EE04673B1 - Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid - Google Patents

Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid

Info

Publication number: EE04673B1
Authority: EE; Estonia
Prior art keywords: pharmaceuticals; preparation; pharmaceutical compositions; compositions containing; quinoline derivatives
Prior art date: 1998-07-15

Application number

EEP200100010A

Other languages

English (en)

Estonian (et)

Inventor

Bj�rk Anders

J�nsson Stig

Fex Tomas

Hedlund Gunnar

Original Assignee

Active Biotech Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-07-15

Filing date

1999-07-14

Publication date

2006-08-15

1999-07-14 Application filed by Active Biotech Ab filed Critical Active Biotech Ab

2002-06-17 Publication of EE200100010A publication Critical patent/EE200100010A/xx

2006-08-15 Publication of EE04673B1 publication Critical patent/EE04673B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Neurosurgery (AREA)
Diabetes (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Quinoline Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

EEP200100010A 1998-07-15 1999-07-14 Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid EE04673B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9802549A SE9802549D0 (sv)	1998-07-15	1998-07-15	Quinoline derivatives
PCT/SE1999/001270 WO2000003991A1 (en)	1998-07-15	1999-07-14	Quinoline derivatives

Publications (2)

Publication Number	Publication Date
EE200100010A EE200100010A (et)	2002-06-17
EE04673B1 true EE04673B1 (et)	2006-08-15

Family

ID=20412093

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100010A EE04673B1 (et)	1998-07-15	1999-07-14	Kinoliini derivaadid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad farmatseutilised kompositsioonid

Country Status (33)

Country	Link
EP (1)	EP1095021B1 (sv)
JP (1)	JP4045070B2 (sv)
KR (1)	KR100516382B1 (sv)
CN (1)	CN1157378C (sv)
AP (1)	AP1366A (sv)
AT (1)	ATE250036T1 (sv)
AU (1)	AU751103B2 (sv)
BR (1)	BR9912109B1 (sv)
CA (1)	CA2336968C (sv)
CZ (1)	CZ300229B6 (sv)
DE (1)	DE69911415T2 (sv)
DK (1)	DK1095021T3 (sv)
EE (1)	EE04673B1 (sv)
ES (1)	ES2205854T3 (sv)
HK (1)	HK1035715A1 (sv)
HR (1)	HRP20010039B1 (sv)
HU (1)	HU229427B1 (sv)
ID (1)	ID27423A (sv)
IL (2)	IL140346A0 (sv)
IS (1)	IS2208B (sv)
ME (1)	ME00374B (sv)
NO (1)	NO317601B1 (sv)
NZ (1)	NZ508923A (sv)
OA (1)	OA11906A (sv)
PL (1)	PL199783B1 (sv)
PT (1)	PT1095021E (sv)
RS (1)	RS50128B (sv)
RU (1)	RU2213733C2 (sv)
SE (1)	SE9802549D0 (sv)
TR (1)	TR200100087T2 (sv)
UA (1)	UA64791C2 (sv)
WO (1)	WO2000003991A1 (sv)
ZA (1)	ZA200007593B (sv)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE0002320D0 (sv) *	1999-10-25	2000-06-21	Active Biotech Ab	Malignant tumors
US6395750B1 (en) *	1999-10-25	2002-05-28	Active Biotech Ab	Drugs for the treatment of malignant tumors
AU2003242127A1 (en) *	2002-06-05	2003-12-22	Institute Of Medicinal Molecular Design, Inc.	Inhibitors against the activation of ap-1 and nfat
EA011707B1 (ru) *	2002-06-11	2009-04-28	Инститьют Оф Медисинал Молекьюлар Дизайн. Инк.	Лекарственное средство для лечения нейродегенеративных заболеваний
US8314124B2 (en)	2004-02-06	2012-11-20	Active Biotech Ab	Crystalline salts of quinoline compounds and methods for preparing them
SE0400235D0 (sv)	2004-02-06	2004-02-06	Active Biotech Ab	New composition containing quinoline compounds
SE0401578D0 (sv) *	2004-06-18	2004-06-18	Active Biotech Ab	Novel compounds
PT1937642E (pt)	2005-10-19	2014-11-25	Teva Pharma	Cristais de sódio de laquinimod, e processos para o fabrico dos mesmos
EP2035001B1 (en)	2006-06-12	2011-11-09	Teva Pharmaceutical Industries Limited	Stable laquinimod preparations
WO2008113006A1 (en) *	2007-03-14	2008-09-18	Xenon Pharmaceuticals Inc.	Methods of using quinolinone compounds in treating sodium channel-mediated diseases or conditions
US8178127B2 (en)	2007-12-20	2012-05-15	Teva Pharmaceuticals Industries, Ltd.	Stable laquinimod preparations
KR20160079147A (ko)	2008-09-03	2016-07-05	테바 파마슈티컬 인더스트리즈 리미티드	면역 기능을 지닌 ２―옥소―１,２―다이하이드로―퀴놀린 조절제
DE102010048788A1 (de)	2009-02-13	2011-05-19	Amw Gmbh	Transdermales System mit Immunmodulator
DE102009008851A1 (de)	2009-02-13	2010-08-19	Amw Gmbh	Transdermales System mit Immunmodulator
AU2010276748A1 (en)	2009-07-30	2012-03-15	Teva Pharmaceutical Industries Ltd.	Treatment of Crohn's disease with laquinimod
HUE029983T2 (en)	2009-08-10	2017-04-28	Teva Pharma	Treatment of BDNF-related diseases with laquinimod
DE102010026879A1 (de)	2010-02-11	2011-08-11	AMW GmbH, 83627	Transdermales System mit Immunmodulator
MX337614B (es)	2010-03-03	2016-03-10	Teva Pharma	Tratamiento de lupus nefritis usando laquinimod.
KR20130014523A (ko)	2010-03-03	2013-02-07	테바 파마슈티컬 인더스트리즈 리미티드	라퀴니모드 및 메토트렉세이트의 병용에 의한 류마티스 관절염의 치료
KR20130092558A (ko)	2010-07-09	2013-08-20	테바 파마슈티컬 인더스트리즈 리미티드	중수소화된 n-에틸-n-페닐-1,2-다이하이드로-4-하이드록시-5-클로로-1-메틸-2-옥소퀴놀린-3-카복스아마이드, 그의 염 및 용도
CN103189357B (zh) *	2010-08-27	2015-11-25	格吕伦塔尔有限公司	作为kcnq2/3调节剂的取代的2-氧代-和2-硫代-二氢喹啉-3-甲酰胺
BR112013007850A2 (pt)	2010-10-14	2016-06-07	Immunahr Ab	1,2-diidro-4-hidróxi-2-oxo-quinolina-3-carboxanilidas como ativadores de ahr
EP2537517A1 (en) *	2011-06-22	2012-12-26	Active Biotech AB	Deuterium-enriched 4-hydroxy-5-methoxy-n,1-dimethyl-2-oxo-n-[(4-trifluoro-methyl)phenyl]-1,2-dihydroquinoline-3-carboxamide
AU2012322706A1 (en)	2011-10-12	2014-05-22	Teva Pharmaceutical Industries Ltd.	Treatment of multiple sclerosis with combination of laquinimod and fingolimod
CN104093310A (zh)	2012-02-03	2014-10-08	泰华制药工业有限公司	拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
CN104114172A (zh)	2012-02-16	2014-10-22	泰华制药工业有限公司	N-乙基-n-苯基-1,2-二氢-4,5-二-羟基-1-甲基-2-氧代-3-喹啉甲酰胺、其制备和用途
TW201350467A (zh)	2012-05-08	2013-12-16	Teva Pharma	Ｎ－乙基－４－羥基－１－甲基－５－（甲基（２，３，４，５，６－五羥基己基）胺基）－２－側氧－ｎ－苯基－１，２－二氫喹啉－３－甲醯胺
TW201400117A (zh)	2012-06-05	2014-01-01	Teva Pharma	使用拉喹莫德治療眼發炎疾病
TW201410244A (zh)	2012-08-13	2014-03-16	Teva Pharma	用於治療ｇａｂａ媒介之疾病之拉喹莫德（ｌａｑｕｉｎｉｍｏｄ）
MX2015005632A (es)	2012-11-07	2016-02-05	Teva Pharma	Sales de amina de laquinimod.
JP5868839B2 (ja)	2012-12-27	2016-02-24	三菱重工業株式会社	チャー払出管
MX2015011627A (es)	2013-03-14	2016-05-16	Teva Pharma	Cristales de laquinimod sodico y proceso mejorado para la elaboracion de los mismos.
KR20170005434A (ko)	2014-04-29	2017-01-13	테바 파마슈티컬 인더스트리즈 리미티드	높은 장애 상태를 갖는 재발-완화형 다발성 경화증(rrms) 환자 치료용 라퀴니모드
CN105367492B (zh) *	2014-08-28	2018-07-03	杭州普晒医药科技有限公司	他喹莫德的晶型及其制备方法、其药物组合物和用途
EA030948B1 (ru)	2014-09-23	2018-10-31	Эктив Байотек Аб	Хинолинкарбоксамиды для применения в лечении множественной миеломы
PL3180005T3 (pl)	2014-11-19	2018-06-29	Active Biotech Ab	Chinolinokarboksyamidy do stosowania w leczeniu białaczki
EP3067062A1 (en)	2015-03-13	2016-09-14	Ipsen Pharma S.A.S.	Combination of tasquinimod or a pharmaceutically acceptable salt thereof and a pd1 and/or pdl1 inhibitor, for use as a medicament
WO2018105943A1 (ko) *	2016-12-07	2018-06-14	순천향대학교 산학협력단	폐섬유증 또는 천식의 치료 또는 완화용 약학 조성물
US20230085883A1 (en)	2020-03-03	2023-03-23	Active Biotech Ab	Tasquinimod or a pharmaceutically acceptable salt thereof for use in combination therapy
KR20230043916A (ko)	2020-07-23	2023-03-31	에라스무스 유니버시티 메디컬 센터 로테르담	골수증식성 신생물의 새로운 치료학적 표적으로서 s100 단백질
EP4277628A1 (en)	2021-01-18	2023-11-22	Active Biotech AB	Tasquinimod or a pharmaceutically acceptable salt thereof for use in the treatment of myelodysplastic syndrome
US20240285532A1 (en)	2021-05-25	2024-08-29	Active Biotech Ab	A plurality of tasquinimod particles and use thereof
KR20240029029A (ko)	2021-07-02	2024-03-05	액티브 바이오테크 에이비	타스퀴니모드를 함유한 약학적 제품 및 이러한 제품의 순도 평가 방법

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IE52670B1 (en) *	1981-03-03	1988-01-20	Leo Ab	Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation
GB9108547D0 (en) *	1991-04-22	1991-06-05	Fujisawa Pharmaceutical Co	Quinoline derivatives
SE469368B (sv) *	1991-10-09	1993-06-28	Kabi Pharmacia Ab	Ny anvaendning av linomide foer tillverkning av laekemedel foer behandling av multiple sclerosis (ms)
SE9201076L (sv) *	1992-04-06	1993-10-07	Shimon Slavin	Användningen av gamla läkemedel för behandling av diabetes
JPH07224040A (ja) *	1994-02-07	1995-08-22	Fujisawa Pharmaceut Co Ltd	キノリン誘導体
GB9404378D0 (en) *	1994-03-07	1994-04-20	Fujisawa Pharmaceutical Co	Quinoline derivatives
SE9400810D0 (sv) *	1994-03-10	1994-03-10	Pharmacia Ab	New use of Quinoline-3-carboxamide compounds
SE9400809D0 (sv) *	1994-03-10	1994-03-10	Pharmacia Ab	New use of quinoline-3-carboxamide compounds
GB2290786A (en) *	1994-06-30	1996-01-10	Fujisawa Pharmaceutical Co	Quinoline derivatives

1998
- 1998-07-15 SE SE9802549A patent/SE9802549D0/sv unknown
1999
- 1999-07-14 UA UA2000127299A patent/UA64791C2/uk unknown
- 1999-07-14 IL IL14034699A patent/IL140346A0/xx active IP Right Grant
- 1999-07-14 EE EEP200100010A patent/EE04673B1/xx unknown
- 1999-07-14 ES ES99933452T patent/ES2205854T3/es not_active Expired - Lifetime
- 1999-07-14 RU RU2001104342/04A patent/RU2213733C2/ru not_active IP Right Cessation
- 1999-07-14 HU HU0103224A patent/HU229427B1/hu not_active IP Right Cessation
- 1999-07-14 DK DK99933452T patent/DK1095021T3/da active
- 1999-07-14 OA OA00100011A patent/OA11906A/en unknown
- 1999-07-14 CA CA002336968A patent/CA2336968C/en not_active Expired - Fee Related
- 1999-07-14 JP JP2000560098A patent/JP4045070B2/ja not_active Expired - Fee Related
- 1999-07-14 ME MEP-2008-574A patent/ME00374B/me unknown
- 1999-07-14 AU AU49504/99A patent/AU751103B2/en not_active Ceased
- 1999-07-14 EP EP99933452A patent/EP1095021B1/en not_active Expired - Lifetime
- 1999-07-14 BR BRPI9912109-3A patent/BR9912109B1/pt not_active IP Right Cessation
- 1999-07-14 CZ CZ20010094A patent/CZ300229B6/cs not_active IP Right Cessation
- 1999-07-14 WO PCT/SE1999/001270 patent/WO2000003991A1/en not_active Application Discontinuation
- 1999-07-14 DE DE69911415T patent/DE69911415T2/de not_active Expired - Lifetime
- 1999-07-14 AP APAP/P/2001/002041A patent/AP1366A/en active
- 1999-07-14 PL PL345388A patent/PL199783B1/pl unknown
- 1999-07-14 ID IDW20010331A patent/ID27423A/id unknown
- 1999-07-14 AT AT99933452T patent/ATE250036T1/de active
- 1999-07-14 PT PT99933452T patent/PT1095021E/pt unknown
- 1999-07-14 KR KR10-2000-7014618A patent/KR100516382B1/ko not_active IP Right Cessation
- 1999-07-14 CN CNB998085987A patent/CN1157378C/zh not_active Expired - Fee Related
- 1999-07-14 RS YUP-15/01A patent/RS50128B/sr unknown
- 1999-07-14 TR TR2001/00087T patent/TR200100087T2/xx unknown
- 1999-07-14 NZ NZ508923A patent/NZ508923A/xx not_active IP Right Cessation
2000
- 2000-12-14 IL IL140346A patent/IL140346A/en not_active IP Right Cessation
- 2000-12-18 ZA ZA200007593A patent/ZA200007593B/xx unknown
- 2000-12-18 IS IS5775A patent/IS2208B/is unknown
2001
- 2001-01-12 HR HR20010039A patent/HRP20010039B1/xx not_active IP Right Cessation
- 2001-01-12 NO NO20010211A patent/NO317601B1/no not_active IP Right Cessation
- 2001-07-10 HK HK01104765A patent/HK1035715A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1157378C (zh)	2004-07-14
HU229427B1 (en)	2013-12-30
NO317601B1 (no)	2004-11-22
IS5775A (is)	2000-12-18
KR20010053115A (ko)	2001-06-25
KR100516382B1 (ko)	2005-09-26
WO2000003991A1 (en)	2000-01-27
HK1035715A1 (en)	2001-12-07
RU2213733C2 (ru)	2003-10-10
CA2336968C (en)	2005-08-30
BR9912109A (pt)	2001-05-02
JP2002520395A (ja)	2002-07-09
PT1095021E (pt)	2003-12-31
ZA200007593B (en)	2001-07-09
ID27423A (id)	2001-04-05
DK1095021T3 (da)	2003-11-24
IL140346A0 (en)	2002-02-10
EP1095021A1 (en)	2001-05-02
HRP20010039B1 (en)	2009-04-30
ES2205854T3 (es)	2004-05-01
EP1095021B1 (en)	2003-09-17
AP1366A (en)	2005-01-26
CZ300229B6 (cs)	2009-03-25
TR200100087T2 (tr)	2001-06-21
AU751103B2 (en)	2002-08-08
IL140346A (en)	2006-07-05
HUP0103224A2 (hu)	2002-01-28
PL345388A1 (en)	2001-12-17
CA2336968A1 (en)	2000-01-27
JP4045070B2 (ja)	2008-02-13
DE69911415D1 (de)	2003-10-23
SE9802549D0 (sv)	1998-07-15
PL199783B1 (pl)	2008-10-31
EE200100010A (et)	2002-06-17
RS50128B (sr)	2009-03-25
NO20010211L (no)	2001-03-15
NZ508923A (en)	2002-09-27
UA64791C2 (en)	2004-03-15
ATE250036T1 (de)	2003-10-15
BR9912109B1 (pt)	2012-08-21
IS2208B (is)	2007-02-15
CZ200194A3 (en)	2001-05-16
CN1309641A (zh)	2001-08-22
HRP20010039A2 (en)	2001-12-31
AP2001002041A0 (en)	2001-03-31
MEP57408A (en)	2011-05-10
OA11906A (en)	2006-04-10
AU4950499A (en)	2000-02-07
ME00374B (me)	2011-05-10
NO20010211D0 (no)	2001-01-12
DE69911415T2 (de)	2004-07-08
HUP0103224A3 (en)	2002-11-28
YU1501A (sh)	2003-10-31

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Date	Code	Title	Description
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231