EE04432B1 - Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid - Google Patents

Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid

Info

Publication number: EE04432B1
Authority: EE; Estonia
Prior art keywords: cyclin; cdk complexes; inhibit kinases; substituted indolinones; indolinones
Prior art date: 1998-04-15

Application number

EEP200000598A

Other languages

English (en)

Estonian (et)

Inventor

Heckel Armin

Walter Rainer

Grell Wolfgang

C. A. Van Meel Jacobus

Redemann Norbert

Original Assignee

Boehringer Ingelheim Pharma Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-15

Filing date

1999-04-10

Publication date

2005-02-15

1999-04-10 Application filed by Boehringer Ingelheim Pharma Kg filed Critical Boehringer Ingelheim Pharma Kg

2002-04-15 Publication of EE200000598A publication Critical patent/EE200000598A/xx

2005-02-15 Publication of EE04432B1 publication Critical patent/EE04432B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Virology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Hospice & Palliative Care (AREA)
AIDS & HIV (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

EEP200000598A 1998-04-15 1999-04-10 Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid EE04432B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19816624A DE19816624A1 (de)	1998-04-15	1998-04-15	Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1999/002436 WO1999052869A1 (de)	1998-04-15	1999-04-10	Substituierte indolinone mit inhibierender wirkung auf kinasen und cyclin/cdk-komplexe

Publications (2)

Publication Number	Publication Date
EE200000598A EE200000598A (et)	2002-04-15
EE04432B1 true EE04432B1 (et)	2005-02-15

Family

ID=7864562

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000598A EE04432B1 (et)	1998-04-15	1999-04-10	Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid

Country Status (31)

Country	Link
EP (1)	EP1071665B1 (xx)
JP (1)	JP4015365B2 (xx)
KR (1)	KR100588250B1 (xx)
CN (1)	CN100338036C (xx)
AR (1)	AR015763A1 (xx)
AT (1)	ATE251138T1 (xx)
AU (1)	AU749829B2 (xx)
BG (1)	BG64443B1 (xx)
BR (1)	BR9909688A (xx)
CA (1)	CA2323111C (xx)
CO (1)	CO5011040A1 (xx)
DE (2)	DE19816624A1 (xx)
DK (1)	DK1071665T3 (xx)
EA (1)	EA003532B1 (xx)
EE (1)	EE04432B1 (xx)
ES (1)	ES2207209T3 (xx)
HU (1)	HUP0101568A3 (xx)
ID (1)	ID26420A (xx)
IL (1)	IL138036A0 (xx)
MY (1)	MY122357A (xx)
NO (1)	NO317298B1 (xx)
NZ (1)	NZ507967A (xx)
PL (1)	PL343314A1 (xx)
PT (1)	PT1071665E (xx)
SK (1)	SK283824B6 (xx)
TR (1)	TR200002980T2 (xx)
TW (1)	TW510897B (xx)
UA (1)	UA63009C2 (xx)
WO (1)	WO1999052869A1 (xx)
YU (1)	YU59800A (xx)
ZA (1)	ZA200004623B (xx)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6569868B2 (en)	1998-04-16	2003-05-27	Sugen, Inc.	2-indolinone derivatives as modulators of protein kinase activity
GB9904932D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Composition and method for preventing/reducing the severity of side effects of chemotherapy and/or radiation therapy
GB9904995D0 (en) *	1999-03-04	1999-04-28	Glaxo Group Ltd	Substituted aza-oxindole derivatives
US6624171B1 (en)	1999-03-04	2003-09-23	Smithkline Beecham Corporation	Substituted aza-oxindole derivatives
GB9904933D0 (en)	1999-03-04	1999-04-28	Glaxo Group Ltd	Compounds
DE19924401A1 (de) *	1999-05-27	2000-11-30	Boehringer Ingelheim Pharma	Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
EP1212318B1 (de) *	1999-08-27	2006-01-25	Boehringer Ingelheim Pharma GmbH & Co.KG	Substituierte indolinone als tyrosinkinase inhibitoren
US6762180B1 (en)	1999-10-13	2004-07-13	Boehringer Ingelheim Pharma Kg	Substituted indolines which inhibit receptor tyrosine kinases
UA75054C2 (uk) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу
US6620818B1 (en)	2000-03-01	2003-09-16	Smithkline Beecham Corporation	Method for reducing the severity of side effects of chemotherapy and/or radiation therapy
TWI270545B (en)	2000-05-24	2007-01-11	Sugen Inc	Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
US6706709B2 (en)	2000-06-02	2004-03-16	Sugen, Inc.	Indolinone derivatives as protein kinase/phosphatase inhibitors
NZ525892A (en) *	2000-11-27	2004-11-26	Pharmacia Italia S	Phenylacetamido- pyrazole derivatives their use as antitumor agents and preparation process thereof
DE10117204A1 (de)	2001-04-06	2002-10-10	Boehringer Ingelheim Pharma	In 6-Stellung substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
US6599902B2 (en)	2001-05-30	2003-07-29	Sugen, Inc.	5-aralkysufonyl-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives as kinase inhibitors
DE60318188T2 (de)	2002-03-26	2008-12-11	Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield	Glucocorticoid-mimetika, deren herstellung, pharmazeutische zusammensetzungen und verwendung
US7169936B2 (en)	2002-07-23	2007-01-30	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Indolinone derivatives substituted in the 6-position, their preparation and their use as medicaments
DE10233500A1 (de) *	2002-07-24	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel
DE10237423A1 (de) *	2002-08-16	2004-02-19	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verwendung von LCK-Inhibitoren für die Behandlung von immunologischen Erkrankungen
JP4879492B2 (ja) *	2002-11-27	2012-02-22	アラーガン、インコーポレイテッド	疾患の治療のためのキナーゼ阻害剤
US20050043233A1 (en)	2003-04-29	2005-02-24	Boehringer Ingelheim International Gmbh	Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
UY28526A1 (es)	2003-09-24	2005-04-29	Boehringer Ingelheim Pharma	Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
EP1670789B1 (en) *	2003-10-03	2008-11-19	Boehringer Ingelheim Pharmaceuticals Inc.	Fluorescent probes for use in protein kinase inhibitor binding assay
DE102004012070A1 (de) *	2004-03-12	2005-09-29	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue cycloalkyl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel
US7795272B2 (en)	2004-03-13	2010-09-14	Boehringer Ingelheim Pharmaceutical, Inc.	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
PE20060776A1 (es)	2004-12-27	2006-09-26	Boehringer Ingelheim Pharma	Mimeticos de glucocorticoides, metodos para prepararlos y composiciones farmaceuticas
JP5519932B2 (ja) *	2005-06-10	2014-06-11	メルクパテントゲゼルシャフトミットベシュレンクテルハフツング	キナーゼ阻害剤としてのオキシインドール
WO2007057399A2 (en) *	2005-11-15	2007-05-24	Boehringer Ingelheim International Gmbh	Treatment of cancer with indole derivatives
MX2009005264A (es)	2006-12-06	2009-05-28	Boehringer Ingelheim Int	Mimeticos de glucocorticoides, metodos para su fabricacion, composiciones farmaceuticas y usos de los mismos.
CA2726449A1 (en)	2008-06-06	2009-12-10	Boehringer Ingelheim International Gmbh	Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US20170065529A1 (en)	2015-09-09	2017-03-09	Boehringer Ingelheim International Gmbh	Pharmaceutical dosage form for immediate release of an indolinone derivative
WO2011032320A1 (en) *	2009-09-21	2011-03-24	F. Hoffmann-La Roche Ag	Novel alkene oxindole derivatives
US9492430B2 (en) *	2011-11-14	2016-11-15	Ligand Pharmaceuticals, Incorporated	Methods and compositions associated with the granulocyte colony-stimulating factor receptor
WO2014150252A1 (en) *	2013-03-15	2014-09-25	Ligand Pharmaceuticals Incorporated	Methods of treatment associated with the granulocyte colony-stimulating factor receptor
CN107033064B (zh) *	2017-04-28	2019-07-09	西安医学院	一种3-(吗啉取代芳亚胺基)吲哚类化合物及其制备方法和应用
CN111285872B (zh) *	2018-12-06	2022-05-17	北京志健金瑞生物医药科技有限公司	吲哚-2-酮衍生物及其制备方法与用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9501567D0 (en) *	1995-01-26	1995-03-15	Pharmacia Spa	Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5880141A (en) *	1995-06-07	1999-03-09	Sugen, Inc.	Benzylidene-Z-indoline compounds for the treatment of disease
GB9718913D0 (en) *	1997-09-05	1997-11-12	Glaxo Group Ltd	Substituted oxindole derivatives
DE19824922A1 (de) *	1998-06-04	1999-12-09	Boehringer Ingelheim Pharma	Neue substituierte Indolinone, ihre Herstellung und ihre Verwendung als Arzneimittel
UA75054C2 (uk) *	1999-10-13	2006-03-15	Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг	Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу

1998
- 1998-04-15 DE DE19816624A patent/DE19816624A1/de not_active Withdrawn
1999
- 1999-04-10 PL PL99343314A patent/PL343314A1/xx not_active Application Discontinuation
- 1999-04-10 IL IL13803699A patent/IL138036A0/xx not_active IP Right Cessation
- 1999-04-10 JP JP2000543432A patent/JP4015365B2/ja not_active Expired - Lifetime
- 1999-04-10 ID IDW20002062A patent/ID26420A/id unknown
- 1999-04-10 AU AU38149/99A patent/AU749829B2/en not_active Ceased
- 1999-04-10 CA CA002323111A patent/CA2323111C/en not_active Expired - Fee Related
- 1999-04-10 SK SK1513-2000A patent/SK283824B6/sk unknown
- 1999-04-10 EA EA200001021A patent/EA003532B1/ru not_active IP Right Cessation
- 1999-04-10 EE EEP200000598A patent/EE04432B1/xx not_active IP Right Cessation
- 1999-04-10 NZ NZ507967A patent/NZ507967A/xx unknown
- 1999-04-10 AT AT99920635T patent/ATE251138T1/de active
- 1999-04-10 BR BR9909688-9A patent/BR9909688A/pt not_active Application Discontinuation
- 1999-04-10 DE DE59907199T patent/DE59907199D1/de not_active Expired - Lifetime
- 1999-04-10 DK DK99920635T patent/DK1071665T3/da active
- 1999-04-10 KR KR1020007011454A patent/KR100588250B1/ko not_active IP Right Cessation
- 1999-04-10 HU HU0101568A patent/HUP0101568A3/hu unknown
- 1999-04-10 TR TR2000/02980T patent/TR200002980T2/xx unknown
- 1999-04-10 PT PT99920635T patent/PT1071665E/pt unknown
- 1999-04-10 CN CNB998050296A patent/CN100338036C/zh not_active Expired - Fee Related
- 1999-04-10 EP EP99920635A patent/EP1071665B1/de not_active Expired - Lifetime
- 1999-04-10 ES ES99920635T patent/ES2207209T3/es not_active Expired - Lifetime
- 1999-04-10 YU YU59800A patent/YU59800A/sh unknown
- 1999-04-10 WO PCT/EP1999/002436 patent/WO1999052869A1/de active IP Right Grant
- 1999-04-13 MY MYPI99001427A patent/MY122357A/en unknown
- 1999-04-14 CO CO99022218A patent/CO5011040A1/es unknown
- 1999-04-14 AR ARP990101700A patent/AR015763A1/es active Pending
- 1999-04-14 TW TW088105963A patent/TW510897B/zh active
- 1999-10-04 UA UA2000116456A patent/UA63009C2/uk unknown
2000
- 2000-09-04 ZA ZA200004623A patent/ZA200004623B/xx unknown
- 2000-09-29 BG BG104813A patent/BG64443B1/bg active Active
- 2000-10-13 NO NO20005151A patent/NO317298B1/no unknown

Also Published As

Publication number	Publication date
YU59800A (sh)	2003-04-30
EP1071665B1 (de)	2003-10-01
ID26420A (id)	2000-12-21
TR200002980T2 (tr)	2001-02-21
TW510897B (en)	2002-11-21
ATE251138T1 (de)	2003-10-15
HUP0101568A2 (hu)	2001-09-28
AU749829B2 (en)	2002-07-04
DE19816624A1 (de)	1999-10-21
JP4015365B2 (ja)	2007-11-28
PT1071665E (pt)	2004-02-27
HUP0101568A3 (en)	2002-12-28
IL138036A0 (en)	2001-10-31
SK15132000A3 (sk)	2001-03-12
CA2323111C (en)	2009-09-15
CN100338036C (zh)	2007-09-19
DK1071665T3 (da)	2004-01-05
EP1071665A1 (de)	2001-01-31
EE200000598A (et)	2002-04-15
CO5011040A1 (es)	2001-02-28
ZA200004623B (en)	2001-05-30
AU3814999A (en)	1999-11-01
AR015763A1 (es)	2001-05-16
JP2002511449A (ja)	2002-04-16
MY122357A (en)	2006-04-29
SK283824B6 (sk)	2004-02-03
BG104813A (en)	2001-08-31
WO1999052869A1 (de)	1999-10-21
NO20005151D0 (no)	2000-10-13
BR9909688A (pt)	2000-12-19
UA63009C2 (en)	2004-01-15
NO317298B1 (no)	2004-10-04
DE59907199D1 (de)	2003-11-06
CN1297438A (zh)	2001-05-30
PL343314A1 (en)	2001-08-13
EA003532B1 (ru)	2003-06-26
CA2323111A1 (en)	1999-10-21
BG64443B1 (en)	2005-02-28
ES2207209T3 (es)	2004-05-16
KR100588250B1 (ko)	2006-06-13
NO20005151L (no)	2000-10-13
EA200001021A1 (ru)	2001-06-25
NZ507967A (en)	2003-04-29
KR20010042731A (ko)	2001-05-25

Publication	Publication Date	Title
EE200000598A (et)	2002-04-15	Kinaase ja tsükliin/CDK komplekse inhibeerivad asendatud indolinoonid
EE200000622A (et)	2002-02-15	Saatja-vastuvõtja GMSK ja offset-QAM jaoks
HUP0104973A3 (en)	2002-06-28	Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes, process for their use and medicaments containing them
PT904774E (pt)	2003-08-29	Derivados do resorcinol
DE69916691D1 (de)	2004-06-03	Herzschrittmacher
ID26130A (id)	2000-11-23	Penyempurnaan-penyempurnaan dalam alat pengantar obat
FI982525A0 (fi)	1998-11-23	Suojausjärjestely
NO20003154L (no)	2000-06-16	Stikkplugg
DE69906152D1 (de)	2003-04-24	4-alkenyl (und alkinyl)oxoindole als inhibitoren cyclinabhängiger kinasen, insbesondere cdk2
DE59810269D1 (de)	2004-01-08	Selbstkalibrierender ratenadaptiver Herzschrittmacher
EE200100347A (et)	2002-12-16	3,3-biarüülpiperidiini ja 2,2-biarüülmorfoliini derivaadid
NO20010200D0 (no)	2001-01-12	Organiske fosforforbindelser og deres anvendelse
DE69926591D1 (de)	2005-09-15	Fehlersicherer Defribrillator
FR2776660B1 (fr)	2000-05-12	Diazepino-indoles de phosphodiesterases iv
FR2774599B1 (fr)	2001-10-05	Cataplasme
ZA200102260B (en)	2004-04-19	Novel substituted indolinones with an inhibitory effect on various kinases and cyclin/cdk complexes.
ATA15398A (de)	2001-08-15	Verschlussdeckel
DE69920224D1 (de)	2004-10-21	Harnstoffderivate zur Schmerzbekämpfung
DE59911871D1 (de)	2005-05-12	Zweikammer-Herzschrittmacher
DE69803818D1 (de)	2002-03-21	Verbinderverriegelung
DE59813079D1 (de)	2006-02-09	Fräszahn zur Erdbearbeitung
DE59900924D1 (de)	2002-04-11	Selbstkalibrierender ratenadaptiver Herzschrittmacher
FI980566A (fi)	1999-09-14	Uusi täyteaine ja pigmentti
FI19992219A (fi)	2001-04-15	Yhdistetty difibrillaattori ja sydäntahdistin
EE200000179A (et)	2001-04-16	1-oxa, aza ja tianaftaleen-2-1 biseetrid fosfolambaani inhibiitoritena

Legal Events

Date	Code	Title	Description
2003-06-16	HC1A	Change of owner name
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2007-12-17	MM4A	Lapsed by not paying the annual fees	Effective date: 20070410