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NO904059D0 - Fremgangsmaate for fremstilling av nye substituerte isokinoliner. - Google Patents

Fremgangsmaate for fremstilling av nye substituerte isokinoliner.

Info

Publication number
NO904059D0
NO904059D0 NO904059A NO904059A NO904059D0 NO 904059 D0 NO904059 D0 NO 904059D0 NO 904059 A NO904059 A NO 904059A NO 904059 A NO904059 A NO 904059A NO 904059 D0 NO904059 D0 NO 904059D0
Authority
NO
Norway
Prior art keywords
isokinolines
procedure
preparation
new substituted
substituted
Prior art date
Application number
NO904059A
Other languages
English (en)
Other versions
NO177096B (no
NO904059L (no
NO177096C (no
Inventor
T Scott Shoupe
Lloyd J Dolby
Stephen M Coutts
Original Assignee
Euro Celtique Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique Sa filed Critical Euro Celtique Sa
Publication of NO904059D0 publication Critical patent/NO904059D0/no
Publication of NO904059L publication Critical patent/NO904059L/no
Publication of NO177096B publication Critical patent/NO177096B/no
Publication of NO177096C publication Critical patent/NO177096C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18Aralkyl radicals
    • C07D217/20Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24Oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NO904059A 1989-09-19 1990-09-18 Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinoliner NO177096C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/409,521 US4956371A (en) 1989-09-19 1989-09-19 Substituted isoquinolines and methods of using same

Publications (4)

Publication Number Publication Date
NO904059D0 true NO904059D0 (no) 1990-09-18
NO904059L NO904059L (no) 1991-03-20
NO177096B NO177096B (no) 1995-04-10
NO177096C NO177096C (no) 1995-07-26

Family

ID=23620860

Family Applications (1)

Application Number Title Priority Date Filing Date
NO904059A NO177096C (no) 1989-09-19 1990-09-18 Analogifremgangsmåte for fremstilling av terapeutisk aktive, substituerte isokinoliner

Country Status (17)

Country Link
US (2) US4956371A (no)
EP (1) EP0422328A3 (no)
JP (1) JPH03145469A (no)
KR (1) KR940000162B1 (no)
CN (1) CN1050381A (no)
AR (1) AR248131A1 (no)
AU (1) AU627622B2 (no)
CA (1) CA2013961A1 (no)
EG (1) EG20055A (no)
FI (1) FI904447A0 (no)
IE (1) IE902837A1 (no)
IL (1) IL93857A (no)
NO (1) NO177096C (no)
NZ (1) NZ233059A (no)
PH (1) PH26429A (no)
PT (1) PT95361A (no)
ZA (1) ZA902344B (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680510B1 (fr) * 1991-08-20 1995-06-23 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2672595B1 (fr) * 1991-02-07 1995-05-19 Roussel Uclaf Nouveaux derives bicycliques azotes substitues par un radical benzyle, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments.
MX9200299A (es) * 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
FR2680509B1 (fr) * 1991-08-20 1995-07-28 Roussel Uclaf Derives bicycliques azotes substitues par un radical benzyle, leur procede de preparation, les intermediaires obtenus, leur application a titre de medicaments et les compositions les renfermant .
FR2672596B1 (fr) * 1991-02-07 1995-07-13 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
JP3531944B2 (ja) * 1991-02-07 2004-05-31 アベンティス・ファーマ・ソシエテ・アノニム 新規のベンジル基で置換された窒素系二環式誘導体及びその製造方法
CA2103367A1 (en) * 1991-05-20 1992-11-21 Akihide Koda Phellodendrine analogs and allergy type iv suppressor containing the same as active ingredient
JP3276762B2 (ja) * 1993-12-28 2002-04-22 日本臓器製薬株式会社 イソキノリン誘導体を含有する医薬組成物
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
GB9622386D0 (en) * 1996-10-28 1997-01-08 Sandoz Ltd Organic compounds
AU5614198A (en) * 1996-12-18 1998-07-15 Neurogen Corporation Isoquinolinamine and phthalazinamine derivatives which interact with crf receptors
JP2004511465A (ja) 2000-10-10 2004-04-15 カリックス セラピューティックス インコーポレイテッド 三環式化合物およびその使用
WO2008020302A2 (en) * 2006-08-17 2008-02-21 Pfizer Products Inc. Heteroaromatic quinoline-based compounds as phosphodiesterase (pde) inhibitors
JP2008302070A (ja) 2007-06-08 2008-12-18 Tokai Ind Sewing Mach Co Ltd 刺繍ミシン及びその制御方法
CN109810171B (zh) * 2017-11-21 2020-12-01 首都医科大学 二氢异喹啉-3-甲酰-LARGD(aa)aa,其制备,抗静脉血栓活性和应用
EP4096666A4 (en) * 2020-01-29 2024-05-22 Georgetown University COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE, NEURODEVELOPMENTAL, MYODEGENERATIVE AND LYSOSOMAL STORAGE DISORDERS

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5637229B2 (no) * 1972-08-15 1981-08-29
GB1453606A (en) * 1972-12-22 1976-10-27 Siphar Sa Method for synthesis of plus-minus-glaziovine
FR2257275A1 (en) * 1974-01-16 1975-08-08 Houdet Antoine Alkaloid salts of para chlorophenoxy isobutyric acid - useful for inhibiting thromboses and as hyperlipaemics
FR2368277A1 (fr) * 1976-10-21 1978-05-19 Sobio Lab Nouveaux derives hydrogenes de l'isoquinoleine, ayant une activite vasoactive et spasmolytique
DE2717001C2 (de) * 1977-04-18 1984-06-20 Karl O. Helm Ag, 2000 Hamburg Arzneimittel mit antithrombotischer Wirkung
US4115389A (en) * 1977-05-02 1978-09-19 Bristol-Myers Company Process of N-demethylating (-)-1-(p-methoxybenzyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
HU183479B (en) * 1981-06-16 1984-05-28 Chinoin Gyogyszer Es Vegyeszet Process for producing new 6,7-diethoxy-1-aracket-4-ethoxy-3-hydroxy-benzyl-bracket closed-3,4-dihydroisoquinolin
DE3233424A1 (de) * 1982-09-09 1984-03-15 Hoechst Ag, 6230 Frankfurt Isochinolinderivate, verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
DK8386A (da) * 1986-01-15 1987-07-09 Tpo Pharmachim Nye n-substituerede 1-benzyl-2-carbamoyltetrahydroisoquinoliner og fremgangsmaade til fremstilling af samme
JPS63174932A (ja) * 1987-01-16 1988-07-19 Kaken Shiyouyaku Kk 抗血小板凝集剤
GB8800397D0 (en) * 1988-01-08 1988-02-10 Sandoz Ltd Improvements in/relating to organic compounds

Also Published As

Publication number Publication date
IL93857A (en) 1994-11-28
JPH03145469A (ja) 1991-06-20
KR940000162B1 (ko) 1994-01-08
EG20055A (en) 1997-03-27
NO177096B (no) 1995-04-10
FI904447A0 (fi) 1990-09-10
PT95361A (pt) 1991-07-05
NO904059L (no) 1991-03-20
KR910006235A (ko) 1991-04-27
NZ233059A (en) 1991-10-25
US4956371A (en) 1990-09-11
CA2013961A1 (en) 1991-03-19
EP0422328A3 (en) 1991-10-02
CN1050381A (zh) 1991-04-03
PH26429A (en) 1992-07-15
IE902837A1 (en) 1991-03-27
AU627622B2 (en) 1992-08-27
IL93857A0 (en) 1990-12-23
USRE34630E (en) 1994-06-07
ZA902344B (en) 1991-01-30
AR248131A1 (es) 1995-06-30
NO177096C (no) 1995-07-26
EP0422328A2 (en) 1991-04-17
AU6265290A (en) 1991-03-28

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