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EA201890311A1 - Полимерные соединения - иммуномодулирующие средства - Google Patents

Полимерные соединения - иммуномодулирующие средства

Info

Publication number
EA201890311A1
EA201890311A1 EA201890311A EA201890311A EA201890311A1 EA 201890311 A1 EA201890311 A1 EA 201890311A1 EA 201890311 A EA201890311 A EA 201890311A EA 201890311 A EA201890311 A EA 201890311A EA 201890311 A1 EA201890311 A1 EA 201890311A1
Authority
EA
Eurasian Patent Office
Prior art keywords
remedies
polymeric compounds
immune modulating
conjugates
carriers
Prior art date
Application number
EA201890311A
Other languages
English (en)
Inventor
Чарльз Зепп
Грэйсон Б. Липфорд
Юнь Гао
Ллойд Джонстон
Фынь-ни Фу
Марк Дж. Киган
Сэм Болдуин
Original Assignee
Селекта Байосайенсиз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Селекта Байосайенсиз, Инк. filed Critical Селекта Байосайенсиз, Инк.
Publication of EA201890311A1 publication Critical patent/EA201890311A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • C08G63/912—Polymers modified by chemical after-treatment derived from hydroxycarboxylic acids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

Данное изобретение относится к композициям, а также относится к соединениям и способам, из конъюгатов иммуномодулирующих средств и полимеров или его(их) элементарного звена(элементарных звеньев). Конъюгаты могут содержаться в синтетических наноносителях, и иммуномодулирующие средства могут высвобождаться из синтетических наноносителей зависимым от pH способом.
EA201890311A 2009-05-27 2010-05-26 Полимерные соединения - иммуномодулирующие средства EA201890311A1 (ru)

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EA201890311A EA201890311A1 (ru) 2009-05-27 2010-05-26 Полимерные соединения - иммуномодулирующие средства
EA201171478A EA028288B1 (ru) 2009-05-27 2010-05-26 Наноносители, имеющие компоненты с различными скоростями высвобождения
EA201171480A EA030246B1 (ru) 2009-05-27 2010-05-26 Полимерные соединения-иммуномодулирующие средства
EA201791383A EA201791383A1 (ru) 2009-05-27 2010-05-26 Наноносители, имеющие компоненты с различными скоростями высвобождения
EA201171479A EA022699B1 (ru) 2009-05-27 2010-05-26 НАЦЕЛЕННЫЕ СИНТЕТИЧЕСКИЕ НАНОНОСИТЕЛИ С pH-ЧУВСТВИТЕЛЬНЫМ ВЫСВОБОЖДЕНИЕМ ИММУНОМОДУЛИРУЮЩИХ СРЕДСТВ

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