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EG20055A - Process for preparing of substituted isoquinolines and methods of using same - Google Patents

Process for preparing of substituted isoquinolines and methods of using same

Info

Publication number
EG20055A
EG20055A EG26790A EG26790A EG20055A EG 20055 A EG20055 A EG 20055A EG 26790 A EG26790 A EG 26790A EG 26790 A EG26790 A EG 26790A EG 20055 A EG20055 A EG 20055A
Authority
EG
Egypt
Prior art keywords
preparing
methods
same
substituted isoquinolines
isoquinolines
Prior art date
Application number
EG26790A
Other languages
English (en)
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Application granted granted Critical
Publication of EG20055A publication Critical patent/EG20055A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
EG26790A 1989-09-19 1990-05-06 Process for preparing of substituted isoquinolines and methods of using same EG20055A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/409,521 US4956371A (en) 1989-09-19 1989-09-19 Substituted isoquinolines and methods of using same

Publications (1)

Publication Number Publication Date
EG20055A true EG20055A (en) 1997-03-27

Family

ID=23620860

Family Applications (1)

Application Number Title Priority Date Filing Date
EG26790A EG20055A (en) 1989-09-19 1990-05-06 Process for preparing of substituted isoquinolines and methods of using same

Country Status (17)

Country Link
US (2) US4956371A (xx)
EP (1) EP0422328A3 (xx)
JP (1) JPH03145469A (xx)
KR (1) KR940000162B1 (xx)
CN (1) CN1050381A (xx)
AR (1) AR248131A1 (xx)
AU (1) AU627622B2 (xx)
CA (1) CA2013961A1 (xx)
EG (1) EG20055A (xx)
FI (1) FI904447A0 (xx)
IE (1) IE902837A1 (xx)
IL (1) IL93857A (xx)
NO (1) NO177096C (xx)
NZ (1) NZ233059A (xx)
PH (1) PH26429A (xx)
PT (1) PT95361A (xx)
ZA (1) ZA902344B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680510B1 (fr) * 1991-08-20 1995-06-23 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
ES2104862T3 (es) * 1991-02-07 1997-10-16 Roussel Uclaf Derivados biciclicos nitrogenados, su procedimiento de preparacion, sus productos intermedios obtenidos, su aplicacion como medicamentos y composiciones farmaceuticas que los contienen.
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
FR2672595B1 (fr) * 1991-02-07 1995-05-19 Roussel Uclaf Nouveaux derives bicycliques azotes substitues par un radical benzyle, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments.
FR2680509B1 (fr) * 1991-08-20 1995-07-28 Roussel Uclaf Derives bicycliques azotes substitues par un radical benzyle, leur procede de preparation, les intermediaires obtenus, leur application a titre de medicaments et les compositions les renfermant .
FR2672596B1 (fr) * 1991-02-07 1995-07-13 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
CA2103367A1 (en) * 1991-05-20 1992-11-21 Akihide Koda Phellodendrine analogs and allergy type iv suppressor containing the same as active ingredient
JP3276762B2 (ja) * 1993-12-28 2002-04-22 日本臓器製薬株式会社 イソキノリン誘導体を含有する医薬組成物
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
JP2001506653A (ja) 1996-12-18 2001-05-22 ニューロゲン コーポレイション Ｃｒｆレセプターと相互作用するイソキノリナミン及びフタルアジナミン誘導体
AU2002211621A1 (en) 2000-10-10 2002-04-22 Calyx Therapeutics, Inc. Tricyclic compounds and uses thereof
WO2008020302A2 (en) * 2006-08-17 2008-02-21 Pfizer Products Inc. Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors
JP2008302070A (ja) 2007-06-08 2008-12-18 Tokai Ind Sewing Mach Co Ltd 刺繍ミシン及びその制御方法
CN109810171B (zh) * 2017-11-21 2020-12-01 首都医科大学 二氢异喹啉-3-甲酰-LARGD(aa)aa,其制备,抗静脉血栓活性和应用
CA3166527A1 (en) * 2020-01-29 2021-08-05 Charbel MOUSSA Compositions and methods for treating neurodegenerative, neurodevelopmental, myodegenerative, and lysosomal storage disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5637229B2 (xx) * 1972-08-15 1981-08-29
GB1453606A (en) * 1972-12-22 1976-10-27 Siphar Sa Method for synthesis of plus-minus-glaziovine
FR2257275A1 (en) * 1974-01-16 1975-08-08 Houdet Antoine Alkaloid salts of para chlorophenoxy isobutyric acid - useful for inhibiting thromboses and as hyperlipaemics
FR2368277A1 (fr) * 1976-10-21 1978-05-19 Sobio Lab Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique
DE2717001C2 (de) * 1977-04-18 1984-06-20 Karl O. Helm Ag, 2000 Hamburg Arzneimittel mit antithrombotischer Wirkung
US4115389A (en) * 1977-05-02 1978-09-19 Bristol-Myers Company Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
HU183479B (en) * 1981-06-16 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 6,7-diethoxy-1-aracket-4-ethoxy-3-hydroxy-benzyl-bracket closed-3,4-dihydroisoquinolin
DE3233424A1 (de) * 1982-09-09 1984-03-15 Hoechst Ag, 6230 Frankfurt Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
DK8386A (da) * 1986-01-15 1987-07-09 Tpo Pharmachim Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme
JPS63174932A (ja) * 1987-01-16 1988-07-19 Kaken Shiyouyaku Kk 抗血小板凝集剤
GB8800397D0 (en) * 1988-01-08 1988-02-10 Sandoz Ltd Improvements in/relating to organic compounds

Also Published As

Publication number Publication date
IL93857A (en) 1994-11-28
PH26429A (en) 1992-07-15
CN1050381A (zh) 1991-04-03
FI904447A0 (fi) 1990-09-10
IL93857A0 (en) 1990-12-23
EP0422328A3 (en) 1991-10-02
ZA902344B (en) 1991-01-30
IE902837A1 (en) 1991-03-27
AR248131A1 (es) 1995-06-30
NO177096C (no) 1995-07-26
AU6265290A (en) 1991-03-28
KR910006235A (ko) 1991-04-27
PT95361A (pt) 1991-07-05
NO904059L (no) 1991-03-20
NO177096B (no) 1995-04-10
US4956371A (en) 1990-09-11
AU627622B2 (en) 1992-08-27
KR940000162B1 (ko) 1994-01-08
NO904059D0 (no) 1990-09-18
USRE34630E (en) 1994-06-07
CA2013961A1 (en) 1991-03-19
JPH03145469A (ja) 1991-06-20
EP0422328A2 (en) 1991-04-17
NZ233059A (en) 1991-10-25

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