EG24407A - Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors - Google Patents
Carboxyaryl substituted diphenyl ureas as raf kinase inhibitorsInfo
- Publication number
- EG24407A EG24407A EG20000039A EG20000039A EG24407A EG 24407 A EG24407 A EG 24407A EG 20000039 A EG20000039 A EG 20000039A EG 20000039 A EG20000039 A EG 20000039A EG 24407 A EG24407 A EG 24407A
- Authority
- EG
- Egypt
- Prior art keywords
- kinase inhibitors
- raf kinase
- substituted diphenyl
- diphenyl ureas
- carboxyaryl substituted
- Prior art date
Links
- 235000010290 biphenyl Nutrition 0.000 title 1
- 239000004305 biphenyl Substances 0.000 title 1
- 235000013877 carbamide Nutrition 0.000 title 1
- 125000005026 carboxyaryl group Chemical group 0.000 title 1
- -1 diphenyl ureas Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 102000009929 raf Kinases Human genes 0.000 title 1
- 108010077182 raf Kinases Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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TW200530236A (en) * | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
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EP1797037B1 (en) * | 2004-09-29 | 2014-12-17 | Bayer HealthCare LLC | Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenyoxy}n-methylpyridine-2-carboxamide |
DE102005015253A1 (en) * | 2005-04-04 | 2006-10-05 | Merck Patent Gmbh | New pyrazole derivatives are tyrosine kinase inhibitors useful to treat e.g. solid tumors, diabetic retinopathy, age-related macular degeneration or inflammatory disease, osteoarthritis and rickets |
EP1973897B1 (en) | 2005-12-21 | 2014-05-21 | Bayer Intellectual Property GmbH | Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders |
WO2008044688A1 (en) * | 2006-10-11 | 2008-04-17 | Daiichi Sankyo Company, Limited | Urea derivative |
EP2136809A4 (en) * | 2007-03-20 | 2012-01-04 | Curis Inc | Raf kinase inhibitors containing a zinc binding moiety |
JP5438680B2 (en) * | 2007-09-10 | 2014-03-12 | シプラ・リミテッド | Process for producing Raf kinase inhibitor and intermediate used in the process |
CN101372475B (en) * | 2008-03-19 | 2012-01-04 | 南京工业大学 | Aromatic heterocyclic substituted diphenyl urea derivative and application thereof |
CN101298427B (en) * | 2008-06-26 | 2012-03-21 | 中国科学院广州生物医药与健康研究院 | Diaryl urea compound and use thereof |
TW201012467A (en) | 2008-09-16 | 2010-04-01 | Taiho Pharmaceutical Co Ltd | Antitumor agent containing 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoic acid |
CN103254126A (en) * | 2008-09-19 | 2013-08-21 | 苏州泽璟生物制药有限公司 | Deuterated omega-diphenyl carbamide as well as derivative and pharmaceutical composition including compounds |
CN101362717B (en) * | 2008-09-28 | 2013-02-06 | 四川大学 | 4-(4-amidoanilino)-2-(methylcarbamoyl) pyridine, derivates thereof and preparation, application thereof |
JO3101B1 (en) * | 2008-12-02 | 2017-09-20 | Takeda Pharmaceuticals Co | Benzothiazole derivatives as anticancer agents |
WO2010083649A1 (en) * | 2009-01-22 | 2010-07-29 | 沈阳药科大学 | Bisarylurea derivatives and their use |
US9181238B2 (en) * | 2010-02-05 | 2015-11-10 | Novartis Ag | N-(pyridin-2-yl)sulfonamides and compositions thereof as protein kinase inhibitors |
CN102219733A (en) * | 2010-04-14 | 2011-10-19 | 上海医药工业研究院 | Method for preparing sorafenib |
CN101830847B (en) * | 2010-05-18 | 2012-10-10 | 张南 | Anticancer compound and preparation method thereof |
CN102617458A (en) * | 2010-05-18 | 2012-08-01 | 张南 | Preparation method for anticancer compound |
SG189038A1 (en) * | 2010-10-01 | 2013-05-31 | Bayer Ip Gmbh | Substituted n-(2-arylamino)aryl sulfonamide-containing combinations |
US8937088B2 (en) * | 2011-01-06 | 2015-01-20 | Astar Biotech Llc | Ureas for the treatment and prevention of cancer |
CN102875460A (en) * | 2012-05-17 | 2013-01-16 | 上海奥博生物医药技术有限公司 | Method for preparing sorafenib |
CN103508961B (en) * | 2012-06-26 | 2015-07-22 | 中美冠科生物技术(太仓)有限公司 | Antitumor drug |
CN103408488A (en) * | 2013-08-13 | 2013-11-27 | 张家港威胜生物医药有限公司 | Optimal synthetic method of sorafenib |
CN103435553A (en) * | 2013-09-16 | 2013-12-11 | 中国药科大学 | Piperazine structure-based aryl formamide Raf kinase inhibitor and preparation method as well as application thereof |
CN104672129B (en) * | 2013-11-26 | 2019-06-25 | 广东东阳光药业有限公司 | A kind of preparation method of carbamide compounds |
CN106866623A (en) | 2014-04-08 | 2017-06-20 | 北大方正集团有限公司 | Polysubstituted pyridine compounds, preparation method, purposes and pharmaceutical composition |
CN104177292A (en) * | 2014-08-08 | 2014-12-03 | 亿腾药业(泰州)有限公司 | Method for industrial production of sorafenib tosylate polymorphic form I |
WO2016049774A1 (en) * | 2014-10-03 | 2016-04-07 | The Royal Institution For The Advancement Of Learning/Mcgill University | Urea and bis-urea based compounds and analogues thereof useful in the treatment of androgen receptor mediated diseases or disorders |
CN105348186B (en) * | 2015-10-15 | 2018-05-22 | 青岛海洋生物医药研究院股份有限公司 | Deuterated substituted bisarylurea compound and preparation method thereof and the application in anti-tumor drug is prepared |
CN105753841B (en) * | 2016-01-18 | 2018-01-05 | 西安交通大学 | A kind of N indazoles substituting thioureido analog derivative and its preparation method and application |
CN105924390B (en) * | 2016-05-19 | 2018-07-10 | 广州南新制药有限公司 | A kind of synthetic method of Mei Tafeini |
CN106699652B (en) * | 2016-11-07 | 2020-11-13 | 天津大学 | Sorafenib alpha-aminobutyrate and preparation method thereof |
CN108264510A (en) | 2017-01-02 | 2018-07-10 | 上海喆邺生物科技有限公司 | A kind of selective depression kinases compound and application thereof |
CN107417604A (en) * | 2017-07-25 | 2017-12-01 | 新发药业有限公司 | Benzamide compound of 4 substituted pyridines 2 and preparation method and application |
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