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BRPI0007487B8 - diphenyl-ureas substituted with w-carboxy-aryls as raf kinase inhibitors - Google Patents

diphenyl-ureas substituted with w-carboxy-aryls as raf kinase inhibitors

Info

Publication number
BRPI0007487B8
BRPI0007487B8 BRPI0007487A BR0007487A BRPI0007487B8 BR PI0007487 B8 BRPI0007487 B8 BR PI0007487B8 BR PI0007487 A BRPI0007487 A BR PI0007487A BR 0007487 A BR0007487 A BR 0007487A BR PI0007487 B8 BRPI0007487 B8 BR PI0007487B8
Authority
BR
Brazil
Prior art keywords
aryls
diphenyl
carboxy
kinase inhibitors
raf kinase
Prior art date
Application number
BRPI0007487A
Other languages
Portuguese (pt)
Other versions
BRPI0007487B1 (en
BR0007487A (en
Inventor
Riedl Bernd
Dumas Jacques
E Wood Jill
Renick Joel
Monahan Mary-Katherine
Natero Reina
N Sibley Robert
A Smith Roger
B Lowinger Timothy
Khire Uday
J Scott William
Original Assignee
Bayer Healthcare Llc
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27381740&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0007487(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Healthcare Llc, Bayer Corp filed Critical Bayer Healthcare Llc
Priority claimed from PCT/US2000/000648 external-priority patent/WO2000042012A1/en
Publication of BR0007487A publication Critical patent/BR0007487A/en
Publication of BRPI0007487B1 publication Critical patent/BRPI0007487B1/en
Publication of BRPI0007487B8 publication Critical patent/BRPI0007487B8/en

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
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    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
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    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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Abstract

"difenil-uréias substituídas com <sym>-carbóxi-arilas como inibidores de raf cinase". esta invenção refere-se ao uso de um grupo de aril-uréias para tratar doenças mediadas por raf, e composições farmacêuticas para uso nessa terapia."diphenyl-ureas substituted with <sym>-carboxy-aryls as raf kinase inhibitors". this invention relates to the use of a group of aryl ureas to treat raf-mediated diseases, and pharmaceutical compositions for use in such therapy.

BRPI0007487A 1999-01-13 2000-01-12 diphenyl-ureas substituted with w-carboxy-aryls as raf kinase inhibitors BRPI0007487B8 (en)

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US11587799P 1999-01-13 1999-01-13
US25726699A 1999-02-25 1999-02-25
US42522899A 1999-10-22 1999-10-22
PCT/US2000/000648 WO2000042012A1 (en) 1999-01-13 2000-01-12 φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS

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BR0007487A BR0007487A (en) 2003-09-23
BRPI0007487B1 BRPI0007487B1 (en) 2015-07-07
BRPI0007487B8 true BRPI0007487B8 (en) 2021-05-25

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CZ299125B6 (en) 2008-04-30
CN1219764C (en) 2005-09-21
CA2359510C (en) 2007-02-13
HRP20010580B1 (en) 2010-07-31
HU0600871D0 (en) 2007-01-29
MEP36908A (en) 2011-02-10
CY1110177T1 (en) 2015-01-14
HK1045504B (en) 2006-04-07
LU91280I2 (en) 2006-12-13
RS51497B (en) 2011-04-30
BRPI0007487B1 (en) 2015-07-07
HU230863B1 (en) 2018-10-29
NO20013463D0 (en) 2001-07-12
AU2501600A (en) 2000-08-01
EG24407A (en) 2009-05-20
PL360085A1 (en) 2004-09-06
EE04913B1 (en) 2007-10-15
DE60044004D1 (en) 2010-04-22
HUP0300866A3 (en) 2006-04-28
CZ20012489A3 (en) 2002-01-16
HK1045504A1 (en) 2002-11-29
IL144030A (en) 2010-06-30
HUP0300866A2 (en) 2003-07-28
BRPI0017535B8 (en) 2021-09-14
JO2373B1 (en) 2006-12-12
IL144030A0 (en) 2002-04-21
CA2359510A1 (en) 2000-07-20
NO20055863L (en) 2001-09-12
NO321059B1 (en) 2006-03-06
ATE321027T1 (en) 2006-04-15
MA26038A1 (en) 2004-04-01
TR200102020T2 (en) 2003-01-21
HU225780B1 (en) 2007-08-28
NL300242I2 (en) 2007-04-02
AR035310A1 (en) 2004-05-12
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CN100522934C (en) 2009-08-05
BR0007487A (en) 2003-09-23
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CZ302846B6 (en) 2011-12-14
GT200000002AA (en) 2007-06-15
HK1087689A1 (en) 2006-10-20
JP2003526613A (en) 2003-09-09
KR20010103738A (en) 2001-11-23
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