EE05398B1 - Amlodipiinbenseensulfonaadi valmistamise meetod - Google Patents

Amlodipiinbenseensulfonaadi valmistamise meetod

Info

Publication number: EE05398B1
Authority: EE; Estonia
Prior art keywords: preparation; methyl; amlodipine benzenesulfonate; formula; amalodipine
Prior art date: 1999-07-05

Application number

EEP200100686A

Other languages

English (en)

Estonian (et)

Inventor

βnos Fischer J

Sz�ke Katalin

βszl� Dobay L

βndor L�vai S

Original Assignee

Richter Gedeon Vegy�szeti Gy βr Rt.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-05

Filing date

1999-07-05

Publication date

2011-04-15

1999-07-05 Application filed by Richter Gedeon Vegy�szeti Gy βr Rt. filed Critical Richter Gedeon Vegy�szeti Gy βr Rt.

2003-04-15 Publication of EE200100686A publication Critical patent/EE200100686A/xx

2011-04-15 Publication of EE05398B1 publication Critical patent/EE05398B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicinal Preparation (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Pyridine Compounds (AREA)

EEP200100686A 1999-07-05 1999-07-05 Amlodipiinbenseensulfonaadi valmistamise meetod EE05398B1 (et)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/HU1999/000050 WO2001002360A1 (en)	1999-07-05	1999-07-05	Process for preparing amlodipine benzenesulphonate

Publications (2)

Publication Number	Publication Date
EE200100686A EE200100686A (et)	2003-04-15
EE05398B1 true EE05398B1 (et)	2011-04-15

Family

ID=10991279

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100686A EE05398B1 (et)	1999-07-05	1999-07-05	Amlodipiinbenseensulfonaadi valmistamise meetod

Country Status (24)

Country	Link
US (1)	US6596874B1 (xx)
EP (1)	EP1196383B1 (xx)
JP (1)	JP3764386B2 (xx)
KR (1)	KR100585442B1 (xx)
CN (1)	CN1141297C (xx)
AT (1)	ATE283841T1 (xx)
AU (1)	AU777565B2 (xx)
BG (1)	BG65657B1 (xx)
CA (1)	CA2376540C (xx)
CZ (1)	CZ300509B6 (xx)
DE (1)	DE69922417T2 (xx)
DK (1)	DK1196383T3 (xx)
EA (1)	EA004208B1 (xx)
EE (1)	EE05398B1 (xx)
ES (1)	ES2234272T3 (xx)
HK (1)	HK1044151B (xx)
MX (1)	MXPA01013407A (xx)
NO (1)	NO321714B1 (xx)
NZ (1)	NZ517013A (xx)
PL (1)	PL194193B1 (xx)
PT (1)	PT1196383E (xx)
SK (1)	SK285611B6 (xx)
UA (1)	UA72768C2 (xx)
WO (1)	WO2001002360A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100354806B1 (ko) *	2000-06-21	2002-10-05	한국유나이티드제약 주식회사	암로디핀 베실레이트의 신규 중간체 및 그의 제조방법
WO2003004025A1 (en) *	2001-07-06	2003-01-16	Lek Pharmaceutical And Chemical Company D.D.	High purity amlodipine benzenesulfonate and a process for its preparation
US6680334B2 (en)	2001-08-28	2004-01-20	Pfizer Inc	Crystalline material
AR037565A1 (es) *	2001-11-21	2004-11-17	Synthon Bv	Formas de sales de amlodipina y procedimientos para prepararlas.
KR100496436B1 (ko) *	2002-07-30	2005-06-20	씨제이 주식회사	암로디핀의 유기산염
KR100462304B1 (ko) *	2002-07-30	2004-12-17	씨제이 주식회사	암로디핀의 유기산염
KR100467669B1 (ko) *	2002-08-21	2005-01-24	씨제이 주식회사	암로디핀의 유기산염
US6784297B2 (en)	2002-09-04	2004-08-31	Kopran Limited	Process for the preparation of anti-ischemic and anti-hypertensive drug amlodipine besylate
JP2008013489A (ja) *	2006-07-06	2008-01-24	Ohara Yakuhin Kogyo Kk	ベシル酸アムロジピン含有錠剤
EP1975167A1 (en)	2007-03-30	2008-10-01	Esteve Quimica, S.A.	Acetone solvate of phthaloyl amlodipine
CN101812014B (zh) *	2010-04-28	2011-08-24	王明	一种苯磺酸氨氯地平化合物及其制法
CN102993083A (zh) *	2012-12-21	2013-03-27	王学军	一种苯磺酸氨氯地平的制备方法
CN104262237A (zh) *	2014-09-28	2015-01-07	常州瑞明药业有限公司	氨氯地平自由碱的合成方法
US11452690B1 (en)	2021-01-27	2022-09-27	ECI Pharmaceuticals, LLC	Oral liquid compositions comprising amlodipine besylate and methods of using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK161312C (da) *	1982-03-11	1991-12-09	Pfizer	Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8608335D0 (en)	1986-04-04	1986-05-08	Pfizer Ltd	Pharmaceutically acceptable salts
SI9200344B (sl)	1992-11-26	1998-06-30	Lek,	Postopek za pripravo amlodipin benzensulfonata
HU221810B1 (hu) *	1997-08-12	2003-01-28	EGIS Gyógyszergyár Rt.	Eljárás amlodipin-bezilát előállítására és az eljárás intermedierjei
DE19738943B4 (de)	1997-09-05	2008-01-03	Siemens Ag	Verfahren und Einrichtung zur Bestimmung von Eigenschaften eines Stahls

1999
- 1999-05-07 UA UA2002020897A patent/UA72768C2/uk unknown
- 1999-07-05 KR KR1020027000052A patent/KR100585442B1/ko not_active IP Right Cessation
- 1999-07-05 EA EA200200125A patent/EA004208B1/ru not_active IP Right Cessation
- 1999-07-05 AT AT99933061T patent/ATE283841T1/de active
- 1999-07-05 US US10/019,424 patent/US6596874B1/en not_active Expired - Lifetime
- 1999-07-05 CN CNB998167746A patent/CN1141297C/zh not_active Expired - Lifetime
- 1999-07-05 NZ NZ517013A patent/NZ517013A/en not_active IP Right Cessation
- 1999-07-05 DE DE69922417T patent/DE69922417T2/de not_active Expired - Lifetime
- 1999-07-05 PL PL99352493A patent/PL194193B1/pl unknown
- 1999-07-05 ES ES99933061T patent/ES2234272T3/es not_active Expired - Lifetime
- 1999-07-05 EE EEP200100686A patent/EE05398B1/xx unknown
- 1999-07-05 AU AU49237/99A patent/AU777565B2/en not_active Expired
- 1999-07-05 CA CA002376540A patent/CA2376540C/en not_active Expired - Lifetime
- 1999-07-05 EP EP99933061A patent/EP1196383B1/en not_active Expired - Lifetime
- 1999-07-05 CZ CZ20014690A patent/CZ300509B6/cs unknown
- 1999-07-05 PT PT99933061T patent/PT1196383E/pt unknown
- 1999-07-05 SK SK2-2002A patent/SK285611B6/sk not_active IP Right Cessation
- 1999-07-05 JP JP2001507800A patent/JP3764386B2/ja not_active Expired - Lifetime
- 1999-07-05 WO PCT/HU1999/000050 patent/WO2001002360A1/en active IP Right Grant
- 1999-07-05 DK DK99933061T patent/DK1196383T3/da active
- 1999-07-05 MX MXPA01013407A patent/MXPA01013407A/es not_active IP Right Cessation
2001
- 2001-12-03 BG BG106164A patent/BG65657B1/bg unknown
2002
- 2002-01-04 NO NO20020029A patent/NO321714B1/no not_active IP Right Cessation
- 2002-08-06 HK HK02105733.9A patent/HK1044151B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ517013A (en)	2003-08-29
DK1196383T3 (da)	2005-02-21
PT1196383E (pt)	2005-03-31
KR20020022760A (ko)	2002-03-27
ES2234272T3 (es)	2005-06-16
HK1044151B (zh)	2004-09-10
WO2001002360A1 (en)	2001-01-11
AU777565B2 (en)	2004-10-21
EA200200125A1 (ru)	2002-06-27
SK22002A3 (en)	2002-05-09
EE200100686A (et)	2003-04-15
CN1141297C (zh)	2004-03-10
CZ300509B6 (cs)	2009-06-03
NO20020029D0 (no)	2002-01-04
BG65657B1 (bg)	2009-05-29
HK1044151A1 (en)	2002-10-11
DE69922417T2 (de)	2005-12-01
NO321714B1 (no)	2006-06-26
MXPA01013407A (es)	2003-09-04
SK285611B6 (sk)	2007-04-05
ATE283841T1 (de)	2004-12-15
CA2376540A1 (en)	2001-01-11
CN1352634A (zh)	2002-06-05
PL352493A1 (en)	2003-08-25
EA004208B1 (ru)	2004-02-26
EP1196383A1 (en)	2002-04-17
EP1196383B1 (en)	2004-12-01
BG106164A (en)	2002-07-31
US6596874B1 (en)	2003-07-22
CZ20014690A3 (cs)	2002-04-17
DE69922417D1 (de)	2005-01-05
KR100585442B1 (ko)	2006-06-02
AU4923799A (en)	2001-01-22
JP2003503477A (ja)	2003-01-28
CA2376540C (en)	2007-03-13
PL194193B1 (pl)	2007-05-31
NO20020029L (no)	2002-03-05
UA72768C2 (en)	2005-04-15
JP3764386B2 (ja)	2006-04-05

Publication	Publication Date	Title
EE05398B1 (et)	2011-04-15	Amlodipiinbenseensulfonaadi valmistamise meetod
CY1106096T1 (el)	2011-06-08	Μεθοδος για την παρασκευη παραγωγων βενζοθειοφαινιου
PT923554E (pt)	2002-07-31	N-benzilpiperidina e derivados tetrahidropiridina
ES2195510T3 (es)	2003-12-01	Derivados de imidazopiridina y procedimiento para prepararlos.
IS6435A (is)	2002-06-19	Aðferð til framleiðslu á sítalóprami
NO20032731L (no)	2003-06-16	Fremgangsmåte for fremstilling av sulfonamid-substituerte imidazotriazinoner
NO20002490D0 (no)	2000-05-12	FremgangsmÕte for fremstilling av 1,4-dihydropyridiner og forbindelser anvendt ved denne fremgangsmÕten
PT1307423E (pt)	2008-06-09	Processos de produção da fexofenadina
DK1404642T3 (da)	2010-05-17	Fremgangsmåde til fremstillimg af 7-amino-syn-3,5-dihydroxyheptansyrederivater, mellemprodukter derfor og fremgangsmåder til deres fremstilling
EA200200939A1 (ru)	2003-02-27	Способ получения циталопрама
DK1105392T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af mellemprodukter for imidazodiazepin
NO20026198D0 (no)	2002-12-23	Cykliske ketoner, deres fremstilling og deres anvendelse ved syntese av aminosyrer
DK1581504T3 (da)	2009-06-29	Fremgangsmåde til fremstilling af subsituterede imidazolderivater og intermediater anvendt i fremgangsmåden
EA199900282A2 (ru)	1999-10-28	Способ получения феноксифенилсульфонилгалогенидов
TR200003360T2 (tr)	2001-06-21	Farmasotik norbenzomorfan türevleri imalatı için iyileştirilmiş yöntem
DE60127979D1 (de)	2007-05-31	Verfahren zur herstellung von 3,5-bisalkylphenolen
ATE479661T1 (de)	2010-09-15	Verfahren zur herstellung von pestiziden verbindungen
WO1999057095A3 (en)	2000-01-13	Process for the preparation of a pharmaceutical intermediate
DK1320527T3 (da)	2008-12-01	Fremgangsmåde til fremstilling af 1-substituerede 5-chlor-4-methylpytrazoler
TR200001161A2 (tr)	2000-12-21	8-Siklopentil-6-etil-3-[ikame edilmiş]-5, 8-Dihidro-4H-1, 2, 3A, 7, 8-Pentaaza-As-Indasenlerin hazırlandığı işlem ve burada yararlı ara bağlar.
UA33033A (uk)	2001-02-15	Спосіб одержання безилату амлодипіну
HUP0002772A2 (hu)	2000-12-28	Eljárás királis 3,4-dehidroprolinok előállítására
DK1163257T3 (da)	2003-03-03	Fremgangsmåde til fremstilling af 4,4-dimethyl-3beta-hydroxypregna-8,14-dien-21-carboxylsyreestere og mellemprodukter i fremgangsmåden
TH52886A3 (th)	2002-09-04	กรรมวิธีที่ปรับปรุงดีขึ้นสำหรับการเตรียมอนุพันธ์ของนอร์เบนโซมอร์เฟนที่ใช้ประโยชน์ทางเภสัชวิทยา