom, an amino, C _1-4 alkylamino, or di (C ₁ -C ₄ alkyl) amino group, a pyrrolidine, piperidine or morpholine residue, or the group -NH-CH ₂ - J, where J is a pyridyl, furyl, thienyl or phenyl radical, the phenyl radical being substituted by 1 to 3 radicals from the group halogen, hydroxy, C ₁ -C ₄ -alkoxy) carbonyl or C ₁ -C ₄ -alkyl can be,

or a group -NHL, in which L is a 5- or 6-membered heterocyclic group which has 1 N, 0 or S atom and optionally 1 to 2 further N atoms, the heterocyclic group consisting of a radical the group cyano, hydroxy, C ₁ -C ₄ alkoxy, amino, C ₁ -C ₄ alkylamino, di (C ₁ -C ₄ alkyl) amino, (C ₁ -C ₄ alkoxy) carbonyl, aminocarbonyl or C ₁ -C ₄ alkanoyl or by 1 to 3 C ₁ -C ₄ alkyl groups, it being possible for one of these C ₁ -C ₄ alkyl groups to be substituted by a hydroxyl group or the radical R ¹⁹ R ²⁰ N, where R ¹⁹ and R ²⁰ independently of one another represent hydrogen atoms, C ₁ -C ₄ alkyl radicals, benzyl or phenethyl groups or the group R ¹⁹ R ²⁰ N represents a pyrrolidine, piperidine or morpholine radical, can be substituted;

or a uracil derivative of the general formula III

in which R ³ , R ⁴ and R ⁵ , A and B have the meanings given for formula I,

R ^{19 is} a hydrogen atom, a C ₁ -C ₄ -alkyl group, a C ₁ -C ₄ -hydroxy-alkyl group, a C ₁ -C ₄ -alkanoyl-, a hydroxycarbonyl, a (C ₁ -C ₄ -alkoxy) carbonyl- , an aminocarbonyl, a cyano group or a group of formula IIIa

means where

R ^{23 represents} a hydrogen atom or a C ₁ -C ₆ alkyl group, or

R ²² and R ²³ together with the N atom to which they are attached represent a pyrrolidine, piperidine or piperazine residue which can be substituted by a phenyl group and / or a hydroxy group,

R ^{24 represents} a C ₁ -C ₄ alkyl idene group, and

or the physiologically tolerable salts of the compounds of the general formula I, II and III.

2. Composition according to claim 1, containing at least one uracil derivative of the general formula I.

in the

A and B either each represent a hydrogen atom or together form a bond,

D represents an oxygen atom, R ^{1 has} the following meaning:

a) a hydrogen atom or

in which the dashed line can mean an additional bond, and R ^{6 is} a hydrogen atom, a methyl group, a phenyl group which may optionally be substituted by 1 or 2 methyl, methoxy groups or chlorine atoms, or a group of the formula R ⁸ R ⁹ N means in which R ^{8 represents} a hydrogen atom or a phenyl group and R9 represents a propionyl or benzoyl group or R ⁸ and R ⁹ together with the nitrogen atom form a benzimidazol-2-one-1-yl group, R ^{7 represents} a hydrogen atom, a methyl represents a hydroxy, an acetyl, an ethoxycarbonyl or a cyano group,

m stands for 1, or

a group of formula Ib

p represents the number 2, or a group of formula Ic,

a group of formula Id,

where n is the number 2, or

a group of formula Ie, wherein G represents a hydrogen atom and the heterocyclic ring can be substituted by 1 to 2 C ₁ -C ₄ alkyl groups, or

c) a C ₂ -C ₄ alkenyl group which can be substituted by a phenyl group, or

d) a C ₃ -C ₄ alkynyl group or

f) a phenyl group which can be substituted by 1 to 2 methyl groups, 1 to 2 methoxy groups, 1 to 2 chlorine atoms, a carboxy group or an ethoxycarbonyl group, or g) a pyridyl group, which can be substituted by 1 to 3 methyl groups, or

k) a C ₃ -C ₄ alkynyloxy group, which can be substituted by a phenyl radical, or

l) a C ₃ -C ₆ cycloalkoxy group or

m) a phenoxy group or

n) a methyl mercapto group or

R ^{2 represents} a hydrogen atom

or R ¹ and R ² together form a C ₂ -C ₄ alkylidene group which can be substituted by 1 to 2 methyl groups,

R ³ and R ⁴ independently represent

a) a hydrogen atom or

in which the dashed line can mean an additional bond, and R ^{6 is} a hydrogen atom, a methyl group, a phenyl group which may optionally be substituted by 1 or 2 methyl, methoxy groups or chlorine atoms, or a group of the formula R ⁸ R ⁹ N means in which R ^{8 represents} a hydrogen atom or a phenyl group and R ^{9 represents} a propionyl or benzoyl group or R ⁸ and R ⁹ together with the nitrogen atom form an 8enzimidazol-2-one-1-yl group, R ^{7 represents} a hydrogen atom, a Is methyl, a hydroxy, an acetyl, an ethoxycarbonyl or a cyano group,

m stands for 1 or

a group of the formula Ig,

p represents the number 2, or

a group of the formula Ih

c) a C ₂ -C ₄ alkenyl group which can be substituted by a phenyl group, or

d) a C ₃ -C ₄ alkynyl group or e) a C ₃ -C ₆ cycloalkyl group which can be substituted by 1 to 2 methyl groups and / or 1 to 2 chlorine atoms and / or a phenyl group, or

g) a pyridyl group, which can be substituted by 1 to 3 methyl groups, or

1) a C ₃ -C ₆ cycloalkoxy group or

m) a phenoxy group or

n) a methyl mercapto group or

R ⁵

a) a hydrogen atom

represents;

or a uracil derivative of the general formula II

in the

A, B, D, R ³ , R ⁴ and R ^{5 have} the meanings given for formula I in this claim; and

R ¹⁵

a) a hydrogen atom

b) a C ₁ -C ₄ alkyl radical,

d) a piperidine residue

e) the group NHCH ₂ J, where J is a pyridyl, furyl, thionyl or phenyl radical,

represents; or a uracil derivative of the general formula III

in the

the rest

in total stands for one of the following radicals: an imidazol-1-yl radical which can be substituted by 1-3 methyl groups or a hydroxymethyl group,

or a 1,2,4-triazol-1-yl radical, a pyrazol-1-yl radical, or a pyrrol-1-yl radical which is represented by a hydroxymethyl group, a formyl group, an acetyl group or a group of the formula purple,

is substituted, in which R ^{22 represents} a C ₁ -C ₃ alkyl, a benzyl, a C ₁ -C ₄ alkanoyl or a benzoyl group, R ^{23 represents} a hydrogen atom or a C ₁ -C ₆ alkyl group , or R ²² and R ²³ together with the N atom represent a piperidine or piperazine residue which is substituted by a phenyl group, and

R24 ^{* represents} a C ₁ -C ₃ alkylidene group;

3. Composition according to one of claims 1 or 2 in the form of animal feed,

Drinking water for animals, additive for animal feed and drinking water or in the form of a praetnix.

4. Use of the uracil derivatives of the general formulas I, II and III according to one of claims 1 to 2 for increasing performance in animal breeding, in particular for promoting growth, improving feed conversion, increasing the protein content and / or reducing the fat content in animals.